Stress relaxation test for the characterization of the viscoelasticity of pellets

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 67, Issue 2, 2007, Pages 476-484

  Cespi, Marco ^a   Bonacucina, Giulia ^a   Misici Falzi, Monica ^a   Golzi, Roberto ^b   Boltri, Luigi ^b   Palmieri, Giovanni F ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b Eurand Spa ^*  (Italy)

Author keywords

Compression; Extrusion; Mechanical properties; Pellets; Spheronization; Stress relaxation; Viscoelasticity

Indexed keywords

EXCIPIENT; LACTOSE; MICROCRYSTALLINE CELLULOSE; SORBOLAC 400; UNCLASSIFIED DRUG;

ARTICLE; COMPRESSION; DRUG FORMULATION; DRUG MANUFACTURE; DRUG PELLET; MECHANICAL STRESS; PARAMETER; PELLET EXTRUSION; PHARMACEUTICAL ENGINEERING; SPHERONIZATION; TENSILE STRENGTH; VISCOELASTICITY;

CELLULOSE; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; LACTOSE; MICROSCOPY; PARTICLE SIZE; POROSITY; RHEOLOGY; STRESS, MECHANICAL; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS; VISCOSITY;

EID: 34547776255     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2007.03.013     Document Type: Article

References (43)

1. Davis S.S., Hardy J.G., Whalley R.D., and Wilson C.G. The effect of food intake on the gastro-intestinal transit of pellets and an osmotic device (Osmet). Int. J. Pharm. 21 (1984) 331-340
2. Bechgaard H. Critical factors influencing gastro-intestinal absorption. What is the role of pellets?. Acta Pharm. Technol. 28 (1982) 149-157
3. El-Mahdi I.M., and Deasy P.B. Tableting of coated ketoprofen pellets. J. Microencapsulat. 17 (2000) 133-144
4. Wan L.S.C., and Lai W.F. A multiple-unit tablet formulation for multi-layer drug-coated granules. STP Pharm. Sci. 4 (1994) 336-342
5. Béchard S.R., and Leroux J.C. Coated pellettized dosage form: effect of compaction on drug release. Drug Dev. Ind. Pharm. 18 (1992) 1927-1944
6. Beckert T.E., Lehmann K., and Schmidt P.C. Compression of enteric-coated pellets to disintegrating tablets. Int. J. Pharm. 143 (1996) 13-23
7. Schwarts J.B., Nguyen N.H., and Schnaare R.L. Compaction studies on beads: compression and consolidation parameters. Drug Dev. Ind. Pharm. 20 (1994) 3105-3129
8. Haslam J.L., Forbes A.E., Rork G.S., Pipkin T.L., Slade D.A., and Khossravi D. Tableting of controlled release multiparticulates, the effect of millisphere size and protective overcoating. Int. J. Pharm. 173 (1998) 233-242
9. Gold G., Duvall R.N., Palermo B.T., and Hurtle R.L. Granule strength as a formulation factor I: instrumentation. J. Pharm. Sci. 60 (1971) 922-925
10. Wikberg M., and Alderborn G. Compression Characteristics of granulated materials V. Mechanical properties of individual granules, assessed by diametral compression, in granulations with different volume reduction behaviour. STP Pharm. Sci. 2 (1992) 313-319
11. Aulton M.E., Dyer A.M., and Khan K.A. The strength and compaction of millispheres. Drug Dev. Ind. Pharm. 20 (1994) 3069-3104
12. Salako M., Podczeck F., and Newton J.M. Investigation into the deformability and tensile strength of pellets. Int. J. Pharm. 168 (1998) 49-57
13. Schmidt C., and Kleinebudde P. Influence of the granulation step on pellets prepared by extrusion/spheronization. Chem. Pharm. Bull. 47 (1999) 405-412
14. Kleinebudde P., Schreder M., Schultz P., Muller B.W., Waaler T., and Nymo L. Importance of the fraction of microcrystalline cellulose and spheronization speed on the properties of extruded pellets made from binary mixtures. Pharm. Development Technol. 4 (1999) 397-404
15. Horisawa E., Danjo K., and Sunada H. Influence of granulating method on physical and mechanical properties, compression behaviour, and compactability of lactose and microcrystalline cellulose granules. Drug Dev. Ind. Pharm. 26 (2000) 583-593
16. Sousa J.J., Sousa A., Podczeck F., and Newton J.M. Factors influencing the physical characteristics of pellets obtained by extrusion-spheronization. Int. J. Pharm. 232 (2002) 91-106
17. Santos H., Veiga F., Pina M., Podczeck F., and Sousa J. Physical properties of chitosan pellets produced by extrusion-spheronization: influence of formulation variables. Int. J. Pharm. 246 (2002) 153-169
18. Bashaiwoldu A.B., Podczeck F., and Newton J.M. A study on the effect of drying technique on the mechanical properties of pellets and compacted pellets. Eur. J. Pharm. Sci. 21 (2004) 119-129
