Endogenous interleukin-10 produced by antigen-irrelevant cells promotes the development of experimental murine allergic conjunctivitis

International Archives of Allergy and Immunology

Volumn 144, Issue 1, 2007, Pages 79-84

  Fukushima, Atsuki ^a   Sumi, Tamaki ^a   Fukuda, Ken ^b   Kumagai, Naoki ^b   Nishida, Teruo ^b   Ueno, Hisayuki ^a  

^a KOCHI MEDICAL SCHOOL   (Japan)

^b YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Allergic conjunctivitis; Eosinophil; Interleukin 10; Knockout mouse

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN; INTERLEUKIN 10; RAGWEED ANTIGEN;

ALLERGIC CONJUNCTIVITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD; CELL INFILTRATION; CELL POPULATION; CELL PROLIFERATION; CONJUNCTIVA; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHIL; HISTOLOGY; IMMUNIZATION; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOREGULATION; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAGWEED; SPLEEN; SPLEEN CELL; TH2 CELL;

ADOPTIVE TRANSFER; AMBROSIA; ANIMALS; ANTIGENS, PLANT; CONJUNCTIVA; CONJUNCTIVITIS, ALLERGIC; DISEASE MODELS, ANIMAL; INTERLEUKIN-10; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SPLEEN; TH2 CELLS; UP-REGULATION;

EID: 34547806243     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000102618     Document Type: Article

References (24)

1. Fukagawa K, Nakajima T, Tsubota K, Shimmura S, Saito H, Hirai K: Presence of eotaxin in tears of patients with atopic keratoconjunctivitis with severe corneal damage. J Allergy Clin Immunol 1999;103:1220-1221.
2. Bonini S, Magrini L, Rotiroti G, Lambiase A, Tomassini M, Rumi C, Bonini S: The eosinophil and the eye. Allergy 1997;52:44-47.
3. Yoshida O, Yoshida H, Iwamoto H, Nishino K, Fukushima A, Ueno H: Genetic background determines the nature of immune responses and experimental immune-mediated blepharoconjunctivitis (EC). Curr Eye Res 1999;18:117-124.
4. Fukushima A, Ozaki A, Fukata K, Ishida W, Ueno H: Ag-specific recognition, activation, and effector function of T cells in the conjunctiva with experimental immune-mediated blepharoconjunctivitis. Invest Ophthalmol Vis Sci 2003;44: 4366-4374.
5. Fukushima A, Ozaki A, Jian Z, Ishida W, Fukata K, Ueno H, Liu FT: Dissection of antigen-specific humoral and cellular immune responses for the development of experimental immune-mediated blepharoconjunctivitis in C57BL/6 mice. Curr Eye Res 2005;30:241-248.
6. Fukushima A, Yamaguchi T, Ishida W, Fukata K, Taniguchi T, Liu FT, Ueno H: Genetic background determines susceptibility to experimental immune-mediated blepharoconjunctivitis: comparison of Balb/c and C57BL/6 mice. Exp Eye Res 2006;82:210-218.
7. Fukushima A, Yoshida H, Iwamoto H, Yoshida O, Ueno H: The role of cellular immunity both in the induction and effector phases of experimental allergic blepharoconjunctivitis (EAC) in rats. Exp Eye Res 1997;65:631-637.
8. Taylor A, Verhagen J, Blaser K, Akdis M, Akdis CA: Mechanisms of immune suppression by interleukin-10 and transforming growth factor-β: the role of T regulatory cells. Immunology 2006;117:433-442.
9. Mosmann TR, Schumacher JH, Fiorentino DF, Leverah J, Moore KW, Bond MW: Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmuno-adsorbent assay. J Immunol 1990;145:2938-2945.
10. Rott O, Fleischer B, Cash E: Interleukin-10 prevents experimental allergic encephalomyelitis in rats. Eur J Immunol 1994;24:1434-1440.
11. Kezuka T, Takeuchi M, Keino H, Usui Y, Takeuchi A, Yamakawa N, Usui M: Peritoneal exudate cells treated with calcitonin gene-related peptide suppress murine experimental autoimmune uveoretinitis via IL-10. J Immunol 2004;173:1454-1462.
12. Hall G, Houghton CG, Rahbek JU, Lamb JR, Jarman ER: Suppression of allergen reactive Th2 mediated responses and pulmonary eosinophilia by intranasal administration of an immunodominant peptide is linked to IL-10 production. Vaccine 2003;21:549-561.
13. Nakagome K, Dohi M, Okunishi K, Komagata Y, Nagatani K, Tanaka R, Miyazaki J, Yamamoto K: In vivo IL-10 gene delivery suppresses airway eosinophilia and hyperreactivity by down-regulating APC functions and migration without impairing the antigen-specific systemic immune response in a mouse model of allergic airway inflammation. J Immunol 2005;174:6955-6966.
14. Fukushima A, Sumi T, Fukuda K, Kumagai N, Nishida T, Yagita H, Ueno H: IL-10 and TGF-β contribute to the development of experimentally induced allergic conjunctivitis in mice during the effector phase. Br J Ophthalmol 2006;90:1535-1541.
15. Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W: Interleukin-10- deficient mice develop chronic enterocolitis. Cell 1993;75:263-274.
16. Fukushima A, Yamaguchi T, Fukuda K, Sumi T, Kumagai N, Nishida T, Imai S, Ueno H: CD8+ T cells play disparate roles in the induction and the effector phases of murine experimental allergic conjunctivitis. Microbiol Immunol 2006;50:719-728.
17. Fukushima A, Yamaguchi T, Ishida W, Fukata K, Yagita H, Ueno H: The interaction between ICOS and B7RP-1 is not required for the development of experimental murine allergic conjunctivitis. Biochem Biophys Res Commun 2005;338:1726-1731.
18. Makela MJ, Kanehiro A, Borish L, Dakhama A, Loader J, Joetham A, Xing Z, Jordana M, Larsen GL, Gelfand EW: IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization. Proc Natl Acad Sci USA 2000;97:6007-6012.
19. Yang X, Wang S, Fan Y, Han X: IL-10 deficiency prevents IL-5 overproduction and eosinophilic inflammation in a murine model of asthma-like reaction. Eur J Immunol 2000;30:382-391.
20. Enk AH, Saloga J, Becker D, Mohamadzadeh M, Knop J: Induction of hapten-specific tolerance by interleukin 10 in vivo. J Exp Med 1994;179:1397-1402.
21. Oh JW, Seroogy CM, Meyer EH, Akbari O, Berry G, Fathman CG, Dekruyff RH, Umetsu DT: CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation. J Allergy Clin Immunol 2002;110:460-468.
22. Grunig G, Corry DB, Leach MW, Seymour BW, Kurup VP, Rennick DM: Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis. J Exp Med 1997;185:1089-1099.
23. Tournoy KG, Kips JC, Pauwels RA: Endogenous interleukin-10 suppresses allergen-induced airway inflammation and nonspecific airway responsiveness. Clin Exp Allergy 2000;30:775-783.
24. Leonardi A, Curnow SJ, Zhan H, Calder VL: Multiple cytokines in human tear specimens in seasonal and chronic allergic eye disease and in conjunctival fibroblast cultures. Clin Exp Allergy 2006;36:777-784.