α3β4-Nicotinic receptors mediate adrenergic nerve- and peptidergic (CGRP) nerve-dependent vasodilation induced by nicotine in rat mesenteric arteries

British Journal of Pharmacology

Volumn 151, Issue 8, 2007, Pages 1216-1223

  Eguchi, S ^a   Miyashita, S ^a   Kitamura, Y ^a   Kawasaki, H ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

3 4 nicotinic receptor subtype; Adrenergic nerves; Calcitonin gene related peptide containing nerves; Nicotine; Rat mesenteric resistance artery; Vasodilation

Indexed keywords

ALPHA BUNGAROTOXIN; ALPHA3 BETA4 NICOTINIC RECEPTOR; ALPHA4 BETA2 NICOTINIC RECEPTOR; BUNGAROTOXIN RECEPTOR; CAPSAICIN; CYTISINE; DIHYDRO BETA ERYTHROIDINE; EPIBATIDINE; GUANETHIDINE; MECAMYLAMINE; METHOXAMINE; METHYLLYCACONITINE; NICOTINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; ALPHA-BUNGAROTOXIN RECEPTOR; CALCITONIN GENE RELATED PEPTIDE; GANGLION STIMULATING AGENT; NICOTINIC RECEPTOR ALPHA3BETA4; NICOTINIC RECEPTOR ALPHA4BETA2;

ADRENERGIC NERVE; ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; MALE; MESENTERIC ARTERY; NONHUMAN; PERFUSION PRESSURE; PRESSURE MEASUREMENT; PRESSURE TRANSDUCER; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; VASCULAR ENDOTHELIUM; ANIMAL; DOSE RESPONSE; DRUG EFFECT; METABOLISM; PERIPHERAL NERVOUS SYSTEM; VASODILATATION; WISTAR RAT;

ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; GANGLIONIC STIMULANTS; MALE; MESENTERIC ARTERIES; NICOTINE; NICOTINIC AGONISTS; PERIPHERAL NERVOUS SYSTEM; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; VASODILATION;

EID: 34547897347     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707331     Document Type: Article

References (29)

