Effect and structure-activity study of nine kinds of anthraquinone derivatives on recombinant human protein kinase CK2 holoenzyme

Chinese Pharmacological Bulletin

Volumn 23, Issue 6, 2007, Pages 733-737

  Lin, Xiao Cong ^a   Li, Chun Mei ^b   Liu, Xin Guang ^a   Chen, Xiao Wen ^c   Liang, Nian Ci ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

^b GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

^c SHENZHEN CHILDREN'S HOSPITAL   (China)

Author keywords

Anthraquinone derivatives; IC50; Protein kinase CK2; Structure activity relationship

Indexed keywords

1,2 DIAMINOANTHRAQUINONE; ADENOSINE TRIPHOSPHATE; ANTHRAQUINONE 2 CARBOXYLIC ACID; ANTHRAQUINONE DERIVATIVE; CASEIN KINASE II; DANTRON; MITOXANTRONE; QUINIZARIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVITY; IC 50; IN VITRO STUDY; NONHUMAN;

EID: 34547959700     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Liu Z J, Liu X G, Liang N C. The role of protein kinase CK2 in cell cycle control [J]. Chin Pharmacol Bull, 2006,22(11):1281-5.
2. Huang G H, Liu X G, Liang N C. Investigate progression of protein kinase CK2[J]. Chem Life, 2003,23(3):169-71.
3. Xu X, Landesman-Bollag E, Channavajhala P L, et al. Murine protein kinase CK2:gene and oncogene[J]. Mol Cell Biochem, 1999,191(1-2):65-74.
4. Landesman-Bollag E, Song D H, Romieu-Mourez R, et al. Protein kinase CK2: signaling and tumorigenesis in the mammary gland [J]. Mol Cell Biochem, 2001,227(1-2):153-65.
5. Li C M, Liu X G, Liang N C. Protein kinase CK2 and the life cycle of HIV-1 [J]. Clin Biochem Lab Med Fore Med Sci, 2002,23(4):208-11.
6. Samo S, Mora S, Meggio F, et al. Toward the rational design of protein kinase casein kinase-2 inhibitors [J]. Pharmacol Ther, 2002,93:159-68.
7. Wan S H, Xu Q T, Pu X H, et al. Action of hydroxyanthroquinones from Rheum Palmatum L on jaundice model of rat induced by ANIT [J]. Chin Pharmacol Bull, 2006,22(10):1271-4.
8. 4 [J]. Chin Pharmacol Bull, 2006,22(11): 1405-6.
9. Zhu F, Liu X G, Liang N C. Effect of emodin and apigenin on invasion of human ovarian carcinoma HO-8910PM cells in vitro[J]. Ai Zheng, 2003,22(4):358-62.
10. Chen X W, Liu X G, Liang J Y, et al. Cloning, expression of human protein kinase CK2α′ subunit in E. coli and purification and characterization of the recombinant protein [J]. Chin J Biochem Mol Biol, 2004,20(2):176-182.
11. Liu X G, Liang N C, Ma J Q, et al. Cloning and sequencing of recombinant cDNA encoding human protein kinase CK2β subunit [J]. Chin J Biochem Mol Biol, 1999,15(2):228-31.
12. Liu X G, Liang N C, Ma J Q. Prokaryotic expression, purification and characterization of recombinant human protein kinase CK2β subunit [J]. Prog Biochem Biophys, 2000,27(2):201-5.
13. Yang S Q. Chinese medical encyclopedia - Medical Statistics [M]. Shanghai:Shanghai Science & Technology Press, 1985:197-202.
14. Guerra B, Boldyreff B, Sarno S, et al. CK2 : A protein kinase in need of control[J]. Pharmacol Ther, 1999,82:303-13.
15. Lin X C, Liu X G, Chen X W, et al. Inhibitory effect of luteolin on protein kinase CK2 [J]. Chin Pharmacol Bull, 2006,22(11):1314-9.
16. De Moliner E, Moro S, Sarno S, et al. Inhibition of protein kinase CK2 by anthraquinone-related compounds[J]. A Structural Insight J Biol Chem, 2003,278(3):1831-6.
17. Li C M, Liu X G, Liang N C. Investigate progression of protein kinase CK2 inhibitor [J]. Foreign Med Sci Sec Pathophysiolo Clin Med, 2002,22(6):546-8.
18. Yim H, Lee Y H, Lee C H, et al. Emodin, an anthraquinone derivative isolated from the rhizomes of Rheum palmatum, selectively inhibits the activity of casein kinase II as a competitive inhibitor [J]. Planta Med, 1999,65(1):9-13.
19. Guerra B, Boldyreff B, Sarno S, et al. CK2 : A protein kinase in need of control[J]. Pharmacol Ther, 1999,82:303-13.
20. Pinna L A, Meggio F. Protein kinase CK2("casein kinase-2") and its implication in cell division and proliferation[J]. Prog Cell Cycle Res, 1997,3:77-97.
21. Guerra B, Issinger O G. Protein kinase CK2 and its role in cellular proliferation, development and pathology [J]. Electrophoresis, 1999,20(2):391-408.
22. Liu X G, Liang N C. Inhibitory effect of AG1109 on recombinant human protein kinase CK2 holoenzyme [J]. Ai Zheng, 2002,21(2):153-7.