Antizyme and antizyme inhibitor activities influence cellular responses to polyamine analogs

Amino Acids

Volumn 33, Issue 2, 2007, Pages 291-297

  Mitchell, J L A ^a   Thane, T K ^a   Sequeira, J M ^a   Marton, L J ^b   Thokala, R ^a  

^a NORTHERN ILLINOIS UNIVERSITY   (United States)

^b Cellgate Incorporated   (United States)

Author keywords

Antizyme; Antizyme inhibitor; Polyamine analogs; Polyamine mimetics; Polyamines

Indexed keywords

ANTIZYME; CGC 11047; CGC 11102; CGC 11144; INHIBITOR PROTEIN; POLYAMINE; POLYAMINE DERIVATIVE; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CANCER INHIBITION; CELL GROWTH; CHO CELL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STEADY STATE; TUMOR CELL;

ANIMALS; BIOGENIC POLYAMINES; CARRIER PROTEINS; CHO CELLS; CRICETINAE; CRICETULUS; LIVER NEOPLASMS, EXPERIMENTAL; POLYAMINES; PROTEINS; RATS; SPERMINE; TUMOR CELLS, CULTURED;

EID: 34547691625     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-007-0523-2     Document Type: Article

References (21)

1. RA Casero PM Woster 2001 Terminally alkylated polyamine analogues as chemotherapeutic agents J Med Chem 44 1 26
2. SS Cohen 1998 A guide to the polyamines Oxford University Press Oxford
3. S Hayashi Y Murakami S Matsufuji 1996 Ornithine decarboxylase antizyme - a novel type of regulatory protein Trends Biochem Sci 21 27 30
4. MH Jung SC Kim GA Jeon SH Kim Y Kim KS Choi SI Park MK Joe K Kimm 2000 Identification of differentially expressed genes in normal and tumor human gastric tissue Genomics 69 281 286
5. A Keren-Paz Z Bercovich Z Porat O Erez C Kahana 2006 Overexpression of antizyme-inhibitor in NIH3t3 fibroblasts provides growth advantage through neutralization of antizyme functions Oncogene 25 5163 5172
6. SW Kim U Mangold C Waghorne A Mobascher LM Shantz J Banyard BR Zetter 2006 Regulation of cell proliferation by the antizyme inhibitor: evidence for an antizyme-independent mechanism J Cell Sci 119 2853 2861
7. DL Kramer 1996 Polyamine inhibitors and analogs K Nishioka Polyamines in cancer: basic mechanisms and clinical approaches R.G. Landes Austin 151 189
8. U Mangold 2006 Antizyme inhibitor: mysterious modulator of cell proliferation Cell Mol Life Sci 63 2095 2101
9. LJ Marton AE Pegg 1995 Polyamines as targets for therapeutic intervention Annu Rev Pharmacol Toxicol 35 55 91
10. S Matsufuji T Matsufuji Y Miyazaki Y Murakami JF Atkins RF Gesteland S Hayashi 1995 Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme Cell 80 51 60
11. JLA Mitchell RR Diveley Jr A Bareyal-Leyser 1992 Feedback repression of polyamine uptake into mammalian cells requires active protein synthesis Biochem Biophys Res Commun 186 81 88
12. JLA Mitchell GG Judd A Bareyal-Leyser SY Ling 1994 Feedback repression of polyamine transport is mediated by antizyme in mammalian tissue culture cells Biochem J 299 19 22
13. JLA Mitchell A Leyser MS Holtorff JS Bates B Frydman AL Valasinas VK Reddy LJ Marton 2002 Antizyme induction by polyamine analogues as a factor in cell growth inhibition Biochem J 366 663 672
14. JLA Mitchell CL Simkus TK Thane P Tokarz MM Bonar B Frydman AL Valasinas VK Reddy LJ Marton 2004 Antizyme induction mediates feedback limitation of the incorporation of specific polyamine analogs in tissue culture Biochem J 384 271 279
15. J Nilsson B Grahn O Heby 2000 Antizyme inhibitor is rapidly induced in growth-stimulated mouse fibroblasts and releases ornithine decarboxylase from antizyme suppression Biochem J 346 699 704
16. AE Pegg 2006 Regulation of ornithine decarboxylase J Biol Chem 281 14529 14532
17. VK Reddy A Valasinas A Sarkar HS Basu LJ Marton B Frydman 1998 Conformationally restricted analogues of n-1,n-12-bisethylspermine - synthesis and growth inhibitory effects on human tumor cell lines J Med Chem 41 4723 4732
18. N Seiler 2005 Pharmacological aspects of cytotoxic polyamine analogs and derivatives for cancer therapy [Review] Pharmacol Ther 107 99 119
19. N Seiler CL Atanassov F Raul 1998 Polyamine metabolism as target for cancer chemoprevention Int J Oncol 13 993 1006
20. A Valasinas A Sarkar VK Reddy LJ Marton HS Basu B Frydman 2001 Conformationally restricted analogues of N-1,N-14-bisethylhomospermine (BE-4-4-4): Synthesis and growth inhibitory effects on human prostate cancer cells J Med Chem 44 390 403
21. A Valasinas VK Reddy AV Blokhin HS Basu S Bhattacharya A Sarkar LJ Marton B Frydman 2003 Long chain polyamines (oligoamines) exhibit strong cytotoxicities against human prostate cancer cells Bioorg Med Chem 11 4121 4131