Temporal integration in nasal lateralization of homologous alcohols

Toxicological Sciences

Volumn 99, Issue 1, 2007, Pages 254-259

  Wise, Paul M ^a   Toczydlowski, Sean E ^a   Wysocki, Charles J ^a  

^a MONELL CHEMICAL SENSES CENTER   (United States)

Author keywords

Chemesthesis; Chemical irritation; Inhalation toxicology; Pungency; Volatile organic compound

Indexed keywords

ALCOHOL; BUTANOL; HEXANOL;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPOTHESIS; INHALATION TEST; LIPID SOLUBILITY; MALE; NORMAL HUMAN; NOSE IRRITATION; OLFACTORY DISCRIMINATION; PERCEPTIVE THRESHOLD; PREDICTION; STIMULUS RESPONSE; TOXIC INHALATION;

1-BUTANOL; ADMINISTRATION, INHALATION; ADULT; ALCOHOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FEMALE; FUNCTIONAL LATERALITY; HEXANOLS; HUMANS; IRRITANTS; MIDDLE AGED; NASAL MUCOSA; SENSORY THRESHOLDS; SMELL; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; VOLATILIZATION;

EID: 34547893420     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm144     Document Type: Article

References (39)

1. Abraham, M. H., Gola, J. M. R., Cometto-Muñz, J. E., and Cain, W. S. (2001). The correlation and prediction of VOC thresholds for nasal pungency, eye irritation and odour in humans. Indoor Built Environ. 10, 252-257.
2. Abraham, M. H., Hassanisadi, M., Jalali-Heravi, M., Ghafourian, T., Cain, W. S., and Cometto-Muniz, J. E. (2003). Draize rabbit eye test compatibility with eye irritation thresholds in humans: A quantitative structure-activity relationship analysis. Toxicol. Sci. 76, 384-391.
3. 2 pulses Applied to the nasal mucosa. Pain 49, 53-60.
4. Baumgardt, E. (1972). Threshold quantal problems. Io Visual Psychophysics (D. Jameson and J. Hurvich, Eds.), pp. 29-55. Springer-Verlag, New York.
5. Bryant, B. P., and Silver, W. L. (2000). Chemesthesis: The common chemical sense. In The Neurobiology of Taste and Smell (T. E. Finger, W. L. Silver, and D. Restrepo, Eds.), pp. 73-100. Wiley-Liss, New York.
6. Cain, W. S. (1990). Perceptual characteristics of nasal irritation. In Chemical Senses (Vol. 2): Irritation (B. G. Green, J. R. Mason M. R. Kare, Eds.), pp. 43-58. Marcel Decker, New York.
7. Cain, W. S. (1996). Overview: Odors and irritation in indoor pollution. In Indoor Air and Human Health, 2nd ed. (R. B. Gammage and B. A. Berven, Eds.), pp. 23-30. Lewis, Boca Raton, FL.
8. Cain, W. S., Gent, J. F., Goodspeed, R. B., and Leonard, G. ([988). Evaluation of olfactory dysfunction in the Connecticut Chemosensory Clinical Research Center. Laryngoscope 98, 83-88.
9. Cain, W. S., Lee, N. S., Wise, P. M., Schmidt, R., Ahn, B. H., Cometto-Muniz, J. E., and Abraham, M. H. (2006). Chemesthesis from volatile organic compounds: Psychophysical and neural responies. Physiol. Behav. 88, 317-324.
10. Cain, W. S., See, L. C., and Tosun, T. (1986). Irritation and odor from formaldehyde: Chamber studies. IAQ '86: Managing the Indoor Air for Health and Energy Conservation, pp. 126-137. ASHRAE, Atlanta.
11. Cometto-Muñiz, J. E., and Cain, W. S. (1984). Temporal integration of pungency. Chem. Senses 8, 315-327.
12. Cometto-Muñiz, J. E., Cain, W. S., Abraham, M. H., and Sanchez-Moreno, R. (2007). Cutoff in detection of eye irritation from vapors of homologous carboxylic acids and aliphatic aldehydes. Neuroscience 145, 1130-1137.
13. Dalton, P., Wysocki, C. J., Brody, M. J., and Lawley H. J. (1997). The influence of cognitive bias on the perceived odor, irritation and health symptoms from chemical exposure. Int. Arch. Occup. Environ. Health 69, 407-417.
14. Doty, R. L., and Cometto-Muñiz, J. E. (2003). Trigeminal chemosensation. In Handbook of Olfaction and Gustation, 2nd ed. (R. L. Doty, Ed.), pp. 981-999. Marcell Decker, New York.
15. Doty, R. L., Cometto-Muniz, J. E., Jalowayski, A. A., Dalton, P., Kendal-Reed, M., and Hodgson, M. (2004). Assessment of upper respiratory tract and ocular irritative effects of volatile chemicals in humans. Crit. Rev. Toxicol. 34, 85-142.
16. Finger, T. E., Getchell, M. L., Getchell, T. V., and Kinnamon, J. C. (1990). Affector and effector functions of peptidergic innervation of the nasal cavity. In Chemical Senses (Vol. 2): Irritation (B. G. Green, J. R. Mason, and M. R. Kate, Eds.), pp. 1-20. Marcell Dekker, New York.
17. Frasnelli, J., Lötsch, J., and Hummel, T. (2003). Event-related potentials to intranasal trigeminal stimuli change in relation to stimulus concentration and stimulus duration. J. Clin. Neurophysiol. 20, 80-86.
