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Volumn 74, Issue 4, 2007, Pages 221-231

The sea urchin embryo, an invertebrate model for mammalian developmental neurotoxicity, reveals multiple neurotransmitter mechanisms for effects of chlorpyrifos: Therapeutic interventions and a comparison with the monoamine depleter, reserpine

Author keywords

Acetylcholine; Cannabinoids; Chlorpyrifos; Development; Dopamine; Neurotoxicity; Organophosphate pesticides; Reserpine; Sea urchin; Serotonin

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINE DERIVATIVE; CANNABINOID DERIVATIVE; CHLORPYRIFOS; DOPAMINE; MONOAMINE; NEUROTRANSMITTER; RESERPINE; SEROTONIN;

EID: 34548062394     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2007.06.012     Document Type: Article
Times cited : (30)

References (83)
  • 1
    • 19044372536 scopus 로고    scopus 로고
    • Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression
    • Aldridge J.E., Levin E.D., Seidler F.J., and Slotkin T.A. Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression. Environ. Health Perspect. 113 (2005) 527-531
    • (2005) Environ. Health Perspect. , vol.113 , pp. 527-531
    • Aldridge, J.E.1    Levin, E.D.2    Seidler, F.J.3    Slotkin, T.A.4
  • 2
    • 23844498721 scopus 로고    scopus 로고
    • Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure
    • Aldridge J.E., Meyer A., Seidler F.J., and Slotkin T.A. Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure. Environ. Health Perspect. 113 (2005) 1027-1031
    • (2005) Environ. Health Perspect. , vol.113 , pp. 1027-1031
    • Aldridge, J.E.1    Meyer, A.2    Seidler, F.J.3    Slotkin, T.A.4
  • 3
    • 0242539881 scopus 로고    scopus 로고
    • Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods
    • Aldridge J.E., Seidler F.J., Meyer A., Thillai I., and Slotkin T.A. Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods. Environ. Health Perspect. 111 (2003) 1736-1743
    • (2003) Environ. Health Perspect. , vol.111 , pp. 1736-1743
    • Aldridge, J.E.1    Seidler, F.J.2    Meyer, A.3    Thillai, I.4    Slotkin, T.A.5
  • 4
    • 1042303694 scopus 로고    scopus 로고
    • Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling
    • Aldridge J.E., Seidler F.J., and Slotkin T.A. Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. Environ. Health Perspect. 112 (2004) 148-155
    • (2004) Environ. Health Perspect. , vol.112 , pp. 148-155
    • Aldridge, J.E.1    Seidler, F.J.2    Slotkin, T.A.3
  • 5
    • 0034102319 scopus 로고    scopus 로고
    • Interactions between pesticides and glia: an unexplored experimental field
    • Aschner M. Interactions between pesticides and glia: an unexplored experimental field. Neurotoxicology 21 (2000) 175-180
    • (2000) Neurotoxicology , vol.21 , pp. 175-180
    • Aschner, M.1
  • 6
    • 0017750585 scopus 로고
    • Ornithine decarboxylase in developing rat heart and brain: role of sympathetic development for responses to autonomic stimulants and the effects of reserpine on maturation
    • Bartolome J., Lau C., and Slotkin T.A. Ornithine decarboxylase in developing rat heart and brain: role of sympathetic development for responses to autonomic stimulants and the effects of reserpine on maturation. J. Pharmacol. Exp. Ther. 202 (1977) 510-518
    • (1977) J. Pharmacol. Exp. Ther. , vol.202 , pp. 510-518
    • Bartolome, J.1    Lau, C.2    Slotkin, T.A.3
  • 7
    • 0035610106 scopus 로고    scopus 로고
    • Arachidonoylcholine and O-arachidonoyldimethylaminoethanol as new cholinergic substances
    • Bezuglov V.V., Zinchenko G.N., Nikitina L.A., and Buznikov G.A. Arachidonoylcholine and O-arachidonoyldimethylaminoethanol as new cholinergic substances. Russ. J. Bioorg. Chem. 207 (2001) 200-203
    • (2001) Russ. J. Bioorg. Chem. , vol.207 , pp. 200-203
    • Bezuglov, V.V.1    Zinchenko, G.N.2    Nikitina, L.A.3    Buznikov, G.A.4
  • 8
    • 0013971304 scopus 로고
    • The effect of reserpine on growth and catecholamine content of Tetrahymena
    • Blum J.J., Kirshner N., and Utley J. The effect of reserpine on growth and catecholamine content of Tetrahymena. Mol. Pharmacol. 2 (1966) 606-613
    • (1966) Mol. Pharmacol. , vol.2 , pp. 606-613
    • Blum, J.J.1    Kirshner, N.2    Utley, J.3
  • 9
    • 33845988586 scopus 로고    scopus 로고
    • Neurotoxicology and behavior
    • Bingham E., Cohrseen B., and Powell C.H. (Eds), John Wiley & Sons, New York