1. Alkondon M, Pereira EF, Eisenberg HM, Albuquerque EX (2000). Nicotinic receptor activation in human cerebral cortical interneurons: a mechanism for inhibition and disinhibition of neuronal networks. J Neurosci 20: 66-75.
2. Bevan JA, Brayden JE (1987). Nonadrenergic neural vasodilator mechanisms. Circ Res 60: 309-326.
3. Chavez-Noriega LE, Crona JH, Washburn MS, Urrutia A, Elliott KJ, Johnson EC (1997). Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors hα2β2, hα2β4, hα3β2, hα3β4, hα4β2, hα4β4 and hα7 expressed in Xenopus oocytes. J Pharmacol Exp Ther 280: 346-356.
4. Eguchi S, Tezuka S, Hobara N, Akiyama S, Kurosaki Y, Kawasaki H (2004). Vanilloid receptors mediate adrenergic nerve- and CGRP-containing nerve-dependent vasodilation induced by nicotine in rat mesenteric resistance arteries. Br J Pharmacol 142: 1137-1146.
5. Fisher M, Huangfu D, Shen TY, Guyenet PG (1994). Epibatidine, an alkaloid from the poison frog Epipedobates tricolor, is a powerful ganglionic depolarizing agent. J Pharmacol Exp Ther 270: 702-707.
6. Furchgott RF, Zawadzki JV (1980). The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373-376.
7. Gerzanich V, Peng X, Wang F, Wells G, Anand R, Fletcher S et al. (1995). Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors. Mol Pharmacol 48: 774-782.
8. Hisayama T, Shinkai M, Takayanagi I, Morimoto S, Ishida K (1988). Mechanism of action of nicotine in isolated iris sphincter preparations of rabbit. Br J Pharmacol 95: 459-464.
9. Kawasaki H, Takasaki K (1984). Vasoconstrictor response induced by 5-hydroxytryptamine released from vascular adrenergic nerves by periarterial nerve stimulation. J Pharmacol Exp Ther 299: 816-822.
10. Kawasaki H, Takasaki K, Saito S, Goto K (1988). Calcitonin gene-related peptide acts as a novel vasodilator neurotransmitter in mesenteric resistance vessels of the rat. Nature 335: 54-56.
11. 2+ ions in nicotinic facilitation of GABA release in mouse thalamus. J Neurosci 17: 576-585.
12. Lopez MG, Montiel C, Herrero CJ, Garcia-Palomero E, Mayorgas I, Hernandez-Guijo JM et al. (1998). Unmasking the functions of the chromaffin cell alpha7 nicotinic receptor by using short pulses of acetylcholine and selective blockers. Proc Natl Acad Sci USA 95: 14184-14189.
13. Luetje CW, Patrick J (1991). Both α- and β-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors. J Neurosci 11: 837-845.
14. Lukas RJ, Changeux JP, Le Novere N, Albuquerque EX, Balfour DJ, Berg DK et al. (1999). Inernational Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits. Pharmacol Rev 51: 397-401.
15. Lundberg MJ, Terenius L, Hokfelt T, Martling RC, Tatemoto K, Mutt V et al. (1982). Neuropeptide Y (NPY)-like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function. Acta Physiol Scand 116: 477-480.
16. Papke RL, Heinemann SF (1994). Partial agonist properties of cytisine on neuronal nicotinic receptors containing the β2 subunit. Mol Pharmacol 45: 142-149.
17. Papke RL, Sanberg PR, Shytle RD (2001). Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes. J Pharmacol Exp Ther 297: 646-656.
18. Rust G, Burgunder JM, Lauterburg TE, Cachelin AB (1994). Expression of neuronal nicotinic acetylcholine receptor subunit genes in the rat autonomic nervous system. Eur J Neurosci 6: 478-485.
19. Sacaan AI, Menzaghi F, Dunlop JL, Correa LD, Whelan KT, Lloyd GK (1996). Epibatidine: a nicotinic acetylcholine receptor agonist releases monoaminergic neurotransmitters: in vitro and in vivo evidence in rats. J Pharmacol Exp Ther 276: 509-515.
20. Sargent PB (1993). The diversity of neuronal nicotinic acetylcholine receptors. Annu Rev Neurosci 16: 403-443.
21. Shiraki H, Kawasaki H, Tezuka S, Nakatsuma A, Kurosaki U (2000). Endogenous calcitonin gene-related peptide (CGRP) mediates adrenergic dependent vasodilation induced by nicotine in mesenteric resistance arteries of the rat. Br J Pharmacol 130: 1083-1091.
22. Si LM, Lee TJF (2001). Presynaptic α7-nicotinic acetylcholine receptors mediate nicotine-induced nitric oxidergic neurogenic vasodilation in porcine basilar arteries. J Pharmacol Exp Ther 298: 122-128.
23. Spande TF, Garraffo HM, Yeh HJ, Pu QL, Pannell LK, Daly JW (1992). A new class of alkaloids from a dendrobatid poison frog; a structure for alkaloid 251F. J Nat Prod 55: 707-722.
24. Suemaru K, Araki H, Gomita Y (2002). Involvement of neuronal nicotinic receptor in psychiatric disorders. Nippon Yakurigaku Zasshi 119: 295-300.
25. Takeda D, Nakatsuka T, Papke R, Gu JG (2003). Modulation of inhibitory synaptic activity by a non-α4β2, non-α7 subtype of nicotinic receptors in the substantia gelatinosa of adult rat spinal cord. Pain 101: 13-23.
26. Takenaga M, Kawasaki H, Wada A, Eto T (1995). Calcitonin gene-related peptide mediates acetylcholine-induced endothelium-independent vasodilation in mesenteric resistance blood vessels of the rat. Circ Res 76: 935-941.
27. Taraschenko OD, Panchal V, Maisonneuve IM, Glick SD (2005). Is antagonism of alpha3beta4 nicotinic receptors a strategy to reduce morphine dependence? Eur J Pharmacol 513: 207-218.
28. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y et al. (1988). A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332: 411-415.
29. Yokotani K, Wang M, Okada S, Murakami Y, Hirata M (2000). Characterization of nicotinic acetylcholine receptor-mediated noradrenaline release from the isolated rat stomach. Eur J Pharmacol 402: 223-229.