Granule deformation and densification during compression of binary mixtures of granules

International Journal of Pharmaceutics

Volumn 222, Issue 1, 2001, Pages 65-76

  Tunón, Åsa ^a   Alderborn, Göran ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Deformation; Densification; Extrusion spheronisation; Intragranular porosity; Microcrystalline cellulose; Mode of deformation

Indexed keywords

MICROCRYSTALLINE CELLULOSE;

ARTICLE; DENSITY; DRUG FORMULATION; PELLET EXTRUSION; POROSITY; PRIORITY JOURNAL; SURFACE PROPERTY; TABLET COMPRESSION; TENSILE STRENGTH; THICKNESS;

CELLULOSE; DRUG IMPLANTS; EXCIPIENTS; TABLETS; TECHNOLOGY, PHARMACEUTICAL;

EID: 0035800227     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00686-X     Document Type: Article

References (23)

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10. Formulation and compaction of nonfracturing deformable coated beads
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13. Occurrence of fragmentation during compression of pellets prepared from a 4 to 1 mixture of dicalcium phosphate dihydrate and microcrystalline cellulose
14. Measurement of particle size of free-flowing material with a ring gap sizer
15. Investigations of tablets prepared from pellets produced by extrusion and spheronisation. Part I: The application of canonical analysis to correlate the properties of the tablets to the factors studied in combination with principal component analysis to select the most relevant factors
16. Granule consolidation during compaction
17. Investigations into the deformability and tensile strength of pellets
18. Compaction studies on beads: Compression and consolidation parameters
19. An investigation of the pore structure of tablets of sucrose and lactose by mercury porosimetry
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21. The compaction and mechanical properties of agglomerated materials
22. Compression characteristics of granulated materials: II. Evaluation of granule fragmentation during compression by tablet permeability and porosity measurements