The herpes simplex virus gene pol expressed in herpes-associated erythema multiforme lesions upregulates/activates SP1 and inflammatory cytokines

Dermatology

Volumn 215, Issue 2, 2007, Pages 97-106

  Gober, Michael D ^a   Laing, Jennifer M ^a   Burnett, Joseph W ^a   Aurelian, Laure ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Erythema multiforme; Herpes simplex virus; Inflammation, skin

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; CYTOKINE; GAMMA INTERFERON; HEAT SHOCK PROTEIN 27; POL PROTEIN; TRANSCRIPTION FACTOR SP1; TRANSFORMING GROWTH FACTOR BETA; VIRUS PROTEIN;

ADULT; ARTICLE; CELL LINE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVATION; ERYTHEMA MULTIFORME; GENE CONTROL; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN DEFECT; STRUCTURAL GENE; UPREGULATION; VIRUS GENE;

ADULT; CARCINOMA, SQUAMOUS CELL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYTOKINES; DRUG ERUPTIONS; ERYTHEMA MULTIFORME; GENES, POL; HUMANS; IMMUNOBLOTTING; INFLAMMATION; INTERFERON TYPE II; KERATINOCYTES; PROTEIN-SERINE-THREONINE KINASES; SIMPLEXVIRUS; SP1 TRANSCRIPTION FACTOR; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 34547749491     PISSN: 10188665     EISSN: None     Source Type: Journal    
DOI: 10.1159/000104259     Document Type: Article

References (51)