    • Boyes W.K. Neurotoxicology and behavior. In: Bingham E., Cohrseen B., and Powell C.H. (Eds). Patty's Toxicology. 5th ed. (2001), John Wiley & Sons, New York 55-121
    • (2001) Patty's Toxicology. 5th ed. , pp. 55-121
    • Boyes, W.K.1
  • 11
    • 33748895752 scopus 로고    scopus 로고
    • The mysterious trace amines: protean neuromodulators of synaptic transmission in mammalian brain
    • Burchett S.A., and Hicks T.P. The mysterious trace amines: protean neuromodulators of synaptic transmission in mammalian brain. Prog. Neurobiol. 79 (2006) 223-246
    • (2006) Prog. Neurobiol. , vol.79 , pp. 223-246
    • Burchett, S.A.1    Hicks, T.P.2
  • 12
    • 0003941677 scopus 로고
    • Sea urchin embryos as a test system to detect embryotoxicity of chemical compounds
    • Buznikov G.A. Sea urchin embryos as a test system to detect embryotoxicity of chemical compounds. Biol. Int. 8 (1983) 5-8
    • (1983) Biol. Int. , vol.8 , pp. 5-8
    • Buznikov, G.A.1
  • 14
    • 0034266265 scopus 로고    scopus 로고
    • 5-Hydroxytryptamides and 3-hydroxytyramides of polyenoic fatty acids as a tool for studying the pre-nervous biogenic monoamines functions
    • Buznikov G.A., and Bezuglov V.V. 5-Hydroxytryptamides and 3-hydroxytyramides of polyenoic fatty acids as a tool for studying the pre-nervous biogenic monoamines functions. Russ. Physiol. J. 86 (2000) 1093-1108
    • (2000) Russ. Physiol. J. , vol.86 , pp. 1093-1108
    • Buznikov, G.A.1    Bezuglov, V.V.2
  • 16
    • 0003944571 scopus 로고    scopus 로고
    • Sea urchin embryos and larvae as biosensors for screening and detailed study of pharmacologically active substances
    • Buznikov G.A., Jokanovic M., Kovacevic N., and Rakic L. Sea urchin embryos and larvae as biosensors for screening and detailed study of pharmacologically active substances. Arch. Toxicol. Kinet. Xenobiot. Metab. 5 (1997) 393-400
    • (1997) Arch. Toxicol. Kinet. Xenobiot. Metab. , vol.5 , pp. 393-400
    • Buznikov, G.A.1    Jokanovic, M.2    Kovacevic, N.3    Rakic, L.4
  • 17
    • 0014804376 scopus 로고
    • The role of neurohumours in early embryogenesis. 3. Pharmacological analysis of the role of neurohumours in cleavage divisions
    • Buznikov G.A., Kost A.N., Kucherova N.F., Mndzhoyan A.L., Suvorov N.N., and Berdysheva L.V. The role of neurohumours in early embryogenesis. 3. Pharmacological analysis of the role of neurohumours in cleavage divisions. J. Embryol. Exp. Morphol. 23 (1970) 549-569
    • (1970) J. Embryol. Exp. Morphol. , vol.23 , pp. 549-569
    • Buznikov, G.A.1    Kost, A.N.2    Kucherova, N.F.3    Mndzhoyan, A.L.4    Suvorov, N.N.5    Berdysheva, L.V.6
  • 19
    • 0034858544 scopus 로고    scopus 로고
    • An invertebrate model of the developmental neurotoxicity of insecticides: effects of chlorpyrifos and dieldrin in sea urchin embryos and larvae
    • Buznikov G.A., Nikitina L.A., Bezuglov V.V., Lauder J.M., Padilla S., and Slotkin T.A. An invertebrate model of the developmental neurotoxicity of insecticides: effects of chlorpyrifos and dieldrin in sea urchin embryos and larvae. Environ. Health Perspect. 109 (2001) 651-661
    • (2001) Environ. Health Perspect. , vol.109 , pp. 651-661
    • Buznikov, G.A.1    Nikitina, L.A.2    Bezuglov, V.V.3    Lauder, J.M.4    Padilla, S.5    Slotkin, T.A.6
  • 20
    • 0041035139 scopus 로고
    • The sea urchins Strongylocentrotus droebachiensis, S. nudus and S. intermedius
    • Dettlaff T.A., and Vassetzky S.G. (Eds), Invertebrates, Consultants Bureau, New York/London
    • Buznikov G.A., and Podmarev V.I. The sea urchins Strongylocentrotus droebachiensis, S. nudus and S. intermedius. In: Dettlaff T.A., and Vassetzky S.G. (Eds). Animal Species for Developmental Studies vol. 1 (1990), Invertebrates, Consultants Bureau, New York/London 251-283
    • (1990) Animal Species for Developmental Studies , vol.1 , pp. 251-283
    • Buznikov, G.A.1    Podmarev, V.I.2
  • 21
    • 0034128189 scopus 로고    scopus 로고
    • Cholinoreceptors of early (pre-nervous) sea urchin embryos
    • Buznikov G.A., and Rakic L. Cholinoreceptors of early (pre-nervous) sea urchin embryos. Neurosci. Behav. Physiol. 30 (2000) 53-62
    • (2000) Neurosci. Behav. Physiol. , vol.30 , pp. 53-62
    • Buznikov, G.A.1    Rakic, L.2
  • 22
    • 0029860131 scopus 로고    scopus 로고
    • From oocyte to neuron: do neurotransmitters function in the same way throughout development?
