Oral lichen planus treated with 13-cis-retinoic acid (isotretinoin): Effects on the apoptotic process

Clinical Oral Investigations

Volumn 11, Issue 3, 2007, Pages 283-288

  Piattelli, Adriano ^a   Carinci, Francesco ^b   Iezzi, Giovanna ^a   Perrotti, Vittoria ^a   Goteri, Gaia ^c   Fioroni, Massimiliano ^c   Rubini, Corrado ^c  

^a UNIVERSITY OF CHIETI   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

^c UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

13 cis retinoic acid; Apoptosis; bcl 2; Isotretinoin; Ki 67; Oral lichen planus

Indexed keywords

ISOTRETINOIN; KERATOLYTIC AGENT; KI 67 ANTIGEN; PLACEBO; PROTEIN BCL 2;

ADULT; AGED; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EPITHELIUM; FEMALE; GINGIVA DISEASE; HUMAN; IMMUNOHISTOCHEMISTRY; LICHEN PLANUS; MALE; MIDDLE AGED; MOUTH MUCOSA; PATHOLOGY; PILOT STUDY; REMISSION; TONGUE DISEASE;

ADULT; AGED; APOPTOSIS; CELL PROLIFERATION; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EPITHELIUM; FEMALE; GINGIVAL DISEASES; HUMANS; IMMUNOHISTOCHEMISTRY; ISOTRETINOIN; KERATOLYTIC AGENTS; KI-67 ANTIGEN; LICHEN PLANUS, ORAL; MALE; MIDDLE AGED; MOUTH MUCOSA; PILOT PROJECTS; PLACEBOS; PROTO-ONCOGENE PROTEINS C-BCL-2; REMISSION INDUCTION; TONGUE DISEASES;

EID: 34547697281     PISSN: 14326981     EISSN: 14363771     Source Type: Journal    
DOI: 10.1007/s00784-007-0117-0     Document Type: Article

References (23)

1. Da Silva Fonseca M, Do Carmo MAV (2001) Identification of the AgNORs, PCNA and CK16 proteins in oral lichen planus lesions. Oral Dis 7:344-348
2. Dekker NP, Lozada-Nur F, Lagenaur LA, MacPhail LA, Bloom CY, Regezi JA (1997) Apoptosis-associated markers in oral lichen planus. J Oral Pathol Med 26:170-175
3. Flohil CC, Janssen PA, Bosman FT (1996) Expression of bcl-2 protein in hyperplastic polyps, adenomas, and carcinomas of the colon. J Pathol 178:393-397
4. Harada H, Mitsuyasu T, Seta Y, Maruoka Y, Toyoshima K, Yasumoto S (1998) Overexpression of bcl-2 protein inhibits terminal differentiation of oral keratinocytes in vitro. J Oral Pathol Med 27:11-17
5. Hirota M, Ito T, Okudela K, Kawabe R, Yazawa T, Hayashi H, Nakatani Y, Fujita K, Kitamura H (2002) Cell proliferation activity and the expression of cell cycle regulatory proteins in oral lichen planus. J Oral Pathol Med 31:204-212
6. Kalemkerian GP, Ramrath N (1996) Retinoids and apoptosis in cancer therapy. Apoptosis 1:11-24
7. Karatsaidis A, Schreurs O, Helgeland K, Axell T, Schenk K (2003) Erythematous and reticular forms of oral lichen planus and oral lichenoid reactions differ in pathological features related to disease activity. J Oral Pathol Med 32:275-281
8. Kawamura E, Nakamura S, Sasaki M, Ohyama Y, Kadena T, Kumamaru W, Shirasuna K (2003) Accumulation of oligoclonal T cells in the infiltrating lymphocytes in oral lichen planus. J Oral Pathol Med 32:282-289
9. Lo Muzio L, della Valle A, Mignogna MD, Pannone G, Bucci P, Bucci E, Sciubba J (2001) The treatment of oral aphthous ulceration or erosive lichen planus with topical clobetasol propionate in three preparations: a clinical and pilot study on 54 patients. J Oral Pathol Med 30:611-617
10. Lotan R, Xu XC, Lippman SM, RO JY, Lee JS, Lee JJ, Hong WK (1995) Suppression of retinoic acid receptor-β in premalignant oral lesions and its up-regulation by isotretinoin. N Engl J Med 332:1405-1410
11. Lu QL, Abel P, Foster CS, Lalani EN (1996) Bcl-2 role in epithelial differentiation and oncogenesis. Hum Pathol 27:102-110
12. Oridate N, Suzuki S, Higuchi M, Mitchell MF, Ong WK, Lotan R (1997) Involvement of reactive oxygen species in N-(4-hydroxyphenyl) retinamide-induced apoptosis in cervical carcinoma cells. J Natl Cancer Inst 89:1191-1198
13. Petruzzi M, De Benedittis M, Grassi R, Cassano N, Vena G, Serpico R (2002) Oral lichen planus: A preliminary clinical study on treatment with tazarotene. Oral Dis 8:291-295
14. Ramsay JA, From L, Kahn HJ (1995) Bcl-2 protein expression in melanocytic neoplasms of the skin. Mod Pathol 8:150-154
15. Scardina GA, Messina P, Carini F, Maresi E (2006) A randomized trial assessing the effectiveness of different concentrations of isotretinoin in the management of lichen planus. Int J Oral Maxillofac Surg 35:67-71
16. Shalinsky DR, Bischoff ED, Gregory ML, Gottardis MM, Hayes JS, Lamph WW, Heyman RA, Shirley MA, Cooke TA, Davies PJ et al (1995) Retinoid induced suppression of squamous cell differentiation in human oral squamous cell carcinoma xenografts (line 1483) in athymic nude mice. Cancer Res 55:3183-3191
17. Sklavounou A, Chrysomali E, Scorilas A, Karameris A (2000) TNF-alpha expression and apoptosis-regulating proteins in oral lichen planus: A comparative immunohistochemical evaluation. J Oral Pathol Med 29:370-375
18. Ter Hamsel B, Smedts F, Kuijpers J, Jeunink M, Trimbos B, Ramaekers F (1996) bcl-2 Immunoreactivity increases with severity of CIN: A study of normal cervical epithelia, CIN, and cervical carcinoma. J Pathol 179:26-30
19. Thongprasom K, Luengvisut P, Wongwatanakij A, Boonjatturus C (2003) Clinical evaluation in treatment of oral lichen planus with topical fluocinolone acetonide: A 2-year follow-up. J Oral Pathol Med 32:315-322
20. Tjalma W, Weyler J, Goovaerts G, De Pooter C, Van Marck E, Van Dam P (1997) Prognostic value of bcl-2 expression in patients with operable carcinoma of the uterine cervix. J Clin Pathol 50:33-36
21. Toma S, Mangiante PE, Margarino G, Nicolà G, Palumbo R (1992) Progressive 13- cis -retinoic acid dosage in the treatment of oral leukoplakia. Eur J Cancer B Oral Oncol 28B:121-123
22. Villaroel Dorrego M, Correnti M, Delgado R, Tapia FJ (2002) Oral lichen planus: Immunohistology of mucosal lesions. J Oral Pathol Med 31:410-414
23. Zhao ZZ, Savage NW, Sugerman PB, Walsh LJ (2002) Mast cell/T cell interactions in oral lichen planus. J Oral Pathol Med 31:189-195