Preservation of outer retina and its synaptic connectivity following subretinal injections of human RPE cells in the Royal College of Surgeons rat

Experimental Eye Research

Volumn 85, Issue 3, 2007, Pages 381-392

  Pinilla, Isabel ^a,b   Cuenca, Nicolás ^a,c   Sauvé, Yves ^a,d   Wang, Shaomei ^a,e   Lund, Raymond D ^a,e  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b HOSPITAL UNIVERSITARIO MIGUEL SERVET   (Spain)

^c UNIVERSITY OF ALICANTE   (Spain)

^d UNIVERSITY OF ALBERTA   (Canada)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

cell therapy; immunocytochemistry; photoreceptors; retinitis pigmentosa; transplant

Indexed keywords

CALBINDIN; CELL MARKER; GLUTAMIC ACID; PROTEIN KINASE C ALPHA; SYNAPTOPHYSIN;

ALPHA RHYTHM; AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BETA RHYTHM; CELL STRUCTURE; CELL TRANSPLANTATION; CONTROLLED STUDY; ELECTRORETINOGRAPHY; HUMAN; HUMAN CELL; NONHUMAN; PHOTORECEPTOR CELL; PRESERVATION; PRIORITY JOURNAL; RAT; RETINA BIPOLAR GANGLION CELL; RETINA CELL; RETINA CONE; RETINA ROD OUTER SEGMENT; STAINING; SURGEON; SYNAPTIC MEMBRANE;

ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; HUMANS; NEURAL PATHWAYS; PHOTORECEPTORS, VERTEBRATE; PIGMENT EPITHELIUM OF EYE; RATS; RATS, MUTANT STRAINS; RETINA; RETINAL BIPOLAR CELLS; RETINITIS PIGMENTOSA; SYNAPSES;

EID: 34547880446     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2007.06.002     Document Type: Article

References (37)