    • Buznikov G.A., Shmukler Y.B., and Lauder J.M. From oocyte to neuron: do neurotransmitters function in the same way throughout development?. Cell Mol. Neurobiol. 16 (1996) 532-559
    • (1996) Cell Mol. Neurobiol. , vol.16 , pp. 532-559
    • Buznikov, G.A.1    Shmukler, Y.B.2    Lauder, J.M.3
  • 23
    • 84872136000 scopus 로고    scopus 로고
    • Sea urchin embryos and larvae as biosensors for neurotoxins
    • Maines M.D., Costa L.G., Hodgson E., and Reed D.J. (Eds), John Wiley & Sons, New York
    • Buznikov G.A., Slotkin T.A., and Lauder J.M. Sea urchin embryos and larvae as biosensors for neurotoxins. In: Maines M.D., Costa L.G., Hodgson E., and Reed D.J. (Eds). Current Protocols in Toxicology (2003), John Wiley & Sons, New York 1.6.1-11.6.
    • (2003) Current Protocols in Toxicology
    • Buznikov, G.A.1    Slotkin, T.A.2    Lauder, J.M.3
  • 24
    • 4243148518 scopus 로고    scopus 로고
    • Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets
    • Casida J.E., and Quistad G.B. Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets. Chem. Res. Toxicol. 17 (2004) 983-998
    • (2004) Chem. Res. Toxicol. , vol.17 , pp. 983-998
    • Casida, J.E.1    Quistad, G.B.2
  • 25
    • 0015677223 scopus 로고
    • Decreased synthesis of DNA in regenerating rat liver after the administration of reserpine
    • Cihak A., and Vaptzarova K. Decreased synthesis of DNA in regenerating rat liver after the administration of reserpine. Br. J. Pharmacol. 49 (1973) 253-257
    • (1973) Br. J. Pharmacol. , vol.49 , pp. 253-257
    • Cihak, A.1    Vaptzarova, K.2
  • 26
    • 0034177780 scopus 로고    scopus 로고
    • Testing methods for developmental neurotoxicity of environmental chemicals
    • Claudio L., Kwa W.C., Russell A.L., and Wallinga D. Testing methods for developmental neurotoxicity of environmental chemicals. Toxicol. Appl. Pharmacol. 164 (2000) 1-14
    • (2000) Toxicol. Appl. Pharmacol. , vol.164 , pp. 1-14
    • Claudio, L.1    Kwa, W.C.2    Russell, A.L.3    Wallinga, D.4
  • 27
    • 30344433298 scopus 로고    scopus 로고
    • A case for revisiting the safety of pesticides: a closer look at neurodevelopment
    • Colborn T. A case for revisiting the safety of pesticides: a closer look at neurodevelopment. Environ. Health Perspect. 114 (2006) 10-17
    • (2006) Environ. Health Perspect. , vol.114 , pp. 10-17
    • Colborn, T.1
  • 28
    • 0031859987 scopus 로고    scopus 로고
    • Neurotoxicity testing: a discussion of in vitro alternatives
    • Costa L.G. Neurotoxicity testing: a discussion of in vitro alternatives. Environ. Health Perspect. 106 Suppl. 2 (1998) 505-510
    • (1998) Environ. Health Perspect. , vol.106 , Issue.SUPPL. 2 , pp. 505-510
    • Costa, L.G.1
  • 29
    • 33644664469 scopus 로고    scopus 로고
    • Current issues in organophosphate toxicology
    • Costa L.G. Current issues in organophosphate toxicology. Clin. Chim. Acta 366 (2006) 1-13
    • (2006) Clin. Chim. Acta , vol.366 , pp. 1-13
    • Costa, L.G.1
  • 30
    • 0032804284 scopus 로고    scopus 로고
    • Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways
    • Dam K., Garcia S.J., Seidler F.J., and Slotkin T.A. Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways. Dev. Brain Res. 116 (1999) 9-20
    • (1999) Dev. Brain Res. , vol.116 , pp. 9-20
    • Dam, K.1    Garcia, S.J.2    Seidler, F.J.3    Slotkin, T.A.4
  • 31
    • 0033433986 scopus 로고    scopus 로고
    • Chlorpyrifos releases norepinephrine from adult and neonatal rat brain synaptosomes
    • Dam K., Seidler F.J., and Slotkin T.A. Chlorpyrifos releases norepinephrine from adult and neonatal rat brain synaptosomes. Dev. Brain Res. 118 (1999) 120-133
    • (1999) Dev. Brain Res. , vol.118 , pp. 120-133
    • Dam, K.1    Seidler, F.J.2    Slotkin, T.A.3
  • 32
    • 0030964557 scopus 로고    scopus 로고
    • Developmental neurotoxicity of environmental agents in the neonate
