Molecular mechanisms of hereditary persistence of α-fetoprotein (AFP) in two Japanese families. A hepatocyte nuclear factor-1 site mutation leads to induction of the AFP gene expression in adult livers

Hepatology Research

Volumn 31, Issue 2, 2005, Pages 79-87

  Nagata Tsubouchi, Yoshiko ^a,b   Ido, Akio ^b   Uto, Hirofumi ^a   Numata, Masatsugu ^a,b   Moriuchi, Akihiro ^b   Kim, Ildeok ^b   Hasuike, Satoru ^a   Nagata, Kenji ^a   Sekiya, Toru ^a   Hayashi, Katsuhiro ^a   Tsubouchi, Hirohito ^a,b  

^a UNIVERSITY OF MIYAZAKI   (Japan)

^b KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Fetoprotein; Hepatocyte nuclear factor 1; Hereditary persistence of AFP; Hydrodynamic based gene transfer; Nuclear factor I; Transcription

Indexed keywords

ALPHA FETOPROTEIN; NUCLEAR FACTOR I;

ADULT; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME REPRESSION; GENE EXPRESSION REGULATION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HEPATOMA CELL; HEREDITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; JAPAN; LIVER; LIVER DEVELOPMENT; MALE; MOUSE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PEDIGREE ANALYSIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; TRANSCRIPTION REGULATION; WILD TYPE;

EID: 20144382857     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hepres.2004.12.002     Document Type: Article

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