Inhibition of plasma-mediated adherence of sickle erythrocytes to microvascular endothelium by conformationally constrained RGD-containing peptides

American Journal of Hematology

Volumn 53, Issue 2, 1996, Pages 92-98

  Kumar, Anjali ^a   Eckman, James R ^a   Wick, Timothy M ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Georgia Institute of Technology   (United States)

Author keywords

Integrins; Plasma; RGD peptides; Sickle erythrocytes; Sickle cell adhesion

Indexed keywords

INTEGRIN; PEPTIDE;

ARTICLE; CELL ADHESION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; PLASMA; PRIORITY JOURNAL; SICKLE CELL; VASCULAR ENDOTHELIUM;

ANEMIA, SICKLE CELL; CELL ADHESION; CELLS, CULTURED; COCULTURE TECHNIQUES; ENDOTHELIUM, VASCULAR; ERYTHROCYTES, ABNORMAL; HUMANS; INTEGRINS; OLIGOPEPTIDES; PROTEIN CONFORMATION;

EID: 0029861597     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8652(199610)53:2<92::AID-AJH6>3.0.CO;2-Z     Document Type: Article

References (30)

1. Hoover R, Rubin R, Wise G, Warren R: Adhesion of normal and sickle erythrocytes to endothelial monolayer cultures. Blood 54:872, 1979.
2. Hebbel RP, Yamada O, Moldow CF, Jacob HS, White JG, Eaton JW: Abnormal adherence of sickle erythrocytes to cultured vascular endothelium Possible mechanism for microvascular occlusion. J Clin Invest 65:154, 1980.
3. Eaton WA, Hofrichter J, Ross PD: Delay time of gelation. A possible determinant of clinical severity in sickle cell disease. Blood 47:621, 1976.
4. Mozzarelli A, Hofrichter J, Eaton WA: Delay time of HbS polymerization prevents most cells from sticking in vivo. Science 237:500, 1987.
5. Kaul DK, Nagel RL: Sickle cell vaso-occlusion: Many issues and some answers. Experientia 49:5, 1993.
6. Charache S, Lubin B, Reid CD: "Management and Therapy of Sickle Cell Disease." Washington, D.C.: NIH Publication No. 89-2117, 1989, pp 15-19.
7. Platt AF, Eckman JR: The multidisciplinary management of pain in patients with sickle cell syndromes. J Am Acad Phys Assist 2:104, 1989.
8. Kaul DK, Fabry ME, Nagel RL: Microvascular sites and characteristics of sickle cell adhesion to vascular endothelium in shear flow conditions: Pathophysiological implications. Proc Natl Acad Sci USA 86:3356, 1989.
9. Brittain HA, Eckman JR, Wick TM: Sickle erythrocyte adherence to large vessel and microvascular endothelium under physiologic flow is qualitatively different. J Lab Clin Med 19:538, 1992.
10. Hebbel RP, Moldow CF, Steinberg MH: Modulation of erythrocyte-endothelial interactions and the vaso-occlusive severity of sickling disorders. Blood 58:947, 1981.
11. Wick TM, Eckman JR: Molecular basis of sickle cell-endothelial cell interactions. Curr Opin Hematol 3:118, 1996.
12. Wick TM, Moake JL, Udden MM, Eskin SG, Sears DA, McIntire LV: Unusually large von Willebrand factor multimers increase adhesion of sickle erythrocytes to human endothelial cells under controlled flow. J Clin Invest 80:905, 1987.
13. Wick TM, Moake JL, Udden MM, McIntire LV: Unusually large von Willebrand factor multimers preferentially promote young sickle and non-sickle erythrocyte adhesion to endothelial cells. Am J Hematol 42:284, 1993.
14. Sugihara K, Sugihara T, Mohandas N, Hebbel RP: Thrombospondin mediates adherence of CD36+ sickle reticulocytes to endothelial cells. Blood 80:2634, 1992.
15. Brittain HA, Eckman JR, Howard RJ, Wick TM: Thrombospondin from activated platelets promotes sickle erythrocyte adherence to human microvascular endothelium under physiologic flow: A potential role for platelet activation in sickle cell vaso-occlusion. Blood 81:2137, 1993.
16. 1-integrin expression on sickle reticulocytes: Vascular cell adhesion molecule-1-dependent binding to endothelium. Blood 82:1891, 1993.
17. 1 and glycoprotein IV (CD36) are expressed on circulating reticulocytes in sickle cell anemia. Blood 82:3548, 1993.
18. Gee BE, Platt OS: Sickle reticulocytes adhere to VCAM-1. Blood 85:268, 1995.
19. 1 integrin on sickle reticulocytes and fibronectin on endothelium. Blood 84:408, 1994.
20. Natarajan M, Udden MM, McIntire LV: Adhesion of sickle red blood cells and damage to Interleuken-1β stimulated endothelial cells under flow in vitro. Blood 87:4845-4852.
21. Hynes RO: Integrins: A family of cell surfaced receptors. Cell 48: 549, 1987.
22. Hynes RO: Integrins: Versatility, modulation, and signaling in cell adhesion. Cell 69:11, 1992.
23. Ruoslahti E: Integrins. J Clin Invest 87:1, 1991.
24. Brittain HA: "Adherence of Sickle Red Cells to Human Microvascular Endothelial Versus Umbilical Vein Endothelial Cells; a Role for Plasma, von Willebrand Factor and Platelet Thrombospondin." Ph.D. Dissertation, Georgia Institute of Technology, 1992.
25. 3 Antagonists. J Med Chem 37:1, 1994.
26. Pierschbacher MD, Ruoslahti E: Influence of the stereochemistry of the sequence Arg-Gly-Asp-Xaa on binding specificity in cell adhesion. J Biol Chem 262:17294, 1987.
27. Hines WW, Montgomery DC: "Probability and Statistics in Engineering and Management Science." New York: John Wiley & Sons, Inc., 262, 1990, pp 304.
28. Ruoslahti E, Pierschbacher MD: Arg-Gly-Asp: A versatile cell recognition signal. Cell 44:517, 1986.
29. Ruoslahti E, Pierschbacher MD: New perspectives in cell adhesion: RGD and integrins. Science 238:491, 1987.
30. Liu DY, Harlan JM: Outlook for the Future. In Harlan JM, Liu DY (eds): "Adhesion: Its Role in Inflammatory Disease." New York: W.H. Freeman and Company, 1991, p 183.