A novel cycloheptapeptide exerts strong anticancer activity via stimulation of multiple apoptotic pathways in caspase-3 deficient cancer cells

Anticancer Research

Volumn 27, Issue 4 B, 2007, Pages 2473-2479

  Ubol, Sukathida ^a   Kramyu, Jarin ^a   Masrinoul, Promsin ^a   Kachangchaeng, Chongkon ^a   Pittayanurak, Prapadsorn ^a   Sophasan, Samaisuk ^a   Reutrakul, Vichai ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Anticancer agent; Apoptosis; Caspase; Cell cycle; Cyclic peptide; ER stress; Mitochondrial dependent death

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; CASPASE 10; CASPASE 3; CASPASE 8; COMPLEMENTARY DNA; CYCLOHEPTAPEPTIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL 2; UNCLASSIFIED DRUG; VR 3848;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CELL CYCLE ARREST; CELL STRAIN MCF 7; CYTOPLASM; DNA MICROARRAY; DNA STRAND BREAKAGE; DOWN REGULATION; DRUG INHIBITION; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTO ONCOGENE; UPREGULATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BREAST NEOPLASMS; CASPASE 3; CELL GROWTH PROCESSES; CELL LINE, TUMOR; EUPHORBIACEAE; HUMANS; MITOCHONDRIA; PEPTIDES, CYCLIC; PLANT EXTRACTS; PLANT PROTEINS;

