Morphological approach to tumours of the testis and paratestis

Journal of Clinical Pathology

Volumn 60, Issue 8, 2007, Pages 866-880

  Emerson, Robert E ^a   Ulbright, Thomas M ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; CA 125 ANTIGEN; CALRETININ; CHROMOGRANIN; CYTOKERATIN; CYTOKERATIN 5; CYTOKERATIN 6; EOSIN; HEMATOXYLIN; INHIBIN; MELAN A; OCTAMER TRANSCRIPTION FACTOR 4;

ANAMNESIS; CELL PROLIFERATION; CELL STRUCTURE; CYTOPLASM; DIFFERENTIAL DIAGNOSIS; EMBRYONAL CARCINOMA; GERM CELL TUMOR; GRANULOSA CELL TUMOR; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; METASTASIS; PRIORITY JOURNAL; REVIEW; SEMINOMA; SERTOLI CELL TUMOR; SPINDLE CELL; TESTIS TUMOR; TUMOR LOCALIZATION; YOLK SAC TUMOR;

ALGORITHMS; CHILD; CYTOPLASM; DIAGNOSIS, DIFFERENTIAL; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; NEOPLASMS, GERM CELL AND EMBRYONAL; SEMINOMA; SERTOLI-LEYDIG CELL TUMOR; TESTICULAR NEOPLASMS; TESTIS;

EID: 34547796485     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.2005.036475     Document Type: Review

References (106)

1. Lawrence WD, Young RH, Scully RE. Juvenile granulosa cell tumor of the infantile testis. A report of 14 cases. Am J Surg Pathol 1985;9:87-94.
2. Talerman A. Endodermal sinus (yolk sac) tumor elements in testicular germ-cell tumors in adults: comparison of prospective and retrospective studies. Cancer 1980;46:1213-7.
3. Bergada I, Del Toro K, Katz O, et al. Serum inhibin B concentration in a prepubertal boy with gynecomastia and Peutz-Jeghers syndrome. J Pediatr Endocrinol Metab 2000;13:101-3.
4. Toppari J, Kaipia A, Kaleva M, et al. Inhibin gene expression in a large cell calcifying Sertoli cell tumour and serum inhibin and activin levels. APMIS 1998;106:101-13.
5. Fung L, Honey R, Gardiner G. Testicular seminoma presenting with features of androgen excess. Urology 1994;44:927-9.
6. Nagi DK, Jones WG, Belchetz PE. Gynaecomastia caused by a primary mediastinal seminoma. Clin Endocrinol (Oxf) 1994;40:545-9.
7. Fox H, Reeve NL. Endocrine effects of testicular neoplasms. Invest Cell Pathol 1979;2:63-73.
8. Morrish DW, Venner PM, Siy O, et al. Mechanisms of endocrine dysfunction in patients with testicular cancer. J Natl Cancer Inst 1990;82:412-8.
9. da Silva MA, Edmondson JW, Eby C, et al. Humoral hypercalcemia in seminomas. Med Pediatr Oncol 1992;20:38-41.
10. Kim I, Young RH, Scully RE. Leydig cell tumors of the testis. A clinicopathological analysis of 40 cases and review of the literature. Am J Surg Pathol 1985;9:177-92.
11. Waxman M, Damjanov I, Khapra A, et al. Large cell calcifying Sertoli tumor of the testis. Light microscopic and ultrastructural study. Cancer 1984;54:1574-81.
12. Berdjis CC, Mostofi FK. Carcinoid tumors of the testis. J Urol 1977;118:777-82.
13. Kirkland RT, Kirkland JL, Keenan BS, et al. Bilateral testicular tumors in congenital adrenal hyperplasia. J Clin Endocrinol Metab 1977;44:369-78.
14. Rutgers JL, Young RH, Scully RE. The testicular "tumor" of the adrenogenital syndrome. A report of six cases and review of the literature on testicular masses in patients with adrenocortical disorders. Am J Surg Pathol 1988;12:503-13.
15. Venara M, Rey R, Bergada I, et al. Sertoli cell proliferations of the infantile testis: an intratubular form of Sertoli cell tumor? Am J Surg Pathol 2001;25:1237-44.
16. Ulbright TM, Amin MB, Young RH. Intratubular large cell hyalinizing Sertoli cell neoplasia of the testis: a report of 8 cases of a distinctive lesion of the Peutz-Jeghers syndrome. Am J Surg Pathol 2007;31:827-35.