19. Johansson B., Wikberg M., Ek R., and Alderborn G. Compression behaviour and compactability of microcrystalline cellulose pellets in relationship to their pore structure and mechanical properties. Int. J. Pharm. 117 (1995) 57-73
20. Horisawa E., Komura A., Danjo K., and Otsuka A. Effect of granule strength on compressed tablets strengths. Chem. Pharm. Bull. 43 (1995) 2261-2263
21. Johansson B., and Alderborn G. Degree of pellets deformation during compaction and its relationship to the tensile strength of tablets formed of microcrystalline cellulose pellets. Int. J. Pharm. 132 (1996) 207-220
22. Pinto J.F., Podczeck F., and Newton J.M. Investigation of tablets prepared from pellets produced by extrusion and spheronisation: part I: the application of canonical analysis to correlate the properties of the tablets to the factors studied in combination with principal component analysis to select the most relevant factors. Int. J. Pharm. 147 (1997) 79-93
23. Johansson B., Nicklasson F., and Alderborn G. Effect of pellet size on degree of deformation and densification during compression and on compactability of microcrystalline cellulose pellets. Int. J. Pharm. 163 (1998) 35-48
24. Nicklasson F., Johansson B., and Alderborn G. Tabletting behaviour of pellets of a series of porosities: a comparison between pellets of two different compositions. Eur. J. Pharm. Sci. 8 (1999) 11-17
25. Tunón Å., and Alderborn G. Granule deformation and densification during compression of binary mixtures. Int. J. Pharm. 222 (2001) 65-76
26. Berggren J., and Alderborn G. Effect of drying rate on porosity and tabletting behaviour of cellulose pellets. Int. J. Pharm. 227 (2001) 81-96
27. Podczeck F., and Almeida S.M. Determination of the mechanical properties of pellets and film coated pellets using dynamic mechanical analysis (DMA). Eur. J. Pharm. Sci. 16 (2002) 209-214
28. Bashaiwoldu A.B., Podczeck F., and Newton J.M. Application of dynamic mechanical analysis (DMA) to determine the mechanical properties of pellets. Int. J. Pharm. 269 (2004) 329-342
29. Bashaiwoldu A.B., Podczeck F., and Newton J.M. Application of dynamic mechanical analysis (DMA) to determine the mechanical properties of coated pellets. Int. J. Pharm. 274 (2004) 53-63
30. McKenna A., and McCafferty D.F. Effect of particle size on the compaction mechanism and tensile strength of tablets. J. Pharm. Pharmacol. 34 (1981) 347-351
31. Rees J.E., and Rue P.J. Work required to cause failure of tablets in diametral compression. Drug Dev. Ind. Pharm. 4 (1978) 131-156
32. Hersey J.A., Rees J.E., and Cole E.T. Density changes in lactose tablets. J. Pharm. Sci. 60 (1973) 2060
33. Bassam F., York P., Rowe R.C., and Roberts R.J. Young's modulus of powders used as pharmaceutical excipients. Int. J. Pharm. 64 (1990) 55-60
34. Cox E.P. A method of assigning numerical and percentage values to the degree of roundness. J. Paleontol. 1 (1927) 179-183
35. McCarthy C.J. Recent advances in the characterization of particulates using automatic evaluation of shape descriptors. Microstruct. Sci. 4 (1976) 339-346
36. Bhattacharya M. Stress relaxation of starch/synthetic polymer blends. J. Material Sci. 33 (1998) 4131-4139
37. Ward I.M., and Hadley D.W. An introduction to the mechanical properties of solid polymer (1993), John Wiley and Sons Ltd., Chichester
38. Tschoegl N.W. The phenomenological theory of linear viscoelastic behaviour (1989), Springer-Verlag, New York
39. Palmieri G.F., Joiris E., Bonacucina G., Cespi M., and Mercuri A. Differences between eccentric and rotary tablet machines in the evaluation of powder densification behaviour. Int. J. Pharm. 298 (2005) 164-175
40. Heckel R.W. Density-pressure relationships in powder compaction. Trans. Metall. Soc. AIME 221 (1961) 671-675
41. Heckel R.W. An analysis of powder compaction phenomena. Trans. Metall. Soc. AIME 221 (1961) 1001-1008
42. Doelker E. Assessment of powder compaction. In: Chulia D., Deleuil M., and Pourcelot Y. (Eds). Powder Technology and Pharmaceutical Process (1994), Elsevier, Amsterdam 403-471
43. Fell J.T., and Newton J.M. The tensile strength of lactose tablets. J. Pharm. Pharmacol. 20 (1968) 657-658