-
1
-
-
31644436321
-
From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates
-
Walling J. From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates. Invest New Drugs 2006 ; 24 : 37-77.
-
(2006)
Invest New Drugs
, vol.24
, pp. 37-77
-
-
Walling, J.1
-
2
-
-
33846053517
-
Pemetrexed Expanded Access Program Investigators. Single-arm, open label study of pemetrexed plus cisplatin in chemotherapy naïve patients with malignant pleural mesothelioma : Outcomes of an expanded access program
-
Obasaju CK, Ye Z, Wozniak AJ, Belani CP, Keohan ML, Ross HJ, et al., Pemetrexed Expanded Access Program Investigators. Single-arm, open label study of pemetrexed plus cisplatin in chemotherapy naïve patients with malignant pleural mesothelioma : Outcomes of an expanded access program. Lung Cancer 2007 ; 55 : 187-94.
-
(2007)
Lung Cancer
, vol.55
, pp. 187-194
-
-
Obasaju, C.K.1
Ye, Z.2
Wozniak, A.J.3
Belani, C.P.4
Keohan, M.L.5
Ross, H.J.6
-
3
-
-
0026494947
-
Dideazatetrahydrofolate analogue lacking a chiral center at C-6, N [4- [2-(2-Amino-3,4-dihydro-4-oxo-7H-pyrrolo [2,3-d]pyrimidin-5-yl) ethyl] benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase
-
Taylor EC, Kuhnt D, Shin C, Rinzek SM, Grindey GB, Barreto J, et al. Dideazatetrahydrofolate analogue lacking a chiral center at C-6, N [4- [2-(2-Amino-3,4-dihydro-4-oxo-7H-pyrrolo [2,3-d]pyrimidin-5-yl) ethyl] benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase. J Med Chem 1992 ; 35 : 4450-4.
-
(1992)
J Med Chem
, vol.35
, pp. 4450-4454
-
-
Taylor, E.C.1
Kuhnt, D.2
Shin, C.3
Rinzek, S.M.4
Grindey, G.B.5
Barreto, J.6
-
4
-
-
27144494007
-
Pemetrexed : New multitargeted antimetabolite
-
4S5-4S7
-
Lokiec F. Pemetrexed : new multitargeted antimetabolite. Rev Pneumol Clin 2005 ; 61 : 4S5-4S7.
-
(2005)
Rev Pneumol Clin
, pp. 61
-
-
Lokiec, F.1
-
5
-
-
27744438167
-
Pemetrexed : A multitargeted antifolate
-
Rollins KD, Lindley C. Pemetrexed : a multitargeted antifolate. Clin Ther 2005 ; 27 : 1343-82.
-
(2005)
Clin Ther
, vol.27
, pp. 1343-1382
-
-
Rollins, K.D.1
Lindley, C.2
-
6
-
-
0036987083
-
Molecular, biochemical, and cellular pharmacology of Pemetrexed
-
Goldman ID, Zhao R. Molecular, biochemical, and cellular pharmacology of Pemetrexed. Semin Oncol 2002 ; 29 : 3-17.
-
(2002)
Semin Oncol
, vol.29
, pp. 3-17
-
-
Goldman, I.D.1
Zhao, R.2
-
7
-
-
0031852056
-
Multiples folate enzyme inhibition : Mechanism of a novel pytrolopyrimidine-based antifolate LY231514 (MTA)
-
Shih C, Habeck LL, Mendelsohn LG, Chen VJ, Schultz RM. Multiples folate enzyme inhibition : mechanism of a novel pytrolopyrimidine-based antifolate LY231514 (MTA). Adv Enzyme Regul 1998 ; 38 : 135-52.
-
(1998)
Adv Enzyme Regul
, vol.38
, pp. 135-152
-
-
Shih, C.1
Habeck, L.L.2
Mendelsohn, L.G.3
Chen, V.J.4
Schultz, R.M.5
-
9
-
-
0032832573
-
LY231514. A multitargeted antifolate (MTA)
-
Lansiaux A, Degardin M, Bailly C. LY231514. A multitargeted antifolate (MTA). Bull Cancer 1999 ; 86 : 727-31.
-
(1999)
Bull Cancer
, vol.86
, pp. 727-731
-
-
Lansiaux, A.1
Degardin, M.2
Bailly, C.3
-
10
-
-
2942618206
-
Alimta® : A new generation antifolate
-
Zhao R, et al. Alimta® : a new generation antifolate. Oncologist 2004 ; 9 : 242-4.
