Effect of metabolite I of erdosteine on the release of human neutrophil elastase

Pharmacology

Volumn 77, Issue 3, 2006, Pages 150-154

  Braga, Pier Carlo ^a,c   Dal Sasso, Monica ^a   Culici, Maria ^a   Verducci, Paola ^b   Lo Verso, Rosa ^b   Marabini, Laura ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b AVIS   (Italy)

^c Department of Pharmacology ^*  (Italy)

Author keywords

Erdosteine; fMLP; Inhibitory effects; Met I; Neutrophil elastase

Indexed keywords

COUMARIN DERIVATIVE; DRUG METABOLITE; ERDOSTEINE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; FREE RADICAL; LEUKOCYTE ELASTASE; METHYLSUCCINYLALANYLPROLYLVALINE METHYLCOUMARIN AMIDE; OXIDIZING AGENT; UNCLASSIFIED DRUG;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG EFFECT; ENZYME INHIBITION; ENZYME RELEASE; EXOCYTOSIS; HUMAN; HUMAN CELL; INCUBATION TIME; INFLAMMATION; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL;

ADULT; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; HUMANS; LEUKOCYTE ELASTASE; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; THIOGLYCOLATES; THIOPHENES;

EID: 33746336628     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000094379     Document Type: Article

References (35)

