Exercise-induced liver β2-microglobulin expression is related to lower IgG clearance in the blood

Brain, Behavior, and Immunity

Volumn 21, Issue 7, 2007, Pages 946-952

  Suzuki, Koutarou ^a   Suk, Park Jun ^a   Hong, Chunlan ^a   Imaizumi, Satoru ^a   Tagami, Kazumi ^b  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

2 Microglobulin; Circulating IgG; Liver; Mouse; Voluntary wheel running exercise

Indexed keywords

ANTIBODY; BETA 2 MICROGLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G I 125; RADIOLIGAND; TETANUS TOXOID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG HALF LIFE; EXERCISE; GENE EXPRESSION; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; ISOTOPE LABELING; LIVER; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RADIOACTIVITY; TREADMILL; UPREGULATION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BETA 2-MICROGLOBULIN; GENE EXPRESSION; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; IODINE RADIOISOTOPES; LIVER; MALE; MICE; MICE, INBRED C57BL; PHYSICAL CONDITIONING, ANIMAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 34548039721     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2007.03.012     Document Type: Article

References (19)

1. Bogers W.M., Stad R.K., Janssen D.J., van Rooijen N., van Es L.A., and Daha M.R. Kupffer cell depletion in vivo results in preferential elimination of IgG aggregates and immune complexes via specific Fc receptors on rat liver endothelial cells. Clin. Exp. Immunol. 86 2 (1991) 323-328
2. Borvak J., Richardson J., Medesan C., Antohe F., Radu C., Simionescu M., Ghetie V., and Ward E.S. Functional expression of the MHC class I-related receptor, FcRn, in endothelial cells of mice. Int. Immunol. 10 9 (1998) 1289-1298
3. Cannon J.G., and Kluger M.J. Exercise enhances survival rate in mice infected with Salmonella typhimurium. Proc. Soc. Exp. Biol. Med. 175 4 (1984) 518-521
4. Christianson G.J., Brooks W., Vekasi S., Manolfi E.A., Niles J., Roopenian S.L., Roths J.B., Rothlein R., and Roopenian D.C. Beta 2-microglobulin-deficient mice are protected from hyper gammaglobulinemia and have defective antibody responses because of increased IgG catabolism. J. Immunol. 159 10 (1997) 4781-4792
5. Douglass J.H. The effects of physical tracing on the immunological response in mice. J. Sports Med. Phys. Fitness 14 1 (1974) 48-54
6. Elphick G.F., Wieseler-Frank J., Greenwood B.N., Campisi J., and Fleshner M. B-1 cell (CD5+/CD11b+) numbers and nIgM levels are elevated in physically active vs. sedentary rats. J. Appl. Physiol. 95 1 (2003) 199-206
7. Ghetie V., Hubbard J.G., Kim J.K., Tsen M.F., Lee Y., and Ward E.S. Abnormally short serum half-lifes of IgG in beta 2-microglobulin-deficient mice. Eur. J. Immunol. 26 3 (1996) 690-696
8. Ghetie V., and Ward E.S. Multiple roles for the major histocompatibility complex class I- related receptor FcRn. Annu. Rev. Immunol. 18 (2000) 739-766
9. Junghans R.P., and Waldmann T.A. Metabolism of Tac (IL2Ralpha): physiology of cell surface shedding and renal catabolism, and suppression of catabolism by antibody binding. J. Exp. Med. 183 4 (1996) 1587-1602
10. Junghans R.P. Finally! The Brambell receptor (FcRB). Mediator of transmission of immunity and protection from catabolism for IgG. Immunol. Res. 16 1 (1997) 29-57
11. Kapasi Z.F., Catlin P.A., Beck J., Roehling T., and Smith K. The role of endogenous opioids in moderate exercise training-induced enhancement of the secondary antibody response in mice. Phys. Ther. 81 11 (2001) 1801-1809
12. Kaufman J.C., Harris T.J., Higgins J., and Maisel A.S. Exercise-induced enhancement of immune function in the rat. Circulation 90 (1994) 525-532
13. Kohut M.L., Arntson B.A., Lee W., Rozeboom K., Yoon K.J., Cunnick J.E., and McElhaney J. Moderate exercise improves antibody response to influenza immunization in older adults. Vaccine 22 17-18 (2004) 2298-2306
14. Liu Y.G., and Wang S.Y. The enhancing effect of exercise on the production of antibody to Salmonella typhi in mice. Immunol. Lett. 14 2 (1987) 117-120
15. Lowder T., Padgett D.A., and Woods J.A. Moderate exercise protects mice from death due to influenza virus. Brain Behav. Immun. 19 5 (2005) 377-380
16. Sharkey R.M., Natale A., Goldenberg D.M., and Mattes M.J. Rapid blood clearance of immunoglobulin G2a and immunoglobulin G2b in nude mice. Cancer Res. 51 12 (1991) 3102-3107
17. Schuler P.B., LeBlanc P.A., and Westerfield C.R. The effect of moderate physical activity on the production of antibody in response to bovine serum albumin in rats. Med. Exerc. Nutr. Health 4 (1995) 363-368
18. Suzuki K., and Tagami K. Voluntary wheel running exercise enhances antigen specific antibody producing splenic B cell response and prolongs IgG half-life in the blood. Eur. J. Appl. Physiol. 94 (2005) 514-519
19. Telleman P., and Junghans R.P. The role of the Brambell receptor (FcRB) in liver: protection of endocytosed immunoglobulin G (IgG) from catabolism in hepatocytes rather than transport of IgG to bile. Immunology 100 2 (2000) 245-251