Platelet storage temperature - How low can we go?

Transfusion Medicine and Hemotherapy

Volumn 34, Issue 4, 2007, Pages 253-261

  Josefsson, Emma C ^a   Hartwig, John H ^a   Hoffmeister, Karin M ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Hematology; Platelet storage; Platelet transfusion; Platelets

Indexed keywords

BLEEDING; CRYOPRESERVATION; FREEZE DRYING; FREEZING; MACROPHAGE; REVIEW; ROOM TEMPERATURE; STORAGE TEMPERATURE; THROMBOCYTE PRESERVATION; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA;

EID: 34547779412     PISSN: 16603796     EISSN: None     Source Type: Journal    
DOI: 10.1159/000103920     Document Type: Review

References (131)

1. Blajchman MA: Reducing the risk of bacterial contamination of cellular blood components. Dev Biol (Basel) 2000;102:183-193.
2. Bode AP: Platelet activation may explain the storage lesion in platelet concentrates. Blood Cells 1990;16:109-125; discussion 125-106.
3. Blajchman MA, Beckers EA, Dickmeiss E, Lin L, Moore G, Muylle L: Bacterial detection of platelets: current problems and possible resolutions. Transfus Med Rev 2005;19:259-272.
4. Mohammadi T, Pietersz RN, Vandenbroucke-Grauls CM, Savelkoul PH, Reesink HW: Detection of bacteria in platelet concentrates: comparison of broad-range real-time 16S rDNA polymerase chain reaction and automated culturing. Transfusion 2005;45:731-736.
5. McCullough J, Vesole DH, Benjamin RJ, Slichter SJ, Pineda A, Snyder E, Stadtmauer EA, Lopez-Plaza I, Coutre S, Strauss RG, Goodnough LT, Fridey JL, Raife T, Cable R, Murphy S, Howard Ft, Davis K, Lin JS, Metzel P, Corash L, Koutsoukos A, Lin L, Buchholz DH, Conlan MG: Therapeutic efficacy and safety of platelets treated with a photochemical process for pathogen inactivation: the SPRINT Trial. Blood 2004;104:1534-1541.
6. Hogman CF: Aspects of platelet storage. Transfus Sci 1994;15:351-355.
7. Murphy S: The efficacy of synthetic media in the storage of human platelets for transfusion. Transfus Med Rev 1999;13:153-163.
8. Gulliksson H: Additive solutions for the storage of platelets for transfusion. Transfus Med 2000;10:257-264.
9. Holme S: Platelet storage in a liquid environment. Transfus Sci 1994;15:117-130.
10. Currie LM, Harper JR, Allan H, Connor J: Inhibition of cytokine accumulation and bacterial growth during storage of platelet concentrates at 4 degrees C with retention of in vitro functional activity. Transfusion 1997;37:18-24.
11. Babic AM, Josefsson EC, Bergmeier W, Wagner DD, Kaufman RM, Silberstein LE, Stossel TP, Hartwig JH, Hoffmeister KM: In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration. Transfusion 2007;47:442-451.
12. Sandgren P, Shanwell A, Gulliksson H: Storage of buffy coat-derived platelets in additive solutions: in vitro effects of storage at 4 degrees C. Transfusion 2006;46:828-834.
13. Murphy S, Gardner FH: Effect of storage temperature on maintenance of platelet viability - deleterious effect of refrigerated storage. N Engl J Med 1969;280:1094-1098.
14. Murphy S, Rebulla P, Bertolini F, Holme S, Moroff G, Snyder E, Stromberg R: In vitro assessment of the quality of stored platelet concentrates. The BEST (Biomedical Excellence for Safer Transfusion) Task Force of the International Society of Blood Transfusion. Transfus Med Rev 1994;8:29-36.
15. Guidance for industry for platelet testing and evaluation of platelet substitute products (Internet); in Rockville MD: Center for Biologics Evaluation and Research (CBER) FDA (ed);www.fda.gov/cber/gdlns/platelet.htm, 1999:1-7.
