Abnormal function and glucose metabolism in the type-2 diabetic db/db mouse heart

Canadian Journal of Physiology and Pharmacology

Volumn 85, Issue 3-4, 2007, Pages 289-294

  Panagia, Marcello ^a   Schneider, Jürgen E ^a   Brown, Ben ^a   Cole, Mark A ^a   Clarke, Kieran ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Cine magnetic resonance imaging; Db db; Diabetic cardiomyopathy; Energy metabolism; Glucose uptake; GLUT 4

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HEART EJECTION FRACTION; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL;

3-HYDROXYBUTYRIC ACID; ANIMALS; BLOOD GLUCOSE; CARDIAC OUTPUT; DIABETES MELLITUS, TYPE 2; FATTY ACIDS; GLUCOSE TRANSPORTER TYPE 4; HEART; HEART RATE; INSULIN; ISCHEMIA; MALE; MICE; MICE, INBRED STRAINS; MYOCARDIUM; STROKE VOLUME; TRIGLYCERIDES;

EID: 34547911466     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y07-028     Document Type: Article

References (31)

1. Aasum, E., Hafstad, A.D., Severson, D.L., and Larsen, T.S. 2003. Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db/db mice. Diabetes, 52: 434-441. PMID:12540618.
2. Aronson, D., Rayfield, E.J., and Chesebro, J.H. 1997. Mechanisms determining course and outcome of diabetic patients who have had acute myocardial infarction. Ann. Intern. Med. 126: 296-306. PMID:9036802.
3. Barouch, L.A., Berkowitz, D.E., Harrison, R.W., O'Donnell, C.P., and Hare, J.M. 2003. Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. Circulation, 108: 754-759. doi:10.1161/01.CIR.0000083716. 82622.FD. PMID:12885755.
4. Belke, D.D., Larsen, T.S., Gibbs, E.M., and Severson, D.L. 2000. Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db/) mice. Am. J. Physiol. Endocrinol. Metab. 279: E1104-E1113. PMID:11052966.
5. Buchanan, J., Mazumder, P.K., Hu, P., Chakrabarti, G., Roberts, M.W., Yun, U.J., et al. 2005. Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity. Endocrinology, 146: 5341-5349. doi:10. 1210/en.2005-0938. PMID:16141388.
6. Celentano, A., Vaccaro, O., Tammaro, P., Galderisi, M., Crivaro, M., Oliviero, M., et al. 1995. Early abnormalities of cardiac function in non-insulin-dependent diabetes mellitus and impaired glucose tolerance. Am. J. Cardiol. 76: 1173-1176. doi:10.1016/ S0002-9149(99)80330-0. PMID:7484905.
7. de Leiris, J., Harding, D.P., and Pestre, S. 1984. The isolated perfused rat heart: a model for studying myocardial hypoxia or ischaemia. Basic Res. Cardiol. 79: 313-321. doi:10.1007/ BF01908032. PMID:6332619.
8. Diamant, M., Lamb, H.J., Groeneveld, Y., Endert, E.L., Smit, J.W., Bax, J.J., et al. 2003. Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus. J. Am. Coll. Cardiol. 42: 328-335. doi:10.1016/S0735-1097(03)00625-9. PMID:12875772.
9. Dulce, M.C., Mostbeck, G.H., Friese, K.K., Caputo, G.R., and Higgins, C.B. 1993. Quantification of the left ventricular volumes and function with cine MR imaging: comparison of geometric models with three-dimensional data. Radiology, 188: 371-376. PMID:8327680.
10. Frustaci, A., Kajstura, J., Chimenti, C., Jakoniuk, I., Leri, A., Maseri, A., Nadal-Ginard, B., and Anversa, P. 2000. Myocardial cell death in human diabetes. Circ. Res. 87: 1123-1132. PMID:11110769.
11. Gathercole, D.V., and Dutka, D., Bonser, R.S., and Camici, P.G. 2002. GLUT4 protein is reduced in the myocardium of patients with type 2 diabetes and post-ishaemic heart failure. Keystone Symposia. Diabetes Mellitus: molecular mechanisms, genetics and new therapies, p. A214.
12. Hafstad, A.D., Solevag, G.H., Severson, D.L., Larsen, T.S., and Aasum, E. 2006. Perfused hearts from type 2 diabetic (db/db) mice show metabolic responsiveness to insulin. Am. J. Physiol. Heart Circ. Physiol. 290: H1763-H1769. doi:10.1152/ajpheart. 01063.2005. PMID:16327015.
13. How, O.J., Aasum, E., Severson, D.L., Chan, W.Y., Essop, M.F., and Larsen, T.S. 2006. Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice. Diabetes, 55: 466-473. doi:10.2337/diabetes. 55.02.06.db05-1164. PMID: 16443782.