    • Eriksson P. Developmental neurotoxicity of environmental agents in the neonate. Neurotoxicology 18 (1997) 719-726
    • (1997) Neurotoxicology , vol.18 , pp. 719-726
    • Eriksson, P.1
  • 33
    • 0028300476 scopus 로고
    • Neuropathology of organophosphate-induced delayed neuropathy (OPIDN) in young chicks
    • Funk K.A., Henderson J.D., Liu C.H., Higgins R.J., and Wilson B.W. Neuropathology of organophosphate-induced delayed neuropathy (OPIDN) in young chicks. Arch. Toxicol. 68 (1994) 308-316
    • (1994) Arch. Toxicol. , vol.68 , pp. 308-316
    • Funk, K.A.1    Henderson, J.D.2    Liu, C.H.3    Higgins, R.J.4    Wilson, B.W.5
  • 34
    • 0035830772 scopus 로고    scopus 로고
    • Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells
    • Garcia S.J., Seidler F.J., Crumpton T.L., and Slotkin T.A. Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells. Brain Res. 891 (2001) 54-68
    • (2001) Brain Res. , vol.891 , pp. 54-68
    • Garcia, S.J.1    Seidler, F.J.2    Crumpton, T.L.3    Slotkin, T.A.4
  • 35
    • 17044426781 scopus 로고    scopus 로고
    • Developmental neurotoxicity of chlorpyrifos: targeting glial cells
    • Garcia S.J., Seidler F.J., and Slotkin T.A. Developmental neurotoxicity of chlorpyrifos: targeting glial cells. Environ. Toxicol. Pharmacol. 19 (2005) 455-461
    • (2005) Environ. Toxicol. Pharmacol. , vol.19 , pp. 455-461
    • Garcia, S.J.1    Seidler, F.J.2    Slotkin, T.A.3
  • 36
    • 26844554963 scopus 로고    scopus 로고
    • Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation
    • Guizzetti M., Pathak S., Giordano G., and Costa L.G. Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation. Toxicology 215 (2005) 182-190
    • (2005) Toxicology , vol.215 , pp. 182-190
    • Guizzetti, M.1    Pathak, S.2    Giordano, G.3    Costa, L.G.4
  • 37
    • 0014843683 scopus 로고
    • On the role of serotonin and acetylcholine in sea urchin morphogenesis
    • Gustafson T., and Toneby M. On the role of serotonin and acetylcholine in sea urchin morphogenesis. Exp. Cell Res. 62 (1970) 102-117
    • (1970) Exp. Cell Res. , vol.62 , pp. 102-117
    • Gustafson, T.1    Toneby, M.2
  • 38
    • 84982026234 scopus 로고
    • The sea urchin egg as a testing object in toxicology
    • Hagstrom B.E., and Lonning S. The sea urchin egg as a testing object in toxicology. Acta Pharmacol. Toxicol. 32 (1973) 1-39
    • (1973) Acta Pharmacol. Toxicol. , vol.32 , pp. 1-39
    • Hagstrom, B.E.1    Lonning, S.2
  • 39
    • 33646361039 scopus 로고    scopus 로고
    • Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells
    • Jameson R.R., Seidler F.J., Qiao D., and Slotkin T.A. Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells. Environ. Health Perspect. 114 (2006) 667-672
    • (2006) Environ. Health Perspect. , vol.114 , pp. 667-672
    • Jameson, R.R.1    Seidler, F.J.2    Qiao, D.3    Slotkin, T.A.4
  • 40
    • 0018854254 scopus 로고
    • Combination antitumor effect with central nervous system depressants on rat ascites hepatomas
    • Koshiura R., Miyamoto K., and Sanae F. Combination antitumor effect with central nervous system depressants on rat ascites hepatomas. Gann 71 (1980) 45-51
    • (1980) Gann , vol.71 , pp. 45-51
    • Koshiura, R.1    Miyamoto, K.2    Sanae, F.3
  • 41
    • 0028307229 scopus 로고
    • Environmental neurotoxic illness: research for prevention
    • Landrigan P.J., Graham D.G., and Thomas R.D. Environmental neurotoxic illness: research for prevention. Environ. Health Perspect. 102 Suppl. 2 (1994) 117-120
    • (1994) Environ. Health Perspect. , vol.102 , Issue.SUPPL. 2 , pp. 117-120
    • Landrigan, P.J.1    Graham, D.G.2    Thomas, R.D.3
  • 42
    • 0017709719 scopus 로고
    • Critical period for effects of prenatal reserpine administration on development of rat brain and adrenal medulla
    • Lau C., Bartolomé J., Seidler F.J., and Slotkin T.A. Critical period for effects of prenatal reserpine administration on development of rat brain and adrenal medulla. Neuropharmacology 16 (1977) 799-809
