Hypertrophic cardiomyopathy caused by a novel α-tropomyosin mutation (V95A) is associated with mild cardiac phenotype, abnormal calcium binding to troponin, abnormal myosin cycling, and poor prognosis

Circulation

Volumn 103, Issue 1, 2001, Pages 65-71

  Karibe, Akihiko ^a   Tobacman, Larry S ^b   Strand, James ^b   Butters, Carol ^b   Back, Nick ^c   Bachinski, Linda L ^a   Arai, Andrew E ^d   Ortiz, Anne ^d   Roberts, Robert ^a   Homsher, Earl ^c   Fananapazir, Lameh ^d,e  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e MSC 1650 ^*  (United States)

Author keywords

Cardiomyopathy; Death, sudden; Genetics; Prognosis

Indexed keywords

ADENOSINE TRIPHOSPHATASE (MAGNESIUM); CALCIUM; CALCIUM BINDING PROTEIN; MUTANT PROTEIN; MYOSIN; RECOMBINANT PROTEIN; TROPOMYOSIN; TROPONIN;

ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; ENZYME ASSAY; ETHNIC GROUP; GENE MUTATION; GENE SEQUENCE; HEART FAILURE; HEART LEFT VENTRICLE HYPERTROPHY; HUMAN; HUMAN CELL; HYPERTROPHIC CARDIOMYOPATHY; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BINDING; SUDDEN DEATH; SURVIVAL; THIN FILAMENT;

EID: 0035830394     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.103.1.65     Document Type: Article

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