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Volumn 1, Issue , 2008, Pages 151-181

Adenovirus-based Gene Therapy: Therapeutic Angiogenesis with Adenovirus 5 Fibroblast Growth Factor-4 (Ad5FGF-4) in Patients with Chronic Myocardial Ischemia

Author keywords

Adenovirus 5; Fractogel; Ischemia; Shuttle vector; Ultra filtration

Indexed keywords


EID: 34547806456     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527620982.ch6     Document Type: Chapter
Times cited : (4)

References (54)
  • 1
    • 0031053265 scopus 로고    scopus 로고
    • Management of stable angina pectoris: recommendation of the Task Force of the European Society of Cardiology
    • European Society of Cardiology.
    • European Society of Cardiology. Management of stable angina pectoris: recommendation of the Task Force of the European Society of Cardiology. Eur Heart J 1997; 18:394-413.
    • (1997) Eur Heart J , vol.18 , pp. 394-413
  • 2
    • 0004458963 scopus 로고    scopus 로고
    • Angiogenesis and collateral formation
    • In: March KL, Ed. Gene Transfer in the Cardiovascular System: Experimental Approaches and Therapeutic Implications, Boston: Kluwer Academic Publishers
    • Isner JM. Angiogenesis and collateral formation. In: March KL, Ed. Gene Transfer in the Cardiovascular System: Experimental Approaches and Therapeutic Implications. Boston: Kluwer Academic Publishers, 1997; pp. 307-330.
    • (1997) , pp. 307-330
    • Isner, J.M.1
  • 3
    • 0034915984 scopus 로고    scopus 로고
    • The future of human gene therapy
    • Rubanyi GM. The future of human gene therapy. Mol Aspects Med 2001; 22:113-142.
    • (2001) Mol Aspects Med , vol.22 , pp. 113-142
    • Rubanyi, G.M.1
  • 4
    • 0038372757 scopus 로고    scopus 로고
    • Is there functional collateral flow during vascular occlusion in angiographically normal coronary arteries?
    • Wustman K, Zbinden S, Windecker S, Meier B, Seiler C. Is there functional collateral flow during vascular occlusion in angiographically normal coronary arteries? Circulation 2003; 107:2213-2220.
    • (2003) Circulation , vol.107 , pp. 2213-2220
    • Wustman, K.1    Zbinden, S.2    Windecker, S.3    Meier, B.4    Seiler, C.5
  • 5
    • 0024562809 scopus 로고
    • Coronary collateral circulation: clinical significance and influence on survival in patients with coronary artery occlusion
    • Hansen JF. Coronary collateral circulation: clinical significance and influence on survival in patients with coronary artery occlusion. Am Heart J 1989; 117:290-295.
    • (1989) Am Heart J , vol.117 , pp. 290-295
    • Hansen, J.F.1
  • 6
    • 85047678529 scopus 로고
    • A model to assess interventions to improve collateral blood flow: continuous administration of agents into the left coronary artery in dogs
    • Unger EF, Banai S, Shou M, Jaklitsch M, Hodge E, Correa R, Jaye M, Epstein SE. A model to assess interventions to improve collateral blood flow: continuous administration of agents into the left coronary artery in dogs. Cardiovasc Res 1993; 27:785-791.
    • (1993) Cardiovasc Res , vol.27 , pp. 785-791
    • Unger, E.F.1    Banai, S.2    Shou, M.3    Jaklitsch, M.4    Hodge, E.5    Correa, R.6    Jaye, M.7    Epstein, S.E.8
  • 7
    • 0028098738 scopus 로고
    • Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts
    • Harada K, Grossman W, Friedman M, et al. Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts. J Clin Invest 1994; 94:623-630.
    • (1994) J Clin Invest , vol.94 , pp. 623-630
    • Harada, K.1    Grossman, W.2    Friedman, M.3
  • 8
    • 0029877965 scopus 로고    scopus 로고
    • Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart
    • Giordano FJ, Ping P, McKirnan MD, et al. Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart. Nature Med 1996; 2:534-539.
    • (1996) Nature Med , vol.2 , pp. 534-539
    • Giordano, F.J.1    Ping, P.2    McKirnan, M.D.3
  • 9
    • 0032578961 scopus 로고    scopus 로고
    • Gene therapy for myocardial angio-genesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia
    • Losordo DW, Vale PR, Symes JF, et al. Gene therapy for myocardial angio-genesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia. Circulation 1998; 98:2800-2804.