    • (1977) Neuropharmacology , vol.16 , pp. 799-809
    • Lau, C.1    Bartolomé, J.2    Seidler, F.J.3    Slotkin, T.A.4
  • 43
    • 0017653710 scopus 로고
    • Effect of reserpine on cell proliferation in the developing rat brain: a quantitative histological study
    • Lewis P.D., Patel A.J., Béndek G., and Balázs R. Effect of reserpine on cell proliferation in the developing rat brain: a quantitative histological study. Brain Res. 129 (1977) 299-308
    • (1977) Brain Res. , vol.129 , pp. 299-308
    • Lewis, P.D.1    Patel, A.J.2    Béndek, G.3    Balázs, R.4
  • 45
    • 0032502754 scopus 로고    scopus 로고
    • Comparative presynaptic neurochemical changes in rat striatum following exposure to chlorpyrifos or parathion
    • Liu J., and Pope C.N. Comparative presynaptic neurochemical changes in rat striatum following exposure to chlorpyrifos or parathion. J. Toxicol. Environ. Health 53 (1998) 531-544
    • (1998) J. Toxicol. Environ. Health , vol.53 , pp. 531-544
    • Liu, J.1    Pope, C.N.2
  • 46
    • 33846017875 scopus 로고    scopus 로고
    • Regulatory considerations in developmental neurotoxicity of organophosphorus and carbamate pesticides
    • Gupta R.C. (Ed), Elsevier Academic Press, San Diego
    • Makris S. Regulatory considerations in developmental neurotoxicity of organophosphorus and carbamate pesticides. In: Gupta R.C. (Ed). Toxicity of Organophosphate and Carbamate Pesticides (2006), Elsevier Academic Press, San Diego 633-641
    • (2006) Toxicity of Organophosphate and Carbamate Pesticides , pp. 633-641
    • Makris, S.1
  • 47
    • 0034659286 scopus 로고    scopus 로고
    • Maturation-dependent effects of chlorpyrifos and parathion and their oxygen analogs on acetylcholinesterase and neuronal and glial markers in aggregating brain cell cultures
    • Monnet-Tschudi F., Zurich M.G., Schilter B., Costa L.G., and Honegger P. Maturation-dependent effects of chlorpyrifos and parathion and their oxygen analogs on acetylcholinesterase and neuronal and glial markers in aggregating brain cell cultures. Toxicol. Appl. Pharmacol. 165 (2000) 175-183
    • (2000) Toxicol. Appl. Pharmacol. , vol.165 , pp. 175-183
    • Monnet-Tschudi, F.1    Zurich, M.G.2    Schilter, B.3    Costa, L.G.4    Honegger, P.5
  • 48
    • 33748754631 scopus 로고    scopus 로고
    • Modulation of paraoxon toxicity by the cannabinoid receptor agonist WIN 55,212-2
    • Nallapaneni A., Liu J., Karanth S., and Pope C. Modulation of paraoxon toxicity by the cannabinoid receptor agonist WIN 55,212-2. Toxicology 227 (2006) 173-183
    • (2006) Toxicology , vol.227 , pp. 173-183
    • Nallapaneni, A.1    Liu, J.2    Karanth, S.3    Pope, C.4
  • 49
    • 0018373568 scopus 로고
    • Effect of reserpine on cell proliferation and energy stores in the developing rat brain
    • Patel A.J., Bailey P., and Balázs R. Effect of reserpine on cell proliferation and energy stores in the developing rat brain. Neuroscience 4 (1979) 139-143
    • (1979) Neuroscience , vol.4 , pp. 139-143
    • Patel, A.J.1    Bailey, P.2    Balázs, R.3
  • 50
    • 0037290117 scopus 로고    scopus 로고
    • Biological targets of neurotoxic pesticides analysed by alteration of developmental events in the Mediterranean sea urchin Paracentrotus lividus
    • Pesando D., Huitorel P., Dolcini V., Angelini C., Guidetti P., and Falugi C. Biological targets of neurotoxic pesticides analysed by alteration of developmental events in the Mediterranean sea urchin Paracentrotus lividus. Mar. Environ. Res. 55 (2003) 39-57
    • (2003) Mar. Environ. Res. , vol.55 , pp. 39-57
    • Pesando, D.1    Huitorel, P.2    Dolcini, V.3    Angelini, C.4    Guidetti, P.5    Falugi, C.6
  • 51
    • 0033369584 scopus 로고    scopus 로고
    • Organophosphorus pesticides: do they all have the same mechanism of toxicity?
