MR microscopy of transgenic mice that spontaneously acquire experimental allergic encephalomyelitis

Magnetic Resonance in Medicine

Volumn 40, Issue 1, 1998, Pages 119-132

  Ahrens, Eric T ^a,d   Laidlaw, David H ^a   Readhead, Carol ^b   Brosnan, Celia F ^c   Fraser, Scott E ^a   Jacobs, Russell E ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Demyelination; Diffusion tensor; EAE; Transgenic

Indexed keywords

CELL MEMBRANES; DIFFUSION; HISTOLOGY; MAGNETIC RESONANCE IMAGING; MAMMALS; PATHOLOGY; T-CELLS; TENSORS; TISSUE;

DEMYELINATING DISEASE; DEMYELINATION; DIFFUSION ANISOTROPY; DIFFUSION TENSOR; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; HISTOLOGICAL SECTION; MYELIN BASIC PROTEIN; TRANSGENICS;

DIFFUSION TENSOR IMAGING;

MYELIN BASIC PROTEIN; T LYMPHOCYTE RECEPTOR;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANISOTROPY; ARTICLE; DIFFUSION; MICROSCOPY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGICAL ANATOMY; SPINAL CORD; TRANSGENIC MOUSE; WHITE MATTER;

EID: 0031866373     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.1910400117     Document Type: Article

References (60)