16. Mason KD, Carpinelli MR, Fletcher JI, Collinge JE, Hilton AA, Ellis S, Kelly PN, Ekert PG, Metcalf D, Roberts AW, Huang DC, Kile BT: Programmed anuclear cell death delimits platelet life span. Cell 2007;128:1173-1186.
17. Bergmeier W, Burger PC, Piffath CL, Hoffmeister KM, Hartwig JH, Nieswandt B, Wagner DD: Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets. Blood 2003;102:4229-4235.
18. Brown S, Clarke M, Magowan L, Sanderson H: Constitutive death of platelets leading to scavenger receptor-mediated phagocytosis. A caspase independent program. J Biol Chem 2000;275:5987-5995.
19. Li J, Xia Y, Bertino AM, Coburn JP, Kuter DJ: The mechanism of apoptosis in human platelets during storage. Transfusion 2000;40:1320-1329.
20. Vance JE, Steenbergen R: Metabolism and functions of phosphatidylserine. Prog Lipid Res 2005;44:207-234.
21. Schlegel RA, Williamson P: Phosphatidylserine, a death knell. Cell Death Differ 2001;8:551-563.
22. Bertino AM, Qi XQ, Li J, Xia Y, Kuter DJ: Apoptotic markers are increased in platelets stored at 37 degrees C. Transfusion 2003;43:857-866.
23. Perrotta PL, Perrotta CL, Snyder EL: Apoptotic activity in stored human platelets. Transfusion 2003;43:526-535.
24. Bratosin D, Mazurier J, Debray H, Lecocq M, Boilly B, Alonso C, Moisei M, Motas C, Montreuil J: Flow cytofluorimetric analysis of young and senescent human erythrocytes probed with lectins. Evidence that sialic acids control their life span. Glycoconj J 1995;12:258-267.
25. Bratosin D, Mazurier J, Tissier JP, Estaquier J, Huart JJ, Ameisen JC, Aminoff D, Montreuil J: Cellular and molecular mechanisms of senescent erythrocyte phagocytosis by macrophages. A review. Biochimie 1998;80:173-195.
26. Bovenschen N, Rijken DC, Havekes LM, van Vlijmen BJ, Mertens K: The B domain of coagulation factor VIII interacts with the asialoglycoprotein receptor. J Thromb Haemost 2005;3:1257-1265.
27. Aminoff D, Bruegge WF, Bell WC, Sarpolis K, Williams R: Role of sialic acid in survival of erythrocytes in the circulation: interaction of neuraminidase-treated and untreated erythrocytes with spleen and liver at the cellular level. Proc Natl Acad Sci U S A 1977;74:1521-1524.
28. Reimers HJ, Greenberg J, Cazenave JP, Packham MA, Mustard JF: Experimental modification of platelet survival. Adv Exp Med Biol 1977;82:231-233.
29. Steiner M, Vancura S: Asymmetrical loss of sialic acid from membrane glycoproteins during platelet aging. Thromb Res 1985;40:465-471.
30. Greenberg J, Packham MA, Cazenave JP, Reimers HJ, Mustard JF: Effects on platelet function of removal of platelet sialic acid by neuraminidase. Lab Invest 1975;32:476-484.
31. Kotze HF, van Wyk V, Badenhorst PN, Heyns AD, Roodt JP, Lotter MG: Influence of platelet membrane sialic acid and platelet-associated IgG on ageing and sequestration of blood platelets in baboons. Thromb Haemost 1993;70:676-680.
32. Ellies L, Ditto D, Levy G, Wahrenbrock M, Ginsburg D, Varki A, Le D, Marth J: Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands. Proc Natl Acad Sci U S A 2002;99:10042-10047.
33. Soslau G, Giles J: The loss of sialic acid and its prevention in stored human platelets. Thromb Res 1982;26:443-455.
34. Chernoff A, Snyder EL: The cellular and molecular basis of the platelet storage lesion: a symposium summary. Transfusion 1992;32:386-390.
35. Seghatchian J, Krailadsiri P: The platelet storage lesion. Transfus Med Rev 1997;11:130-144.
36. Scharf R, Hanfland P: Platelet storage lesions: analysis of platelet membrane glycoproteins and platelet-derived microparticles by fluorescence-activated flow cytometry. Transfus Sci 1993;14:189-194.
