Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells

Toxicology and Applied Pharmacology

Volumn 223, Issue 1, 2007, Pages 28-38

  Khan, Shaheen ^a   Liu, Shengxi ^b   Stoner, Matthew ^a   Safe, Stephen ^a,b  

^a TEXAS A AND M UNIVERSITY   (United States)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

Ah receptor; BRCA1; CYP1A1 inhibition; Hypoxia

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; COBALT CHLORIDE; CYCLOHEXIMIDE; CYTOCHROME P450 1A1; ESTROGEN RECEPTOR; GENOMIC DNA; TRANSCRIPTION FACTOR RELA;

ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYPOXIA; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR BINDING; TRANSACTIVATION; WESTERN BLOTTING;

ANTIMUTAGENIC AGENTS; BLOTTING, NORTHERN; BREAST NEOPLASMS; CELL HYPOXIA; CELL LINE, TUMOR; CELL NUCLEUS; COBALT; CYCLOHEXIMIDE; CYTOCHROME P-450 CYP1A1; CYTOSOL; DRUG ANTAGONISM; ENVIRONMENTAL POLLUTANTS; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; HUMANS; PROTEIN SYNTHESIS INHIBITORS; RECEPTORS, ARYL HYDROCARBON; RNA, MESSENGER; TETRACHLORODIBENZODIOXIN; UBIQUITIN-PROTEIN LIGASES;

EID: 34547684111     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.05.010     Document Type: Article

References (43)

