Differential p63 and p53 expression in human keloid fibroblasts and hypertrophic scar fibroblasts

DNA and Cell Biology

Volumn 26, Issue 8, 2007, Pages 541-547

  De Felice, Bruna ^a   Ciarmiello, L F ^a   Mondola, P ^b   Damiano, S ^b   Seru, R ^b   Argenziano, C ^a   Nacca, M ^c   Santoriello, M ^b   Garbi, C ^b  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c General Hospital   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; PROTEIN P63;

ARTICLE; CELL FATE; CELL PROLIFERATION; CELL RENEWAL; CONTROLLED STUDY; EPIDERMIS; FIBROBLAST; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HYPERTROPHIC SCAR; KELOID; KERATINOCYTE; MULTIGENE FAMILY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

BLOTTING, WESTERN; CELLS, CULTURED; CICATRIX, HYPERTROPHIC; FIBROBLASTS; FLUOROIMMUNOASSAY; HUMANS; KELOID; MEMBRANE PROTEINS; PROTEIN ISOFORMS; RNA; SEQUENCE DELETION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34547855813     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.2007.0591     Document Type: Article

References (26)

1. Atiyeh, B.S., Costagliola, M., and Hayek, S.N. (2005). Keloid or hypertrophic scar: review of the literature. Ann. Plast. Surg. 54, 676-680.
2. Chen, W., Fu, X., Sun, X., Sun, T., Zao, Z., and Sheng, Z. (2003). Analysis of differentially expressed genes in keloids and normal skin with DNA microarray. J. Surg. Res. 113, 208-216.
3. Crook, T., Nicholls, J.M., Brooks, L., O'Nions, J., and Allday, M.J. (2000). High level expression in DN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC) Oncogene 19, 3439-3444.
4. De Felice, B., Wilson, R.R., Nacca, M., Ciarmiello, L.F., and Pinelli, C. (2004). p63 isoforms expression in human keloids. Mol. Genet. Genomics 272, 28-34.
5. Di Como, C.J., Urist, M.J., Babayan, I., Drobnjak, M., Hedvat, C.V., Teruya-Feldstein, J., Pohar, K., Hoos, A., and Cordon-Cardo, C. (2002). p63 expression profiles in human normal and tumor tissues. Clin. Cancer Res. 8, 494-501.
6. Ehrlich, H.P., Desmouliere, A., Diegelmann, R.F., Cohen, I.K., Compton, C.C., Garner, W.L., Kapanci, Y., and Gabbiani, G. (1994). Morphological and immunochemical differences between keloids and hypertrophic scar. Am. J. Pathol. 145, 105-113.
7. Friedman, D.W., Boyd, C.D., Mackienzie, J.W., Norton, P., Olson, R.M., and Deak, S.B. (1993). Regulation of collagen gene expression in keloids and hypertrophic scars. J. Surg. Res. 55, 214-222.
8. Hu, H., Xia, S.-H., Li, A.-D., Xu, X., Cai, Y., Han, Y.-L., Wei, F., Chen, B.-S., Huang, X.-P., Han, Y.-S., Zhang, J.-W., Zhang, X., Wu, M., and Wang, M.-R. (2002). Elevated expression of p63 protein in human esophageal squamous cell carcinomas. Int. J. Cancer 102, 580-583.
9. Ladin, D.A., Hou, Z., Patel, D., McPhail, M., Olson, J.C., Saed, G.M., and Fivenson, D.P. (1998). p53 and apoptosis alterations in keloids and keloid fibroblasts. Wound Repair Regen. 6, 28-37.
10. Lee, H., Lee, J.-H., Choi, E., Seol, J.Y., Yun, Y., and Lee, H. (2006). A dominant negative form of p63 inhibits apoptosis in a p53-independent manner. Biochem. Biophys. Res. Commun. 344, 166-172.
11. Lee, J.Y., Yang, C.C., Chao, S.C., and Wong, T.W. (2004). Histopathological differential diagnosis of keloid and hypertrophic scar. Am. J. Dermatopathol. 26, 379-384.