17. Caroll P, Morse M, Koduru P, et al. Testicular cerm cell tumor in patient with Klinefelter syndrome. Urology 1988;31:72-4.
18. Albores-Saavedra J, Huffman H, Alvarado-Cabrero I, et al. Anaplastic variant of spermatocyte seminoma. Hum Pathol 1996;27:650-5.
19. Kraggerud SM, Berner A, Bryne M, et al. Spermatocyte seminoma as compared to classical seminoma: an immunohistochemical and DNA flow cytometric study. APMIS 1999;107:297-302.
20. Cummings OW, Ulbright TM, Eble JN, et al. Spermatocyte seminoma: an immunohistochemical study. Hum Pathol 1994;25:54-9.
21. Looijenga LH, Stoop H, de Leeuw HP, et al. POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors. Cancer Res 2003;63:2244-50.
22. Jones TD, Ulbright TM, Eble JN, et al. OCT4 staining in testicular tumors: a sensitive and specific marker for seminoma and embryonal carcinoma. Am J Surg Pathol 2004;28:935-40.
23. Cheville JC, Rao S, Iczkowski KA, et al. Cytokeratin expression in seminoma of the human testis. Am J Clin Pathol 2000;113:583-8.
24. Niehans GA, Manivel JC, Copland GT, et al. Immunohistochemistry of germ cell and trophoblastic neoplasms. Cancer 1988;62:1113-23.
25. Leroy X, Augusto D, Leteurtre E, et al. CD30 and CD117 (c-kit) used in combination are useful for distinguishing embryonal carcinoma from seminoma. J Histochem Cytochem 2002;50:283-5.
26. Bentley AJ, Parkinson MC, Harding BN, et al. A comparative morphological and immunohistochemical study of testicular seminomas and intracranial germinomas. Histopatholoqy 1990;17:443-9.
27. Izquierdo MA, Van der Valk P, Van Ark-Otte J, et al. Differential expression of the c-kit proto-oncogene in germ cell tumours. J Pathol 1995;177:253-8.
28. Ferreiro JA. Ber-H2 expression in testicular germ cell tumors. Hum Pathol 1994;25:522-4.
29. Suster S, Moran CA, Dominguez-Malagon H, et al. Germ cell tumors of the mediastinum and testis: a comparative immunohistochemical study of 120 cases. Hum Pathol 1998;29:737-42.
30. Badve S, Morimiya A, Agarwal B, et al. Podoplanin: a histological marker for seminoma. Mod Pathol 2006;1988:129A.
31. Eglen DE, Ulbright TM. The differential diagnosis of yolk sac tumor and seminoma. Usefulness of cytokeratin, alpha-fetoprotein, and alpha-1-antitrypsin immunoperoxidase reactions. Am J Clin Pathol 1987;88:328-32.
32. Zynger DL, Dimov ND, Luan C, et al. Glypican 3: a novel marker in testicular germ cell tumors. Am J Surg Pathol 2006;30:1570-5.
33. Henley JD, Young RH, Ulbright TM. Malignant Sertoli cell tumors of the testis: a study of 13 examples of a neoplasm frequently misinterpreted as seminoma. Am J Surg Pathol 2002;26:541-50.
34. Kommoss F, Oliva E, Bittinger F, et al. Inhibin-alpha CD99, HEA125, PLAP, and chromogranin immunoreactivity in testicular neoplasms and the androgen insensitivity syndrome. Hum Pathol 2000;31:1055-61.
35. Iczkowski KA, Bostwick DG, Roche PC, et al. Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. Mod Pathol 1998;11:774-9.
36. de Jong J, Stoop H, Dohle GR, et al. Diagnostic value of OCT3/4 for preinvasive and invasive testicular germ cell tumours. J Pathol 2005;206:242-9.
37. Shen SS, Krishna B, Chirala R, et al. Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasms. Mod Pathol 2005;18:933-40.
38. Avery AK, Beckstead J, Renshaw AA, et al. Use of antibodies to RCC and CD10 in the differential diagnosis of renal neoplasms. Am J Surg Pathol 2000;24:203-10.
39. Wang HY, Mills SE. KIT and RCC are useful in distinguishing chromophobe renal cell carcinoma from the granular variant of clear cell renal cell carcinoma. Am J Surg Pathol 2005;29:640-6.
40. McGregor DK, Khurana KK, Cao C, et al. Diagnosing primary and metastatic renal cell carcinoma: the use of the monoclonal antibody 'Renal Cell Carcinoma Marker'. Am J Surg Pathol 2001;25:1485-92.