14. King, L.M., and Opie, L.H. 1998. Glucose and glycogen utilisation in myocardial ischemia-changes in metabolism and consequences for the myocyte. Mol. Cell. Biochem. 180: 3-26. doi:10.1023/A:1006870419309. PMID:9546626.
15. King, L.M., Sidell, R.J., Wilding, J.R., Radda, O.K., and Clarke, K. 2001. Free fatty acids, but not ketone bodies, protect diabetic rat hearts during low-flow ischemia. Am. J. Physiol. Heart Circ. Physiol. 280: H1173-H1181. PMID:11179061.
16. Linnemann, B., and Janka, H.U. 2003. Prolonged QTc interval and elevated heart rate identify the type 2 diabetic patient at high risk for cardiovascular death. The Bremen Diabetes Study. Exp. Clin. Endocrinol. Diabetes, 111: 215-222. PMID:12845560.
17. Malhotra, A., Penpargkul, S., Schaible, T., and Scheuer, J. 1981. Contractile proteins and sarcoplasmic reticulum in physiologic cardiac hypertrophy. Am. J. Physiol. 241: H263-H267. PMID:6455923.
18. Norhammar, A., and Malmberg, K. 2000. Heart failure and glucose abnormalities: an increasing combination with poor functional capacity and outcome. Eur. Heart J. 21: 1293-1294. doi:10. 1053/euhj.2000.2198. PMID:10952820.
19. Ohtake, T., Yokoyama, I., Watanabe, T., Momose, T., Serezawa, T., Nishikawa, J., and Sasaki, Y. 1995. Myocardial glucose metabolism in noninsulin-dependent diabetes mellitus patients evaluated by FDG-PET. J. Nucl. Med. 36: 456-463. PMID:7884509.
20. Opie, L.H. 1988. Hypothesis glycolytic rates control cell viability in ischemia. J. Appl. Cardiol. 3: 407-414.
21. Panagia, M., Gibbons, G.F., Radda, G.K., and Clarke, K. 2005. PPAR-alpha activation required for decreased glucose uptake and increased susceptibility to injury during ischemia. Am. J. Physiol. Heart Circ. Physiol. 288: H2677-H2683. doi:10.1152/ ajpheart.00200.2004. PMID:15665064.
22. 2+], transient decrease in cardiomyopathy of db/db type 2 diabetic mice. Diabetes, 55: 608-615. doi:10.2337/diabetes.55.03.06.db051284. PMID: 16505222.
23. Robertson, M.D., Currie, J.M., Morgan, L.M., Jewell, D.P., and Frayn, K.M. 2003. Prior short-term consumption of resistant starch enhances postprandial insulin sensitivity in healthy subjects. Diabetologia, 46: 659-665. PMID:12712245.
24. Savabi, F., and Kirsch, A. 1990. Altered functional activity and anoxic tolerance in diabetic rat isolated atria. Arch. Biochem. Biophys. 279: 183-187. doi:10.1016/0003-9861(90)90479-I. PMID: 2337350.
25. Scheuermann-Freestone, M., Madsen, P., Manners, D., Blamire, A.M., Buckingham, R.E., Styles, P., et al. 2003. Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes. Circulation, 107: 3040-3046. doi:10.1161/01. CIR.0000072789.89096.10. PMID:12810608.
26. Schneider, J.E., Cassidy, P.J., Lygate, C., Tyler, D.J., Wiesmann, F., Grieve, S.M., et al. 2003. Fast, high-resolution in vivo cine magnetic resonance imaging in normal and failing mouse hearts on a vertical 11.7 T system. J. Magn. Reson. Imaging, 18: 691-701. doi:10.1002/jmri.10411. PMID:14635154.
27. Semeniuk, L.M., Kryski, A.J., and Severson, D.L. 2002. Echocardiographic assessment of cardiac function in diabetic db/db and transgenic db/db-hGLUT4 mice. Am. J. Physiol. Heart Circ. Physiol. 283: H976-H982. PMID:12181126.
28. Sutherland, F.J., Shattock, M.J., Baker, K.E., and Hearse, D.J. 2003. Mouse isolated perfused heart: characteristics and cautions. Clin. Exp. Pharmacol. Physiol. 30: 867-878. doi:10.1046/ J.1440-1681.2003.03925.x. PMID:14678252.
29. Teshima, Y., Takahashi, N., Saikawa, T., Kara, M., Yasunaga, S., Hidaka, S., and Sakata, T. 2000. Diminished expression of sarcoplasmic reticulum Ca-ATPase and ryanodine sensitive Ca channel mRNA in streptozotocin-induced diabetic rat heart. J. Mol. Cell. Cardiol. 32: 655-664. doi:10.1006/jmcc.2000.1107. PMID:10756121.
30. Utriainen, T., Takala, T., Luotolahti, M., Ronnemaa, T., Laine, H., Ruotsalainen, U., et al. 1998. Insulin resistance characterizes glucose uptake in skeletal muscle but not in the heart in NIDDM. Diabetologia, 41: 555-559. doi:10.1007/ s001250050946. PMID:9628273.
31. Uusitupa, M.I., Mustonen, J.N., and Airaksinen, K.E. 1990. Diabetic heart muscle disease. Ann. Med. 22: 377-386. PMID:2076269.