37. Hoffmeister KM, Felbinger TW, Falet H, Denis CV, Bergmeier W, Mayadas TN, von Andrian UH, Wagner DD, Stossel TP, Hartwig JH: The clearance mechanism of chilled blood platelets. Cell 2003;112:87-97.
38. Leytin V, Allen DJ, Gwozdz A, Garvey B, Freedman J: Role of platelet surface glycoprotein Ibalpha and P-selectin in the clearance of transfused platelet concentrates. Transfusion 2004;44:1487-1495.
39. Snyder EL: Release of beta-thromboglobulin during storage of platelet concentrates. Vox Sang 1981;40(suppl 1):115-116.
40. Perez-Ceballos E, Rivera J, Lozano ML, Candela MJ, Corral J, Guerrero JA, Vicente V: Evaluation of refrigerated platelet concentrates supplemented with low doses of second messenger effectors. Clin Lab Haematol 2004;26:275-286.
41. Zucker MB, Borrelli J: Viscous metamorphosis produced by chilling and by clotting failure to find specific defect of viscous metamorphosis in PTA syndrome. Thromb Diath Haemorrh 1960;4:424-434.
42. Anstall HB, Hawkey CM: Observations on platelet clumping and related phenomena: a reappraisal and a clarification of terms. Transfusion 1962;2:44-51.
43. Lindenblatt N, Menger MD, Klar E, Vollmar B: Sustained hypothermia accelerates microvascular thrombus formation in mice. Am J Physiol Heart Circ Physiol 2005;289:H2680-2687.
44. Robblee LS, Shepro D, Vecchione JJ, Valeri CR: Increased thrombin sensitivity of human platelets after storage at 4 C. Transfusion 1979;19:45-52.
45. Becker GA, Tuccelli M, Kunicki T, Chalos MK, Aster RH: Studies of platelet concentrates stored at 22 C nad 4 C. Transfusion 1973;13:61-68.
46. Rock G, Figueredo A: Metabolic changes during platelet storage. Transfusion 1976;16:571-579.
47. Choi JW, Pai SH: Influence of storage temperature on the responsiveness of human platelets to agonists. Ann Clin Lab Sci 2003;33:79-85.
48. McGill M, Brindley DC: Effects of storage on platelet reactivity to arterial subendothelium during blood flow. J Lab Clin Med 1979;94:370-380.
49. Shively JA, Gott CL, De Jongh DS: The effect of storage on adhesion and aggregation of platelets. Vox Sang 1970;18:204-215.
50. Mondoro TH, Vostal JG: Cold temperatures reduce the sensitivity of stored platelets to disaggregating agents. Platelets 2002;13:11-20.
51. Kattlove HE, Alexander B, White F: The effect of cold on platelets. II. Platelet function after short-term storage at cold temperatures. Blood 1972;40:688-696.
52. Zhang JN, Wood J, Bergeron AL, McBride L, Ball C, Yu Q, Pusiteri AE, Holcomb JB, Dong JF: Effects of low temperature on shear-induced platelet aggregation and activation. J Trauma 2004;57:216-223.
53. Han Q, Chen J, Peng Y, Bergeron AL, Liu L, Dong J, Lopez JA: The mechanism of cold-induced platelet hyperfunction. Blood (ASH Annual Meeting Abstracts) 2005;106:1651.
54. Berger G, Hartwell DW, Wagner DD: P-Selectin and platelet clearance. Blood 1998;92:4446-4452.
55. Michelson A, Barnard M, Hechtman H, MacGregor H, Connolly R, Loscalzo J, Valeri C: In vivo tracking of platelets: circulating degranulated platelets rapidly lose suface P-selectin but continue to circulate and function. Proc Natl Acad Sci U S A 1996;93:11877-11882.
56. Hoffmeister KM, Josefsson EC, Isaac NA, Clausen H, Hartwig JH, Stossel TP: Glycosylation restores survival of chilled blood platelets. Science 2003;301:1531-1534.