-
(2004)
Oncologist
, vol.9
, pp. 242-244
-
-
Zhao, R.1
-
11
-
-
1042301957
-
The role of alpha-folate receptor-mediated transport in the antitumor activity of antifolate drugs
-
Theti DS, Jackman AL. The role of alpha-folate receptor-mediated transport in the antitumor activity of antifolate drugs. Clin Cancer Res 2004 ; 10 : 1080-9.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 1080-1089
-
-
Theti, D.S.1
Jackman, A.L.2
-
12
-
-
0030891198
-
LY231514, a pyrrolo [2,3-d ]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes
-
Shih C, Chen VJ, Gossett LS, Gates SB, MacKellar WC, Habeck LL, et al. LY231514, a pyrrolo [2,3-d ]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res 1997 ; 57 : 1116-23.
-
(1997)
Cancer Res
, vol.57
, pp. 1116-1123
-
-
Shih, C.1
Chen, V.J.2
Gossett, L.S.3
Gates, S.B.4
MacKellar, W.C.5
Habeck, L.L.6
-
13
-
-
0032527904
-
Super in vitro synergy between inhibitors of dihydrofolate reductase and inhibitors of other folate-requiring enzymes : Their critical role in polyglutamylation
-
Faessel HM, Slocum HK, Jackson RC, Boritzki TJ, Rustum YM, Nair MG, et al. Super in vitro synergy between inhibitors of dihydrofolate reductase and inhibitors of other folate-requiring enzymes : their critical role in polyglutamylation. Cancer Res 1998 ; 58 : 3036-50.
-
(1998)
Cancer Res
, vol.58
, pp. 3036-3050
-
-
Faessel, H.M.1
Slocum, H.K.2
Jackson, R.C.3
Boritzki, T.J.4
Rustum, Y.M.5
Nair, M.G.6
-
14
-
-
0029157160
-
Substrate specificity of mammalian folylpolysynthetase for 5,10-dideazatetrahydrofolare analogs
-
Habeck LL, Shih C, Gossett LS, Leitner TA, Schultz RM, Andis SL, et al. Substrate specificity of mammalian folylpolysynthetase for 5,10-dideazatetrahydrofolare analogs. Mol Pharmacol 1995 ; 48 : 326-33.
-
(1995)
Mol Pharmacol
, vol.48
, pp. 326-333
-
-
Habeck, L.L.1
Shih, C.2
Gossett, L.S.3
Leitner, T.A.4
Schultz, R.M.5
Andis, S.L.6
-
15
-
-
0028853821
-
Folate-based thymidylate synthase inhibitors as anticancer drugs
-
Jackman AL, Calvert AH. Folate-based thymidylate synthase inhibitors as anticancer drugs. Ann Oncol 1995 ; 6 : 871-81.
-
(1995)
Ann Oncol
, vol.6
, pp. 871-881
-
-
Jackman, A.L.1
Calvert, A.H.2
-
16
-
-
0031858217
-
Preclinical cellular pharmacology of LY231514 (MTA) : A comparison with methotrexate, LY309887 and reltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells
-
Chen VJ, Bewley JR, Andis SL, Schultz RM, Iversen PW, Shih C, et al. Preclinical cellular pharmacology of LY231514 (MTA) : a comparison with methotrexate, LY309887 and reltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells. Br J Cancer 1998 ; 78 : 27-34.
-
(1998)
Br J Cancer
, vol.78
, pp. 27-34
-
-
Chen, V.J.1
Bewley, J.R.2
Andis, S.L.3
Schultz, R.M.4
Iversen, P.W.5
Shih, C.6
-
17
-
-
0031024897
-
Cell cycle effects of antifolate antimetabolites : Implications for cytotoxicity and cytostasis
-
Tonkinson JL, Marder P, Andis SL, Schulrz RM, Gossett LS, Shih Cn Mendelsohn LG. Cell cycle effects of antifolate antimetabolites : implications for cytotoxicity and cytostasis. Cancer Chemother Pharmacol 1997 ; 39 : 521-31.