41. Patel SR, Richardson RL, Kvols L. Metastatic cancer to the testes: a report of 20 cases and review of the literature. J Urol 1989;142:1003-5.
42. Tu SM, Reyes A, Maa A, et al. Prostate carcinoma with testicular or penile metastases. Clinical, pathologic, and immunohistochemical features. Cancer 2002;94:2610-7.
43. Baykal K, Yildirim S, Inal H, et al. Metastasis of prostate adenocarcinoma to testis. Int J Urol 1997;4:104-5.
44. Ulbright TM, Srigley JR, Hatzianastassiou DK, et al. Leydig cell tumors of the testis with unusual features: adipose differentiation, calcification with ossification, and spindle-shaped tumor cells. Am J Surg Pathol 2002;26:1424-33.
45. Ferry JA, Harris NL, Young RH, et al. Malignant lymphoma of the testis, epididymis, and spermatic cord. A clinicopathologic study of 69 cases with immunophenotypic analysis. Am J Surg Pathol 1994;18:376-90.
46. Ulbright TM, Young RH. Seminoma with tubular, microcystic, and related patterns: a study of 28 cases of unusual morphologic variants that often cause confusion with yolk sac tumor. Am J Surg Pathol 2005;29:500-5.
47. Manivel JC, Jessurun J, Wick MR, et al. Placental alkaline phosphatase immunoreactivity in testicular germ-cell neoplasms. Am J Surg Pathol 1987;11:21-9.
48. McCluggage WG, Ashe P, McBride H, et al. Localization of the cellular expression of inhibin in trophoblastic tissue. Histopathology 1998;32:252-6.
49. Mostofi FK, Sesterhenn IA, Davis CJ Jr. Immunopathology of germ cell tumors of the testis. Semin Diagn Pathol 1987;4:320-41.
50. Ulbright TM, Gersell DJ. Rete testis hyperplasia with hyaline globule formation. A lesion simulating yolk sac tumor. Am J Surg Pathol 1991;15:66-74.
51. Amin MB. Selected other problematic testicular and paratesticular lesions: rete testis neoplasms and pseudotumors, mesothelial lesions and secondary tumors. Mod Pathol 2005;18(Suppl 2):S131-45.
52. Weirich G, Nahrig J, Treiber U, et al. Immunohistochemical assessment of a testicular tumor in a 63-year-old patient: proposal for an integrated clinicopathologic approach. Appl Immunohistochem Mol Morphol 2003;11:96-100.
53. Billings SD, Roth LM, Ulbright TM. Microcystic Leydig cell rumors mimicking yolk sac tumor: a report of four cases. Am J Surg Pathol 1999;23:546-51.
54. Young RH, Koelliker DD, Scully RE. Sertoli cell tumors of the testis, not otherwise specified: a clinicopathologic analysis of 60 cases. Am J Surg Pathol 1998;22:709-21.
55. McCluggage WG, Shanks JH, Whiteside C, et al. Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. Am J Surg Pathol 1998;22:615-9.
56. Busam KJ, Iversen K, Coplan KA, et al. Immunoreactivity for A103, an antibody to melan-A (Mart-1), in adrenocortical and other steroid tumors. Am J Surg Pathol 1998;22:57-63.
57. Lugli A, Forster Y, Haas P, et al. Calretinin expression in human normal and neoplastic tissues: a tissue microarray analysis on 5233 tissue samples. Hum Pathol 2003;34:994-1000.
58. Movahedi-Lankarani S, Kurman RJ. Calretinin, a more sensitive but less specific marker than alpha-inhibin for ovarian sex cord-stromal neoplasms: an immunohistochemical study of 215 cases. Am J Surg Pathol 2002;26:1477-83.
59. Schwartz EJ, Longacre TA. Adenomatoid rumors of the female and male genital tracts express WT1. Int J Gynecol Pathol 2004;23:123-8.
60. Renshaw AA, Gordon M, Corless CL. Immunohistochemistry of unclassified sex cord-stromal tumors of the testis with a predominance of spindle cells. Mod Pathol 1997;10:693-700.
61. Plata C, Algaba F, Andujar M, et al. Large cell calcifying Sertoli cell tumour of the testis. Histopathology 1995;26:255-9.
62. Kratzer SS, Ulbright TM, Talerman A, et al. Large cell calcifying Sertoli cell tumor of the testis: contrasting features of six malignant and six benign tumors and a review of the literature. Am J Surg Pathol 1997;21:1271-80.