1. Bok D., Yasumura D., Matthes M.T., et al. Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation. Exp. Eye Res. 74 (2002) 719-735
2. Bourne M.C., Campbell D.A., and Tansley K. Hereditary degeneration of the rat retina. Br. J. Ophthalmol 22 (1938) 613-623
3. Coffey P.J., Girman S., Wang S.M., et al. Long-term preservation of cortically dependent visual function in RCS rats by transplantation. Nat. Neurosci. 5 (2002) 53-56
4. Cuenca N., Pinilla I., Sauvé Y., Wang S., Lu B., and Lund R.D. Regressive and reactive changes in the connectivity patterns of rod and cone pathways of P23H transgenic rat retina. Neuroscience 127 (2004) 301-317
5. Cuenca N., Pinilla I., Sauvé Y., and Lund R.D. Changes in synaptic connectivity following progressive photoreceptor degeneration in RCS rats. Eur. J. Neurosci. 22 (2005) 1057-1072
6. Dowling J.E., and Sidman R.L. Inherited retinal dystrophy in the rat. J. Cell Biol. 14 (1962) 73-109
7. Girman S.V., Wang S., and Lund R.D. Cortical visual functions can be preserved by subretinal RPE cell grafting in RCS rats. Vis. Res. 43 (2003) 1817-1827
8. Girman S.V., Wang S., and Lund R.D. Time course of deterioration of rod and cone function in RCS rat and the effects of subretinal cell grafting: a light- and dark-adaptation study. Vis. Res. 45 (2005) 343-354
9. Gouras P., Lopez R., Kjeldbye H., Sullivan B., and Brittis M. Transplantation of retinal epithelium prevents photoreceptor degeneration in the RCS rat. Prog. Clin. Biol. Res. 314 (1989) 659-671
10. Jones B.W., Watt C.B., Frederick J.M., et al. Retinal remodeling triggered by photoreceptor degenerations. J. Comp. Neurol. 464 (2003) 1-16
11. Kanuga N., Winton H.L., Beauchène L., et al. Characterization of genetically modified human retinal pigment epithelial cells developed for in vitro and transplantation studies. Invest. Ophthalmol. Vis. Sci. 43 (2002) 546-555
12. Klimanskaya I., Hipp J., Rezai K.A., West M., Atala A., and Lanza R. Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics. Cloning Stem Cells 6 (2004) 217-245
13. LaVail M.M. Legacy of the RCS rat: impact of a seminal study on retinal cell biology and retinal degenerative diseases. Prog. Brain Res. 131 (2001) 617-627
14. Li L.X., and Turner J.E. Inherited retinal dystrophy in the RCS rat: prevention of photoreceptor degeneration by pigment epithelial cell transplantation. Exp. Eye Res. 47 (1988) 911-917
15. Lin N., Fan W., Sheedlo H.J., Aschenbrenner J.E., and Turner J.E. Photoreceptor repair in response to RPE transplants in RCS rats: outer segment regeneration. Curr. Eye Res. 15 (1996) 1069-1077
16. Little C.W., Castillo B., DiLoreto D.A., et al. Transplantation of human fetal retinal pigment epithelium rescues photoreceptor cells from degeneration in the Royal College of Surgeons rat retina. Invest. Ophthalmol. Vis. Sci. 37 (1996) 204-211
17. Lund R.D., Adamson P., Sauvé Y., et al. Subretinal transplantation of genetically modified human cell lines attenuates loss of visual function in dystrophic rats. Proc. Natl. Acad. Sci. USA 98 (2001) 9942-9947
18. Lund R.D., Ono S.J., Keegan D.J., and Lawrence J.M. Retinal transplantation: progress and problems in clinical application. J. Leukoc. Biol. 74 (2003) 151-160
19. Marc R.E., Jones B.W., Watt C.B., and Strettoi E. Neural remodeling in the retinal degeneration. Prog. Ret. Eye Res. 22 (2003) 607-655
20. McGill T.J., Douglas R.M., Lund R.D., and Prusky G.T. Quantification of spatial vision in the Royal College of Surgeons rat. Invest. Ophthalmol. Vis. Sci. 45 (2004) 932-936
21. McGill T.J., Lund R.D., Douglas R.M., Wang S., Lu B., and Prusky G.T. Preservation of vision following cell-based therapies in a model of retinal degenerative disease. Vis. Res. 44 (2004) 2559-2566
22. McGinnis J.F., Stepanik P.L., Chen W., Elias R., Cao W., and Lerious V. Unique retina cell phenotypes revealed by immunological analysis of recoverin expression in rat retina cells. J. Neurosci. Res. 55 (1999) 252-260
23. Peng Y.W., Senda T., Hao Y., Matsuno K., and Wong F. Ectopic synaptogenesis during retinal degeneration in the royal college of surgeons rat. Neuroscience 119 (2003) 813-820
24. Perlman I. Dark-adaptation in abnormal (RCS) rats studied electroretinographically. J. Physiol. 278 (1978) 161-175
25. Perlman I. Kinetics of bleaching and regeneration of rhodopsin in abnormal (RCS) and normal albino rats in vivo. J. Physiol. 278 (1978) 141-159
26. Pignatelli V., Cepko C.L., and Strettoi E. Inner retinal abnormalities in a mouse model of Leber's congenital amaurosis. J. Comp. Neurol. 469 (2004) 351-359
27. Pinilla I., Lund R.D., and Sauvé Y. Contribution of rod and cone pathways to the dark-adapted electroretinogram (ERG) b-wave following retinal degeneration in RCS rats. Vis. Res. 44 (2004) 2467-2474
28. Pinilla I., Lund R.D., Lu B., and Sauvé Y. Measuring the cone contribution to the ERG b-wave to assess function and predict anatomical rescue in RCS rats. Vis. Res. 45 (2005) 635-641
29. Sauvé Y., Girman S.V., Wang S., Keegan D.J., and Lund R.D. Preservation of visual responsiveness in the superior colliculus of RCS rats after retinal pigment epithelium cell transplantation. Neuroscience 114 (2002) 389-401
30. Sauvé Y., Lu B., and Lund R.D. The relationship between full field electroretinogram and perimetry-like visual thresholds in RCS rats during photoreceptor degeneration and rescue by cell transplants. Vis. Res. 44 (2004) 9-18
31. Sauvé Y., Pinilla I., and Lund R.D. Partial preservation of rod and cone ERG function following subretinal injection of ARPE-19 cells in RCS rats. Vis. Res. 46 (2006) 1459-1472
32. Sheedlo H.J., Li L., and Turner J.E. Photoreceptor cell rescue at early and late RPE-cell transplantation periods during retinal disease in RCS dystrophic rats. J. Neural Transplant. Plast. 2 (1991) 55-63
33. Spencer B., Agarwala S., Gentry L., and Brandt C.R. HSV-1 vector-delivered FGF2 to the retina is neuroprotective but does not preserve functional responses. Mol. Ther. 3 (2001) 746-756
34. Vaney D.I. Retinal neurons: cell types and coupled networks. Prog. Brain Res. 136 (2002) 239-254
35. Villegas-Pérez M.P., Lawrence J.M., Vidal-Sanz M., LaVail M.M., and Lund R.D. Ganglion cell loss in RCS rat retina: a result of compression of axons by contracting intraretinal vessels linked to the pigment epithelium. J. Comp. Neurol. 392 (1998) 58-77
36. Vollrath D., Feng W., Duncan J.L., et al. Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk. Proc. Natl. Acad. Sci. USA 98 (2001) 12584-12589
37. Wang S., Lu B., and Lund R.D. Morphological changes in the RCS retina during photoreceptor degeneration and after cell-based therapy. J. Comp. Neurol. 491 (2005) 400-417