-
(1997)
Cancer Chemother Pharmacol
, vol.39
, pp. 521-531
-
-
Tonkinson, J.L.1
Marder, P.2
Andis, S.L.3
Schulrz, R.M.4
Gossett, L.S.5
Shih, C.6
Mendelsohn, L.G.7
-
18
-
-
29444433139
-
Pemetrexed : MRNA expression of the target genes TS, GARFT and DHFR correlates with the in vitro chemosensitivity of human solid tumors
-
Eismann U, Oberschmidt O, Ehnert M, Fleeth J, Ludtke FE, Struck S, et al. Pemetrexed : mRNA expression of the target genes TS, GARFT and DHFR correlates with the in vitro chemosensitivity of human solid tumors. Int J Clin Pharmacol Ther 2005 ; 43 : 567-9.
-
(2005)
Int J Clin Pharmacol Ther
, vol.43
, pp. 567-569
-
-
Eismann, U.1
Oberschmidt, O.2
Ehnert, M.3
Fleeth, J.4
Ludtke, F.E.5
Struck, S.6
-
19
-
-
0031730802
-
Role of folic acid in modulating the toxicity and efficacy of the multitargeted antifolate, LY231514
-
Worzalla JF, Shih C, Schultz RM. Role of folic acid in modulating the toxicity and efficacy of the multitargeted antifolate, LY231514. Anticancer Res 1998 ; 18 : 3235-40.
-
(1998)
Anticancer Res
, vol.18
, pp. 3235-3240
-
-
Worzalla, J.F.1
Shih, C.2
Schultz, R.M.3
-
20
-
-
0032990562
-
Acrivity of the multitargeted Antifolate LY231514 in the human tumor cloning assay
-
Britten CD, Izbicka E, Hilsenbeck S, Lawrence R, Davidson K, Cerna C, et al. Acrivity of the multitargeted Antifolate LY231514 in the human tumor cloning assay. Cancer Chemother Pharmacol 1999 ; 44 : 105-10.
-
(1999)
Cancer Chemother Pharmacol
, vol.44
, pp. 105-110
-
-
Britten, C.D.1
Izbicka, E.2
Hilsenbeck, S.3
Lawrence, R.4
Davidson, K.5
Cerna, C.6
-
21
-
-
0032898580
-
Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY231514
-
Schultz RM, Patel VF, Worzalla JF, Shih C. Role of thymidylate synthase in the antitumor activity of the multitargeted antifolate, LY231514. Anticancer Res 1999 ; 19 : 437-43.
-
(1999)
Anticancer Res
, vol.19
, pp. 437-443
-
-
Schultz, R.M.1
Patel, V.F.2
Worzalla, J.F.3
Shih, C.4
-
22
-
-
33644975527
-
The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line
-
Chattopadhyay S, Zhao R, Krupenko SA, Krupenko N, Goldman ID. The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line. Mol Cancer Ther 2006 ; 5 : 438-49.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 438-449
-
-
Chattopadhyay, S.1
Zhao, R.2
Krupenko, S.A.3
Krupenko, N.4
Goldman, I.D.5
-
23
-
-
33750975065
-
The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis
-
Assaraf YG. The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis. Drug Resist Updat 2006 ; 9 : 227-46.
-
(2006)
Drug Resist Updat
, vol.9
, pp. 227-246
-
-
Assaraf, Y.G.1
-
24
-
-
33645976121
-
Multidrug resistance proteins and folate supplementation : Therapeutic implications for antifolates and other classes of drugs in cancer treatment
-
Hooijberg JH, de Vries NA, Kaspers GJ, Pieters R, Jansen G, Peters GJ. Multidrug resistance proteins and folate supplementation : therapeutic implications for antifolates and other classes of drugs in cancer treatment. Cancer Chemother Pharmacol 2006 ; 58 : 1-12.
-
(2006)
Cancer Chemother Pharmacol
, vol.58
, pp. 1-12
-
-
Hooijberg, J.H.1
de Vries, N.A.2
Kaspers, G.J.3
Pieters, R.4
Jansen, G.5
Peters, G.J.6
-
25
-
-
0037377560
-
Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line
-
Wang Y, Zhao R, Goldman ID. Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line. Biochem Pharmacol 2003 ; 65 : 1163-70.
-
(2003)
Biochem Pharmacol
, vol.65
, pp. 1163-1170
-
-
Wang, Y.1
Zhao, R.2
Goldman, I.D.3
-
26
-
-
0032833775
-
Glutamyl hydrolase and the multitargeted antifolate LY231514
-
Rhee MS, Ryan TJ, Galivan J. Glutamyl hydrolase and the multitargeted antifolate LY231514. Cancer Chemother Pharmacol 1999 ; 44 : 427-32.