1. J. Goverman, A. Woods, L. Larson, L. P. Weiner, L. Hood, D. M. Zaller, Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 72, 551-560 (1993).
2. C. S. Raine, Biology of disease: analysis of autoimmune demyelination: its impact upon multiple sclerosis. Lab. Invest. 50, 608-635 (1984).
3. S. S. Zamvil, L. Steinman, The T lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 8, 579-621 (1990).
4. S. P. Morrissey, R. Deichmann, J. Syha, C. Simonis, U. Zettl, J. J. Archelos, S. Jung, H. Stodal, H. Lassmann, K. V. Toyka, A. Haase, H. P. Hartung, Partial inhibition of AT-EAE by an antibody to ICAM-1-clinico-histological and MRI studies. J. Neuroimmunol. 69, 85-93 (1996).
5. M. R. Verhoye, E. J. s'-Gravenmade, E. R. Roman, J. Van Reempts, A. Van der Linden, In vivo noninvasive determination of abnormal water diffusion in the rat brain studied in an animal model for multiple sclerosis by diffusion-weighted NMR imaging. Magn. Reson. Imaging 14, 521-532 (1996).
6. S. P. Morrissey, H. Stodal, U. Zettl, C. Simmons, S. Jung, R. Kiefer, H. Lassmann, H. P. Hartung, A. Haase, K. V. Toyka, In-vivo MRI and its histological correlates in acute adoptive transfer experimental allergic encephalomyelitis - quantification of inflammation and edema. Brain 119, 239-248 (1996).
7. T. L. Richards, E. C. Alvord, J. Peterson, S. Cosgrove, R. Petersen, K. Petersen, A. C. Heide, J. Clutf, L. M. Rose, Experimental allergic encephalomyelitis in non-human primates - MRI and MRS may predict the type of brain damage. NMR Biomed. 8, 49-58 (1995).
8. C. P. Genain, T. Roberts, R. L. Davis, M. H. Nguyen, A. Uccelli, D. Faulds, Y. Li, J. Hedgpeth, S. L. Hauser, Prevention of autoimmune demyelination in nonhuman-primates by a CAMP-specific phosphodiesterase inhibitor. Proc. Natl. Acad. Sci. U S A 92, 3601-3605 (1995).
9. I. J. Namer, J. Steibel, P. Poulet, Y. Mauss, J. P. Armspach, B. Eclancher, J. Chambron, Hyperbaric-oxygen treatment in acute experimental allergic encephalomyelitis - contribution of magnetic resonance-imaging study. NeuroImage 1, 308-312 (1994).
10. I. J. Namer, J. Steibel, S. J. Piddlesden, M. Mohr, P. Poulet, J. Chambron, Magnetic-resonance-imaging of antibody-mediated demyelinating experimental allergic encephalomyelitis. J. Neuroimmunol. 54, 41-50 (1994).
11. D. Lanens, A. Van der Linden, P. O. Gerrits, E. J. 's-Gravenmade, In vitro NMR micro imaging of the spinal cord of chronic relapsing EAE rats. Magn. Reson. Imaging 12, 469-475 (1994).
12. P. A. Seeldrayers, J. Syha, S. P. Morrissey, H. Stodal, K. Vass, S. Jung, T. Gneiting, H. Lassmann, A. Haase, H. P. Hartung, K. V. Toyka, Magnetic-resonance-imaging investigation of blood-brain-barrier damage in adoptive transfer experimental allergic encephalomyelitis. J. Neuroimmunol. 46, 199-206 (1993).
13. S. J. Karlik, E. A. Grant, D. Lee, J. H. Noseworthy, Gadolinium enhancement in acute and chronic-progressive experimental allergic encephalomyelitis in the guinea-pig. Magn. Reson. Med. 30, 326-331 (1993).
14. A. C. Heide, T. L. Richards, E. C. Alvord, J. Peterson, L. M. Rose, Diffusion imaging of experimental allergic encephalomyelitis. Magn. Reson. Med. 29, 478-484 (1993).
15. I. J. Namer, J. Steibel, P. Poulet, J. P. Armspach, M. Mohr, Y. Mauss, J. Chambron, Blood-brain-barrier breakdown in MBP-specific T-cell induced experimental allergic encephalomyelitis - a quantitative in vivo MRI study. Brain 116, 147-159 (1993).
16. W. A. Stewart, E. C. Alvord, S. Hruby, L. D. Hall, D. W. Paty, Magnetic-resonance-imaging of experimental allergic encephalomyelitis in primates. Brain 114, 1069-1096 (1991).
17. C. P. Hawkins, F. Mackenzie, P. Tofts, E. P. G. H. Doboulay, W. I. Mcdonald, Patterns of blood-brain-barrier breakdown in inflammatory demyelination. Brain 114, 801-810 (1991).
18. S. J. Karlik, J. J. Gilbert, C. Wong, M. K. Vandervoort, J. H. Noseworthy, NMR studies in experimental allergic encephalomyelitis: factors which contribute to T1 and T2 values. Magn. Reson. Med. 14, 1-11 (1990).
19. D. Le Bihan, "Diffusion and Perfusion Magnetic Resonance Imaging - Applications to Functional MRI." Raven Press, New York, 1995.
20. P. J. Basser, C. Pierpaoli, Microstructural and physiological features of tissues elucidated by quantitative-diffusion tensor MRI. J. Magn. Reson. B 111, 209-219 (1996).
21. P. J. Basser, Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. NMR Biomed. 8, 333-344 (1995).
22. A. Haase, Snapshot FLASH MRI. Applications to T1, T2, and chemical shift imaging. Magn. Reson. Med. 13, 77-89 (1990).
23. P. J. Basser, J. Mattiello, D. LeBihan, MR diffusion tensor spectroscopy and imaging. Biophys. J. 66, 259-267 (1994).
24. P. J. Basser, J. Mattiello, D. LeBihan, Estimation of the effective self-diffusion tensor from the NMR spin-echo. J. Magn. Reson. B 103, 247-254 (1994).
25. C. Pierpaoli, P. J. Basser, Toward a quantitative assessment of diffusion anisotropy. Magn. Reson. Med. 36, 893-906 (1996).
26. C. Thompson, O. Henriksen, P. Ring, In vivo measurement of water self diffusion in the human brain by magnetic resonance imaging. Acta. Radiol. Scand. 28, 353-358 (1987).
27. M. E. Moseley, Y. Cohen, J. Kucharczyk, J. Mintorovitch, H. S. Asgari, M. F. Wendland, J. Tsudura, D. Norman, Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system. Radiology 176, 439-445 (1990).
