Inhibition of Stenotrophomonas maltophilia dihydrofolate reductase by methotrexate: A single slow-binding process

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 22, Issue 4, 2007, Pages 377-382

  Navarro Martinez M D ^a   Cabezas Herrera, J ^b   Garcia Canovas F ^a   Rodriguez Lopez J N ^a  

^a UNIVERSITY OF MURCIA   (Spain)

^b HOSPITAL UNIVERSITARIO VIRGEN DE LA ARRIXACA   (Spain)

Author keywords

Antifolates; Dihydrofolate reductase; Methotrexate; Slow binding inhibitors; Stenotrophomonas maltophilia

Indexed keywords

BACTERIAL ENZYME; DIHYDROFOLATE REDUCTASE; METHOTREXATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; BACTERIAL INFECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PURIFICATION; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; STENOTROPHOMONAS MALTOPHILIA;

BIOCHEMISTRY; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; KINETICS; METHOTREXATE; MODELS, CHEMICAL; STENOTROPHOMONAS MALTOPHILIA; TEMPERATURE; TETRAHYDROFOLATE DEHYDROGENASE;

STENOTROPHOMONAS MALTOPHILIA;

EID: 34547788915     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360601141653     Document Type: Article

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