Synthesis and optimization of novel and selective muscarinic M3 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 18, 2007, Pages 5256-5260

  Kumar, Naresh ^a   Kaur, Kirandeep ^a   Aeron, Shelly ^a   Dharmarajan, Sankaranarayanan ^a   Silamkoti, Arun D V ^a   Mehta, Anita ^a   Gupta, Suman ^a   Chugh, Anita ^a   Gupta, Jang B ^a   Salman, Mohammad ^a   Palle, Venkata P ^a   Cliffe, Ian A ^a  

^a RANBAXY RESEARCH LABORATORIES   (India)

Author keywords

Azabicyclohexanes; M3 selective muscarinic antagonists

Indexed keywords

2 THIOPHENE CARBOXALDEHYDE; 4 METHYLACETOPHENONE; DARIFENACIN; HYDROCINNAMALDEHYDE; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M3 RECEPTOR ANTAGONIST; PIPERIDINE DERIVATIVE; SOLEFENACIN; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; BINDING ASSAY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS;

MUSCARINIC ANTAGONISTS; RECEPTOR, MUSCARINIC M3; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34547909593     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.06.081     Document Type: Article

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