28. M. E. Moseley, J. Kucharczyk, H. S. Asgari, D. Norman, Anisotropy in diffusion-weighted MRI. Magn. Reson. Med. 19, 321-326 (1991).
29. C. T. W. Moonen, J. Pekar, M. H. M. de Vleeschouwer, P. van Gelderen, P. C. M. van Zijl, D. DesPres, Restricted and anisotropic displacement of water in healthy cat brain and in stroke studied by NMR diffusion imaging. Magn. Reson. Med. 19, 327-332 (1991).
30. J. V. Hajnal, M. Doran, A. S. Hall, A. G. Collins, A. Oatridge, J. M. Pennock, I. R. Young, G. M. Bydder, MR imaging of anisotropically restricted diffusion of water in the nervous system: technical, anatomic and pathologic considerations. J. Comput. Assist. Tomogr. 15, 1-18 (1991).
31. A. M. Ulug, O. Bahkt, R. N. Bryan, P. C. M. van Zijl, Mapping of human brain fibers using diffusion tensor imaging, in "Proc., ISMRM, 4th Annual Meeting, New York, 1996," p. 1325.
32. C. Pierpaoli, P. Jezzard, P. J. Basser, High-resolution diffusion tensor imaging of the human brain. in "Proc., SMR/ESMRMB, Nice, 1995," p. 899.
33. R. Fritz, D. E. McFarlin, Encephalitogenic epitopes of myelin basic protein. Chem. Immunol. 46, 101-108 (1989).
34. S. S. Zamvil, D. J. Mitchell, A. C. Moore, K. Kitamura, L. Steinman, J. Rothbard, T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature 324, 258-260 (1986).
35. P. T. Callaghan, "Principles of Nuclear Resonance Microscopy," Oxford University Press, New York, 1991.
36. E. O. Stejskal, J. E. Tanner, Spin diffusion measurements: spin echos in the presence of a time-dependent field gradient. J. Chem. Phys. 42, 288-292 (1965).
37. T. E. Conturo, R. C. McKinstry, J. A. Aronovitz, J. J. Neil, Diffusion MRI: precision, accuracy and flow effects. NMR Biomed. 8, 307-332 (1995).
38. G. Liu, P. van Geldereu, C. T. W. Moonen, Single shot diffusion MRI on a conventional clinical instrument, in "Proc., SMR, 2nd Annual Meeting, San Francisco, 1994," p. 1034.
39. G. Y. Liu, P. van Gelderen, J. Duyn, C. T. W. Moonen, Single-shot diffusion MRI of human brain on a conventional clinical instrument. Magn. Reson. Med. 35, 671-677 (1996).
40. H. Weingartner, Self diffusion in liquid water. A reassessment. Z. Phys. Chem. (Neue Folge) 132, 129-149 (1982).
41. C. S. Raine, F. Mokhtarian, D. E. McFarlin, Adoptively transferred chronic relapsing experimental autoimmune encephalomyelitis in the mouse. Lab. Invest. 51, 534-546 (1984).
42. J. Mattiello, P. J. Basser, D. LeBihan, Analytical expression for the b matrix in NMR diffusion imaging and spectroscopy. J. Magn. Reson. A 108, 131-141 (1994).
43. W. H. Press, S. A. Teukolsky, W. T. Vetterling, B. P. Flannery. "Numerical Recipies in C: The Art of Scientific Computing," Cambridge University Press, New York, 1992.
44. "NAG Fortran Library," Numerical Algorithms Group, Downers Grove, IL, 1993.
45. G. Arfken, "Mathematical Methods for Physicists," Academic Press Inc., Orlando, 1985.
46. P. van Gelderen, M. H. M. de Vleeschouwer, D. DesPres, J. Pekar, P. C. M. van Zijl, C. T. W. Moonen, Water diffusion and acute stroke. Magn. Reson. Med. 31, 154-163 (1994).
47. C. Pierpaoli, P. Jezzard, P. J. Basser, A. Barnett, G. Di Chiro, Diffusion tensor MR imaging of the human brain. Radiology 201, 637-648 (1996).
48. J. Crank, "The Mathematics of Diffusion," Oxford University Press, Oxford, 1975.
49. L. Claudio, Y. Kress, J. Factor, C. F. Brosnan, Mechanisms of edema formation in experimental autoimmune encephalomyelitis. The contribution of inflammatory cells. Am. J. Pathol. 137, 1033 (1990).
50. C. F. Brosnan, L. Claudio, Brain microvasculature and multiple sclerosis, in "An Introduction to the Blood-Brain Barrier: Methodology and Biology" (W. M. Partridge, Ed.), Cambridge University Press, Cambridge, in press.
51. J. S. Pober, R. S. Cotran, Overview: the role of endothelial cells in inflammation. Transplantation 50, 537 (1990).
52. C. F. Brosnan, C. S. Raine, Mechanisms of immune injury in multiple sclerosis. Brain Pathol. 6, 243 (1996).
53. C. Beaulieu, P. S. Allen, Determinants of anisotropic water diffusion in nerves. Magn. Reson. Med. 31, 394-400 (1994).
54. D. M. Wimberger, T. P. Roberts, A. J. Barkovich, L. M. Prayer, M. E. Moseley, J. Kucharczyk, Identification of "premyelination" by diffusion-weighted MRI. J. Comput. Assist. Tomogr. 19(1), 28-33 (1995).
55. C. Beaulieu, P. S. Allen, An in vitro evaluation of the effects of local magnetic-susceptibility-induced gradients on anisotropic water diffusion in nerve. Magn. Reson. Med. 36, 39-44 (1996).
56. G. J. Stanisz, A. Szafer, G. A. Wright, R. M. Henkelman, An analytical model of restricted diffusion in bovine optic nerve. Magn. Reson. Med. 37, 103-111 (1997).
57. L. L. Latour, K. Svoboda, P. P. Mitra, C. H. Sotak, Time-dependent diffusion of water in a biological model system. Proc. Natl. Acad. Sci. U S A 91, 1229-1233 (1994).
58. M. L. Mehta, "Random Matrices," Academic Press Inc., San Diego, 1991.
59. V. Gulani, H. Jiang, G. A. Iwamoto, P. C. Lauterbur, Rapid diffusion tensor microimaging of excised rat spinal cords, in "Proc., ISMRM, 4th Annual Meeting, New York, 1996," p. 1321.
60. M. A. Horsfield, M. Lai, S. L. Webb, G. J. Barker, P. S. Tofts, R. Turner, P. Rudge, D. H. Miller, Apparent diffusion coefficients in benign and secondary progressive multiple sclerosis by nuclear magnetic resonance. Magn. Reson. Med. 36, 393-400 (1996).