Prediction of BRCA1 and BRCA2 mutation status using post-irradiation assays of lymphoblastoid cell lines is compromised by inter-cell-line phenotypic variability

Breast Cancer Research and Treatment

Volumn 104, Issue 3, 2007, Pages 257-266

  Lovelock, Paul K ^a,b   Wong, Ee Ming ^c,d   Sprung, Carl N ^d   Marsh, Anna ^b   Hobson, Karen ^b   French, Juliet D ^a   Southey, Melissa ^c,e   Sculley, Tom ^b   Pandeya, Nirmala ^b   Brown, Melissa A ^a   Chenevix Trench, Georgia ^b   Spurdle, Amanda B ^b   McKay, Michael J ^d  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d PETER MACCALLUM CANCER CENTRE   (Australia)

^e INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

BRCA1; BRCA2; Lymphoblastoid cell lines; Post IR metabolism

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN;

ARTICLE; CANCER; CELL VIABILITY; CONTROLLED STUDY; DNA SEQUENCE; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN CELL; IRRADIATION; LYMPHOBLASTOID CELL; ONCOGENE; PHENOTYPE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; WESTERN BLOTTING;

CELL LINE, TUMOR; CELL SURVIVAL; DNA MUTATIONAL ANALYSIS; DOSE-RESPONSE RELATIONSHIP, RADIATION; GENES, BRCA1; GENES, BRCA2; GENOTYPE; HUMANS; LYMPHOCYTES; MICRONUCLEUS TESTS; MUTATION; PHENOTYPE; RADIATION, IONIZING; TELOMERE; VARIATION (GENETICS);

EID: 34547799616     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10549-006-9415-5     Document Type: Article

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