1. Arellano L.O., Wang X., and Safe S. Effects of cycloheximide on the induction of CYP1A1 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in three human breast cancer cell lines. Carcinogenesis 14 (1993) 219-222
2. Bindra R.S., Gibson S.L., Meng A., Westermark U., Jasin M., Pierce A.J., Bristow R.G., Classon M.K., and Glazer P.M. Hypoxia-induced down-regulation of BRCA1 expression by E2Fs. Cancer Res. 65 (2005) 11597-11604
3. Chan W.K., Yao G., Gu Y.-Z., and Bradfield C.A. Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways. J. Biol. Chem. 274 (1999) 12115-12123
4. Denison M.S., and Nagy S.R. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu. Rev. Pharmacol. Toxicol. 43 (2003) 309-334
5. Denison M.S., Seidel S.D., Rogers W.J., Ziccardi M., Winter G.M., and Heath-Pagliuso S. Natural and synthetic ligands for the Ah receptor. In: Puga A., and Kendall R.J. (Eds). Molecular Biology Approaches to Toxicology (1998), Taylor and Francis 3-33
6. Duan R., Porter W., Samudio I., Vyhlidal C., Kladde M., and Safe S. Transcriptional activation of c-fos protooncogene by 17b-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition. Mol. Endocrinol. 13 (1999) 1511-1521
7. Gillesby B., Santostefano M., Porter W., Wu Z.F., Safe S., and Zacharewski T. Identification of a motif within the 5′-regulatory region on pS2 which is responsible for Ap1 binding and TCDD-mediated suppression. Biochemistry 36 (1997) 6080-6089
8. Gradin K., McGuire J., Wenger R.H., Kvietikova I., Fhitelaw M.L., Toftgard R., Tora L., Gassmann M., and Poellinger L. Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor. Mol. Cell. Biol. 16 (1996) 5221-5231
9. Hestermann E.V., and Brown M. Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor. Mol. Cell. Biol. 23 (2003) 7920-7925
10. Jeong H.J., Hong S.H., Park R.K., Shin T., An N.H., and Kim H.M. Hypoxia-induced IL-6 production is associated with activation of MAP kinase, HIF-1, and NF-kB on HEI-OC1 cells. Hear. Res. 207 (2005) 59-67
11. Joiakim A., Mathieu P.A., Elliott A.A., and Reiners Jr. J.J. Superinduction of CYP1A1 in MCF10A cultures by cycloheximide, anisomycin, and puromycin: a process independent of effects on protein translation and unrelated to suppression of aryl hydrocarbon receptor proteolysis by the proteasome. Mol. Pharmacol. 66 (2004) 936-947
12. Kang H.J., Kim H.J., Kim S.K., Barouki R., Cho C.H., Khanna K.K., Rosen E.M., and Bae I. BRCA1 modulates xenobiotic stress-inducible gene expression by interacting with ARNT in human breast cancer cells. J. Biol. Chem. 281 (2006) 14654-14662
13. Karchner S.I., Franks D.G., Powell W.H., and Hahn M.E. Regulatory interactions among three members of the vertebrate aryl hydrocarbon receptor family: AHR repressor, AHR1, and AHR2. J. Biol. Chem. 277 (2002) 6949-6959
14. Ke S., Rabson A.B., Germino J.F., Gallo M.A., and Tian Y. Mechanism of suppression of cytochrome P-450 1A1 expression by tumor necrosis factor-a and lipopolysaccharide. J. Biol. Chem. 276 (2001) 39638-39644
15. Kim J.E., and Sheen Y.Y. Inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-stimulated Cyp1a1 promoter activity by hypoxic agents. Biochem. Pharmacol. 59 (2000) 1549-1556
16. Koliopanus A., Kleeff J., Xiao Y., Safe S., Zimmerman A., Buchler M.W., and Friess H. Increased aryl hydrocarbon receptor expression offers a potential therapeutic target in pancreatic cancer. Oncogene 21 (2002) 6059-6070
17. Krishnan V., Porter W., Santostefano M., Wang X., and Safe S. Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells. Mol. Cell. Biol. 15 (1995) 6710-6719
18. Lee K., Burgoon L.D., Lamb L., Dere E., Zacharewski T.R., Hogenesch J.B., and LaPres J.J. Identification and characterization of genes susceptible to transcriptional cross-talk between the hypoxia and dioxin signaling cascades. Chem. Res. Toxicol. 19 (2006) 1284-1293
19. Lusska A., Wu L., and Whitlock Jr. J.P. Superinduction of CYP1A1 transcription by cycloheximide: role of the DNA binding site for the liganded Ah receptor. J. Biol. Chem. 267 (1992) 15146-15151
20. Ma Q., Renzelli A.J., Baldwin K.T., and Antonini J.M. Superinduction of CYP1A1 gene expression. Regulation of 2,3,7, 8-tetrachlorodibenzo-p-dioxin-induced degradation of Ah receptor by cycloheximide. J. Biol. Chem. 275 (2000) 12676-12683
21. McDougal A., Wormke M., Calvin J., and Safe S. Tamoxifen-induced antitumorigenic/antiestrogenic action synergized by a selective Ah receptor modulator. Cancer Res. 61 (2001) 3901-3907
22. Meyer M.E., Gronemeyer H., Turcotte B., Bocquel M.T., and Chambon P. Steroid hormone receptors compete for factors that mediate their enhancer function. Cell 57 (1989) 433-442
23. Mimura J., Ema M., Sogawa K., and Fujii-Kuriyama Y. Identification of a novel mechanism of regulation of Ah (dioxin) receptor function. Genes Dev. 13 (1999) 20-25
24. Morrow D., Qin C., Smith III R., and Safe S. Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation. J. Steroid Biochem. Mol. Biol. 88 (2004) 27-36
25. Ohtake F., Baba A., Takada I., Okada M., Iwasaki K., Miki H., Takahashi S., Kouzmenko A., Nohara K., Chiba T., Fujii-Kuriyama Y., and Kato S. Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature 446 (2007) 562-566
26. Poland A., and Knutson J.C. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons. Examinations of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol. 22 (1982) 517-554
27. Poland A., Glover E., and Kende A.S. Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol: evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. J. Biol. Chem. 251 (1976) 4936-4946
28. Pollenz R.S., Davarinos N.A., and Shearer T.P. Analysis of aryl hydrocarbon receptor-mediated signaling during physiological hypoxia reveals lack of competition for the aryl hydrocarbon nuclear translocator transcription factor. Mol. Pharmacol. 56 (1999) 1127-1137
29. Porter W., Wang F., Duan R., Qin C., Castro-Rivera E., and Safe S. Transcriptional activation of heat shock protein 27 gene expression by 17b-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists: estrogenic activity of ICI 164,384. J. Mol. Endocrinol. 26 (2001) 31-42
30. Prasch A.L., Andreasen E.A., Peterson R.E., and Heideman W. Interactions between 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and hypoxia signaling pathways in zebrafish: hypoxia decreases responses to TCDD in zebrafish embryos. Toxicol. Sci. 78 (2004) 68-77
31. Reyes H., Reisz-Porszasz S., and Hankinson O. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science 256 (1992) 1193-1195
32. Rowlands C., Krishnan V., Wang X., Santostefano M., Safe S., Miller W.R., and Langdon S. Characterization of the aryl hydrocarbon (Ah) receptor and Ah-responsiveness in human ovarian carcinoma cell lines. Cancer Res. 53 (1993) 1802-1807
33. Safe S., and Wormke M. Inhibitory aryl hydrocarbon-estrogen receptor a cross-talk and mechanisms of action. Chem. Res. Toxicol. 16 (2003) 807-816
34. Safe S., McDougal A., Gupta M.S., and Ramamoorthy K. Selective Ah receptor modulators (SAhRMs): progress towards development of a new class of inhibitors of breast cancer growth. J. Women's Cancer 3 (2001) 37-45
35. Stoner M. Differential Regulation of Vascular Endothelial Growth Factor (VEGF) Gene Expression by 17β-Estradiol in Human Breast and Endometrial Cancer Cell Lines (2002), Texas A&M University, College Station, TX
36. Stoner M., Saville B., Wormke M., Dean D., Burghardt R., and Safe S. Hypoxia induces proteasome-dependent degradation of estrogen receptor a in ZR-75 breast cancer cells. Mol. Endocrinol. 16 (2002) 2231-2242
37. Stoner M., Wormke M., Saville B., Samudio I., Qin C., Abdelrahim M., and Safe S. Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor a and Sp proteins. Oncogene 23 (2004) 1052-1063
38. Swanson H.I., and Bradfield C.A. The Ah-receptor: genetics, structure and function. Pharmacogenetics 3 (1993) 213-223
39. Tian Y., Ke S., Denison M.S., Rabson A.B., and Gallo M.A. Ah receptor and NF-kB interactions, a potential mechanism for dioxin toxicity. J. Biol. Chem. 274 (1999) 510-515
40. Wang X., Thomsen J.S., Santostefano M., Rosengren R., Safe S., and Perdew G.H. Comparative properties of the nuclear Ah receptor complex from several human cell lines. Eur. J. Pharmacol. 293 (1995) 191-205
41. Whitlock Jr. J.P. Induction of cytochrome P4501A1. Annu. Rev. Pharmacol. Toxicol. 39 (1999) 103-125
42. Wilson C.L., and Safe S. Mechanisms of ligand-induced aryl hydrocarbon receptor-mediated biochemical and toxic responses. Toxicologic Pathol. 26 (1998) 657-671
43. Wormke M., Stoner M., Saville B., Walker K., Abdelrahim M., Burghardt R., and Safe S. The aryl hydrocarbon receptor mediates degradation of the estrogen receptor a through activation of proteasomes. Mol. Cell. Biol. 23 (2003) 1843-1855