Effect of octanol:water partition coefficients of organophosphorus compounds on biodistribution and percutaneous toxicity

Journal of Biochemical and Molecular Toxicology

Volumn 20, Issue 5, 2006, Pages 241-246

  Czerwinski, Steven E ^a   Skvorak, John P ^b   Maxwell, Donald M ^c   Lenz, David E ^c   Baskin, Steven I ^c  

^a U S ARMY CENTER FOR HEALTH PROMOTION AND PREVENTIVE MEDICINE   (United States)

^b UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^c US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Fluorophosphonate Fragment; Organophosphates; Organophosphorus Compounds; Partition Coefficient; Percutaneous Penetration

Indexed keywords

CYCLOSARIN; FLUOROPHOSPHONATE; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; OCTANOL; ORGANOPHOSPHORUS COMPOUND; PHOSPHONIC ACID DERIVATIVE; SARIN; SOMAN; TABUN; UNCLASSIFIED DRUG; WATER;

ABSORPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD; CONCENTRATION RESPONSE; CORRELATION ANALYSIS; FASCICULATION; GAS CHROMATOGRAPHY; GUINEA PIG; MALE; NONHUMAN; PARTITION COEFFICIENT; SKIN TOXICITY; TISSUE DISTRIBUTION; TOXICITY TESTING;

ADMINISTRATION, CUTANEOUS; ANIMALS; CHEMICAL WARFARE AGENTS; GUINEA PIGS; LETHAL DOSE 50; MALE; OCTANOLS; ORGANOPHOSPHORUS COMPOUNDS; SKIN; SKIN ABSORPTION; SOLUBILITY; TISSUE DISTRIBUTION; WATER;

CAVIA;

EID: 33750001722     PISSN: 10956670     EISSN: 10990461     Source Type: Journal    
DOI: 10.1002/jbt.20140     Document Type: Article

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