New insight into the mechanism of action of and resistance to isoniazid: Interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP

Journal of the American Chemical Society

Volumn 129, Issue 31, 2007, Pages 9582-9583

  Argyrou, Argyrides ^a,b   Vetting, Matthew W ^a   Blanchard, John S ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; DIHYDROFOLATE REDUCTASE; ENOYL ACYL CARRIER PROTEIN REDUCTASE (NADH); FATTY ACID; ISONIAZID; KATG PROTEIN; MYCOLIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANTIBIOTIC RESISTANCE; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CRYSTALLIZATION; ENANTIOMER; GROWTH INHIBITION; INHIBITION KINETICS; ISOMER; ISOMERIZATION; MOLECULAR INTERACTION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTON TRANSPORT; STRUCTURE ANALYSIS;

BACTERIAL PROTEINS; DRUG RESISTANCE, BACTERIAL; ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (NADH); ENZYME INHIBITORS; HYDRAZINES; ISONIAZID; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; NADP; NIACIN; OXIDOREDUCTASES;

EID: 34547729339     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja073160k     Document Type: Article

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