1. Fabbri P, Panconesi E: Erythema multiforme ('minus' and 'maius') and drug intake. Clin Dermatol 1993;11:479-489.
2. Roujeau JC, Stern RS: Severe adverse cutaneous reactions to drugs. N Engl J Med 1994;331:1272-1285.
3. Dalle S, Skowron F, Ronger-Savle S, Balme B, Thomas L: Erythema multiforme induced by fluconazole. Dermatology 2005;211:169.
4. Aurelian L, Ono F, Burnett JW: Herpes simplex virus (HSV)-associated erythema multiforme (HAEM): a viral disease with an autoimmune component. Dermatol Online J 2003;9:1.
5. Margolis RJ, Tonnesen MG, Harrist TJ, Bhan AK, Wintroub BU, Mihm MC Jr, Soter NA: Lymphocyte subsets and Langerhans cells/ indeterminate cells in erythema multiforme. J Invest Dermatol 1983;81:403-406.
6. Kokuba H, Aurelian L, Burnett J: Herpes simplex virus associated erythema multiforme (HAEM) is mechanistically distinct from drug-induced erythema multiforme: interferon-gamma is expressed in HAEM lesions and tumor necrosis factor-alpha in drug-induced erythema multiforme lesions. J Invest Dermatol 1999;113:808-815.
7. Li AG, Lu SL, Han G, Hoot KE, Wang XJ: Role of TGFbeta in skin inflammation and carcinogenesis. Mol Carcinog 2006;45:389-396.
8. Ono F, Sharma BK, Smith CC, Burnett JW, Aurelian L: CD34+ cells in the peripheral blood transport herpes simplex virus DNA fragments to the skin of patients with erythema multiforme (HAEM). J Invest Dermatol 2005;124:1215-1224.
9. Imafuku S, Kokuba H, Aurelian L, Burnett J: Expression of herpes simplex virus DNA fragments located in epidermal keratinocytes and germinative cells is associated with the development of erythema multiforme lesions. J Invest Dermatol 1997;109:550-556.
10. Kokuba S, Imafuku S, Huang S, Aurelian L, Burnett JW: Expression of a herpes simplex virus (HSV) gene and the qualitative nature of the HSV-specific T cell response are associated with the development of erythema multiforme lesions. Br J Dermatol 1998;138:952-964.
11. Miura S, Smith CC, Burnett JW, Aurelian L: Detection of viral DNA within skin of healed recurrent herpes simplex infection and erythema multiforme lesions. J Invest Dermatol 1992;98:68-72.
12. Dorsky DI, Crumpacker CS: Expression of herpes simplex virus type 1 DNA polymerase gene by in vitro translation and effects of gene deletions on activity. J Virol 1988;62:3224-3232.
13. Smith CC, Peng T, Kulka M, Aurelian L: The PK domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) is required for immediate-early gene expression and virus growth. J Virol 1998;72:9131-9141.
14. Kim SJ, Glick A, Sporn MB, Roberts AB: Characterization of the promoter region of the human transforming growth factor-beta 1 gene. J Biol Chem 1989;264:402-408.
15. Koutsodontis G, Moustakas A, Kardassis D: The role of Sp1 family members, the proximal GC-rich motifs, and the upstream enhancer region in the regulation of the human cell cycle inhibitor p21WAF-1/Cip1 gene promoter. Biochemistry 2002;41:12771-12784.
16. Botella LM, Sanchez-Elsner T, Sanz-Rodriguez F, Kojima S, Shimada J, Guerrero-Esteo M, Cooreman MP, Ratziu V, Langa C, Vary CP, Ramirez JR, Friedman S, Bernabeu C: Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury. Blood 2002;100:4001-4010.
17. Oesterreich S, Hickey E, Weber LA, Fuqua SA: Basal regulatory promoter elements of the hsp27 gene in human breast cancer cells. Biochem Biophys Res Commun 1996;222:155-163.
18. Sancéau J, Kaisho T, Hirano T, Wietzerbin J: Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1, NF kappa B, and Sp1 transcription factors. J Biol Chem 1995;270:27920-27931.
19. Kokuba H, Imafuku S, Huang S, Aurelian L, Burnett JW: Expression of a herpes simplex virus (HSV) gene and the qualitative nature of the HSV-specific T cell response are associated with the development of erythema multiforme lesions. Br J Dermatol 1998;138:952-964.
20. Kuwahara J, Azumano M, Takeda T: Nuclear localization of transcription factor Sp1. Nucleic Acids Symp Ser 1999;42:293-294.
21. Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC: Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 2001;3:245-252.
22. Jeong HW, Kim IS: TGF-beta1 enhances betaig-h3-mediated keratinocyte cell migration through the alpha3beta1 integrin and PI3K. J Cell Biochem 2004;92:770-780.
23. Lee YI, Kwon YJ, Joo CK: Integrin-linked kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition. Biochem Biophys Res Commun 2004;316:997-1001.
24. Roizman B, Sears AE: Herpes simplex viruses and their replication; in Fields BN, Knipe DM, Howley PM (eds): Virology, ed 3. Philadelphia, Lippincott-Raven Publishers, 1996, pp 2231-2295.
