Minocycline HCl microspheres reduce red-complex bacteria in periodontal disease therapy

Journal of Periodontology

Volumn 78, Issue 8, 2007, Pages 1568-1579

  Goodson, J Max ^a   Gunsolley, John C ^b   Grossi, Sara G ^c   Bland, Paul S ^d   Otomo Corgel, Joan ^e   Doherty, Frances ^f,g   Comiskey, Judy ^g  

^a FORSYTH INSTITUTE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c EAST CAROLINA UNIVERSITY   (United States)

^d UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^e UCLA SCHOOL OF DENTISTRY   (United States)

^f Oral Health Consultants   (United States)

^g OraPharma Inc   (United States)

Author keywords

Bacteria; Dental scaling; Drug delivery systems; Microbiology; Minocycline; Periodontitis

Indexed keywords

EID: 34548092080     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2007.060488     Document Type: Article

References (24)

1. Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in subgingival plaque. J Clin Periodontol 1998;25:134-144.
2. Socransky SS, Haffajee AD. Periodontal microbial ecology. Periodontol 2000 2005;38:135-187.
3. Holt SC, Ebersole JL. Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: The "red complex," a prototype polybacterial pathogenic consortium in periodontitis. Periodontol 2000 2005;38: 72-122.
4. Socransky SS, Haffajee AD, Smith C, et al. Use of checkerboard DNA-DNA hybridization to study complex microbial ecosystems. Oral Microbiol Immunol 2004;19:352-362.
5. Socransky SS, Smith C, Martin L, Paster BJ, Dewhirst FE, Levin AE. "Checkerboard" DNA-DNA hybridization. Biotechniques 1994;17:788-792.
6. Williams RC, Paquette DW, Offenbacher S, et al. Treatment of periodontitis by local administration of minocycline microspheres: A controlled trial. J Periodontol 2001;72:1535-1544.
7. Page RC. The microbiological case for adjunctive therapy for periodontitis. J Int Acad Periodontol 2004; 6(Suppl.):143-149.
8. Cortelli JR, Querido SM, Aquino DR, Ricardo LH, Pallos D. Longitudinal clinical evaluation of adjunct minocycline in the treatment of chronic periodontitis. J Periodontol 2006;77:161-166.
9. Hung HC, Douglass CW. Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss. J Clin Periodontol 2002;29:975-986.
10. Lessem J, Hanlon A. A post-marketing study of 2805 patients treated for periodontal disease with Arestin. J Int Acad Periodontol 2004;6(Suppl.):150-153.
11. Meinberg TA, Barnes CM, Dunning DG, Reinhardt RA. Comparison of conventional periodontal maintenance versus scaling and root planing with subgingival minocycline. J Periodontol 2002;73:167-172.
12. Niederman R, Abdelshehid G, Goodson JM. Periodontal therapy using local delivery of antimicrobial agents. Dent Clin North Am 2002;46:665-677.
13. Paquette DW, Hanlon A, Lessem J, Williams RC. Clinical relevance of adjunctive minocycline microspheres in patients with chronic periodontitis: Secondary analysis of a phase 3 trial. J Periodontol 2004;75:531-536.
14. Renvert S, Lessem J, Dahlen G, Lindahl C, Svensson M. Topical minocycline microspheres versus topical chlorhexidine gel as an adjunct to mechanical debridement of incipient peri-implant infections: A randomized clinical trial. J Clin Periodontol 2006;33: 362-369.
15. Skaleric U, Schara R, Medvescek M, Hanlon A, Doherty F, Lessem J. Periodontal treatment by Arestin and its effects on glycemic control in type 1 diabetes patients. J Int Acad Periodontol 2004;6(Suppl.):160-165.
16. Van Dyke TE, Offenbacher S, Braswell L, Lessem J. Enhancing the value of scaling and root-planing: Arestin clinical trial results. J Int Acad Periodontol 2002;4:72-76.
17. Faveri M, Gursky LC, Feres M, Shibli JA, Salvador SL, de Figueiredo LC. Scaling and root planing and chlorhexidine mouthrinses in the treatment of chronic periodontitis: A randomized, placebo-controlled clinical trial. J Clin Periodontol 2006;33:819-828.
18. Carvalho LH, D'Avila GB, Leao A, et al. Scaling and root planing, systemic metronidazole and professional plaque removal in the treatment of chronic periodontitis in a Brazilian population II - Microbiological results. J Clin Periodontol 2005;32:406-411.
19. Feres M, Haffajee AD, Allard K, Som S, Socransky SS. Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole. J Clin Periodontol 2001;28:597-609.
20. Teles RP, Haffajee AD, Socransky SS. Microbiological goals of periodontal therapy. Periodontol 2000 2006; 42:180-218.
21. Haffajee AD, Cugini MA, Dibart S, Smith C, Kent RL Jr., Socransky SS. The effect of SRP on the clinical and microbiological parameters of periodontal diseases. J Clin Periodontol 1997;24:324-334.
22. Haffajee AD, Teles RP, Socransky SS. The effect of periodontal therapy on the composition of the subgingival microbiota. Periodontol 2000 2006;42: 219-258.
23. Maiden MF, Tanner A, McArdle S, Najpauer K, Goodson JM. Tetracycline fiber therapy monitored by DNA probe and cultural methods. J Periodontal Res 1991;26:452-459.
24. Papapanou PN, Madianos PN, Dahlen G, Sandros J. "Checkerboard" versus culture: A comparison between two methods for identification of subgingival microbiota. Eur J Oral Sci 1997;105:389-396.