12. Levine, A.J. (1997). p53, the cellular gatekeeper for growth and division. Cell 88, 323-331.
13. Liefer, K.M., Koster, M.I., Wang, X.J., Yang, A., McKeon, F., and Roop, D.R. (2000). Down-regulation of p63 is required for epidermal UV-B-induced apoptosis. Cancer Res. 60, 4016-4020.
14. Lim, I.J., Phan, T.T., Song, C., Tan, W.T., and Longaker, M.T. (2001). Investigation of the influence of keloid-derived keratinocytes on fibroblast growth and proliferation in vitro. Plast. Reconstr. Surg. 107, 797-808.
15. Nishi, H., Isaka, K., Sagawa, Y., Usuda, S., Fujito, A., Ito, H., Senoo, M., Kato, H., and Takayama, M. (1999). Mutation and transcription analyses of the p63 gene in cervical carcinoma. Int. J. Oncol. 15, 1149-1153.
16. Park, B.J., Lee, S.J., Kim, J.I., Lee, S.J., Lee, C.H., Chang, S.G., Park, J.H., and Chi, S.G. (2000). Frequent alteration of p63 expression in human primary bladder carcinomas. Cancer Res. 60, 3370-3374.
17. Parsa, R., Yang, A., McKeon, F., and Green, H. (1999). Association of p3 with proliferative potential in normal and neoplastic human keratinocytes. J. Invest. Dermatol. 113, 1099-1105.
18. Phan, T.T., Lim, I.J., Aalami, O., Lorget, F., Khoo, A., Tan, E.K., Mukhopadhyay, A., and Longaker, M.T. (2005). Smad3 signalling plays an important role in keloid pathogenesis via epithelial-mesenchymal interactions. J. Pathol. 207, 232-242.
19. Ratovitski, A., Patturajan, M., Hibi, K., Trink, B., Yamaguchi, K., and Sidransky, D. (2001). p53 associates with and targets delta Np63 into a protein degradation pathway. Proc. Natl. Acad. Sci. USA 98, 1817-1822.
20. Teofoli, P., Barduagni, S., Ribuffo, M., Campanella, A., De Pita, O., and Puddu, P. (1999). Expression of bcl-2, p53, c-jun and c-fos protooncogenes in keloids and hypertrophic scars. J. Dermatol. Sci. 22, 31-37.
21. Wang, T.Y., Chen, B.F., Yang, Y.C., Chen, H., Wang, Y., Cviko, A., Quade, B.J., Sun, D., Yang, A., McKeon, F.D., and Crum, C.P. (2001). Histologic and immunophenotypic classification of cervical carcinomas by expression of the p53 homologue p63: a study of 250 cases. Hum. Pathol. 32, 479-486.
22. Yamaguchi, K., Wu, L., Caballero, O.L., Hibi, K., Trink, B., Resto, V., Cairns, P., Okami, K., Koch, W.M., Sidransky, D., and Jen, J. (2000). Frequent gain of the p40/p51/p63 gene locus in primary head and neck squamous cell carcinoma. Int. J. Cancer 86, 684-689.
23. Yang, A., and McKeon, F. (2000). p63 and p73: p53 mimics, menaces, and more. Nat. Rev. Mol. Cell Biol. 1, 199-207.
24. Yang, A., Kaghad, M., Wang, Y., Gillett, E., Fleming, M.D., Dotsch, V., Andrews, N.C., Caput, D., and McKeon, F. (1998). p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol. Cell 2, 305-316.
25. Yang, A., Schweitzer, R., Sun, D., Kaghad, M., Walker, N., Bronson, R.T., Tabin, C., Sharpe, A., Caput, D., Crum, C., and McKeon, F. (1999). p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398, 714-718.
26. Yang, A., Walker, N., Bronson, R., Kaghad, M., Oosterwegel, M., Bonnin, J., Vagner, C., Bonnet, H., Dikkes, P., Sharpe, A., McKeon, F., and Caput, D. (2000). p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 404, 99-103.