57. Italiano JE Jr, Bergmeier W, Tiwari S, Falet H, Hartwig JH, Hoffmeister KM, Andre P, Wagner DD, Shivdasani RA: Mechanisms and implications of platelet discoid shape. Blood 2003;101:4789-4796.
58. Rao AK, Murphy S: Secretion defect in platelets stored at 4 degrees C. Thromb Haemost 1982;47:221-225.
59. Zappia GC, Steiner M, Ando Y, Baldini M: Effect of chilling on platelet cyclic adenosine 3:5-monophosphate and adenylate cyclase activity. Transfusion 1976;16:122-129.
60. Heldt HW, Klingenberg M: Differences between the reactivity of endogenous and exogenous adenine nucleotides in mitochondria as studied at low temperature. Eur J Biochem 1968;4:1-8.
61. Penefsky HS, Warner RC: Partial resolution of the enzymes catalyzing oxidative phosphorylation. VI. Studies on the mechanism of cold inactivation of mitochondrial adenosine triphosphatase. J Biol Chem 1965;240:4694-4702.
62. Kahn RA, Staggs SD, Miller WV, Heaton WA: Recovery, lifespan, and function of CPD-Adenine (CPDA-1) platelet concentrates stored for up to 72 hours at 4 C. Transfusion 1980;20:498-503.
63. Filip DJ, Aster RH: Relative hemostatic effectiveness of human platelets stored at 4 degrees and 22 degrees C. J Lab Clin Med 1978;91:618-624.
64. Slichter SJ, Harker LA: Preparation and storage of platelet concentrates. II. Storage variables influencing platelet viability and function. Br J Haematol 1976;34:403-419.
65. Handin RI, Valeri CR: Hemostatic effectiveness of platelets stored at 22 degrees C. N Engl J Med 1971;285:538-543.
66. Valeri CR: Circulation and hemostatic effectiveness of platelets stored at 4 C or 22 C: studies in aspirin-treated normal volunteers. Transfusion 1976;16:20-23.
67. Kattlove HE: Platelet preservation-what temperature? A rationale for strategy. Transfusion 1974;14:328-330.
68. Blajchman MA, Lee DH: The thrombocytopenic rabbit bleeding time model to evaluate the in vivo hemostatic efficacy of platelets and platelet substitutes. Transfus Med Rev 1997;11:95-105.
69. Rothwell SW, Maglasang P, Krishnamurti C: Survival of fresh human platelets in a rabbit model as traced by flow cytometry. Transfusion 1998;38:550-556.
70. Tang RC, Huang CY, Pei XP, Chen BA, Li CP, Shi GY: Evaluation of the effects of glycosylation on in vivo survival of cold-storage human platelets by using rabbit model. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2005;13:1113-1116.
71. Pei XP, Chen BA, Huang CY, Li CP, Shi GY, Xiao JY, Gao C, Ding JH, Fei F, Wang J, Sun YY, Cheng J, Zhao G: Cold storage of rabbit platelet suspension by adding uridine diphosphate galactose. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2006;14:1244-1247.
72. Huang CY, Tang RC, Cai L, Cui Y, Liu L: Cold storage of platelet suspension by adding trehalose. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2005;13:904-906.
73. Valeri CR, Ragno G, Marks PW, Kuter DJ, Rosenberg RD, Stossel TP: Effect of thrombopoietin alone and a combination of cytochalasin B and ethylene glycol bis(beta-aminoethyl ether) N,N′-tetraacetic acid-AM on the survival and function of autologous baboon platelets stored at 4 degrees C for as long as 5 days. Transfusion 2004;44:865-870.
74. Valeri CR, Giorgio A, Macgregor H, Ragno G: Circulation and distribution of autotransfused fresh, liquid-preserved and cryopreserved baboon platelets. Vox Sang 2002;83:347-351.
75. Valeri CR, MacGregor H, Barnard MR, Summaria L, Michelson AD, Ragno G: Survival of baboon biotin-X-N-hydroxysuccinimide and (111)In-oxinelabelled autologous fresh and lyophilized reconstituted platelets. Vox Sang 2005;88:122-129.
76. Harker LA, Marzec UM, Hunt P, Kelly AB, Tomer A, Cheung E, Hanson SR, Stead RB: Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates. Blood 1996;88:511-521.
