Apolipoprotein E genotypes and their relation to lipid levels in a rural South African population

Scandinavian Journal of Public Health

Volumn 35, Issue SUPPL. 69, 2007, Pages 60-65

  Masemola, Matshane L ^a   Alberts, Marianne ^a   Urdal, Petter ^b  

^a UNIVERSITY OF LIMPOPO   (South Africa)

^b ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

Apolipoprotein E genotypes; Ethnicity; Gender; Lipid levels; Rural population

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE CONTROL; DNA POLYMORPHISM; ETHNICITY; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; LIFESTYLE MODIFICATION; LIPID BLOOD LEVEL; MALE; NEGRO; NORMAL HUMAN; POPULATION GENETICS; PRIORITY JOURNAL; RISK ASSESSMENT; RURAL POPULATION; SOUTH AFRICA; TRIACYLGLYCEROL BLOOD LEVEL; ALLELE; BLOOD; DEMOGRAPHY; ETHNOLOGY; FEEDING BEHAVIOR; GENETIC POLYMORPHISM; GENETICS; RISK FACTOR; SEX DIFFERENCE;

ADULT; ALLELES; APOLIPOPROTEINS E; CARDIOVASCULAR DISEASES; CHOLESTEROL; DEMOGRAPHY; FEMALE; FOOD HABITS; GENOTYPE; HUMANS; LIPIDS; MALE; POLYMORPHISM, GENETIC; RISK FACTORS; RURAL POPULATION; SEX FACTORS; SOUTH AFRICA; TRIGLYCERIDES; VARIATION (GENETICS);

EID: 34547779019     PISSN: 14034948     EISSN: 16511905     Source Type: Journal    
DOI: 10.1080/14034950701355635     Document Type: Article

References (28)

