Effects of short-term vibration and hypoxia during high-intensity cycling exercise on circulating levels of angiogenic regulators in humans

Journal of Applied Physiology

Volumn 103, Issue 2, 2007, Pages 474-483

  Suhr, Frank ^a   Brixius, Klara ^a   De Marées, Markus ^a   Bölck, Birgit ^b   Kleinöder, Heinz ^a   Achtzehn, Silvia ^a   Bloch, Wilhelm ^a   Mester, Joachim ^a  

^a GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Angiogenesis; Mechanical stimuli

Indexed keywords

COLLAGEN; COLLAGEN 18; ENDOSTATIN; MATRIX METALLOPROTEINASE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ADULT; ALTITUDE; ANALYSIS OF VARIANCE; ANGIOGENESIS; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CYCLING; ENZYME LINKED IMMUNOSORBENT ASSAY; ERGOMETER; EXERCISE; HUMAN; HUMAN EXPERIMENT; HYPOXIA; MALE; MECHANICAL STIMULATION; NORMAL HUMAN; PRIORITY JOURNAL; SHEAR STRESS; TRAINING; VIBRATION; WESTERN BLOTTING;

ADULT; ALTITUDE; ANGIOGENESIS MODULATING AGENTS; BICYCLING; ENDOSTATINS; EXERCISE TEST; EXERTION; HUMANS; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NEOVASCULARIZATION, PHYSIOLOGIC; OXYGEN; RANDOM ALLOCATION; TIME FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VIBRATION;

EID: 34547685847     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01160.2006     Document Type: Article

References (62)