77. Harker LA, Hunt P, Marzec UM, Kelly AB, Tomer A, Hanson SR, Stead RB: Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates. Blood 1996;87:1833-1844.
78. Malpass TW, Hanson SR, Savage B, Hessel EA 2nd, Harker LA: Prevention of acquired transient defect in platelet plug formation by infused prostacyclin. Blood 1981;57:736-740.
79. Krishnamurti C, Maglasang P, Rothwell SW: Reduction of blood loss by infusion of human platelets in a rabbit kidney injury model. Transfusion 1999;39:967-974.
80. Leytin V, Allen DJ, Mody M, Rand ML, Hannach B, Garvey B, Freedman J: A rabbit model for monitoring in vivo viability of human platelet concentrates using flow cytometry. Transfusion 2002;42:711-718.
81. Macchiarini F, Manz MG, Palucka AK, Shultz LD: Humanized mice: are we there yet? J Exp Med 2005;202:1307-1311.
82. Read MS, Reddick RL, Bode AP, Bellinger DA, Nichols TC, Taylor K, Smith SV, McMahon DK, Griggs TR, Brinkhous KM: Preservation of hemostatic and structural properties of rehydrated lyophilized platelets: potential for long-term storage of dried platelets for transfusion. Proc Natl Acad Sci U S A 1995;92:397-401.
83. Tablin F, Walker NJ, Klein SD, Field CL, Crowe JH: Animal models for studies on cold-induced platelet activation in human beings. J Lab Clin Med 2000;135:339-346.
84. Dewanjee MK, Belinskiy VV, Holland JF, Kapadvanjwala M, Wu SM, Novak S, Hsu LC, Sanchez J, Dewanjee S, Serafini AN, Duncan RC, Sfakianakis GN: Effect of thoracotomy and cardiopulmonary bypass on activated platelet and neutrophil dynamics and platelet emboli in a pig model. J Thromb Thrombolysis 1996;3:195-208.
85. Zoghbi SS, Thakur ML, Sostman HD, Greenspan RH, Gottschalk A: Indium-111-oxinate labeled swine platelets and their survival in vivo. Lab Anim Sci 1988;38:444-447.
86. Josefsson EC, Gebhard HH, Stossel TP, Hartwig JH, Hoffmeister KM: The macrophage alphaMbeta2 integrin alphaM lectin domain mediates the phagocytosis of chilled platelets. J Biol Chem 2005;280:18025-18032.
87. Badlou BA, Spierenburg G, Ulrichts H, Deckmyn H, Smid WM, Akkerman JW: Role of glycoprotein Ibalpha in phagocytosis of platelets by macrophages. Transfusion 2006;46:2090-2099.
88. Slichter SJ, Wandall HH, Hoffmeister KM: In vivo studies of autologous platelets stored at room temperture 22 °C, 4 °C, and 4 °C with galactosylation. Blood (ASH Annual Meeting Abstracts) 2006;108:580.
89. Rodriguez P, Bello O, Tablante A, Apitz-Castro R: Galactosylation of endogenous proteins from human platelets. Biochem Med Metab Biol 1988;40:151-161.
90. Rodriguez P, Durante P: Characterization of a protein: glucosyltransferase activity in human platelets. Biochem Med Metab Biol 1990;43:147-158.
91. Bauvois B, Cacan R, Nurden AT, Caen J, Montreuil J, Verbert A: Membrane glycoprotein IIb is the major endogenous acceptor for human platelet ectosialyltransferase. FEBS Lett 1981;125:277-281.
92. Bauvois B, Cacan R, Fournet B, Caen J, Montreuil J, Verbert A: Discrimination between activity of (alpha 2-3)-sialyltransferase and (alpha 2-6)-sialyltransferase in human platelets using p-nitrophenylbeta-D-galactoside as acceptor. Eur J Biochem 1982;121:567-572.
93. Hopper K, Semler A, Chapman G, Davey R: Release of galactosyltransferase from human platelets and a subset of monocytes in culture. Blood 1986;68:176-172.
