Healing of duodenal ulcers is not impaired by indomethacin or rofecoxib, the selective COX-2 inhibitor, in rats

Digestion

Volumn 66, Issue 3, 2002, Pages 145-153

  Araki, Hideo ^a   Komoike, Yusaku ^a   Matsumoto, Masahiro ^a   Tanaka, Akiko ^a   Takeuchi, Koji ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Cyclooxygenase 2; Duodenal ulcer; Gastric ulcer; Healing; Indomethacin; Nitric oxide; Prostaglandin E2; Rat

Indexed keywords

ACETIC ACID; AMINOGUANIDINE; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; PROSTAGLANDIN E2; ROFECOXIB;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DUODENUM MUCOSA; DUODENUM ULCER; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; RAT; STOMACH MUCOSA; STOMACH ULCER; TISSUE; ULCER HEALING; UPREGULATION; WOUND HEALING IMPAIRMENT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE INHIBITORS; DUODENAL ULCER; ENZYME INHIBITORS; GUANIDINES; INDOMETHACIN; LACTONES; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RATS; RATS, SPRAGUE-DAWLEY; STOMACH ULCER; SULFONES; WOUND HEALING;

EID: 0036948174     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000066759     Document Type: Article

References (38)

1. Wang JY, Yamasaki S, Takeuchi K, Okabe S: Delayed healing of acetic acid-induced gastric ulcers in rats by indomethacin. Gastroenterology 1989;96:393-402.
2. Levi S, Goodlad RA, Lee CY, Stamp G, Walport MJ, Wright NA, Hodgson HJF: Inhibitory effect of non-steroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing. Lancet 1990;336:840-843.
3. Konturek PK, Brzozowski T, Konturek SJ, Dembinski A: Role of epidermal growth factor, prostaglandin, and sulfhydryls in stress-induced gastric lesions. Gastroenterology 1990; 99:1607-1615.
4. Schmassmann A, Tarnawski AS, Peskar BM, Varga L, Flogerzi B, Halter F: Influence of acid and angiogenesis on kinetics of gastric ulcer healing in rat: Interaction with indomethacin. Am J Physiol 1995;268:G276-G285.
5. Ukawa H, Yamakuni H, Kato S, Takeuchi K: Effects of cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal anti-inflammatory drugs on gastric ulcerogenic and healing responses in experimental animals. Dig Dis Sci, 1998;43:2003-2011.
6. Mizuno H, Akamatsu T, Kasuga M: Induction of cyclooxygenase-2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology 1997;112:387-397.
7. Halter F, Tarnawski AS, Schmassmann A, Pes-kar BM: Cyclooxygenase 2-implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives. Gut 2001;49:443-453.
8. Shigeta J, Takahashi S, Okabe S: Role of cyclooxygenase-2 in the healing of gastric ulcers in rats. J Pharmacol Exp Ther 1998;286:1383-1390.
9. Jones MK, Wang H, Peskar BM, Levin E, Itani RM, Sarfeh IJ, Tarnawski AS: Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing. Nat Med 1999;5:1418-1423.
10. Tsujii M, DuBois RN: Alterations in cellular adhesion and apoptosis in epithelial cells over-expressing prostaglandin endoperoxide synthase 2. Cell 1995;83:493-501.
11. Kishimoto Y, Wada K, Nakamoto K, Ashida K, Kamisaki Y, Kawasaki H, Itoh T: Quantitative analysis of cyclooxygenase-2 gene expression on acute gastric injury induced by ischemia-reperfusion in rats. Life Sci 1997;60:127-133.
12. Pai R, Szabo IL, Kawanaka H, Soreghan BA, Jones MK, Tarnawski AS: Indomethacin inhibits endothelial cell proliferation by suppressing cell cycle proteins and PRB phosphorylation: A key to its antiangiogenic action? Mol Cell Biol Res Commun 2000;4:111-116.
13. Szabo IL, Pai R, Jones MK, Ehring GR, Kawanaka H, Tarnawski AS: Indomethacin delays gastric restitution: Association with the inhibition of focal adhesion kinase and tensin phosphorylation and reduced actin stress fibers. Exp Biol Med 2002;227:412-424.
14. Singer II, Kawka DW, Schloemann S, Tessner T, Riehl T, Stenson WF: Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease. Gastroenterology 1998;115: 297-306.
15. Moncada S, Palmer RMJ, Higgs EA: Nitric oxide: Physiology, pathophysiology and pharmacology. Phamacol Rev 1991;43:109-142.
16. Whittle BJR, Lopez-Belmonte J. and Moncada S: Regulation of gastric mucosal integrity by endogenous nitric oxide: Interactions with prostaglandins and sensory neuropeptides in the rat. Br J Pharmacol 1990;99:607-611.