1. Mollentze, W. F., Moore, A. J., Steyn, A. F., Joubert, G., Steyn, K., Oosthuizen, G. M. and Weich, D. J. (1995) Coronary heart disease risk factors in a rural and urban Orange Free State black population. SAMJ, 85, pp. 90-96.
2. Haddy, N., De Bacquer, D., Chemaly, M., Maurice, M., Ehnholm, C., Evans, A., Sans, S., Martins, M. C., De Becker, G., Siest, G. and Visvikis, S. (2002) The importance of plasma apolipoprotein E concentration in addition to its common polymorphism on inter-individual variation in lipid levels: Results from Apo Europe. Eur J Hum Genet, 10, pp. 841-850.
3. Lusis, A. J. (2000) Atherosclerosis. Nature, 407, pp. 233-241.
4. Pedro-Botet, J., Senti, M., Nogues, X., Rubies-Prat, J., Roquer, J., D'Olhaberriague, L. and Olive, J. (1992) Lipoprotein and apoprotein profile in men with ischaemic stroke: Role of lipoprotein (a), triglyceride-rich lipoproteins, and apolipoprotein E polymorphism. Stroke, 23, pp. 1556-1562.
5. Wilson, P. F., Myers, R. H., Larson, M. G., Ordovas, J. M., Wolf, P. M. and Schaefer, E. J. (1994) Apolipoprotein E alleles, dyslipidemia, and coronary heart disease. The Framingham Offspring Study. JAMA, 272, pp. 661-671.
6. Farrer, L. A. and Cupples, L. A. (1997) Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: A meta-analysis. J Am Med Assoc, 278, pp. 1349-1358.
7. Gerdes, L. U. (2003) The common polymorphisms of apolipoprotein E: Geographical aspects and new pathophysiological relations. Clin Chem Lab Med, 41, pp. 628-631.
8. Lusis, A. J., Heizman, C. and Sparks, R. S. (1986) Regional mapping of human chromosome 19: Organisation for plasma lipid transport Apo C1, C2 and E and LDLR and the genes C3, PEPD and GP1. Proc Natl Acad Sci USA, 83, pp. 3929-3933.
9. Rexin, M. and Feussner, M. (1998) A comparative reverse transcription-PCR to study apolipoprotein E gene expression. Clin Chem, 44, pp. 773-778.
10. Rall Jr., S. C., Weisgraber, K. H. and Mahley, R. W. (1982) Human apolipoprotein: The complete amino acid sequence. J Biol Chem, 257, pp. 4171-4178.
11. Frikke-Schmidt, R. (2000) Context dependent and invariant associations between APOE genotypes and levels of lipoproteins and risk of ischaemic heart disease. Scand J Clin Invest, 233, pp. 3-26.
12. Davignon, J., Gregg, R. E. and Sing, C. F. (1988) Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis, 8, pp. 1-21.
13. Hagberg, J. M., Wilund, K. R. and Ferrel, R. E. (2000) Apo E gene and gene-environment effects on plasma lipoprotein-lipid levels. Physiol Genomics, 4, pp. 101-108.
14. Steyn, N. P., Burger, S., Monyeki, K. D., Alberts, M. and Nthangeni, G. (2001) Seasonal variation in dietary intake of the adult population of Dikgale. SAfr JClin Nutr, 14, pp. 140-144.
15. Alberts, M. (1998) Dikgale Demographic Study Phase 1., University of the North, Sovenga
16. Miller, S. A., Dykes, D. D. and Polesky, H. F. (1989) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acid Res, 16, p. 1215.
17. Dallinga-Thie, G. M., van Linde-Sibenius, T. M., Kock, L. A. W. and De Bruin, T. W. A. (1995) Apo lipoprotein E2/E3/E4 Genotyping with agarose gels. Clin Chem, 41, pp. 73-75.
18. Loktionov, A., Voster, H., O'Neill, I. K., Nell, T., Bingham, S. A., Runswick, S. A. and Cummings, J. H. (1999) Apolipoprotein E and methylene-tetrahydrofolate reductase genetic polymorphisms in relation to other risk factors for cardiovascular disease in UK Caucasians and Black South Africans. Atherosclerosis, 145, pp. 125-135.
19. Bohnet, K., Raegis-Bailly, A., Vincent-Viry, M., Schlenk, A., Gueguen, R., Siest, G. and Visvikis, S. (1996) Apolipoprotein E genotype ε4/ ε2 in the STANISLAS-cohort study: Dominance of the apoε2 allele?. Ann Hum Genet, 60, pp. 509-516.
20. Roberts, A. D., Muesing, R. A., Parenti, D. M., Hsia, J., Wasserman, A. G. and Simon, G. L. (1999) Alterations in serum lipid levels and lipoproteins with indinavir therapy for human immunodeficiency virus-infected patients. Clin Infect Dis, 29, pp. 441-443.
21. Chikosi, A. B., Moodley, J., Pegorary, P. J., Lanning, P. A. and Rom, L. (2000) Apolipoprotein E polymorphism in South African Zulu women with pre-eclampsia. Hypertensive Pregnancy, 19, pp. 309-314.
22. Corbo, R. M. and Scacchi, R. (1999) Apolipoprotein E allele distribution in the world: Is AHOEz.ast;4 a "thrifty" allele?. Am J Hum Genet, 63, pp. 301-310.
23. Fullerton, S. M., Clark, A. G., Weiss, K. M., Nickerson, D. A., Taylor, S. A., Stengard, S. A., Salomaa, V., Vartiaimen, E., Perda, M., Boerwinkel, E. and Sing, C. F. (2000) Apolipoprotein E variation at the sequence haplotype level: Implications for the origin and maintenance of a major human polymorphism. Am J Hum Genet, 67, pp. 881-900.
24. Sandholzer, C., Delport, R., Vermak, H. and Utermann, G. (1995) High frequency of the apo ε4 allele in Khoi San from South Africa. Hum Genet, 95, pp. 43-48.
25. Dalongville, J., Lussier-Cacan, S. and Davignon, J. (1992) Modulation of plasma triglyceride levels by apo E phenotype: A meta-analysis. J Lipid Res, 33, pp. 447-454.
26. Bergeron, N. and Havel, R. J. (1996) Prolonged postprandial responses of lipids and apolipoproteins in triglyceride-rich lipoproteins of individuals expressing an apolipoprotein ε4 allele. J Clin Invest, 97, pp. 65-72.
27. Yach, D., Hawkes, C., Gould, C. L. and Hofman, K. J. (2004) The global burden of chronic diseases. JAMA, 291, pp. 2616-2622.
28. Alberts, M., Urdal, P., Steyn, K., Stensvold, I., Tverdal, A., Nel, J. H. and Steyn, N. P. (2005) Prevalence of cardiovascular diseases and associated risk factors in a rural black population of South Africa. Eur J Cardiovasc Prev Rehabil, 12, pp. 347-354.