94. Zucker MB, Borrelli J: Reversible alterations in platelet morphology produced by anticoagulants and by cold. Blood 1954;9:602-608.
95. Winokur R, Hartwig JH: Mechanism of shape change in chilled human platelets. Blood 1995;85:1796-1804.
96. Kubisz P, Klener P: Platelet shape change induced by cold and the retraction of reptilase clots. Acta Univ Carol Med (Praha) 1976;22:9-17.
97. White JG, Krumwiede M: Influence of cytochalasin B on the shape change induced in platelets by cold. Blood 1973;41:823-832.
98. Oliver AE, Tablin F, Walker NJ, Crowe JH: The internal calcium concentration of human platelets increases during chilling. Biochim Biophys Acta 1999;1416:349-360.
99. Hoffmeister KM, Falet H, Toker A, Barkalow KL, Stossel TP, Hartwig JH: Mechanisms of cold-induced platelet actin assembly. J Biol Chem 2001;276:24751-24759.
100. Okita JR, Pidard D, Newman PJ, Montgomery RR, Kunicki TJ: On the association of glycoprotein Ib and actin-binding protein in human platelets. J Cell Biol 1985;100:317-321.
101. Fox JE, Aggerbeck LP, Berndt MC: Structure of the glycoprotein Ib.IX complex from platelet membranes. J Biol Chem 1988;263:4882-4890.
102. Nakamura F, Pudas R, Heikkinen O, Permi P, Kilpelainen I, Munday AD, Hartwig JH, Stossel TP, Ylanne J: The structure of the GPIb-filamin A complex. Blood 2005.
103. Ezzell R, Kenney D, Egan S, Stossel T, Hartwig J: Linkage of the membrane glycoprotein GPIb to the actin cytoskeleton by a defined domain of actin-binding protein (ABP) in resting and thrombin-activated human platelets. J Cell Biol 1987;105:211a.
104. Ganguly P, Fossett NG: The role of sialic acid in the activation of platelets by wheat germ agglutinin. Blood 1984;63:181-187.
105. Gousset K, Tsvetkova NM, Crowe JH, Tablin F: Important role of raft aggregation in the signaling events of cold-induced platelet activation. Biochim Biophys Acta 2004;1660:7-15.
106. Gousset K, Wolkers W, Tsvetkova N, Oliver A, Field C, Walker N, Crowe J, Tablin F: Evidence for a physiological role for membrane rafts in human platelets. J Cell Physiol 2002;190:117-128.
107. Bode AP, Knupp CL: Effect of cold storage on platelet glycoprotein Ib and vesiculation. Transfusion 1994;34:690-696.
108. Josefsson EC, Bergmeier W, Wagner DD, Stossel TP, Hartwig JH, Hoffmeister KM: Differential changes in platelet VWF receptor following refrigeration for short or long periods. Blood (ASH Annual Meeting Abstracts) 2005;106:3564.
109. Ashwell G, Harford J: Carbohydrate-specific receptors of the liver. Annu Rev Biochem 1982;51:531-554.
110. Hoyle GW, Hill RL: Molecular cloning and sequencing of a cDNA for a carbohydrate binding receptor unique to rat Kupffer cells. J Biol Chem 1988;263:7487-7492.
111. Nakamura K, Funakoshi H, Tokunaga F, Nakamura T: Molecular cloning of a mouse scavenger receptor with C-type lectin (SRCL)(1), a novel member of the scavenger receptor family. Biochim Biophys Acta 2001;1522:53-58.
112. Nakamura K, Funakoshi H, Miyamoto K, Tokunaga F, Nakamura T: Molecular cloning and functional characterization of a human scavenger receptor with C-type lectin (SRCL), a novel member of a scavenger receptor family. Biochem Biophys Res Commun 2001;280:1028-1035.
113. Coombs PJ, Taylor ME, Drickamer K: Two categories of mammalian galactose-binding receptors distinguished by glycan array profiling. Glycobiology 2006;16:1C-7C.
114. Klein E, Toch R, Farber S, Freeman G, Fiorentino R: Hemostasis in thrombocytopenic bleeding following infusion of stored, frozen platelets. Blood 1956;11:693-699.