    • (1998) Circulation , vol.98 , pp. 2800-2804
    • Losordo, D.W.1    Vale, P.R.2    Symes, J.F.3
  • 10
    • 0033520056 scopus 로고    scopus 로고
    • Angiogenesis gene therapy: phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease
    • Rosengart TK, Lee LY, Patel SR, et al. Angiogenesis gene therapy: phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease. Circulation 1999; 100:468-474.
    • (1999) Circulation , vol.100 , pp. 468-474
    • Rosengart, T.K.1    Lee, L.Y.2    Patel, S.R.3
  • 11
    • 0033503798 scopus 로고    scopus 로고
    • Sixmonth assessment of a phase I trial of angiogenic gene therapy for the treatment of coronary artery disease using direct intramyocardial administration of an adenovirus vector expressing the VEGF121 cDNA
    • Rosengart TK, Lee LY, Patel SR, et al. Sixmonth assessment of a phase I trial of angiogenic gene therapy for the treatment of coronary artery disease using direct intramyocardial administration of an adenovirus vector expressing the VEGF121 cDNA. Ann Surg 1999; 230:466-470.
    • (1999) Ann Surg , vol.230 , pp. 466-470
    • Rosengart, T.K.1    Lee, L.Y.2    Patel, S.R.3
  • 12
    • 6644223710 scopus 로고    scopus 로고
    • Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ven- tricular electromechanical mapping in patients with chronic myocardial ischemia
    • Vale PR, Losordo DW, Milliken CE, et al. Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ven- tricular electromechanical mapping in patients with chronic myocardial ischemia. Circulation 2001; 103:2138-2143.
    • (2001) Circulation , vol.103 , pp. 2138-2143
    • Vale, P.R.1    Losordo, D.W.2    Milliken, C.E.3
  • 13
    • 0037133624 scopus 로고    scopus 로고
    • Angiogenic Gene Therapy (AGENT) trial in patients with stable angina pectoris
    • Grines CL, Watkins MW, Helmer G, et al. Angiogenic Gene Therapy (AGENT) trial in patients with stable angina pectoris. Circulation 2002; 105(11):1291-1297.
    • (2002) Circulation , vol.105 , Issue.11 , pp. 1291-1297
    • Grines, C.L.1    Watkins, M.W.2    Helmer, G.3
  • 14
    • 0142107372 scopus 로고    scopus 로고
    • A randomized double blind placebo-controlled trial of Ad5FGF-4 gene therapy and its effect on myocardial perfusion in patients with stable angina
    • Grines CL, Watkins M, Mahmarian J, et al. A randomized double blind placebo-controlled trial of Ad5FGF-4 gene therapy and its effect on myocardial perfusion in patients with stable angina. J Am Coll Cardiol 2003; 42:1339-1347.
    • (2003) J Am Coll Cardiol , vol.42 , pp. 1339-1347
    • Grines, C.L.1    Watkins, M.2    Mahmarian, J.3
  • 15
    • 0034650348 scopus 로고    scopus 로고
    • Cardiovascular gene therapy
    • Ylä-Herttuala S, Martin JF. Cardiovascular gene therapy. Lancet 2000; 355:213-222.
    • (2000) Lancet , vol.355 , pp. 213-222
    • Ylä-Herttuala, S.1    Martin, J.F.2
  • 16
    • 0032562232 scopus 로고    scopus 로고
    • Induction of neoangiogenesis in ischemic myocardium by human growth factors: first clinical results of a new treatment of coronary heart disease
    • Schumacher B, Pecher P, von Specht BU, et al. Induction of neoangiogenesis in ischemic myocardium by human growth factors: first clinical results of a new treatment of coronary heart disease. Circulation 1998; 97:645-650.
    • (1998) Circulation , vol.97 , pp. 645-650
    • Schumacher, B.1    Pecher, P.2    von Specht, B.U.3
  • 17
    • 0034688216 scopus 로고    scopus 로고
    • Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty
    • Laitinen M, Hartikainen J, Hiltunen MO, et al. Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty. Hum Gene Ther 2000; 11:263-270.
