Discovery of 2-aminothiazole-4-carboxamides, a novel class of muscarinic M3 selective antagonists, through solution-phase parallel synthesis

Chemical and Pharmaceutical Bulletin

Volumn 53, Issue 4, 2005, Pages 437-440

  Sagara, Yufu ^a   Mitsuya, Morihiro ^a   Uchiyama, Minaho ^a   Ogino, Yoshio ^a   Kjmura, Toshifumi ^a   Ohtake, Norikazu ^a   Mase, Toshiaki ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

2 aminothiazole 4 carboxamide; Antagonist; Muscarine M3 receptor; Parallel synthesis

Indexed keywords

ACETAMIDE; AMIDE; MUSCARINIC M3 RECEPTOR; MUSCARINIC M3 RECEPTOR ANTAGONIST; N [1 (CYCLONONEN 1 YLMETHYL)PIPERIDIN 3 YLMETHYL] 2 (N METHYL N PHENYLAMINO)THIAZOLE 4 CARBOXAMIDE; N [1 (CYCLOOCTEN 1 YLMETHYL)PIPERIDIN 3 YLMETHYL] 2 (N METHYL N PHENYLAMINO)THIAZOLE 4 CARBOXAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DERIVATIZATION; DRUG POTENCY; DRUG SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; SOLUTION AND SOLUBILITY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMIDES; ANIMALS; CHO CELLS; CRICETINAE; HUMANS; INDICATORS AND REAGENTS; KINETICS; MUSCARINIC ANTAGONISTS; RECEPTOR, MUSCARINIC M3; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 21144443385     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.53.437     Document Type: Article

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