63. De Raeve H, Schoonooghe P, Wibowo R, et al. Malignant large cell calcifying Sertoli cell tumor of the testis. Pathol Res Pract 2003;199:113-7.
64. Cano-Valdez AM, Chanona-Vilchis J, Dominguez-Malagon H. Large cell calcifying Sertoli cell tumor of the testis: a clinicopathological, immunohistochemical, and ultrastructural study of two cases. Ultrastruct Pathol 1999;23:259-65.
65. Bufo P, Pennella A, Serio G, Mastropasqua MG, et al. Malignant large cell calcifying Sertoli cell tumor of the testis (LCCSCTT). Report of a case in an elderly man and review of the literature. Pathologica 1999;91:107-14.
66. Bennett A, Ulbright TM, Ramnani D, et al. Immunohistochemical expression of calretinin, CD99, and alpha-inhibin in Sertoli and Leydig cells and their lesions, emphasizing large cell calcifying Sertoli cell tumor. Mod Pathol 2005;18:128A.
67. Talerman A, Roth LM. Pathology of the testis and its adnexa. New York: Churchill Livingstone, 1986.
68. Reyes A, Moran CA, Suster S, et al. Neuroendocrine carcinomas (carcinoid tumor) of the testis. A clinicopathologic and immunohistochemical study of ten cases. Am J Clin Pathol 2003;120:182-7.
69. Zavala-Pompa A, Ro JY, el-Naggar A, et al. Primary carcinoid tumor of testis. Immunohistochemical, ultrastructural, and DNA flow cytometric study of three cases with a review of the literature. Cancer 1993;72:1726-32.
70. Comperat E, Tissier F, Boye K, et al. Non-Leydig sex-cord tumors of the testis. The place of immunohistochemistry in diagnosis and prognosis. A study of twenty cases. Virchows Arch, 2004;444:567- 71.
71. Kremer M, Ott G, Nathrath M, et al. Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis. J Pathol 2005;205:92-101.
72. Ferry JA, Young RH, Scully RE. Testicular and epididymal plasmacytoma: a report of 7 cases, including three that were the initial manifestation of plasma cell myeloma. Am J Surg Pathol 1997;21:590-8.
73. Goswitz JJ, Pettinato G, Manivel JC. Testicular sex cord-stromal tumors in children: clinicopathologic study of sixteen children with review of the literature. Pediatr Pathol Lab Med 1996;16:451-70.
74. Skakkebaek NE. Carcinoma in situ of the testis: frequency and relationship to invasive germ cell tumours in infertile men. Histopathology 1978;2:157-70.
75. Skakkebaek NE, Berthelsen J, Visfeld J. Clinical aspects of testicular carcinoma-in-situ. Int J Androl 1981;4(Suppl):153-62.
76. Burke AP, Mostofi FK. Intratubular malignant germ cells in testicular biopsies: clinical course and identification by staining for placental alkaline phosphatase. Mod Pathol 1988;1:475-9.
77. Kuczyk MA, Serth J, Bokemeyer C, et al. Overexpression of the p53 oncoprotein in carcinoma in situ of the testis. Pathol Res Pract 1994;190:993-8.
78. Ramani P, Yeung CK, Habeebu SS. Testicular intratubular germ cell neoplasia in children and adolescents with intersex. Am J Surg Pathol 1993;17:1124-33.
79. Loftus BM, Gilmartin LG, O'Brien MJ, et al. Intratubular germ cell neoplasia of the testis: identification by placental alkaline phosphatase immunostaining and argyrophilic nucleolar organizer region quantification. Hum Pathol 1990;21:941-8.
80. Giwercman A, Cantell L, Marks A. Placental-like alkaline phosphatase as a marker of carcinoma-in-situ of the testis. Comparison with monoclonal antibodies M2A and 43-9F. APMIS 1991;99:586-94.
81. Hustin J, Collette J, Franchimont P. Immunohistochemical demonstration of placental alkaline phosphatase in various states of testicular development and in germ cell tumours. Int J Androl 1987;10:29-35.
82. Rajpert-De Meyts E, Skakkebaek NE. Expression of the c-kit protein product in carcinoma-in-situ and invasive testicular germ cell tumours. Int J Androl 1994;17:85-92.
83. Sandlow JI, Feng HL, Cohen MB, et al. Expression of c-KIT and its ligand, stem cell factor, in normal and subfertile human testicular tissue. J Androl 1996;17:403-8.
84. Berney DM, Lee A, Shamash J, et al. The frequency and distribution of intratubular trophoblast in association with germ cell tumors of the testis. Am J Surg Pathol 2005;29:1300-3.