    • (2000) Hum Gene Ther , vol.11 , pp. 263-270
    • Laitinen, M.1    Hartikainen, J.2    Hiltunen, M.O.3
  • 18
    • 0037383149 scopus 로고    scopus 로고
    • Insights from angiogenesis trials using fibroblast growth factor for advanced arteriosclerotic disease
    • Khurana R, Simons M. Insights from angiogenesis trials using fibroblast growth factor for advanced arteriosclerotic disease. Trends Cardiovasc Med 2003; 13:116-122.
    • (2003) Trends Cardiovasc Med , vol.13 , pp. 116-122
    • Khurana, R.1    Simons, M.2
  • 19
    • 0035073338 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of recombinant FGF-2 in a phase I trial in coronary artery disease
    • Bush MA, Samara E, Whitehouse MJ, et al. Pharmacokinetics and pharmacodynamics of recombinant FGF-2 in a phase I trial in coronary artery disease. J Clin Pharmacol 2001; 41:378-385.
    • (2001) J Clin Pharmacol , vol.41 , pp. 378-385
    • Bush, M.A.1    Samara, E.2    Whitehouse, M.J.3
  • 20
    • 0037133306 scopus 로고    scopus 로고
    • Pharmacological treatment of coronary artery disease with recombinant fibroblast growth factor-2: double-blind, randomized, controlled clinical trial
    • Simons M, Annex BH, Laham RJ, et al. Pharmacological treatment of coronary artery disease with recombinant fibroblast growth factor-2: double-blind, randomized, controlled clinical trial. Circulation 2002; 105:788-793.
    • (2002) Circulation , vol.105 , pp. 788-793
    • Simons, M.1    Annex, B.H.2    Laham, R.J.3
  • 21
    • 0036658287 scopus 로고    scopus 로고
    • Longterm effects of surgical angiogenic therapy with fibroblast growth factor 2 protein
    • Ruel M, Laham RJ, Parker JA, et al. Longterm effects of surgical angiogenic therapy with fibroblast growth factor 2 protein. J Thorac Cardiovasc Surg 2002; 124:28-34.
    • (2002) J Thorac Cardiovasc Surg , vol.124 , pp. 28-34
    • Ruel, M.1    Laham, R.J.2    Parker, J.A.3
  • 22
    • 0035980172 scopus 로고    scopus 로고
    • Assessment of risks associated with cardiovascular gene therapy in human subjects
    • Isner JM, Vale PR, Symes JF, et al. Assessment of risks associated with cardiovascular gene therapy in human subjects. Circ Res 2001; 89:389-400.
    • (2001) Circ Res , vol.89 , pp. 389-400
    • Isner, J.M.1    Vale, P.R.2    Symes, J.F.3
  • 23
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P. Angiogenesis in health and disease. Nature Med 2003; 9:653-660.
    • (2003) Nature Med , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 24
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: role of the HIF system
    • Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nature Med 2003; 9:677-684.
    • (2003) Nature Med , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 25
    • 0037968240 scopus 로고    scopus 로고
    • Gene transfer as a tool to induce therapeutic vascular growth
    • Ylä-Herttuala S, Alitalo K. Gene transfer as a tool to induce therapeutic vascular growth. Nature Med 2003; 9:694-701.
    • (2003) Nature Med , vol.9 , pp. 694-701
    • Ylä-Herttuala, S.1    Alitalo, K.2
  • 26
  • 27
    • 0037265253 scopus 로고    scopus 로고
    • Fibroblast growth factor-4 induces vascular permeability, angiogenesis and arteriogenesis in a rabbit hindlimb ischemia model
    • Rissanen TT, Markkanen JE, Arve K, et al. Fibroblast growth factor-4 induces vascular permeability, angiogenesis and arteriogenesis in a rabbit hindlimb ischemia model. FASEB J 2003; 17:100-102.
    • (2003) FASEB J , vol.17 , pp. 100-102
    • Rissanen, T.T.1    Markkanen, J.E.2    Arve, K.3
  • 28
    • 3042521592 scopus 로고    scopus 로고
    • Nitric oxide and arterial disease
    • Barbato JG, Tzeng E. Nitric oxide and arterial disease. J Vasc Surg 2004; 40:187-193.
    • (2004) J Vasc Surg , vol.40 , pp. 187-193
    • Barbato, J.G.1    Tzeng, E.2
  • 29
    • 0037112560 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 gene transfer can stimulate hepatocyte growth factor expression irrespective of hypoxia-mediated downregulation in ischemic limbs
    • Onimaru M, Yonemitsu Y, Tanii M, et al. Fibroblast growth factor-2 gene transfer can stimulate hepatocyte growth factor expression irrespective of hypoxia-mediated downregulation in ischemic limbs. Circ Res 2002; 91:923-930.
