Protective effects of 4-nerolidylcatechol against genotoxicity induced by cyclophosphamide

Food and Chemical Toxicology

Volumn 45, Issue 10, 2007, Pages 1975-1978

  Valadares, M C ^a   Rezende, K R ^a   Pereira, E R T ^a   Sousa, M C ^a   Goncalves B ^a   de Assis, J C ^a   Kato, M J ^b  

^a FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^b Depto Quim Organ Inst Quim U   (Brazil)

Author keywords

4 Nerolidylcatechol; Cyclophosphamide; Genotoxicity; Micronuclei; Pothomorphe umbellata

Indexed keywords

4 NEROLIDYLCATECHOL; CYCLOPHOSPHAMIDE; PLANT EXTRACT; POTHOMORPHE UMBELLATA ROOT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CELL PROTECTION; CHROMOSOME DAMAGE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; GENOTOXICITY; MALE; MICRONUCLEUS TEST; MOUSE; MUTAGENICITY; NONHUMAN; PIPERACEAE; POTHOMORPHE UMBELLATA; SWISS WEBSTER MOUSE;

ANIMALS; ANTIMUTAGENIC AGENTS; ANTINEOPLASTIC AGENTS, ALKYLATING; CATECHOLS; CHROMOSOME ABERRATIONS; CYCLOPHOSPHAMIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; MALE; MICE; MICRONUCLEUS TESTS; MUTAGENS; PIPERACEAE; PLANT EXTRACTS; PLANT ROOTS;

LEPIANTHES PELTATA; MUS;

EID: 34547757918     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.04.016     Document Type: Article

References (22)

1. Azevedo L., Gomes J.C., Stringheta P.C., Gontijo A.M., Padovani C.R., Ribeiro L.R., and Salvadori D.M. Black bean (Phaseolus vulgaris L.) as a protective agent against DNA damage in mice. Food Chem. Toxicol. 41 (2003) 1671-1676
2. Barros S.B.M., Teixeira D.S., Aznar A.E., et al. Antioxidant activity of ethanolic extracts of Pothomorphe umbellata L. Miq. Ciênc. Cult. 48 (1996) 114-116
3. Barros S., Ropke C.D., Sawada T.C.H., Silva V.V., Pereira S.M.M., and Barros S.B.M. Assessment of acute and subchronic oral toxicity of ethanolic extract of Pothomorphe umbellata L. Miq (Pariparoba) Rev. Bras. Ciênc. Farm. 41 (2005) 53-60
4. Desmarchelier C., Mongelli E., Coussio J., and Ciccia G. Inhibition of lipid peroxidation and iron (II)-dependent DNA damage by extracts of Pothomorphe peltata (L.). Miq. Braz. J. Med. Biol. Res. 30 (1997) 85-91
5. Desmarchelier C., Barros S., Repetto M., et al. 4-Nerolidylcathecol from Pothomorphe umbellata spp. scavenges peroxyl radicals and inhibits Fe(II)-dependent DNA damage. Planta Med. 63 (1997) 561-563
6. Felzenswalb I., Valsa J.O., Araujo A.C., and Alcantara-Gomes R. Absence of mutagenicity of Pothomorphe umbellata and Pothomorphe peltata in the Samonella/mammalian microsome mutagenicity assay. Braz. J. Med. Biol. Res. 20 (1987) 403-405
7. Gustafson K.R., Cardellina II J.H., McMahon J.B., Pannel L.K., Cragg G.M., and Boyd M.R. The peltatolls, nove HIV-inhibitory catechol derivates from P. peltata. J. Org. Chem. 57 (1992) 2809-2811
8. Isobe T., Ohsaki A., and Nagata K. Antibacterial constituents against Helicobacter pylori of Brazilian medicinal plant, pariparoba. Yakuga. Zasshi 122 (2002) 291-294
9. MacGregor J.T., Heddle J.A., Hite M., Margolin B.H., Ramel C., Salamone M.F., Tice R.R., and Wild D. Guidelines for the conduct of micronucleus assay in mammalian bone marrow erythrocytes. Mutat. Res. 189 (1987) 103-112
10. Manoharan K., and Banerjee M.R. β-carotene reduces sister chromatid exchange induce chemical carcinogens in mouse mammary cells in organ culture. Cell Biol. Int. Rep. 9 (1985) 783-789
11. Mateuca R., Lombaert N., Aka P.V., Decordier I., and Kirsch-Volders M. Chromosomal changes: induction, detection methods and applicability in human biomonitoring. Biochimie 88 (2006) 1515-1531
12. Mongelli E., Romano A., Desmarchelier C., Coussio J., and Ciccia G. Cytotoxic 4-nerolidylcatechol from Pothomorphe peltata inhibits topoisomerase I activity. Planta Med. 65 (1999) 376-377
13. Olaharski A.J., Sotelo R., Solorza-Luna G., Gonsebatt M.E., Guzman P., Mohar A., and Eastmond D. Tetraploidy and chromosomal instability are early events during cervical carcinogenesis. Carcinogenesis 27 (2006) 337-343
14. Peckolt W. Contribuição à matéria médica vegetal do Brasil: estudo farmacognóstico de Heckeria umbellata (L.) Kunth. Mem. Inst. Butantan 15 (1941) 59-68
15. Perazzo F.F., Souza G.H.B., Lopes W., Cardoso L.G.V., Carvalho J.C.T., Dhammika Nanayakkara N.P., and Bastos J.K. Anti-inflammatory and analgesic properties of water-ethanolic extract from Pothomorphe umbellata (Piperaceae) aerial parts. J. Ethnopharm. 3 (2005) 215-220
16. Pereira, C.A.B., 1991. Teste estatístico para comparar proporções em problemas de citogenética. In: Rabello-Gay, M.N., Rodrigues, M.A.L.R., Montelleone-Neto, R., (Eds.), Mutagênese, Teratogênese e Carcinogênese. Métodos e Critérios de Avaliação, São Paulo, FCA, pp. 113-121.
17. Rezende K.R., and Barros S.B.M. Quantification of 4-nerolidylcatechol from Pothomorphe umbellata (Piperaceae), in rat plasma samples by HPLC-UV. Braz. J. Pharm. Sci. 40 (2004) 373-380
18. Ropke, C.D., Barros, S., Sawada, T.C.H., et al., 2000. Avaliação da atividade antioxidante de Pothomorphe umbellata L. Miq. na pele. In: Annals of the 14th National Cosmetology Congress of the Brazilian Cosmetology Association, pp. 483-500.
19. Ropke C.D., Meirelles R.R., da Silva V.V., Sawada T.C., and Barros S.B. Pothomorphe umbellata extract prevents alpha-tocopherol depletion after UV-irradiation. Photochem. Photobiol. 78 (2003) 436-439
20. Ropke C.D., Sawada T.C., da Silva V.V., Michalany N.S., and de Moraes Barros S.B. Photoprotective effect of Pothomorphe umbellata root extract against ultraviolet radiation induced chronic skin damage in the hairless mouse. Clin. Exp. Dermatol. 30 (2005) 272-276
21. Ropke C.D., da Silva V.V., Kera C.Z., Miranda D.V., de Almeida R.L., Sawada T.C., and Barros S.B. In vitro and in vivo inhibition of skin matrix metalloproteinases by Pothomorphe umbellata root extract. Photochem. Photobiol. 82 (2006) 439-442
22. Silva, R.A.D., 1926. Pharmacopeia dos Estados Unidos do Brasil. Cia., eds. Nacional, São Paulo.