EID: 34547742664     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. St George JA: Gene therapy progress and prospects: adenoviral vectors. Gene Ther 10: 1135-1141, 2003.
2. Schrump DS and Nguyen DM: Novel molecular targeted therapy for esophageal cancer. J Surg Oncol 92: 257-261, 2005.
3. Uthaisang W, Reutraku V, Krachangchaeng C, Wilairat P and Fadeel B: VR3848, a novel peptide derived from Euphorbiaceae, induces mitochondrial-dependent apoptosis in human leukemia cells. Cancer Lett 208: 171-178, 2004.
4. Pootrakronchai R: Apoptosis induction by VR3848 isolated from Euphorbiaceae in a human lung cancer cell line, Master of Science thesis (Toxicology), Mahidol University, Bangkok, Thailand, 2000.
5. Makin G and Dive C: Apoptosis and cancer chemotherapy. Trends Cell Biol 11: S22-26, 2001.
6. Nagourney RA: Ex vivo programmed cell death and the prediction of response to chemotherapy. Curr Treat Options Oncol 7: 103-110, 2006.
7. Fadeel B and Orrenius S: Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease. J Inter Med 258: 479-517, 2005.
8. Broker LE, Kruyt FAE and Giaccone G: Cell death independent of caspases: a review. Clin Cancer Res 11: 3155-3162, 2005.
9. Bras M, Queenan B and Susin SA: Programmed cell death via mitochondria: different modes of dying. Biochemistry (Mosc) 70: 231-293, 2005.
10. Araki E, Oyadomari S and Mori M: Endoplasmic reticulum stress and diabetes mellitus. Intern Med 42: 7-14, 2003.
11. Liu H and Baliga R: Endoplasmic reticulum stress-associated caspase-12 mediates cisplatin-induced LLC-PK1 cell apoptosis. J Am Soc Nephrol 16: 1985-1992, 2005.
12. Obeng EA and Boise LH: Caspase-12 and caspase-4 are not required for caspase-dependent endoplasmic reticulum stress-induced apoptosis. J Biol Chem 280: 29578-29587, 2005.
13. Schwartz GK: Development of cell cycle active drugs for the treatment of gastrointestinal cancers: A new approach to cancer therapy. J Clin Oncol 23: 4499-4508, 2005.
14. Schwartz GK and Shah MA: Targeting the cell cycle: a new approach to cancer therapy. J Clin Oncol 23: 9408-9421, 2005.
15. Levine AJ: p53, the cellular gatekeeper for growth and division. Cell 88: 323-331, 1997.
16. el-Deiry WS, Harper JW, O'Conner PM, Velculescu VE, Camman CE, Jackman J, Pietenpol JA, Burrell M, Hill DE, Wang Y, Wiman KG, Mercer WE, Kastan MB, Kohn KW, Elledge SJ, Kinzler KW and Vogelstein B: Waf1/Cip1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 54: 1169-1174, 1994.
17. Devarajan E, Chen J, Multani AS, Pathak S, Sahin AA and Mehta K: Human breast cancer MCF-7 cell line contains inherently drug-resistant subclones with distinct genotypic and phenotypic features. Int J Oncol 20: 913-920, 2002.
18. Skehan P, Storeng R, Scudiero D, Monks A, Mcmahon J, Vistica D, Warren JT, Bokesch H, Kennyey S and Boyd MR: New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 82: 1107-1112, 1990.
19. Pitidhammabhorn D, Kantachuvesiri S, Totemchokchyakarn K, Kitiyanant Y and Ubol S: Partial construction of apoptotic pathway in PBMC obtained from active SLE patients and the significance of plasma TNF-alpha on this pathway. Clin Rheumatol 25: 705-14, 2006.
20. Sasai K, Yajima H and Suzuki F: Suppression of post mitochondrial signaling and delayed response to UV-induced nuclear apoptosis in Hela cells. Jpn J Cancer Res 93: 275-283, 2002.
21. Micheau O and Tschopp J: Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114: 181-190, 2003.
22. Michaelson JS, Bader D, Kuo F, Kazak C and Leder P: Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development. Genes Dev 13: 1918-1923, 1999.
23. Michaelson JS and Leder P: RNAi reveals anti-apoptotic and transcriptional repressive activities of Daxx. J Cell Science 116: 345-352, 2003.
24. Chen YL and Chen JD: Daxx silencing sensitizes cells to multiple apoptotic pathways. Mol Cell Biol 23: 7108-7121, 2003.
25. Van Osten PL, Moore JM, Ludwig AT and Griffin TS: Depsipeptide (FR901228) enhances the cytotoxic activity of TRAIL by redistributing TRAIL receptor to membrane lipid rafts. Mol Ther 11: 542-552, 2005.
26. Brauns SC, Dealtry G, Milne P, Naude R and Van de Venter M: Caspase-3 activation and induction of PARP cleavage by cyclic dipeptide cycle (Phe-Pro) in HT-29 cells. Anticancer Res 25: 4197-4202, 2005.
27. Escobar-Diaz E, Lopez-Martin EM, Hernandez de Cerro M, Puig-Kroger A, Soto-Cerrato V, Montaner B, Giralt E, Gareia-Mareo JA, Perez-Tomas R and Gareia-Pardo A: AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells: interference with Akt/NF-kappa B survival pathway. Leukemia 19: 572-579, 2005.
28. Roy MK, Thalang VN, Trakoontivakorn G and Nakahara K: Mahanine, a charbazole alkaloid from Micromelum minutum, inhibits cell growth and induces apoptosis in U937 cells through a mitochondrial dependent pathway. Br J Pharmacol 145: 145-155, 2005.
29. Lee SY, Munerol B, Pollard S, Youdim KA, Pannala AS, Kuhnle GG, Debnam ES, Rice-Evans C and Spencer JP: The reaction of flavonols with nitrous acid protects against N-nitrosamine formation and leads to the formation of nitroso-derivatives which inhibit cancer cell growth. Free Radic Biol Med 40: 323-334, 2006.
30. Zhu B, Zhang LH, Zhao YM, Cui JR and Strada SJ: 8-Chloroadenosine induced HL-60 cell growth inhibition, differentiation, and G(0)/G(1) involves attenuated cyclin D, and telomerase and up-regulated p21 (WAF1/CIP1). J Cell Biochem 97: 166-177, 2006.
31. Aggarwal BB and Ichikawa H: Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle 4: 1201-1205, 2005.
32. Yim D, Singh RP, Agarwal C, Lee S, Chi H and Agarwal R: A novel anticancer agent, Decursin, induces G arrest and apoptosis in human prostate carcinoma cells. Cancer Res 65: 1035-1043, 2005.
33. Georgabis GV, Li Y, Rassidakis GZ, Matinez-Valdez H, Mederros LJ and Younes A: Inhibition of heat shock protein 90 function by 17-alylamino-17- demethoxy-geldanamycin in Hodgkin's lymphoma cells downregulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death. Clin Cancer Res 12: 584-590, 2006.
34. Kim E, Chen F, Wang CC and Harrison LE: CDK5 is a novel regulatory protein in PDAR gamma ligand-induced antiproliferation. Int J Oncol 28: 191-194, 2006.
35. Wang CX, Song JH, Song DK, Yong VW, Shuaiband A and Hoa C: Cyclin-dependent kinase 5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2. Cell Death Differ 13: 1203-1212, 2006.