Effect of Curing Conditions and Plasticizer Level on the Release of Highly Lipophilic Drug from Coated Multiparticulate Drug Delivery System

Pharmaceutical Development and Technology

Volumn 8, Issue 4, 2003, Pages 397-407

  Hamed, Ehab ^a,b   Sakr, Adel ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

^b CIMA Labs Inc Minnesota   (United States)

Author keywords

Bumetanide; Coating; Curing; Multiparticulate drug delivery system; Plasticizer

Indexed keywords

BUMETANIDE; CITRIC ACID TRIETHYL ESTER; EUDRAGIT; HYDROXYPROPYLMETHYLCELLULOSE; PLASTICIZER;

ARTICLE; DISPERSION; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; DRUG STORAGE; FILM COATING; FLUIDIZED BED; LIPOPHILICITY; PARTICULATE MATTER; PRIORITY JOURNAL;

ACRYLIC RESINS; BIOLOGICAL AVAILABILITY; BUMETANIDE; CHEMISTRY, PHARMACEUTICAL; CITRATES; DRUG DELIVERY SYSTEMS; DRUG STORAGE; LACTOSE; METHYLCELLULOSE; OXAZINES; PLASTICIZERS; SOLUBILITY; TEMPERATURE; TIME FACTORS;

EID: 0142031035     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-120024693     Document Type: Article

References (21)

1. Bodmeier, R. Tableting of coated pellets, review. Eur. J. Pharm. Biopharm. 1997, 43, 1-8.
2. Bodmeier, R.; Paeratakul, O. The effect of curing on drug release and morphological properties of ethylcellulose pseudolatex-coated beads. Drug Dev. Ind. Pharm. 1994, 20, 1517-1533.
3. Goodhart, F.W.; Harris, M.R.; Murphy, K.S.; Nesbitt, R.U. An evaluation of aqueous film-forming dispersions for controlled release. Pharm. Technol. 1984, 4, 64-71.
4. Yuen, K.H.; Deshmukh, A.A.; Newton, J.M. Development and in-vitro evaluation of a multiparticulate sustained release theophylline formulation. Drug Dev. Ind. Pharm. 1993, 19, 855 874.
5. Harris, M.R.; Ghebre-Sellasie, I. Aqeous polymeric coating for modified-release pellets. In Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms; McGinity, J.W., Ed.; Mercel Dekker, Inc.: New York, 1997; 63-79.
6. Amighi, K.; Moes, A.J. Influence of plasticizer concentration and storage conditions on the drug release rate from eudragit RS 30 D film coated sustained release theophylline tablets. Eur. J. Pharm. Biopharm. 1996, 42, 29-35.
7. Hutchings, D.; Kuzmak, B.; Sakr, A. Processing considerations for an EC latex coating system: influence of curing time and temperature. Pharm. Res. 1994, 11, 1474-1478.
8. Williams, R.O., III; Liu, J. Influence of processing and curing conditions on beads coated with an aqueous dispersion of cellulose acetate phthalate. Eur. J. Pharm. Biopharm. 2000, 49, 243-252.
9. Alvan, G.; Paintaud, G.; Eckernas, S.A.; Grahnen, A. Discrepancy between bioavailability as estimated from urinary recovery of frusemide and total diuretic effect. Br. J. Clin. Pharmacol. 1992, 34, 47-52.
10. Castaneda-Hernandez, G.; Caille, G.; Du Souich, P. Influence of drug formulation on drug concentration-effect relationship. Clin. Pharmacokinet. 1994, 26, 135-143.
11. Reynolds, J.E.F., et al. Cardiovascular agents. In Martindale, The Extra Pharmacopoeia, 31 Ed.; Royal Pharmaceutical Society: London, 1996; 836-837.
12. Lee, S.H.; Lee, M.G.; Kim, N.D. Pharmacokinetics and pharmacodynamics of bumetanide after intravenous and oral administration to rats: absorption from various GI segments. J. Pharm. Biopharm. 1994, 22, 1-17.
13. Hamed, E.; Sakr, A. Application of multiple response optimization technique to extended release formulations design. J. Control. Release 2001, 73, 329-338.
14. United States Pharmacopoeia. USP XXV; United States Pharmacopeial Convention, Inc.: Rockville, MD, 2002; 2082-2084.
15. Husson, I.; Leclerc, B.; Spenlehauer, G.; Veillard, M.; Couarraze, G. Modelling of drug release from coated pellets with an insoluble polymeric membrane. J. Control. Release 1991, 17, 163-174.
16. Gunder, W.; Lippold, B.H.; Lippold, B.C. Release of drugs from ethyl cellulose microcapsules (diffusion pellets) with pore formers and pore fusion. Eur. J. Pharm. Sci. 1995, 3, 203-214.
17. Frohoff-Hulsnmann, M.A.; Schmitz, A.; Lippold, B.C. Aqueous ethyl cellulose dispersions containing plasticizers of different water solubility and hydroxypropyl methyl cellulose as coating material for diffusion pellets. I: drug release rates from coated pellets. Int. J. Pharm. 1999, 177, 69-82.
18. Lippold, B.C.; Gunder, W.; Lippold, B.H. Drug release from diffusion pellets coated with aqueous ethyl cellulose dispersion aquacoat® ECD-30 and 20% dibutyl sebacate as plasticizer: partition mechanism and pore diffusion. Eur. J. Pharm. Biopharm. 1999, 47, 27-32.
19. Schulze, P.; Kleinebudde, P. A new multiparticulate delayed release system. Part I: dissolution properties and release mechanism. J. Control. Release 1997, 47, 181-189.
20. Hutchings, D.; Sakr, A. Influence of pH and plasticizers on drug release from ethylcellulose pseudolatex coated pellets. J. Pharm. Sci. 1994, 83, 1386-1390.
21. Desai, S.J.; Simonelli, A.P.; Higuchi, W.I. Investigation of factors influencing release of solid drug dispersed in inert matrices. J. Pharm. Sci. 1965, 54, 1459-1464.