Clinical relevance of adjunctive minocycline microspheres in patients with chronic periodontitis: Secondary analysis of a phase 3 trial

Journal of Periodontology

Volumn 75, Issue 4, 2004, Pages 531-536

  Paquette, David W ^a   Hanlon, A ^b   Lessem, J ^b   Williams, R C ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b OraPharma Inc   (United States)

Author keywords

Minocycline therapeutic use; Periodontal probes; Periodontitis; Planing; Scaling; Therapy

Indexed keywords

MICROSPHERE; MINOCYCLINE; POLYGLACTIN;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DENTAL SURGERY; DISEASE SEVERITY; DRUG FORMULATION; DRUG RESPONSE; FEMALE; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MECHANICAL PROBE; MULTICENTER STUDY; PERIODONTITIS; RANDOMIZED CONTROLLED TRIAL; SMOKING;

ANTI-BACTERIAL AGENTS; CHRONIC DISEASE; DENTAL SCALING; FEMALE; HUMANS; LOGISTIC MODELS; MALE; MICROSPHERES; MIDDLE AGED; MINOCYCLINE; PERIODONTITIS; SMOKING; TREATMENT OUTCOME;

EID: 2442534893     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2004.75.4.531     Document Type: Article

References (16)

1. Friedland DJ, Go AS, Davoren JB, et al. Evidence-Based Medicine. A Framework for Clinical Practice. Stamford, CT: Appleton & Lange; 1998:1-8.
2. Koch GG, Paquette DW. Design principles and statistical considerations in periodontal clinical trials. Ann Periodontol 1997;2:42-63.
3. Greenstein G, Lamster I. Efficacy of periodontal therapy: statistical versus clinical significance [guest editorial]. J Periodontol 2000;71:657-666.
4. Killoy WJ. The clinical significance of local chemotherapies. J Clin Periodontol 2002;29(Suppl. 12):22-29.
5. Williams RC, Paquette DW, Offenbacher S, et al. Treatment of periodontitis by local administration of minocycline microspheres: A controlled trial. J Periodontol 2001; 72:1535-1544.
6. Garrett S, Johnson L, Drisko, CH, et al. Two multicenter studies evaluating locally delivered doxycycline hyclate, placebo control, oral hygiene, and scaling and root planing in the treatment of periodontitis. J Periodontol 1999;70:490-503.
7. Jeffcoat MK, Bray KS, Ciancio SG, et al. Adjunctive use of a subgingival controlled release chlorhexidine chip reduces probing depth and improves attachment level compared with scaling and root planing alone. J Periodontol 1998;69:989-997.
8. Greenstein G. The efficacy of minocycline microspheres in the treatment of chronic periodontitis: statistical vs. clinical significance. Compend Continuing Educ Dent 2003;24:121-133.
9. Paquette DW, Oringer R, Lessem J, et al. Locally delivered minocycline microspheres for the treatment of periodontitis in smokers. J Clin Periodontol 2003;30:787-794.
10. Tonetti MS. Cigarette smoking and periodontal diseases: Etiology and management of disease. Ann Periodontol 1999;3:88-101.
11. Haffajee AD, Socransky SS. Relationship of cigarette smoking to attachment level profiles. J Clin Periodontol 2001;28:283-295.
12. Grossi SG, Skrepcinski FB, Decaro T, Zambon JJ, Cummins D, Genco RJ. Response to periodontal therapy in diabetics and smokers. J Periodontol 1996;67: 1094-1102.
13. Preber H, Linder L, Bergström J. Periodontal healing and periopathogenic microflora in smokers and non-smokers. J Clin Periodontol 1995;22:946-952.
14. Lang NP, Joss A, Orsanic T, Gusberti FA, Siegrist BE. Bleeding on probing. A predictor for the progression of penodontal disease? J Clin Periodontol 1986;13:590-596.
15. Hujoel PP, Armitage GC, Garcia RI. A perspective on clinical significance [guest editorial]. J Periodontol 2000; 71:1515-1518.
16. Page RC, Armitage GC, DeRouen TA, et al. Design and Conduct of Clinical Trials of Products Designed for the Prevention, Diagnosis and Therapy of Periodontitis. Chicago: American Academy of Periodontology; 1995:43-44.