85. McClure RF, Keeney GL, Sebo TJ, et al. Serous borderline tumor of the paratestis: a report of seven cases. Am J Surg Pathol 2001;25:373-8.
86. Ulbright TM, Young RH. Primary mucinous tumors of the testis and paratestis: a report of nine cases. Am J Surg Pathol 2003;27:1221- 8.
87. Young RH, Scully RE. Testicular and paratesticular tumors and tumor-like lesions of ovarian common epithelial and mullerian types. A report of four cases and review of the literature. Am J Clin Pathol 1986;86:146-52.
88. Jones MA, Young RH, Srigley JR, et al. Paratesticular serous papillary carcinoma. A report of six cases. Am J Surg Pathol 1995;19:1359-65.
89. Delahunt B, Eble JN, King D, et al. Immunohistochemical evidence for mesothelial origin of paratesticular adenomatoid tumour. Histopathology 2000;36:109-15.
90. Jones MA, Young RH, Scully RE. Malignant mesothelioma of the tunica vaginalis. A clinicopathologic analysis of 11 cases with review of the literature. Am J Surg Pathol 1995;19:815-25.
91. Iczkowski KA, Katz G, Zander DS, et al. Malignant mesothelioma of tunica vaginalis testis: a fatal case with liver metastasis. J Urol 2002;167:645-6.
92. Winstanley AM, London G, Berney D, et al. The immunohistochemical profile of malignant mesotheliomas of the tunica vaginalis: a study of 20 cases. Am J Surg Pathol 2006;30:1-6.
93. Cao QJ, Jones JG, Li M. Expression of calretinin in human ovary, testis, and ovarian sex cord-stromal tumors. Int J Gynecol Pathol 2001;20:346-52.
94. Jones MA, Young RH, Scully RE. Benign fibromatous tumors of the testis and paratesticular region: a report of 9 cases with a proposed classification of fibromatous tumors and tumor-like lesions. Am J Surg Pathol 1997;21:296-305.
95. Shimada S, Ono K, Suzuki Y, et al. Malignant mesothelioma of the tunica vaginalis testis: a case with a predominant sarcomatous component. Pathol Int 2004;54:930-4.
96. Agapitos E, Pavlopoulos PM, Marinos E, et al. Malignant mesothelioma of the tunica vaginalis testis: an immunohistochemical and ultrastructural study of two cases. Br J Urol 1997;80:345-6.
97. Leuschner I, Newton WA Jr, Schmidt D, et al. Spindle cell variants of embryonal rhabdomyosarcoma in the paratesticular region. A report of the Intergroup Rhabdomyosarcoma Study. Am J Surg Pathol 1993;17:221-30.
98. Washecka RM, Mariani AI, Zuna RE, et al. Primary intratesticular sarcoma. Immunohistochemical ultrastructural and DNA flow cytometric study of three cases with a review of the literature. Cancer 1996;77:1524-8.
99. Fisher C, Goldblum JR, Epstein JI, et al. Leiomyosarcoma of the paratesticular region: a clinicopathologic study. Am J Surg Pathol 2001;25:1143-9.
100. Balzer BL, Ulbright TM. Spontaneous regression of testicular germ cell tumors: an analysis of 42 cases. Am J Surg Pathol 2006;30:858-65.
101. Hawkins E, Heifetz SA, Giller R, et al. The prepubertal testis (prenatal and postnatal): its relationship to intratubular germ cell neoplasia: a combined Pediatric Oncology Group and Children's Cancer Study Group. Hum Pathol 1997;28:404-10.
102. Kaufmann O, Koch S, Burghardt J, et al. Tyrosinase, melan-A, and KBA62 as markers for the immunohistochemical identification of metastatic amelanotic melanomas on paraffin sections. Mod Pathol 1998;11:740-6.
103. Leroy X, Zini L, Leteurtre E, et al. Morphologic subtyping of papillary renal cell carcinoma: correlation with prognosis and differential expression of MUC1 between the two subtypes. Mod Pathol 2002;15:1126-30.
104. Polski JM, Janney CG. Ber-H2 (CD30) immunohistochemical staining in malignant melanoma. Mod Pathol 1999;12:903-6.
105. Wick MR, Swanson PE, Manivel JC. Placental-like alkaline phosphatase reactivity in human tumors: an immunohistochemical study of 520 cases. Hum Pathol 1987;18:946-54.
106. Hittmair A, Rogatsch H, Hobisch A, et al. CD30 expression in seminoma. Hum Pathol 1996;27:1166-71.