The influence of core materials and film coating on the drug release from coated pellets

International Journal of Pharmaceutics

Volumn 233, Issue 1-2, 2002, Pages 111-122

  Sousa, J J ^a   Sousa, A ^a   Moura, M J ^b   Podczeck, F ^c   Newton, J M ^c  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b LABGRAN   (Portugal)

^c UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Drug release; Extrusion spheronisation; Film coating; Pellet structure; Pellets

Indexed keywords

BARIUM SULFATE; CALCIUM PHOSPHATE; ETHYL CELLULOSE; LACTOSE; MANNITOL; MICROCRYSTALLINE CELLULOSE; PROPRANOLOL;

ANALYSIS OF VARIANCE; AREA UNDER THE CURVE; ARTICLE; CANONICAL ANALYSIS; CONTROLLED DRUG RELEASE; DATA ANALYSIS; DISSOLUTION; DRUG FORMULATION; DRUG SOLUBILITY; FILM COATING; IN VITRO STUDY; MULTIPLE REGRESSION; PELLET EXTRUSION; POWDER; PRIORITY JOURNAL; SPHERONIZATION; STANDARDIZATION; SURFACE PROPERTY; WEIGHT GAIN;

CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DRUG IMPLANTS; POROSITY; PROPRANOLOL; SOLUBILITY; TABLETS, ENTERIC-COATED;

EID: 0037148652     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00921-8     Document Type: Article

References (12)

1. Some factors influencing the formation and in vitro drug release from matrix pellets prepared by extrusion/spheronization
2. Comparative evaluation of three organic solvent and dispersion-based ethylcellulose coating formulations
3. Shrinking and swelling properties of pellets containing microcrystalline cellulose and low substituted hydroxypropylcellulose: I. Shrinking properties
4. Mechanism of solute release from porous hydrophilic polymers
5. Preparation and evaluation of sodium diclofenac controlled release tablets. II. Dibasic calcium phosphate as a retardant in mixtures for direct compression
6. Matrix type tablet formulations for controlled release of highly water-soluble drugs
7. Mechanism of release from pellets coated with an ethylcellulose-based film
8. The use of statistical moment analysis to evaluate the mechanism of phase of a model drug from pellets produced by extrusion and spheronization
9. In vitro release characteristics of a membrane-coated pellet formulation - Influence of drug solubility and particle size
10. Factors influencing the physical characteristics of pellets obtained by extrusion/spheronization
11. Factors affecting the release of propranolol hydrochloride from beads coated with aqueous polymeric dispersions
12. Modelling of input function to drug absorption by moments