The inhibition of glutamine synthetase sensitizes human sarcoma cells to L-asparaginase

Cancer Chemotherapy and Pharmacology

Volumn 60, Issue 5, 2007, Pages 751-758

  Tardito, S ^a   Uggeri, J ^a   Bozzetti, C ^b   Bianchi, M G ^a   Rotoli, B M ^a   Franchi Gazzola, R ^a   Gazzola, G C ^a   Gatti, R ^a   Bussolati, O ^a  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSITY HOSPITAL OF PARMA   (Italy)

Author keywords

Asparaginase; Glutamine synthetase; HT1080; Methionine sulfoximine; Osteosarcoma; Rhabdomyosarcoma

Indexed keywords

ASPARAGINASE; GLUTAMATE AMMONIA LIGASE; METHIONINE SULFOXIMINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG SENSITIVITY; ENZYME BLOOD LEVEL; ENZYME SYNTHESIS; FIBROSARCOMA; HUMAN; HUMAN CELL; IC 50; LIPOSARCOMA; METABOLIC STRESS; OSTEOSARCOMA CELL; PRIORITY JOURNAL; RHABDOMYOSARCOMA; SARCOMA CELL;

ANTINEOPLASTIC AGENTS; ASPARAGINASE; CASPASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; GLUTAMATE-AMMONIA LIGASE; HUMANS; METHIONINE SULFOXIMINE; SARCOMA; TUMOR CELLS, CULTURED;

EID: 34547838476     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-007-0421-z     Document Type: Article

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