Synthesis of (1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hexane, a Novel Achiral Diamine

Synlett

Volumn 1996, Issue 11, 1996, Pages 1097-1099

  Brighty, Katherine E ^a   Castaldi, Michael J ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0003154786     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1996-5684     Document Type: Article

References (14)

1. Gootz, T.D.; Brighty, K.E., Medicinal Research Reviews 1996, 16, 433.
2. Culbertson, T.P.; Domagala, J.M.; Hagen, S.E.; Hutt, M.P.; Nichols, J.B.; Mich, T.F.; Sanchez, J.P.; Schroeder, M.C.; Solomon, M.; Worth, D.F. In International Telesymposium on Quinolones; Fernandas, P.B., Ed.; J.R. Prous: Barcelona, Spain, 1989; p. 47.
3. Chu, D.T.W; Fernandes, P.B. Adv. Drug. Res. 1991, 21, 39
4. Asahina, Y.; Ishizaki, T.; Suzue, S. Prog. Drug Res. 1992, 38, 57.
5. Brighty, K.E.; Gootz, T.D.; J. Antimicrob. Chemother., in press.
6. Gootz, T.D.; Brighty, K.E.; Anderson, M.R.; Schmieder, B.J.; Haskell, S.L.; Sutcliffe, J.A.; Castaldi, M.J.; McGuirk, P.R., Diagn. Microbiol. Infect. Dis. 1994, 19, 235.
7. Marinozzi, M.; Natalini, B.; Ni, M.H.; Costantino, G.; Pellicciari, R.; Thomsen, C. Il Farmaco 1995, 50, 327.
8. Mustafa, A.; Zayed, S.M.A.D.; Khattab, S. J. Amer. Chem. Soc., 1956, 78, 145.
9. The predominant product in the filtrate was a monocyclic olefinic isomer of 8.
10. Gordon, A.J.; Ford, R.A. The Chemist's Companion; Wiley: New York, 1972, p. 274.
11. Ninomiya, K.; Shioiri, T.; Yamada, S. Tetrahedron 1974, 30, 2151.
12. Oida, S.; Kuwano, H.; Ohashi, Y.; Ohki, E. Chem. Pharm. Bull. 1970, 18, 2478. The protected pyrroline can be purified via silica gel chromatography using 20% ethyl acetate in hexane as eluant.
13. Eisenbraun, E.J. Org. Syn. Coll. Vol. V, 1973, 310.
14. Chu, D.T.W.; Fernandes, P.B.; Claiborne, A.K.; Gracey, E.H.; Pernet, A.G. J. Med. Chem. 1986, 29, 2363.