    • Pope C.N. Organophosphorus pesticides: do they all have the same mechanism of toxicity?. J. Toxicol. Environ. Health 2 (1999) 161-181
    • (1999) J. Toxicol. Environ. Health , vol.2 , pp. 161-181
    • Pope, C.N.1
  • 52
    • 0242456229 scopus 로고    scopus 로고
    • The sea urchin embryo as a model for mammalian developmental neurotoxicity: ontogenesis of the high-affinity choline transporter and its role in cholinergic trophic activity
    • Qiao D., Nikitina L.A., Buznikov G.A., Lauder J.M., Seidler F.J., and Slotkin T.A. The sea urchin embryo as a model for mammalian developmental neurotoxicity: ontogenesis of the high-affinity choline transporter and its role in cholinergic trophic activity. Environ. Health Perspect. 111 (2003) 1730-1735
    • (2003) Environ. Health Perspect. , vol.111 , pp. 1730-1735
    • Qiao, D.1    Nikitina, L.A.2    Buznikov, G.A.3    Lauder, J.M.4    Seidler, F.J.5    Slotkin, T.A.6
  • 53
    • 0034775369 scopus 로고    scopus 로고
    • Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells
    • Qiao D., Seidler F.J., and Slotkin T.A. Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells. Environ. Health Perspect. 109 (2001) 909-913
    • (2001) Environ. Health Perspect. , vol.109 , pp. 909-913
    • Qiao, D.1    Seidler, F.J.2    Slotkin, T.A.3
  • 54
    • 20444404601 scopus 로고    scopus 로고
    • Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos
    • Qiao D., Seidler F.J., and Slotkin T.A. Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos. Toxicol. Appl. Pharmacol. 206 (2005) 17-26
    • (2005) Toxicol. Appl. Pharmacol. , vol.206 , pp. 17-26
    • Qiao, D.1    Seidler, F.J.2    Slotkin, T.A.3
  • 55
    • 1642493774 scopus 로고    scopus 로고
    • Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos
    • Qiao D., Seidler F.J., Violin J.D., and Slotkin T.A. Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos. Dev. Brain Res. 147 (2003) 183-190
    • (2003) Dev. Brain Res. , vol.147 , pp. 183-190
    • Qiao, D.1    Seidler, F.J.2    Violin, J.D.3    Slotkin, T.A.4
  • 56
    • 0035940296 scopus 로고    scopus 로고
    • Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos
    • Raines K.W., Seidler F.J., and Slotkin T.A. Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifos. Dev. Brain Res. 130 (2001) 65-72
    • (2001) Dev. Brain Res. , vol.130 , pp. 65-72
    • Raines, K.W.1    Seidler, F.J.2    Slotkin, T.A.3
  • 57
    • 0031687635 scopus 로고    scopus 로고
    • Chlorpyrifos elicits mitotic abnormalities and apoptosis in neuroepithelium of cultured rat embryos
    • Roy T.S., Andrews J.E., Seidler F.J., and Slotkin T.A. Chlorpyrifos elicits mitotic abnormalities and apoptosis in neuroepithelium of cultured rat embryos. Teratology 58 (1998) 62-68
    • (1998) Teratology , vol.58 , pp. 62-68
    • Roy, T.S.1    Andrews, J.E.2    Seidler, F.J.3    Slotkin, T.A.4
  • 58
    • 5444226431 scopus 로고    scopus 로고
    • Environmental genomics: a key to understanding biology, pathophysiology and disease
    • Schwartz D.A., Freedman J.H., and Linney E.A. Environmental genomics: a key to understanding biology, pathophysiology and disease. Hum. Mol. Gen. 13 (2004) R217-R224
    • (2004) Hum. Mol. Gen. , vol.13
    • Schwartz, D.A.1    Freedman, J.H.2    Linney, E.A.3
  • 59
    • 0032421206 scopus 로고    scopus 로고
    • Functional coupling of neurotransmitters with second messengers during cleavage divisions: facts and hypotheses
    • Shmukier Y.B., and Buznikov G.A. Functional coupling of neurotransmitters with second messengers during cleavage divisions: facts and hypotheses. Perspect. Dev. Neurobiol. 5 (1998) 469-483
    • (1998) Perspect. Dev. Neurobiol. , vol.5 , pp. 469-483
    • Shmukier, Y.B.1    Buznikov, G.A.2
  • 60
    • 0027365880 scopus 로고
    • Possibility of membrane reception of neurotransmitter in sea urchin early embryos
    • Shmukler Y.B. Possibility of membrane reception of neurotransmitter in sea urchin early embryos. Comp. Biochem. Physiol. C 106 (1993) 269-273
    • (1993) Comp. Biochem. Physiol. C , vol.106 , pp. 269-273
    • Shmukler, Y.B.1
  • 61
    • 84908729473 scopus 로고
    • Reserpine
    • Simpson L.L., and Curtis D.R. (Eds), Plenum, New York
    • Slotkin T.A. Reserpine. In: Simpson L.L., and Curtis D.R. (Eds). Neuropoisons (1974), Plenum, New York 1-60
    • (1974) Neuropoisons , pp. 1-60
    • Slotkin, T.A.1
  • 62
    • 0032908419 scopus 로고    scopus 로고
    • Developmental cholinotoxicants: nicotine and chlorpyrifos
    • Slotkin T.A. Developmental cholinotoxicants: nicotine and chlorpyrifos. Environ. Health Perspect. 107 Suppl. 1 (1999) 71-80
    • (1999) Environ. Health Perspect. , vol.107 , Issue.SUPPL. 1 , pp. 71-80
    • Slotkin, T.A.1
  • 63
    • 0842342126 scopus 로고    scopus 로고
    • Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates
    • Slotkin T.A. Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. Toxicol. Appl. Pharmacol. 198 (2004) 132-151