17. Okabe S, Pfeiffer CJ: Chronicity of acetic acid ulcer in the rat stomach. Am J Dig Dis 1972;17: 619-629.
18. Okabe S, Takeuchi K, Nakamura K, Takagi K: Effect of antipeptic and anticholinergic agents on the development and healing of duodenal ulcers in the rat. Digestion 1974;10:113-121.
19. Chan CC, Boyce S, Bridear C, Ford-Hutchinson AW, Gordon R, Guay D, Li CS, Mancini J, Panneton M, Prasit P, Rasori R, Riendeau D, Roy P, Tagari P, Vickers P, Wong E, Rodger IW: Pharmacology of a selective cyclooxygen-ase-2 inhibitor L-745,337: A novel non-steroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and non-human primate stomach. J Pharmacol Exp Ther 1995;274: 1531-1537.
20. Griffiths MJD, Messent M, MacAllister RJ, Evans TW: Aminoguanidine selectively inhibits inducible nitric oxide synthase. Br J Pharmacol 1993;110:963-968.
21. Tanaka A, Araki H, Hase S, Takeuchi K: Roles of COX-1 and COX-2 inhibition in nonsteroidal anti-inflammatory drug-induced gastric damage in rats: Relation to functional responses. Aliment Pharmacol Ther 2002;16:90-101.
22. Tanaka A, Kunikata T, Konaka A, Kato S, Takeuchi K: Dual action of nitric oxide in pathogenesis of indomethacin-induced small intestinal ulceration in rats. J Physiol Pharmacol 1999;50:405-417.
23. Futaki N, Takahashi S, Yokoyama M, Arai I, Higuchi S, Otomo S: NS-938, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclo-oxygenase (COX-2) activity in vitro. Prostaglandins 1994;47:55-59.
24. Ukawa H, Yamakuni H, Kato S, Takeuchi K: Effects of cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal anti-inflammatory drugs on gastric ulcerogenic and healing responses in experimental animals. Dig Dis Sci, 1998;43:2003-2011.
25. - channels in the basolateral membrane of rat gastric parietal cells. Jpn J Physiol 1999;49:365-372.
26. Iso JY, Sun X-H, Kao T-H, Reece KS, Wu R: Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydroge-nase cDNAs: Genomic complexity and molecular evolutiojn of the gene. Nucl Acids Res 1995;13:2485-2502.
27. Kauffman GL Jr, Kolve E, Walfisch S, Mangus J: Role of prostanoids in experimental duodenal ulcer in rat. Dig Dis Sci 1988;33:667-672.
28. Matthews JB, Garner A: Review article. Stomach wars: A mucosal defence initiative. Aliment Pharmacol Ther 1991;5:105-114.
29. Tarnawski A, Szabo IL, Husain SS, Soreghan B: Regeneration of gastric mucosa during ulcer healing is triggered by growth factors and signal transduction pathways. J Physiol Paris 2001; 95:337-344.
30. Szabo S, Folkman J, Vattay P, Morales RE, Pinkus GS, Kato K: Accelerated healing of duodenal ulcers by oral administration of mutein of fibroblast growth factor in rats. Gastroenterology 1994;106:1106-1111.
31. Konturek JW, Brzozowski T, Konturek SJ: Epidermal growth factor in protection, repair, and healing of gastroduodenal mucosa. J Clin Gastroenterol 1991;13(suppl 1):S88-S97.
32. Elliott SN, Wallace JL: Nitric oxide: A regulator of mucosal defense and injury. J Gastroenterol 1998;33:792-803.
33. Sugamoto S, Kawauchi S, Furukawa O, Takeuchi K: Interactive roles of endogenous nitric oxide and prostaglandins in acid-induced bicarbonate response in rat duodenums. Dig Dis Sci 2001;46:1208-1216.
34. Konturek SJ, Brzozowski T, Majka J, Pytko-Polmczyk J, Stachula J: Inhibition of nitric oxide synthase delays healing of chronic gastric ulcers. Eur J Pharmacol 1993;239:215-217.
35. Takeuchi K, Kato S, Takehara K, Asada Y, Yasuhiro T: Role of nitric oxide in mucosal blood flow response and healing of HCl-induced lesions in rat stomachs. Digestion 1997;58:19-27.
36. Akiba Y, Nakamura M, Mori M, Suzuki H, Oda M, Kimura H, Miura S, Tsuchiya M, Ishii H: Inhibition of inducible nitric oxide synthase delays gastric ulcer healing in the rats. J Clin Gastroenterol 1998;27(suppl 1):S64-S73.
37. Ma L, Wallace JL: Endothelial nitric oxide synthase modulates gastric ulcer healing in rats. Am J Physiol 2000;279:G341-G346.
38. Akiba Y, Guth PH, Engel E, Kaunitz JD: Acid-sensing pathways of rat duodenum. Am J Physiol 1999;277:G268-G274.