Epsilon-polylysine microparticle adjuvant drives cytokine production to Th1 profile

Journal of Veterinary Medical Science

Volumn 69, Issue 7, 2007, Pages 717-723

  Wakamoto, Hiroaki ^a,b   Matsuda, Hiroshi ^c   Kawamoto, Keiko ^d   Makino, Sou Ichi ^d  

^a GIFU UNIVERSITY   (Japan)

^b CHISSO CORPORATION   (Japan)

^c TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^d OBIHIRO UNIVERSITY OF AGRICULTURE AND VETERINARY MEDICINE   (Japan)

Author keywords

Adjuvant; Cytokines; Epsilon polylysine; Hydrophobize; Micro particles

Indexed keywords

CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN DERIVATIVE; OVALBUMIN; POLYETHYLENEIMINE; POLYLYSINE;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; DRUG EFFECT; FEMALE; IMMUNIZATION; IMMUNOLOGY; MOUSE; SPLEEN; TH1 CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CYTOKINES; FEMALE; IMMUNIZATION; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERFERON TYPE II; INTERLEUKINS; MICE; MICE, INBRED BALB C; OVALBUMIN; POLYETHYLENEIMINE; POLYLYSINE; SPLEEN; TH1 CELLS;

MUS;

EID: 34548009140     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.69.717     Document Type: Article

References (25)

1. Amlie-Lefond, C., Paz, D.A., Connelly, M.P., Huffnagle, G.B., Whelan, N.T. and Whelan, H.T. 2005. Innate immunity for biodefense: a strategy whose time has come. J. Allergy Clin. Immunol. 116: 1334-1342.
2. Brunel, F., Darbouret, A. and Ronco, J. 1999. Cationic lipid DC-Chol induces an improved and balanced immunity able to overcome the unresponsiveness to the hepatitis B Vaccine. Vaccine 17: 2192-2203.
3. Cher, D.J. and Mosmann, T.R. 1987. Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones. J. Immunol. 138: 3688-3694.
4. Coffman, R.L., Seymour, B.W., Lebman D.A., Hiraki, D.D., Christiansen, J.A., Shrader, B., Cherwinski, H.M., Savelkoul, H.F., Finkelman, F.D. and Bond, M.W. 1988. The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol. Rev. 102: 5-28.
5. Cooper, P.D.1994. The selective induction of different immune responses by vaccine adjuvants. pp. 125-158. In: Strategies in Vaccine Design (Ada, G.L., ed.) R. G. Landes Co., Texas. U.S.A.
6. Cox, J.C., and Coulter, A.R. 1997.Adjuvants-a classification and review of their modes of action. Vaccine 15: 248-256.
7. Dziarski, R. 1985. Comparison of in vitro and in vivo mitogenic and polyclonal antibody and autoantibody responses to peptidoglycan, LPS, proteinA, PWM, PHA and ConA in normal and autoimmune mice. J. Clin. Lab. Immunol. 16: 93-109.
8. Eric, B.L., Martin, J.E., Regina,S. and Rui,A. 1997. Adjuvant modulation of immune responses to tuberculosis subunit vaccines. Infect. Immunity. 65: 623-629.
9. Futami, J. and Yamada, H. 2004. Protein Transduction using Cationic Polymers. pp. 20-27 In: Bio Industry (Kakei T. and Hatsuda T. eds.), CMC, Tokyo(in Japanese).
10. Geissler, M., Tokushige, K., Chante, C.C., Zurawski, V.R.Jr. and Wands, J.R. 1997.Cellular and humoral immune response to hepatitis B virus structural proteins in mice after DNA-based immunization. Gastroenterology 112: 1307-1320.
11. Grun, J.L. and Maurer, P.H. 1989 Different T helper cell subsets elicited in mice utilizing two different adjuvant vehicles: the role of endogenous interleukin 1 in proliferative responses. Cell Immunol. 121: 134-145.
12. Igietseme, J.U., Eko, F.O., He, Q. and Black, C.M. 2004.Antibody regulation of T cell immunity: implications for vaccine strategies against intracellular pathogens. Expert. Rev. Vaccines. 3: 23-34.
13. Ikegawa, T., Yamasaki, Y., Shakushiro, K., Nishikawa, M.and Takakura, Y. 2004. Induction of cytotoxic T lymphocytes following immunization with cationized soluble antigen. Vaccine 22: 2609-2616.
14. LEE, D-Y., CHOI, I-S., HAN, J-H. and YOO, H-S. 2002. Chitosan and D-Glucosamine Induce Expression of Th1 Cytokine Genes in Porcine Spleen Cells. J. Vet. Med. Sci. 64: 645-648.
15. Matsuhashi, T. 1986. pp. 4-5. In: Zoku-seikagakujikkenkouza. 5. Menekiseikagakukenkyuhou.8 (Nihonseikagakukai,ed) Tokyokagakudohjin co., Tokyo (in Japanese).
16. Monamaris, M.B., Antonio, C-N., Paul, S., Keneth, H.G., Philip, J.M., Yasir, A.W.S. and Steven, G.R. 2001. Potent Stimulation of the Innate Immune System by a Leishmania brasiliensis Recombinant Protein. Infect. Immunity. 69: 5270-5277.
17. Oscherwitz, J., Hankenson, F.C., Yu, F. and Cease, K.B. 2006. Low-dose intraperitoneal Freund's adjuvant: toxicity and immunogenicity in mice using an immunogen targeting amyloid-beta peptide. Vaccine 24: 3018-3025.
18. Petra, L., Walter, S., Raphaela, K., Michael, B., Stephan, N.W., Georg, S.and Achim, S. 2002. Induction of Specific Immune Responses by Polycation-Based Vaccines. J. Immunol. 169: 5217-5226.
19. Przetak, M., Chow, J., Cheng, H., Rose, J., Haekins, L.D. and Ishizka, S.T. 2003. Novel Synthetic LPS Receptor Agonist Boost Systemic and Mucosal Antibody Responses in Mice. Vaccine 21: 961-97.
20. Stavnezer, J. 1996 Immunoglobulin class switching. Curr. Opin. Immunol. 8: 199-205.
21. Toth, L.A., Dunlap, A.W., Olson, G.A. and Hessler, J.R. 1989. An evaluation of distress following intraperitoneal immunization with Freund's adjuvant in mice. Lab. Anim. Sci. 39: 122-126.
22. Trinchieri, G. and Gerosa, F. 1996. Immunoregulation by interleukin-12. J. Leukoc. Biol. 59: 505-511.
23. Worm, M., Krah, J.M., Manz, R.A. and Henz, B.M. 1998. Retinoic acid inhibits CD40 + interleukin-4-mediated IgE production in vitro. Blood 92: 1713-1720.
24. Xu, L. and Rothmann, P. 1994. IFN-gamma represses epsilon germline transcription and subsequently down-regulates switch recombination to epsilon. Int. Immunol. 6: 515-521.
25. Yoshida, T. and Nagasawa, T. 2003. Epsilon-poly-L-lysine: microbial production, biodegradation and application potential. Appl. Microbiol. Biotechnol. 62: 21-26.