Quantitative and selective assay of 5-methylindirubine, an inhibitor of cyclin-dependent kinases, in murine plasma using coupled liquid chromatography and electrospray tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 856, Issue 1-2, 2007, Pages 261-266

  Vainchtein, Liia D ^a   Rosing, Hilde ^a   Maier, Armin ^b   Fiebig, Heinz Herbert ^b   Schellens, Jan H M ^a,c   Beijnen, Jos H ^a,c  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b Ontcotest GmbH   (Germany)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

5 MI; Cyclin dependent kinases; Indirubin; Liquid chromatography; Tandem mass spectrometry

Indexed keywords

CYCLIN-DEPENDENT KINASES; INDIRUBIN; MURINE PLASMA; TANDEM MASS SPECTROMETRY;

AMMONIUM COMPOUNDS; ENZYME INHIBITION; ETHERS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHANOL;

BIOASSAY;

5 METHYLINDIRUBINE; AMMONIUM HYDROXIDE; CYCLIN DEPENDENT KINASE INHIBITOR; EDETIC ACID; ETHER; INDIRUBINE 3 MONOXIME; INDOLE DERIVATIVE; METHANOL; UNCLASSIFIED DRUG; WATER;

ACCURACY; ANALYTIC METHOD; ARTICLE; ASSAY; BLOOD SAMPLING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MOUSE; NEGATIVE ION ELECTROSPRAY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STANDARD; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLIN-DEPENDENT KINASES; INDOLES; MICE; PROTEIN KINASE INHIBITORS; REFERENCE STANDARDS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

MURINAE;

EID: 34548119801     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.06.006     Document Type: Article

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