    • (2004) Toxicol. Appl. Pharmacol. , vol.198 , pp. 132-151
    • Slotkin, T.A.1
  • 64
    • 2942514529 scopus 로고    scopus 로고
    • Guidelines for developmental neurotoxicity and their impact on organophosphate pesticides: a personal view from an academic perspective
    • Slotkin T.A. Guidelines for developmental neurotoxicity and their impact on organophosphate pesticides: a personal view from an academic perspective. NeuroToxicology 25 (2004) 631-640
    • (2004) NeuroToxicology , vol.25 , pp. 631-640
    • Slotkin, T.A.1
  • 65
    • 80855125087 scopus 로고    scopus 로고
    • Developmental neurotoxicity of organophosphates: a case study of chlorpyrifos
    • Gupta R.C. (Ed), Elsevier Academic Press, San Diego
    • Slotkin T.A. Developmental neurotoxicity of organophosphates: a case study of chlorpyrifos. In: Gupta R.C. (Ed). Toxicity of Organophosphate and Carbamate Pesticides (2005), Elsevier Academic Press, San Diego 293-314
    • (2005) Toxicity of Organophosphate and Carbamate Pesticides , pp. 293-314
    • Slotkin, T.A.1
  • 66
    • 33646356457 scopus 로고    scopus 로고
    • Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity
    • Slotkin T.A., Levin E.D., and Seidler F.J. Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicity. Environ. Health Perspect. 114 (2006) 746-751
    • (2006) Environ. Health Perspect. , vol.114 , pp. 746-751
    • Slotkin, T.A.1    Levin, E.D.2    Seidler, F.J.3
  • 67
    • 33845982947 scopus 로고    scopus 로고
    • Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine and divalent nickel
    • Slotkin T.A., MacKillop E.A., Ryde I.T., Tate C.A., and Seidler F.J. Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine and divalent nickel. Environ. Health Perspect. 115 (2007) 93-101
    • (2007) Environ. Health Perspect. , vol.115 , pp. 93-101
    • Slotkin, T.A.1    MacKillop, E.A.2    Ryde, I.T.3    Tate, C.A.4    Seidler, F.J.5
  • 68
    • 23644433656 scopus 로고    scopus 로고
    • The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent
    • Slotkin T.A., and Seidler F.J. The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanent. Dev. Brain Res. 158 (2005) 115-119
    • (2005) Dev. Brain Res. , vol.158 , pp. 115-119
    • Slotkin, T.A.1    Seidler, F.J.2
  • 69
    • 34247154767 scopus 로고    scopus 로고
    • Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems
    • Slotkin T.A., and Seidler F.J. Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systems. Brain Res. Bull. 72 (2007) 232-274
    • (2007) Brain Res. Bull. , vol.72 , pp. 232-274
    • Slotkin, T.A.1    Seidler, F.J.2
  • 70
    • 34247116566 scopus 로고    scopus 로고
    • Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects
    • Slotkin T.A., and Seidler F.J. Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effects. Reprod. Toxicol. 23 (2007) 421-427
    • (2007) Reprod. Toxicol. , vol.23 , pp. 421-427
    • Slotkin, T.A.1    Seidler, F.J.2
  • 71
    • 34250163568 scopus 로고    scopus 로고
    • Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily
    • Slotkin T.A., Seidler F.J., and Fumagalli F. Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily. Environ. Health Perspect. 115 (2007) 909-916
    • (2007) Environ. Health Perspect. , vol.115 , pp. 909-916
    • Slotkin, T.A.1    Seidler, F.J.2    Fumagalli, F.3
  • 72
    • 0037186808 scopus 로고    scopus 로고
    • Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure
    • Slotkin T.A., Tate C.A., Cousins M.M., and Seidler F.J. Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposure. Dev. Brain Res. 133 (2002) 163-173
    • (2002) Dev. Brain Res. , vol.133 , pp. 163-173
    • Slotkin, T.A.1    Tate, C.A.2    Cousins, M.M.3    Seidler, F.J.4
  • 73
    • 33749428870 scopus 로고    scopus 로고
    • Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition
    • Slotkin T.A., Tate C.A., Ryde I.T., Levin E.D., and Seidler F.J. Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition. Environ. Health Perspect. 114 (2006) 1542-1546
    • (2006) Environ. Health Perspect. , vol.114 , pp. 1542-1546
    • Slotkin, T.A.1    Tate, C.A.2    Ryde, I.T.3    Levin, E.D.4    Seidler, F.J.5
  • 74
    • 0021073314 scopus 로고
    • Effects of extended periods of reserpine and α-methyl-p-tyrosine treatment on the development of the putamen in fetal rabbits
    • Tennyson V.M., Gershon P., Budininkas-Schoenbeck M., and Rothman T.P. Effects of extended periods of reserpine and α-methyl-p-tyrosine treatment on the development of the putamen in fetal rabbits. Int. J. Dev. Neurosci. 1 (1983) 305-318
    • (1983) Int. J. Dev. Neurosci. , vol.1 , pp. 305-318
    • Tennyson, V.M.1    Gershon, P.2    Budininkas-Schoenbeck, M.3    Rothman, T.P.4
  • 75
    • 0028802370 scopus 로고
    • The concern for developmental neurotoxicology: is it justified and what is being done about it?
