Single nucleotide polymorphism in the promoter region of human alpha-fetoprotein (AFP) gene and its significance in hepatocellular carcinoma (HCC)

European Journal of Surgical Oncology

Volumn 33, Issue 7, 2007, Pages 882-886

  Chen, G G ^a   Ho, R L K ^a   Wong, J ^a   Lee, K F ^a   Lai, P B S ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Alpha fetoprotein; Hepatocellular carcinoma; Polymorphism; Promoter

Indexed keywords

ALPHA FETOPROTEIN; DNA; TRANSCRIPTION FACTOR;

ADULT; AGED; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; GENE LOCATION; GENETIC ASSOCIATION; GENOTYPE; HIGH RISK PATIENT; HUMAN; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR GROWTH;

ADULT; AGED; ALPHA-FETOPROTEINS; CARCINOMA, HEPATOCELLULAR; DNA, NEOPLASM; FEMALE; GENOTYPE; HUMANS; IMMUNOENZYME TECHNIQUES; LIVER NEOPLASMS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; PROMOTER REGIONS (GENETICS); TUMOR MARKERS, BIOLOGICAL;

EID: 34548036689     PISSN: 07487983     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejso.2007.02.036     Document Type: Article

References (20)

1. Gillespie J.R., and Uversky V.N. Structure and function of alpha-fetoprotein: a biophysical overview. Biochim Biophys Acta 1480 (2000) 41-56
2. Farinati F., Marino D., De Giorgio M., et al. Diagnostic and prognostic role of alpha-fetoprotein in hepatocellular carcinoma: both or neither?. Am J Gastroenterol 101 (2006) 524-532
3. Johnson P.J. The role of serum alpha-fetoprotein estimation in the diagnosis and management of hepatocellular carcinoma. Clin Liver Dis 5 (2001) 145-159
4. Nakabayashi H., Taketa K., Yamane T., et al. Hormonal control of α-fetoprotein secretion in human hepatoma cell lines proliferating in chemically defined medium. Cancer Res 45 (1985) 6379-6383
5. Nakabayashi H., Hashimoto T., Miyao Y., et al. A position-dependent silencer plays a major role in repressing alpha-fetoprotein expression in human hepatoma. Mol Cell Biol 11 (1991) 5885-5893
6. Sawadaishi K., Morinaga T., and Tamaoki T. Interaction of a hepatoma-specific nuclear factor with transcription-regulatory sequences of the human alpha-fetoprotein and albumin genes. Mol Cell Biol 8 (1988) 5179-5187
7. Igarashi K., Aoyagi Y., Ohkoshi S., et al. Sequence analysis of the proximal promoter region of the human alpha-fetoprotein gene in hepatocellular carcinoma. Cancer Lett 76 (1994) 93-99
8. Chen G.G., Li M.Y., Ho R.L., et al. Identification of hepatitis B virus X gene mutation in Hong Kong patients with hepatocellular carcinoma. J Clin Virol 34 (2005) 7-12
9. Hoogendoorn B., Coleman S.L., Guy C.A., et al. Functional analysis of human promoter polymorphisms. Hum Mol Genet 12 (2003) 2249-2254
10. Chen H., Dong J.M., Liu Y., et al. Identification of a cis-acting element in the rat alpha-fetoprotein gene and its specific binding proteins in F9 cells during retinoic acid-induced differentiation. J Cell Biochem 72 (1999) 25-34
11. Spear B.T. Alpha-fetoprotein gene regulation: lessons from transgenic mice. Semin Cancer Biol 9 (1999) 109-116
12. Long L., Davidson J.N., and Spear B.T. Striking differences between the mouse and the human alpha-fetoprotein enhancers. Genomics 83 (2004) 694-705
13. Vacher J., and Tilghman S.M. Dominant negative regulation of the mouse alpha-fetoprotein gene in adult liver. Science 250 (1990) 1732-1735
14. Nagata-Tsubouchi Y., Ido A., Uto H., et al. Molecular mechanisms of hereditary persistence of a-fetoprotein (AFP) in two Japanese families. A hepatocyte nuclear factor-1 site mutation leads to induction of the AFP gene expression in adult livers. Hepatol Res 31 (2005) 79-87
15. Wan Y.-J.Y., Cai Y., and Cowan C. Hepatocyte nuclear factor 1 mediates the cell density associated induction of the alpha-fetoprotein gene. Hepatology Research 16 (2000) 195-210
16. White R.J. RNA polymerase III transcription and cancer. Oncogene 23 (2004) 3208-3216
17. White R.J. RNA polymerases I and III, growth control and cancer. Nat Rev Mol Cell Biol 6 (2005) 69-78
18. Tang R.B., Wang H.Y., Lu H.Y., et al. Increased level of polymerase III transcribed Alu RNA in hepatocellular carcinoma tissue. Mol Carcinog 42 (2005) 93-96
19. Um S.H., Mulhall C., Alisa A., et al. Alpha-fetoprotein impairs APC function and induces their apoptosis. J Immunol 173 (2004) 1772-1778
20. Li M., Liu X., Zhou S., et al. Effects of alpha fetoprotein on escape of Bel 7402 cells from attack of lymphocytes. BMC Cancer 5 (2005) 96