-
(1999)
Cancer Chemother Pharmacol
, vol.44
, pp. 427-432
-
-
Rhee, M.S.1
Ryan, T.J.2
Galivan, J.3
-
27
-
-
33746844945
-
Design, conduct, and interpretation of organ impairment studies in oncology patients
-
Takimoto CH, Mita AC. Design, conduct, and interpretation of organ impairment studies in oncology patients. J. Clin Oncol 2006 ; 24 : 3509-10.
-
(2006)
J. Clin Oncol
, vol.24
, pp. 3509-3510
-
-
Takimoto, C.H.1
Mita, A.C.2
-
28
-
-
33644839682
-
Phase I and pharmacokinetic study of pemetrexed administered every 3 weeks to advanced cancer patients with normal and impaired renal function
-
Mita AC, Sweeney CJ, Baker SD, Goetz A, Hammond LA, Patnaik A, et al. Phase I and pharmacokinetic study of pemetrexed administered every 3 weeks to advanced cancer patients with normal and impaired renal function. J Clin Oncol 2006 ; 24 : 552-62.
-
(2006)
J Clin Oncol
, vol.24
, pp. 552-562
-
-
Mita, A.C.1
Sweeney, C.J.2
Baker, S.D.3
Goetz, A.4
Hammond, L.A.5
Patnaik, A.6
-
29
-
-
33644837945
-
Cytotoxic anticancer agents and renal impairment study : The challenge remains
-
Rahman A, White RM. Cytotoxic anticancer agents and renal impairment study : the challenge remains. J Clin Oncol 2006 ; 24 : 533-6.
-
(2006)
J Clin Oncol
, vol.24
, pp. 533-536
-
-
Rahman, A.1
White, R.M.2
-
30
-
-
30644459850
-
Population pharmacokinetic analysis often phase II clinical trials of pemetrexed in cancer patients
-
Latz JE, et al. Population pharmacokinetic analysis often phase II clinical trials of pemetrexed in cancer patients. Cancer Chemother Pharmacol 2006 ; 57 : 401-11.
-
(2006)
Cancer Chemother Pharmacol
, vol.57
, pp. 401-411
-
-
Latz, J.E.1
-
31
-
-
0344980120
-
Clinical and pharmacokinetic phase I study of multitargeted antifolate (LY231514) in combination with cisplatin
-
Thodtmann R, et al. Clinical and pharmacokinetic phase I study of multitargeted antifolate (LY231514) in combination with cisplatin. J Clin Oncol 1999 ; 17 : 3009-16.
-
(1999)
J Clin Oncol
, vol.17
, pp. 3009-3016
-
-
Thodtmann, R.1
-
32
-
-
0032941140
-
Clinical pharmacokinetics of antitumor antifolates
-
Newell DR. Clinical pharmacokinetics of antitumor antifolates. Semin Oncol 1999 ; 26 : 74-81.
-
(1999)
Semin Oncol
, vol.26
, pp. 74-81
-
-
Newell, D.R.1
-
33
-
-
30644468229
-
A semimechanistic-physiologic population pharmacokinetic/pharmacodynamic model for neutropenia following pemetrexed therapy
-
Latz JE, et al. A semimechanistic-physiologic population pharmacokinetic/pharmacodynamic model for neutropenia following pemetrexed therapy. Cancer Chemother Pharmacol 2006 ; 57 : 412-26.
-
(2006)
Cancer Chemother Pharmacol
, vol.57
, pp. 412-426
-
-
Latz, J.E.1
-
34
-
-
30644478368
-
Clinical application of a semi mechanistic-physiologic population PK/PD model for neutropenia following pemetrexed therapy
-
Latz JE, et al. Clinical application of a semi mechanistic-physiologic population PK/PD model for neutropenia following pemetrexed therapy. Cancer Chemother Pharmacol 2006 ; 57 : 427-35.
-
(2006)
Cancer Chemother Pharmacol
, vol.57
, pp. 427-435
-
-
Latz, J.E.1
-
35
-
-
0033797808
-
Population pharmacokinetics of Pemetrexed disodium (ALIMTA) in patients with cancer
-
Ouellet D, et al. Population pharmacokinetics of Pemetrexed disodium (ALIMTA) in patients with cancer. Cancer Chemother Pharmacol 2000 ; 46 : 227-34.