    • (2002) Circ Res , vol.91 , pp. 923-930
    • Onimaru, M.1    Yonemitsu, Y.2    Tanii, M.3
  • 30
    • 0009840776 scopus 로고    scopus 로고
    • Arteriogenesis, collateral blood vessels, and their development
    • In: Rubanyi GM, Ed. Angiogenesis in Health and Disease. New York: Marcel Dekker
    • Deindl E, Fernández B, Höfer IE, et al. Arteriogenesis, collateral blood vessels, and their development. In: Rubanyi GM, Ed. Angiogenesis in Health and Disease. New York: Marcel Dekker; 2000; pp. 31-45.
    • (2000) , pp. 31-45
    • Deindl, E.1    Fernández, B.2    Höfer, I.E.3
  • 31
    • 0346157995 scopus 로고    scopus 로고
    • Cardiacspecific overexpression of fibroblast growth factor-2 protects against myocardial dysfunction and infarction in a murine model of lowflow ischemia
    • House SL, Bolte C, Zhou M, et al. Cardiacspecific overexpression of fibroblast growth factor-2 protects against myocardial dysfunction and infarction in a murine model of lowflow ischemia. Circulation 2003; 108:3140-3148.
    • (2003) Circulation , vol.108 , pp. 3140-3148
    • House, S.L.1    Bolte, C.2    Zhou, M.3
  • 32
    • 0037197740 scopus 로고    scopus 로고
    • Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia
    • Losordo DW, Vale PR, Hendel RC, et al. Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia. Circulation 2002; 105:2012-2018.
    • (2002) Circulation , vol.105 , pp. 2012-2018
    • Losordo, D.W.1    Vale, P.R.2    Hendel, R.C.3
  • 33
    • 0038210219 scopus 로고    scopus 로고
    • Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio Angiogenesis Trial (KAT)
    • Hedman M, Hartikainen J, Syvanne M, et al. Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio Angiogenesis Trial (KAT). Circulation 2003; 107:2677-2683.
    • (2003) Circulation , vol.107 , pp. 2677-2683
    • Hedman, M.1    Hartikainen, J.2    Syvanne, M.3
  • 34
    • 0035320671 scopus 로고    scopus 로고
    • Perspectives on selective retroinfusion of coronary veins as an alternative approach for myocardial gene transfer and angiogenesis
    • Boekstegers P. Perspectives on selective retroinfusion of coronary veins as an alternative approach for myocardial gene transfer and angiogenesis. J Invasive Cardiol 2001; 13:339-342.
    • (2001) J Invasive Cardiol , vol.13 , pp. 339-342
    • Boekstegers, P.1
  • 35
    • 0023613622 scopus 로고
    • An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family
    • Delli Bovi P, Curatola AM, Kern FG, et al. An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family. Cell 1987; 50:729-737.
    • (1987) Cell , vol.50 , pp. 729-737
    • Delli Bovi, P.1    Curatola, A.M.2    Kern, F.G.3
  • 36
    • 0026455171 scopus 로고
    • Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism
    • Gomez-Foix AM, Coats WS, Baque S, et al. Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism. J Biol Chem 1992; 267:25129-25134.
    • (1992) J Biol Chem , vol.267 , pp. 25129-25134
    • Gomez-Foix, A.M.1    Coats, W.S.2    Baque, S.3
  • 37
    • 0023883716 scopus 로고
    • A simple technique for the rescue of early region 1 mutations into infectious human Adenovirus Type 5
    • McGrory WJ, Bautista DS, Graham FL. A simple technique for the rescue of early region 1 mutations into infectious human Adenovirus Type 5. Virology 1988; 163:614-617.
    • (1988) Virology , vol.163 , pp. 614-617
    • McGrory, W.J.1    Bautista, D.S.2    Graham, F.L.3
  • 38
    • 0028879804 scopus 로고
    • DNA sequence of the deletion/insertion in early region 3 of Ad5 dl309
    • Bett AJ, Krougliak V, Graham FL. DNA sequence of the deletion/insertion in early region 3 of Ad5 dl309. Virus Res 1995; 39:75-82.