25. Aravalli RN, Hu S, Rowen TN, Palmquist JM, Lokensgard JR: Cutting edge: TLR2-mediated proinflammatory cytokine and chemokine production by microglial cells in response to herpes simplex virus. J Immunol 2005;175:4189-4193.
26. Lipsker D, Saurat JH: A new concept: paraviral eruptions. Dermatology 2005;211:309-311.
27. Tas S, Simonart T: Herpesviruses in patients with drug hypersensitivity syndrome: culprits, cofactors or innocent bystanders? Dermatology 2006;213:273-276.
28. Mitani N, Aihara M, Yamakawa Y, Yamada M, Itoh N, Mizuki N, Ikezawa Z: Drug-induced hypersensitivity syndrome due to cyanamide associated with multiple reactivation of human herpesviruses. J Med Virol 2005;75:430-434.
29. Bombail V, Taylor K, Gibson GG, Plant N: Role of Sp1, C/EBP alpha, HNF3, and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene. Drug Metab Dispos 2004;32:525-535.
30. Arinze IJ, Kawai Y: Sp family of transcription factors is involved in valproic acid-induced expression of Galphai2. J Biol Chem 2003;278:17785-17791.
31. Lu Q, Kamps MP: Selective repression of transcriptional activators by Pbx1 does not require the homeodomain. Proc Natl Acad Sci USA. 1996;93:470-474.
32. Abramovich C, Shen WF, Pineault N, Imren S, Montpetit B, Largman C, Humphries RK: Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA. J Biol Chem 2000;275:26172-26177.
33. Freiman RN, Herr W: Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP. Genes Dev 1997;11:3122-3127.
34. James JA, Kaufman KM, Farris AD, Taylor-Albert E, Lehman TJ, Harley JB: An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus. J Clin Invest 1997;100:3019-3026.
35. James JA, Neas BR, Moser KL, Hall T, Bruner GR, Sestak AL, Harley JB: Systemic lupus erythematosus in adults is associated with previous Epstein-Barr virus exposure. Arthritis Rheum 2001;44:1122-1126.
36. Parks CG, Cooper GS, Hudson LL, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS, Pandey JP: Association of Epstein-Barr virus with systemic lupus erythematosus: effect modification by race, age, and cytotoxic T lymphocyte-associated antigen 4 genotype. Arthritis Rheum 2005;52:1148-1159.
37. McClain MT, Heinlen LD, Dennis GJ, Roebuck J, Harley JB, James JA: Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry. Nat Med 2005;11:85-89.
38. Burch AD, Weller SK: Herpes simplex virus type 1 DNA polymerase requires the mammalian chaperone hsp90 for proper localization to the nucleus. J Virol 2005;79:10740-10749.
39. Hung JJ, Wu CY, Liao PC, Chang WC: Hsp90alpha recruited by Sp1 is important for transcription of 12(S)-lipoxygenase in A431 cells. J Biol Chem 2005;280:36283-36292.
40. Baumann M, Feederle R, Kremmer E, Hammerschmidt W: Cellular transcription factors recruit viral replication proteins to activate the Epstein-Barr virus origin of lytic DNA replication, oriLyt. EMBO J 1999;18:6095-6105.
41. Han I, Kudlow JE: Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility. Mol Cell Biol 1997;17:2550-2558.
42. Barker JN, Mitra RS, Griffiths CE, Dixit VM, Nickoloff BJ: Keratinocytes as initiators of inflammation. Lancet 1991;337:211-214.
43. Colditz IG, Watson DL: The effect of cytokines and chemotactic agonsist on the migration of T lymphocytes into skin. Immunology 1992;76:272-278.
44. Nacy CA, Maltzer MS: T cell-mediated activation of macrophages. Curr Opin Immunol 1995;3:330-335.
45. Arany I, Brysk MM, Brysk H, Tyring SK: Regulation of inducible nitric oxide synthase mRNA levels by differentiation and cytokines in human keratinocytes. Biochem Biophys Res Commun 1996;220:618-622.
46. Spandau U, Brocker EB, Kampgen E, Gillitzer R: CC and CXC chemokines are differentially expressed in erythema multiforme in vivo. Arch Dermatol 2002;138:1027-1033.
47. Sporn MB, Roberst AB: Transforming growth factor-β: recent progress and new challenges. J Cell Biol 1992;119:1017-1021.
48. McCartney-Francis NL, Wahls SM: Transforming growth factor-β: a matter of life and death. J Leukocyte Biol 1994;55:401-409.
49. Aquino DA, Capello E, Weisstein J, Sanders V, Lopez C, Tourtellotte WW, Brosnan CF, Raine CS, Norton WT: Multiple sclerosis: altered expression of 70- and 27-kDa heat shock proteins in lesions and myelin. J Neuropathol Exp Neurol 1997;56:664-672.
50. Bajramovic JJ, Bsibsi M, Geutskens SB, Hassankhan R, Verhulst KC, Stege GJ, de Groot CJ, van Noort JM: Differential expression of stress proteins in human adult astrocytes in response to cytokines. J Neuroimmunol 2000;106:14-22.
51. Dong Y, Chi SL, Borowsky AD, Fan Y, Weiss RH: Cytosolic p21Waf1/Cip1 increases cell cycle transit in vascular smooth muscle cells. Cell Signal 2004;16:263-269.