1. Adair TH. Growth regulation of the vascular system: an emerging role for adenosine. Am J Physiol Regul Integr Comp Physiol 289: R283-R296, 2005.
2. Berceli SA, Jiang Z, Klingman NV, Schultz GS, Keith Ozaki C. Early differential MMP-2 and -9 dynamics during flow-induced arterial and vein graft adaptations. J Surg Res 134: 327-334, 2006.
3. Birot OJ, Koulmann N, Peinnequin A, Bigard XA. Exercise-induced expression of vascular endothelial growth factor mRNA in rat skeletal muscle is dependent on fibre type. J Physiol 552: 213-221, 2003.
4. Bloch W, Huggel K, Sasaki T, Grose R, Bugnon P, Addicks K, Timpl R, Werner S. The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing. FASEB J 14: 2373-2376, 2000.
5. Bloor CM. Angiogenesis during exercise and training. Angiogenesis 8: 263-271, 2005.
6. Bosco C, Colli R, Introini E, Cardinale M, Tsarpela O, Medella A, Tihanyi J, Viru A. Adaptive responses of human skeletal muscle to vibration exposure. Clin Physiol 19: 183-187, 1999.
7. Bosco C, Iacovelli M, Tsarpela O, Cardinale M, Bonifazi M, Tihanyi J, Viru M, De Lorenzo A, Viru A. Hormonal responses to whole-body vibration in men. Eur J Appl Physiol 81: 449-454, 2000.
8. Brown MD, Hudlicka O. Modulation of physiological angiogenesis in skeletal muscle by mechanical forces: involvement of VEGF and metalloproteinases. Angiogenesis 6: 1-14, 2003.
9. Carmeli E, Moas M, Lennon S, Powers SK. High intensity exercise increases expression of matrix metalloproteinases in fast skeletal muscle fibres. Exp Physiol 90: 613-619, 2005.
10. Carmeli E, Moas M, Reznick AZ, Coleman R. Matrix metalloproteinases and skeletal muscle: a brief review. Muscle Nerve 29: 191-197, 2004.
11. Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med 6: 389-395, 2000.
12. Chavakis E, Dimmeler S. Regulation of endothelial cell survival and apoptosis during angiogenesis. Arterioscler Thromb Vasc Biol 22: 887-893, 2002.
13. Deininger MH, Wybranietz WA, Graepler FT, Lauer UM, Meyermann R, Schluesener HJ. Endothelial endostatin release is induced by general cell stress and modulated by the nitric oxide/cGMP pathway. FASEB J 17: 1267-1276, 2003.
14. Delecluse C, Roelants M, Verschueren S. Strength increase after wholebody vibration compared with resisting training. Med Sci Sports Exerc 35: 1033-1041, 2003.
15. Dong Z, Crawford HC, Lavrovsky V, Taub D, Watts R, Matrisian LM, Colburn NH. A dominant negative mutant of jun blocking 12-O-tetradecanoylphorbol-13-acetate-induced invasion in mouse keratinocytes. Mol Carcinog 19: 204-212, 1997.
16. Ekekezie II, Thibeault DW, Rezaiekhaligh MH, Norberg M, Mabry S, Zhang X, Truog WE. Endostatin and vascular endothelial cell growth factor (VEGF) in piglet lungs: effect of inhaled nitric oxide and hyperoxia. Pediatr Res 53: 440-446, 2003.
17. Ferrara N. The role of VEGF in the regulation of physiological and pathological angiogenesis. EXS: 209-231, 2005.
18. Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 9: 669-676, 2003.
19. Folkman J. How is blood vessel growth regulated in normal and neoplastic tissue? GHA Clowes memorial Award lecture. Cancer Res 46: 467-473, 1986.
20. Genersch E, Hayess K, Neuenfeld Y, Haller H. Sustained ERK phosphorylation is necessary but not sufficient for MMP-9 regulation in endothelial cells: involvement of Ras-dependent and -independent pathways. J Cell Sci 113: 4319-4330, 2000.
21. Gu JW, Adair TH. Hypoxia-induced expression of VEGF is reversible in myocardial vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 273: H628-H633, 1997.
22. Gu JW, Gadonski G, Wang J, Makey I, Adair TH. Exercise increases endostatin in circulation of healthy volunteers. BMC Physiol 4: 2, 2004.
23. Gu JW, Shparago M, Tan W, Bailey AP. Tissue endostatin correlates inversely with capillary network in rat heart and skeletal muscles. Angiogenesis 9: 93-99, 2006.
24. Gunga HC, Kirsch K, Rocker L, Behn C, Koralewski E, Davila EH, Estrada MI, Johannes B, Wittels P, Jelkmann W. Vascular endothelial growth factor in exercising humans under different environmental conditions. Eur J Physiol Occup Physiol 79: 484-490, 1999.
25. Gustafsson T, Puntschart A, Kaijser L, Jansson E, Sundberg CJ. Exercise-induced expression of angiogenesis-related transcription and growth factors in human skeletal muscle. Am J Physiol Heart Circ Physiol 276: H679-H685, 1999.
26. Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86: 353-364, 1996.
27. Heits F, Wiedemann GJ, Jelkmann W. [Vascular endothelial growth factor VEGF stimulates angiogenesis in good and bad situations]. Dtsch Med Wochenschr 123: 259-265, 1998.
28. Heljasvaara R, Nyberg P, Luostarinen J, Parikka M, Heikkila P, Rehn M, Sorsa T, Salo T, Pihlajaniemi T. Generation of biologically active endostatin fragments from human collagen XVIII by distinct matrix metalloproteases. Exp Cell Res 307: 292-304, 2005.
29. Hiscock N, Fischer CP, Pilegaard H, Pedersen BK. Vascular endothelial growth factor mRNA expression and arteriovenous balance in response to prolonged, submaximal exercise in humans. Am J Physiol Heart Circ Physiol 285: H1759-H1763, 2003.
30. Jensen L, Bangsbo J, Hellsten Y. Effect of high intensity training on capillarization and presence of angiogenic factors in human skeletal muscle. J Physiol 557: 571-582, 2004.
31. Kang HY, Shim D, Kang SS, Chang SI, Kim HY. Protein kinase B inhibits endostatin-induced apoptosis in HUVECs. J Biochem Mol Biol 39: 97-104, 2006.
32. Kim CH, Cho YS, Chun YS, Park JW, Kim MS. Early expression of myocardial HIF-1alpha in response to mechanical stresses: regulation by stretch-activated channels and the phosphatidylinositol 3-kinase signaling pathway. Circ Res 90: E25-E33, 2002.