1. Witko-Sarsat V, Rien P, Descamps-Latscha B, Lesavre P, Halbwachs-Mecarelli L: Neutrophils: molecules, functions and pathophysiological aspects. Lab Invest 2000;80:617-653.
2. Siedle B, Gustavsson L, Johansson S, Murillo R, Castro V, Bohlin L, Merfort I: The effect of sesquiterpene lactones on the release of human neutrophil elastase. Biochem Pharmacol 2003;65:897-903.
3. Bekaroglu M, Deger O, Karahan SC, Bilici M, Solylu C, Orem A: Effects of antidepressant treatments on polymorphonuclear elastase levels in patients with depression. J Affect Disord 2000;59:175-182.
4. Werner U, Seitz O, Szelenyi L: Stimulated elastase release from human leukocytes: influence of anti-asthmatic, anti-inflammatory and calcium antagonist drugs in vitro. Agents Actions 1993;38:C112-C114.
5. Fujie K, Shinguh Y, Inamura N, Yasumitsu R, Okamoto M, Okuhara M: Release of neutrophil elastase and its role in tissue injury in acute inflammation: effect of the elastase inhibitor, Fr 134043. Eur J Pharmacol 1999; 374:117-125.
6. Tyagi SC: Reversible inhibition of neutrophil elastase by thiol-modified α-1-protease inhibitor. J Biol Chem 1991;15:5279-5285.
7. 1- proteinase inhibitor complex. J Biol Chem 1998;273:9119-9123.
8. Bernstein PR, Edwards PD, Williams JC: Inhibitors of human leukocyte elastase. Prog Med Chem 1994;31:59-120.
9. Stockley RA: Role of inflammation in respiratory tract infections. Am J Med 1997;29:99.
10. MacNee W: Oxidants/antioxidants and COPD. Chest 2000;117(suppl 1):303S-317S.
11. Peden DB: Air pollution in asthma: effect of pollutants on airway inflammation. Ann Allergy Asthma Immunol 2001;87(suppl 3):12-17.
12. Tonnel A, Wallaert B: Oxidants and bronchial inflammatory diseases. Eur Respir J 1990;3:987-988.
13. Braga PC, Dal Sasso M, Sala MT, Giannelle V: Effects of erdosteine and its metabolites on bacterial adhesiveness. Arzneimittelforschung 1999;49:344-350.
14. Braga PC, Dal Sasso M, Zuccotti T: Assessment of the antioxidant activity of the SH metabolite I of erdosteine on human neutrophil oxidative bursts. Arzneimittelforschung 2000;50:739-746.
15. Dal Sasso M, Culici M, Bianchi T, Fonti E, Braga PC: Inhibitory effects of metabolite I of erdosteine on the generation of nitric oxide and peroxynitrite chemiluminescence by human neutrophils. Pharmacology 2004;71:120-127.
16. Sklar LA, McNeil VM, Jesaitis AJ, Painter RG, Cochrane G: A continuous, spectroscopic analysis of the kinetics of elastase secretion by neutrophils. The dependence of secretion upon receptor occupancy. J Biol Chem 1982;257:5471-5475.
17. De Vries GW, Amdahl LD, Kramer KD, Wheeler LA: Inhibition by manoalide of fMLP-stimulated elastase release from human neutrophils. Biochem Pharmacol 1990;40:2487-2494.
18. Southwick FS, Stossel TP: Contractile proteins in leukocyte function. Semin Hematol 1983;20:305-321.
19. Johansson S, Goransson U, Lujendjk K, Backlund A, Claeson P, Bohlin L: A neutrophil multitarget bioassay to detect anti-inflammatory natural products. J Nat Prod 2002;65:32-41.
20. Carp H, Janoff A: Possible mechanisms of emphysema in smokers. In vitro suppression serum elastase-inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants. Am Rev Respir Dis 1978;118:617-621.
21. Fischer B, Voynow JA: Neutrophil elastase induce MUC5AC messenger RNA expression by an oxidant-dependent mechanism. Chest 2000;117(suppl 1):317S-320S.
22. Voynow JA, Young LR, Wang Y, et al: Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells. Am J Physiol 1999;276:L835-L843.
23. Braga PC, Ziment I, Allegra L: Classification of agents that act on bronchial mucus; in Braga PC, Allegra L (eds): Drugs in Bronchial Mucology. New York, Raven Press, 1989, pp 59-67.
24. Vanderbist F, Maes P, Neve J: In vitro comparative assessment of the antioxidant activity of nacystelyn against three reactive oxygen species. Arzneimittelforschung 1996;46:783-788.
25. Dechant KL, Noble S: Erdosteine. Drugs 1996;52:875-881.
26. Johnson D, Travis J: Structural evidence for methionine at the reactive site of human alpha-1-proteinase inhibitor. J Biol Chem 1978;253:7142-7144.
27. Hubbard RC, Crystal RG: Antiproteases and antioxidant strategies for the pharmacological prevention of lung destruction. Respiration 1986;50(suppl):56- 73.
28. Johnson D, Travis J: The oxidative inactivation of human alpha-1-proteinase inhibitor. J Biol Chem 1979;254:4022-4026.
29. Beatty K, Bieth J, Travis J: Kinetics of association of serine proteases with native and oxidized alpha-1-antitrypsin inhibitor and alpha-1- antichymotrypsin. J Biol Chem 1980;255:3931-3934.
30. Iwamura H, Moore AR, Willoughly DA: Interaction between neutrophil-derived elastase and reactive oxygen species in cartilage degradation. Biochem Biophys Acta 1993;1156:295-301.
31. Gressier B, Cabanis A, Lebegue S, Brunet C, Dine T, Luyckx M, Cazin M, Cazin JC: Comparison of in vitro effects of two thiol-containing drugs on human neutrophils hydrogen peroxide production. Methods Find Exp Clin Pharmacol 1993;15:101-105.
32. Crystal RG: Alpha-1-antitrypsin deficiency, ephysema and liver disease. Genetic basis and strategies for therapy. J Clin Invest 1990;85:1343-1352.
33. Gazzani G, Fregnan GB, Vandoni G: In vitro protection by erdosteine against oxidative inactivation of alpha-1-antitrypsin by cigarette smoke. Respiration 1989;55:113-118.
34. 1-antitrypsin activity in rat lungs. Int J Clin Pharmacol Ther Toxicol 1989;27:235-237.
35. Vagliasindi M, Fregnan GB: Erdosteine protection against cigarette smoking-induced functional antiprotease deficiency in human bronchiolo-alveolar structures. Int J Clin Pharmacol Ther Toxicol 1989;27:238-241.