    • (1995) Virus Res , vol.39 , pp. 75-82
    • Bett, A.J.1    Krougliak, V.2    Graham, F.L.3
  • 39
    • 0032425329 scopus 로고    scopus 로고
    • A high yielding serum-free cell culture process to manufacture recombinant adenoviral vectors for gene therapy
    • Schoofs G, Monica T, Ayala J, et al. A high yielding serum-free cell culture process to manufacture recombinant adenoviral vectors for gene therapy. Cytotechnology 1998; 28:81-89.
    • (1998) Cytotechnology , vol.28 , pp. 81-89
    • Schoofs, G.1    Monica, T.2    Ayala, J.3
  • 40
    • 0028825639 scopus 로고
    • Purification of a type 5 adenovirus encoding human p53 by column chromatography
    • Huyghe BG, Liu X, Sutjipto S., et al. Purification of a type 5 adenovirus encoding human p53 by column chromatography. Human Gene Ther 1995; 6:1403-1416.
    • (1995) Human Gene Ther , vol.6 , pp. 1403-1416
    • Huyghe, B.G.1    Liu, X.2    Sutjipto, S.3
  • 41
    • 0034693397 scopus 로고    scopus 로고
    • Capillary zone electrophoresis of a recombinant adenovirus
    • Mann B, Traina J, Soderbloom C, et al. Capillary zone electrophoresis of a recombinant adenovirus. J Chromatogr A 2000; 895:329-337.
    • (2000) J Chromatogr A , vol.895 , pp. 329-337
    • Mann, B.1    Traina, J.2    Soderbloom, C.3
  • 42
    • 0032844681 scopus 로고    scopus 로고
    • Reversed- phase high performance liquid chromatographic assay for the adenovirus type 5 proteome
    • Lehmberg E, Traina JA, Chakel JA, et al. Reversed- phase high performance liquid chromatographic assay for the adenovirus type 5 proteome. J Chromatogr B 1999; 732:411-423.
    • (1999) J Chromatogr B , vol.732 , pp. 411-423
    • Lehmberg, E.1    Traina, J.A.2    Chakel, J.A.3
  • 43
    • 84889987982 scopus 로고    scopus 로고
    • Analytical assays to characterize adenoviral vectors and theoretic applications
    • In: Subramanian G, Ed. Manufacturing of Gene Therapeutics. Kluwer Academic/Plenum Press
    • Lehmberg E, McCaman M, Traina J, et al. Analytical assays to characterize adenoviral vectors and theoretic applications. In: Subramanian G, Ed. Manufacturing of Gene Therapeutics. Kluwer Academic/Plenum Press, 2004; pp. 210-225.
    • (2004) , pp. 210-225
    • Lehmberg, E.1    McCaman, M.2    Traina, J.3
  • 44
    • 0036000328 scopus 로고    scopus 로고
    • A single short stretch of homology between adenoviral vector and packaging cell line can give rise to cytopathic effect-inducing, helper-dependent E1-positive particles
    • Murakami P, Pungor E, Files J, et al. A single short stretch of homology between adenoviral vector and packaging cell line can give rise to cytopathic effect-inducing, helper-dependent E1-positive particles. Human Gene Ther 2002; 13:909-920.
    • (2002) Human Gene Ther , vol.13 , pp. 909-920
    • Murakami, P.1    Pungor, E.2    Files, J.3
  • 45
    • 2642549761 scopus 로고    scopus 로고
    • Common structure of rare replication-deficient E1-positive particles in adenoviral vector batches
    • Murakami P, Havenga M, Fawaz F, et al. Common structure of rare replication-deficient E1-positive particles in adenoviral vector batches. J Virol 2004; 78:6200-6208.
    • (2004) J Virol , vol.78 , pp. 6200-6208
    • Murakami, P.1    Havenga, M.2    Fawaz, F.3
  • 46
    • 0026670282 scopus 로고
    • A rapid chemiluminescent method for quantitation of human DNA
    • Walsh PS, Varlaro J, Reynolds R. A rapid chemiluminescent method for quantitation of human DNA. Nucleic Acids Res 1992; 20:5061-5065.
    • (1992) Nucleic Acids Res , vol.20 , pp. 5061-5065
    • Walsh, P.S.1    Varlaro, J.2    Reynolds, R.3
  • 47
    • 0026551721 scopus 로고
    • The sequence of the genome of adenovirus type 5 and its comparison with the genome of adenovirus type 2
    • Chroboczek J, Bieber F, Jacrot B. The sequence of the genome of adenovirus type 5 and its comparison with the genome of adenovirus type 2. Virology 1992; 186(1):280-285.