115. Fischer TH, Bode AP, Parker BR, Russell KE, Bender DE, Ramer JK, Read MS: Primary and secondary hemostatic functionalities of rehydrated, lyophilized platelets. Transfusion 2006;46:1943-1950.
116. Bode AP, Fischer TH: Lyophilized platelets: fifty years in the making. Artif Cells Blood Substit Immobil Biotechnol 2007;35:125-133.
117. Crowe J, Tablin F, Wolkers W, Gousset K, Tsvetkova N, Ricker J: Stabilization of membranes in human platelets freeze-dried with trehalose. Chem Phys Lipids 2003;122:41-52.
118. Crowe JH, Tablin F, Tsvetkova N, Oliver AE, Walker N, Crowe LM: Are lipid phase transitions responsible for chilling damage in human platelets? Cryobiology 1999;38:180-191.
119. Tablin F, Oliver A, Walker N, Crowe L, Crowe J: Membrane phase transition of intact human platelets: correlation with cold-induced activation. J Cell Phys 1996;168:305-313.
120. Tablin F, Wolkers W, Walker N, Oliver A, Tsvetkova N, Gousset K, Crowe L, Crowe J: Mem-brane reorganization during chilling: implications for long-term stabilization of platelets. Cryobiology 2001;43:114-123.
121. Sputtek A: Kryokonservierung von Blutzellen und hämatopoetischen Zellen; in Mueller-Eckhardt C, Kiefel V (eds): Transfusionsmedizin. Berlin, Springer, 2004, pp. 133-144.
122. Sputtek A: Cryopreservation of red cells and platelets; in Day JG, Stacey G (eds): Cryopreservation and Freeze Drying Protocols. Totowa, Humana Press, 2007, pp. 281-299.
123. Sputtek A, Sputtek R: Cryopreservation in transfusion medicine and haematology; in Fuller BJ, Lane N, Benson EE (eds): Life in a Frozen State. Boca Raton, CRC Press, 2004, pp. 483-504.
124. Walker RH: Technical manual; American Association of Blood Banks, Bethesda, USA, 1993, pp 733-738.
125. Melaragno AJ, Carciero R, Feingold H, Talarico L, Weintraub L, Valeri CR: Cryopreservation of human platelets using 6% dimethyl sulfoxide and storage at -80 degrees C. Effects of 2 years of frozen storage at -80 degrees C and transportation in dry ice. Vox Sang 1985;49:245-258.
126. Balduini CL, Mazzucco M, Sinigaglia F, Grignani G, Bertolino G, Noris P, Pacchiarini L, Torti M, Salvaneschi L: Cryopreservation of human platelets using dimethyl sulfoxide and glycerol-glucose: effects on 'in vitro' platelet function. Haematologica 1993;78:101-104.
127. Connor J, Currie LM, Allan H, Livesey SA: Recovery of in vitro functional activity of platelet concentrates stored at 4 degrees C and treated with second-messenger effectors. Transfusion 1996;36:691-698.
128. Pedrazzoli P, Noris P, Perotti C, Schiavo R, Ponchio L, Belletti S, Da Prada GA, Balduini CL, Salvaneschi L, Robustelli Della Cuna G, Siena S: Transfusion of platelet concentrates cryopreserved with ThromboSol plus low-dose dimethylsulphoxide in patients with severe thrombocytopenia: a pilot study. Br J Haematol 2000;108:653-659.
129. Vadhan-Raj S, Kavanagh JJ, Freedman RS, Folloder J, Currie LM, Bueso-Ramos C, Verschraegen CF, Narvios AB, Connor J, Hoots WK, Broemeling LD, Lichtiger B: Safety and efficacy of transfusions of autologous cryopreserved platelets derived from recombinant human thrombopoietin to support chemotherapy-associated severe thrombocytopenia: a randomised cross-over study. Lancet 2002;359:2145-2152.
130. Holme S: Storage and quality assessment of platelets. Vox Sang 1998;74(suppl 2):207-216.
131. Vostal JG, Reid TJ, Mondoro TH: Summary of a workshop on in vivo efficacy of transfused platelet components and platelet substitutes. Transfusion 2000;40:742-750.