-
(2000)
Cancer Chemother Pharmacol
, vol.46
, pp. 227-234
-
-
Ouellet, D.1
-
36
-
-
33750620855
-
Randomized phase II trial of pemetrexed combined with either cisplatin or carboplatin in untreated extensive-stage small-cell lung cancer
-
Socinski MA, Weissman C, Hart LL, Beck JT, Choksi JK, Hanson JP, et al. Randomized phase II trial of pemetrexed combined with either cisplatin or carboplatin in untreated extensive-stage small-cell lung cancer. J Clin Oncol 2006 ; 24 : 4840-7.
-
(2006)
J Clin Oncol
, vol.24
, pp. 4840-4847
-
-
Socinski, M.A.1
Weissman, C.2
Hart, L.L.3
Beck, J.T.4
Choksi, J.K.5
Hanson, J.P.6
-
37
-
-
33749605418
-
A phase II trial of pemetrexed plus gemcitabine in locally advanced and/or metastatic transitional cell carcinoma of the urothelium
-
Von der Maase H, Lehmann J, Gravis G, Joensuu H, Geertsen P, Gough J, et al. A phase II trial of pemetrexed plus gemcitabine in locally advanced and/or metastatic transitional cell carcinoma of the urothelium. Ann Oncol 2006 ; 17 : 1533-8.
-
(2006)
Ann Oncol
, vol.17
, pp. 1533-1538
-
-
Von der Maase, H.1
Lehmann, J.2
Gravis, G.3
Joensuu, H.4
Geertsen, P.5
Gough, J.6
-
38
-
-
33745192541
-
Use of pemetrexed in breast cancer
-
Dittrich C. Use of pemetrexed in breast cancer. Semin Oncol 2006 ; 33(3 Suppl 9) : S24-S28.
-
(2006)
Semin Oncol
, vol.33
, Issue.3 SUPPL. 9
-
-
Dittrich, C.1
-
39
-
-
33644840299
-
Phase I/II dose-escalation study of pemetrexed plus irinotecan in patients with advanced colorectal cancer
-
Hochster H, Kettner E, Kroning H, Becker K, Lordick F, Ramanathan RK, et al. Phase I/II dose-escalation study of pemetrexed plus irinotecan in patients with advanced colorectal cancer. Clin Colorectal Cancer 2005 ; 5 : 257-62.
-
(2005)
Clin Colorectal Cancer
, vol.5
, pp. 257-262
-
-
Hochster, H.1
Kettner, E.2
Kroning, H.3
Becker, K.4
Lordick, F.5
Ramanathan, R.K.6
-
40
-
-
0036562507
-
Homocysteine and methylmalonic acid : Markers to predict and avoid toxicity from Pemetrexed therapy
-
Niyikiza C, Baker SD, Seitz DE, Walling JM, Nelson K, Rusthoven JJ, et al. Homocysteine and methylmalonic acid : markers to predict and avoid toxicity from Pemetrexed therapy. Mol Cancer Ther 2002 ; 1 : 545-52.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 545-552
-
-
Niyikiza, C.1
Baker, S.D.2
Seitz, D.E.3
Walling, J.M.4
Nelson, K.5
Rusthoven, J.J.6
-
41
-
-
0041629528
-
Phase III study of Pemetrexed in combination with cisplatin verus cisplatin alone in patients with malignant pleural mesothelioma
-
Vogelzang NJ, Rusthoven JJ, Symanowski J, Denham C, Kaukel E, Ruffie P, et al. Phase III study of Pemetrexed in combination with cisplatin verus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol 2003 ; 21 : 2636-44.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2636-2644
-
-
Vogelzang, N.J.1
Rusthoven, J.J.2
Symanowski, J.3
Denham, C.4
Kaukel, E.5
Ruffie, P.6
-
42
-
-
16244362744
-
Chemotherapy options and new advances in malignant pleural mesothelioma
-
Steele JP, Klabatsa A. Chemotherapy options and new advances in malignant pleural mesothelioma. Ann Oncol 2005 ; 16 : 345-51.
-
(2005)
Ann Oncol
, vol.16
, pp. 345-351
-
-
Steele, J.P.1
Klabatsa, A.2
|