    • Tilson H.A. The concern for developmental neurotoxicology: is it justified and what is being done about it?. Environ. Health Perspect. 103 Suppl. 6 (1995) 147-151
    • (1995) Environ. Health Perspect. , vol.103 , Issue.SUPPL. 6 , pp. 147-151
    • Tilson, H.A.1
  • 76
    • 0034050778 scopus 로고    scopus 로고
    • Neurotoxicology risk assessment guidelines: developmental neurotoxicology
    • Tilson H.A. Neurotoxicology risk assessment guidelines: developmental neurotoxicology. Neurotoxicology 21 (2000) 189-194
    • (2000) Neurotoxicology , vol.21 , pp. 189-194
    • Tilson, H.A.1
  • 77
    • 0024470369 scopus 로고
    • Release and metabolism of dopamine in a clonal line of pheochromocytoma (PC12) cells exposed to fenthion
    • Tuler S.M., Hazen A.A., and Bowen J.M. Release and metabolism of dopamine in a clonal line of pheochromocytoma (PC12) cells exposed to fenthion. Fundam. Appl. Toxicol. 13 (1989) 484-492
    • (1989) Fundam. Appl. Toxicol. , vol.13 , pp. 484-492
    • Tuler, S.M.1    Hazen, A.A.2    Bowen, J.M.3
  • 78
    • 34548092605 scopus 로고    scopus 로고
    • U.S. Environmental Protection Agency, Opportunities to Improve Data Quality and Children's Health Through the Food Quality Protection Act. Report no. 2006-P-00009, 2006: Available: http://www.epa.gov/oig/reports/2006/20060110-2006-P-00009.pdf (accessed July 7, 2006).
  • 79
    • 0035107370 scopus 로고    scopus 로고
    • Age-related effects of chlorpyrifos on acetylcholine release in rat brain
    • Won Y.K., Liu J., Olivier K., Zheng Q., and Pope C.N. Age-related effects of chlorpyrifos on acetylcholine release in rat brain. Neurotoxicology 22 (2001) 39-48
    • (2001) Neurotoxicology , vol.22 , pp. 39-48
    • Won, Y.K.1    Liu, J.2    Olivier, K.3    Zheng, Q.4    Pope, C.N.5
  • 80
    • 10444247394 scopus 로고    scopus 로고
    • Convergent effects on cell signaling mechanisms mediate the actions of different neurobehavioral teratogens: alterations in cholinergic regulation of PKC in chick and avian models
    • Yanai J., Beer A., Huleihel R., Izrael M., Katz S., Levi Y., Rozenboim I., Yaniv S.P., and Slotkin T.A. Convergent effects on cell signaling mechanisms mediate the actions of different neurobehavioral teratogens: alterations in cholinergic regulation of PKC in chick and avian models. Ann. NY Acad. Sci. 1025 (2004) 595-601
    • (2004) Ann. NY Acad. Sci. , vol.1025 , pp. 595-601
    • Yanai, J.1    Beer, A.2    Huleihel, R.3    Izrael, M.4    Katz, S.5    Levi, Y.6    Rozenboim, I.7    Yaniv, S.P.8    Slotkin, T.A.9
  • 81
    • 0036295541 scopus 로고    scopus 로고
    • Cell signaling as a target and underlying mechanism for neurobehavioral teratogenesis
    • Yanai J., Vatury O., and Slotkin T.A. Cell signaling as a target and underlying mechanism for neurobehavioral teratogenesis. Ann. NY Acad. Sci. 965 (2002) 473-478
    • (2002) Ann. NY Acad. Sci. , vol.965 , pp. 473-478
    • Yanai, J.1    Vatury, O.2    Slotkin, T.A.3
  • 82
    • 0033804109 scopus 로고    scopus 로고
    • Use of aggregating brain cell cultures to study developmental effects of organophosphorus insecticides
    • Zurich M.G., Honegger P., Schilter B., Costa L.G., and Monnet-Tschudi F. Use of aggregating brain cell cultures to study developmental effects of organophosphorus insecticides. Neurotoxicology 21 (2000) 599-605
    • (2000) Neurotoxicology , vol.21 , pp. 599-605
    • Zurich, M.G.1    Honegger, P.2    Schilter, B.3    Costa, L.G.4    Monnet-Tschudi, F.5


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