Influence of drug pharmacokinetics on HIV pathogenesis and therapy

Deterministic and Stochastic Models of AIDS Epidemics and HIV Infections with Intervention

Volumn , Issue , 2005, Pages 287-311

  Dixit, Narendra M ^a   Perelson, Alan S ^a  

^a NONE

Author keywords

Antiretroviral therapy; Drug pharmacokinetics; Drug resistance; HIV infection; Viral dynamics

Indexed keywords

EID: 34547684191     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1142/9789812569264_0012     Document Type: Chapter

References (20)

1. Austin DJ, White NJ and Anderson RM (1998) The dynamics of drug action on the within-host population growth of infectious agents: melding pharmacokinetics with pathogen population dynamics, J Theor Biol 194: 313-339.
2. Buss N and Cammack N (2001) Measuring the effectiveness of antiretroviral agents, Antiviral Therapy 6: 1-7.
3. Dixit NM and Perelson AS (2004a) Complex patterns of viral load decay under antiretroviral therapy: influence of pharmacokinetics and intracellular delay, J Theor Biol 226: 95-109.
4. Dixit NM and Perelson AS (2004b) Estimates of intracellular delay and average drug efficacy from viral load data of HIV infected individuals under antiretroviral therapy, Antiviral Therapy in press.
5. Dybul M, Chun T-W, Yoder C, Hidalgo B, Belson M, Hertogs K, Larder B, Dewar RL, Fox CH, Hallahan CW, Justement JS, Migueles SA, Metcalf JA, Davey RT, Daucher M, Pandya P, Baseler M, Ward DJ and Fauci AS (2001) Short-cycle structured intermittent treatment of chronic HIV infection with highly active antiretroviral therapy: effects on virologic, immunologic, and toxicity parameters, Proc Natl Acad Sci USA 98: 15161-15166.
6. Finzi D and Siliciano RF (1998) Viral dynamics in HIV-1 infection, Cell 93: 665-671.
7. Gabrielson J and Weiner D (2000) Pharmacokinetic and pharmacodynamic data analysis: concepts and applications, Swedish Pharmaceutical Press, Stockholm.
8. Herz AVM, Bonhoeffer S, Anderson RM, May RM and Nowak MA (1996) Viral dynamics in vivo: limitations on estimates of intracellular delay and virus decay, Proc Natl Acad Sci USA 93: 7247-7251.
9. Hlavacek WS, Wofsy C and Perelson AS (1999) Dissociation of HIV-1 from follicular dendritic cells during HAART: mathematical analysis, Proc Natl Acad Sci USA 96: 14681-14686.
10. Huang Y, Rosenkranz S and Wu H (2003) Modeling HIV dynamics and antiviral responses with consideration of time-varying drug exposures, sensitivities and adherence, Math Biosci 184: 165-186.
11. Hurwitz SJ and Schinazi RF (2002) Development of a pharmacodynamic model for HIV treatment with nucleoside reverse transcriptase and protease inhibitors, Antiviral Res 56: 115-127.
12. Nowak MA and May RM (2000) Virus dynamics: mathematical principles of immunology and virology, Oxford University Press, Oxford.
13. Paterson D, Swindells S, Mohr J, Brester M, Vergis E, Squier C, Wagener M and Singh N (1999) How much adherence is enough? A prospective study of adherence to protease inhibitor therapy using MEMSCaps. In Proceedings of the Sixth Conference on Retroviruses and Opportunistic Infections, Chicago, IL, Abstract 092.
14. Perelson AS, Neumann AU, Markowitz M, Leonard JM and Ho DD (1996) HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time, Science 271: 1582-1586.
15. Perelson AS, Essunger P, Cao Y, Vesanen M, Hurley A, Saksella K, Markowitz M and Ho DD (1997) Decay characteristics of HIV-1-infected compartments during combination therapy, Nature 387: 188-191.
16. Perelson AS and Nelson PW (2002) Modeling viral infections, in Sneyd J (ed.) An Introduction to Mathematical Modeling in Physiology, Cell Biology, and Immunology, Amer. Math. Soc., Providence RI, pp 139-172.
17. Ribeiro RM, Dixit NM and Perelson AS, Modeling the in vivo growth rate of HIV: implications for vaccination, in Paton R and Leishman D (eds.) Multidisciplinary Approaches to Theory in Medicine, Elsevier, in press.
18. Stafford MA, Corey L, Cao Y, Daar E, Ho DD and Perelson AS (2000) Modeling plasma virus concentration during primary HIV infection, J Theor Biol 203: 285-301.
19. Wahl LM and Nowak MA (2000) Adherence and drug resistance: predictions for therapy outcome, Proc R Soc Lond B 267: 835-843.
20. Welling PG (1986) Pharmacokinetics: Processes and Mathematics, American Chemical Society, Washington DC.