33. Koskinen SO, Heinemeier KM, Olesen JL, Langberg H, Kjaer M. Physical exercise can influence local levels of matrix metalloproteinases and their inhibitors in tendon-related connective tissue. J Appl Physiol 96: 861-864, 2004.
34. Koskinen SO, Hoyhtya M, Turpeenniemi-Hujanen T, Martikkala V, Makinen TT, Oksa J, Rintamaki H, Lofberg M, Somer H, Takala TE. Serum concentrations of collagen degrading enzymes and their inhibitors after downhill running. Scand J Med Sci Sports 11: 9-15, 2001.
35. Laufs U, Werner N, Link A, Endres M, Wassmann S, Jurgens K, Miche E, Bohm M, Nickenig G. Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation 109: 220-226, 2004.
36. Malemud CJ. Matrix metalloproteinases (MMPs) in health and disease: an overview. Front Biosci 11: 1696-1701, 2006.
37. Mester J, Kleinöder H, Yue Z. Vibration training: benefits and risks. J Biomech 39: 1056-1065, 2006.
38. Morbidelli L, Donnini S, Chillemi F, Giachetti A, Ziche M. Angiosuppressive and angiostimulatory effects exerted by synthetic partial sequences of endostatin. Clin Cancer Res 9: 5358-5369, 2003.
39. Moses MA. The regulation of neovascularization of matrix metalloproteinases and their inhibitors. Stem Cells 15: 180-189, 1997.
40. Muragaki Y, Timmons S, Griffith CM, Oh SP, Fadel B, Quertermous T, Olsen BR. Mouse Col18a1 is expressed in a tissue-specific manner as three alternative variants and is localized in basement membrane zones. Proc Natl Acad Sci USA 92: 8763-8767, 1995.
41. O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, Flynn E, Birkhead JR, Olsen BR, Folkman J. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88: 277-285, 1997.
42. O'Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, Lane WS, Cao Y, Sage EH, Folkman J. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79: 315-328, 1994.
43. Oh SP, Warman ML, Seldin MF, Cheng SD, Knoll JH, Timmons S, Olsen BR. Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the alpha 1(XVIII) collagen gene to mouse chromosome 10 and human chromosome 21. Genomics 19: 494-499, 1994.
44. Paddenberg R, Faulhammer P, Goldenberg A, Kummer W. Hypoxia-induced increase of endostatin in murine aorta and lung. Histochem Cell Biol 125: 497-508, 2006.
45. Pages G, Pouyssegur J. Transcriptional regulation of the Vascular Endothelial Growth Factor gene-a concert of activating factors. Cardiovasc Res 65: 564-573, 2005.
46. Petersen W, Varoga D, Zantop T, Hassenpflug J, Mentlein R, Pufe T. Cyclic strain influences the expression of the vascular endothelial growth factor (VEGF) and the hypoxia inducible factor 1 alpha (HIF-1alpha) in tendon fibroblasts. J Orthop Res 22: 847-853, 2004.
47. Prior BM, Yang HT, Terjung RL. What makes vessels grow with exercise training? J Appl Physiol 97: 1119-1128, 2004.
48. Pufe T, Lemke A, Kurz B, Petersen W, Tillmann B, Grodzinsky AJ, Mentlein R. Mechanical overload induces VEGF in cartilage discs via hypoxia-inducible factor. Am J Pathol 164: 185-192, 2004.
49. Rehn M, Pihlajaniemi T. Alpha 1(XVIII), a collagen chain with frequent interruptions in the collagenous sequence, a distinct tissue distribution, and homology with type XV collagen. Proc Natl Acad Sci USA 91: 4234-4238, 1994.
50. Schmidt A, Addicks K, Bloch W. Opposite effects of endostatin on different endothelial cells. Cancer Biol Ther 3: 1162-8, 2004.
51. Schmidt A, Wenzel D, Ferring I, Kazemi S, Sasaki T, Hescheler J, Timpl R, Addicks K, Fleischmann BK, Bloch W. Influence of endostatin on embryonic vasculo- and angiogenesis. Dev Dyn 230: 468-480, 2004.
52. Shichiri M, Hirata Y. Antiangiogenesis signals by endostatin. FASEB J 15: 1044-1053, 2001.
53. Stammers R, Robinson CJ, Forster MJ, Mulloy B, Rafferty B. Vascular endothelial growth factor (VEGF): modulation of heparin-binding activity and bioactivity by site-directed mutagenesis. Endocr Abstr 10: P27, 2005.
54. Tang K, Breen EC, Gerber HP, Ferrara NM, Wagner PD. Capillary regression in vascular endothelial growth factor-deficient skeletal muscle. Physiol Genomics 18: 63-69, 2004.
55. Urbich C, Reissner A, Chavakis E, Dernbach E, Haendeler J, Fleming I, Zeiher AM, Kaszkin M, Dimmeler S. Dephosphorylation of endothelial nitric oxide synthase contributes to the anti-angiogenic effects of endostatin. FASEB J 16: 706-708, 2002.
56. Wenger RH. Mammalian oxygen sensing, signalling and gene regulation. J Exp Biol 203: 1253-1263, 2000.
57. Wenzel D, Schmidt A, Reimann K, Hescheler J, Pfitzer G, Bloch W, Fleischmann BK. Endostatin, the proteolytic fragment of collagen XVIII, induces vasorelaxation. Circ Res 98: 1203-1211, 2006.
58. Yamaguchi N, Anand-Apte B, Lee M, Sasaki T, Fukai N, Shapiro R, Que I, Lowik C, Timpl R, Olsen BR. Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding. EMBO J 18: 4414-4423, 1999.
59. Yue Z, Mester J. Hydrodynamic analysis for the effects of whole body vibration on blood circulation. In: Proceedings of the 8th Annual Congress of the European College of Sports Science, Salzburg, 9-12 July, 2003, edited by Müller E, Schwameder H, Zallinger G, and Fastenbauer V, 2003, p. 377.
60. Yue Z, Mester J. On the cardiovascular effects of whole-body vibration. I. Longitudinal effects: hydrodynamic analysis. Studies Appl Math 119: 95-109, 2007.
61. Yue Z, Kleinöder H, de Marées M, Speicher U, Wahl P, Mester J. On the cardiovascular effects of whole-body vibration. II: Statistical analysis. Studies Appl Math 119: 111-125, 2007.
62. Zatterstrom UK, Felbor U, Fukai N, Olsen BR. Collagen XVIII/endostatin structure and functional role in angiogenesis. Cell Struct Funct 25: 97-101, 2000.