    • (1992) Virology , vol.186 , Issue.1 , pp. 280-285
    • Chroboczek, J.1    Bieber, F.2    Jacrot, B.3
  • 48
    • 0018573867 scopus 로고
    • A mutation which alters initiation of transcription by RNA Polymerase III on the Ad5 chromosome
    • Thimmappaya B, Jones N, Shenk T. A mutation which alters initiation of transcription by RNA Polymerase III on the Ad5 chromosome. Cell 1979; 18:947-954.
    • (1979) Cell , vol.18 , pp. 947-954
    • Thimmappaya, B.1    Jones, N.2    Shenk, T.3
  • 49
    • 4544277367 scopus 로고    scopus 로고
    • The complete nucleic acid sequence of the Adenovirus Type 5 Reference Material (ARM) genome
    • Sugarman BJ, Hutchins BM, McAllister DL, et al. The complete nucleic acid sequence of the Adenovirus Type 5 Reference Material (ARM) genome. Bioprocess J 2003; 2(5):27-33.
    • (2003) Bioprocess J , vol.2 , Issue.5 , pp. 27-33
    • Sugarman, B.J.1    Hutchins, B.M.2    McAllister, D.L.3
  • 50
    • 0032853699 scopus 로고    scopus 로고
    • Immune responses to adenovirus and adeno-associated virus in humans
    • Chirmule N, Propert K, Magosin S, et al. Immune responses to adenovirus and adeno-associated virus in humans. Gene Ther 1999; 6:1574-1583.
    • (1999) Gene Ther , vol.6 , pp. 1574-1583
    • Chirmule, N.1    Propert, K.2    Magosin, S.3
  • 51
    • 0033865751 scopus 로고    scopus 로고
    • Immune response to recombinant adenovirus in humans: capsid components from the viral input are targets for vector-specific cytotoxic T lymphocytes
    • Molinier-Frenkel V, Gahery-Segard H, Mehtali M, et al. Immune response to recombinant adenovirus in humans: capsid components from the viral input are targets for vector-specific cytotoxic T lymphocytes. J Virol 2000; 74(16):7678-7682.
    • (2000) J Virol , vol.74 , Issue.16 , pp. 7678-7682
    • Molinier-Frenkel, V.1    Gahery-Segard, H.2    Mehtali, M.3
  • 52
    • 84889828923 scopus 로고    scopus 로고
    • Gene therapy for coronary artery disease: Preclinical and initial clinical results with intracoronary administration of Ad5FGF-4
    • In: Rubanyi GM & Ylä-Herttuala S, Eds. Human Gene Therapy: Current Opportunities and Future Trends. Berlin: Springer
    • Watkins MW, Rubanyi GM. Gene therapy for coronary artery disease: Preclinical and initial clinical results with intracoronary administration of Ad5FGF-4. In: Rubanyi GM & Ylä-Herttuala S, Eds. Human Gene Therapy: Current Opportunities and Future Trends. Berlin: Springer, 2003; pp. 61-80.
    • (2003) , pp. 61-80
    • Watkins, M.W.1    Rubanyi, G.M.2
  • 53
    • 4043109454 scopus 로고    scopus 로고
    • Increased regional function and perfusion after intracoronary delivery of adenovirus encoding fibroblast growth factor-4: Report of preclinical data
    • Gao MH, Lai NC, McKirnan MD, et al. Increased regional function and perfusion after intracoronary delivery of adenovirus encoding fibroblast growth factor-4: Report of preclinical data. Human Gene Ther 2004; 15:574-587.
    • (2004) Human Gene Ther , vol.15 , pp. 574-587
    • Gao, M.H.1    Lai, N.C.2    McKirnan, M.D.3
  • 54
    • 4043136596 scopus 로고    scopus 로고
    • The design and preclinical testing of Ad5FGF-4 to treat chronic myocardial ischemia
    • Rubanyi GM. The design and preclinical testing of Ad5FGF-4 to treat chronic myocardial ischemia. Eur Heart J (Suppl. E) 2004; 6:E12-E17.
    • (2004) Eur Heart J , vol.6 , Issue.SUPPL. E
    • Rubanyi, G.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.