18. Frederick, C. B., Bush, M. L., Lomax, L. G., Black, K. A., Finch, L., Kimbell, J. S., Morgan, K. T., Subramaniam, R. P., Morris, J. B., and Ultman, J. S. (1998). Application of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry extrapolation of acidic vapors in the upper airways. Toxicol. Appl. Pharmacol. 152, 211-231.
19. Frederick, C. B., Morris, J. B., Kimbell, J. S., Morgan, K. T., and Scherer, P. T. (1994). Comparison of four biologically based dosimetry models for the deposition of rapidly metabolized vapors in the rodent nasal cavity. Inhal. Toxicol. 6(Suppl.), 135-157.
20. Garner, W. R., and Miller, G. A. (1947). The masked threshold of pure tones as a function of duration. J. Exp. Psychol. 37, 293-305.
21. Green, B. G., Mason, J. R., and Kare, M. R. (1990). Preface. In Chemical, Senses (Vol. 2): Irritation (B. G. Green, J. R. Mason, and M. R. Kare, Eds.), pp. v-vii. Marcel Decker, New York.
22. Hau, K. M., Connell, D. W., and Richardson, B. J. (1999). Quantitative structure-activity relationships for nasal pungency thresholds of volatile organic compounds. Toxicol. Sci. 47, 93-98.
23. Hempel-Jorgensen, A., Kjaergaard, S. K., Molhave, L., and Hudnell, H. K. (1999). Time course of sensory eye irritation in humans exposed to N-butanol and 1-octene. Arch. Environ. Health 54, 86-94.
24. Kasanen, J. P., Pasanen, A. L., Pasanen, P., Liesivuori, J., Kosma, V. M., and Alarie, Y. (1998). Stereospecificity of the sensory irritation receptor for nonreactive chemicals illustrated by pinene enantiomers. Arch. Toxicol. 72, 514-523.
25. Kobal, G., and Hummel, T. (1991). Olfactory evoked potentials in humans. In Smell and Taste in Health and Disease (T. V. Getchell, R. L. Doty, L. Bartoshuk, and J. B. Snow, Eds.), pp. 255-275. Raven Press, New York.
26. Kurtz, D. B., Zhao, K., Hornung, D. E., and Scherer, P. (2004). Experimental and numerical determination of odorant solubility in nasal and olfactory mucosa. Chem. Senses 29, 763-773.
27. Miller, F. J., Schlosser, P. M., and Janszen, D. B. (2000). Haber's rule: A special case in a family of curves relating concentration and duration of exposure to a fixed level of response for a given endpoint. Toxicology 149, 21-34.
28. Morris, J. B. (2001). Overview of upper respiratory tract vapor uptake studies. Inhal. Toxicol. 13, 335-345.
29. NIOSH (1994). NIOSH Pocket Guide to Chemical Hazards (Publication No. 94-116). National Institute for Occupational Safety and Health, Cincinnati.
30. Shusterman, D. (2002). Individual factors in nasal chemesthesis. Chem. Senses 27, 551-564.
31. Shusterman, D., and Avila, P. C. (2003). Real-time monitoring of nasal mucosal pH during carbon dioxide stimulation: Implications for stimulus dynamics. Chem. Senses 28, 595-4601.
32. Shusterman, D., Matovinovic, E., and Salmon, A. (2006). Does Haber's law apply to human sensory irritation? Inhal. Toxicol. 18, 457-471.
33. Thüerauf, N., Kaegler, M., Dietz, R., Barocka, A, and Kobal, G. (1999). Dosedependent stereoselective activation of the trigenminal sensory system by nicotine in man. Psychopharmacology 142, 236-243.
34. Wise, P. M., Canty, T. M., and Wysocki, C. J. (2005). Temporal integration of nasal irritation from ammonia at threshold and supra-threshold levels. Toxicol. Sci. 87, 223-231.
35. Wise, P. M., Canty, T. M., and Wysocki, C. J. (20M). Temporal integration in nasal lateralization of ethanol. Chem. Senses 31 227-235.
36. Wise, P. M., Radil, T., and Wysocki, C. J. (2004). Temporal integration in nasal lateralization and nasal detection of carbon dioxide. Chem. Senses 29, 137-142.
37. Wise, P. M., Wysocki, C. J., and Radil, T. (2003) Time-intensity ratings of nasal irritation from carbondioxide. Chem. Senses 28, 751-760.
38. Wysocki, C. J., and Wise, P. (2003). Methods, approaches, and caveats for functionally evaluating olfaction and chemesthesis. In Handbook of Flavor Characterization: Sensory, Chemical and Physiological (K. Deibler and J. F. Delwiche, Eds.), pp. 1-40. Marcel Dekker, New York.
39. Zhang, X., Zhang, Q. Y., Liu, D., Su, T., Weng, Y., Ling, G., Chen, Y., Gu, J., Schilling, B., and Ding, X. (2005). Expression of cytochrome p450 and other biotransformation genes in fetal and adult human nasal mucosa. Drug Metab. Dispos. 33, 1423-1428.