Antidepressant-like effect of hyperfoliatin, a polyisoprenylated phloroglucinol derivative from Hypericum perfoliatum (Clusiaceae) is associated with an inhibition of neuronal monoamines uptake

European Journal of Pharmacology

Volumn 569, Issue 3, 2007, Pages 197-203

  do Rego, Jean Claude ^a   Benkiki, Naïma ^b   Chosson, Elizabeth ^c   Kabouche, Zahia ^b   Seguin, Elisabeth ^c   Costentin, Jean ^a  

^a CNRS   (France)

^b Universite Mentouri Constantine   (Algeria)

^c Normandie Université   (France)

Author keywords

Antidepressant drug; Forced swimming test; Hyperfoliatin; Hypericum perfoliatum; Monoaminergic system

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN MONOAMINE; HYPERFOLIATIN; PHLOROGLUCINOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG BINDING; DRUG INHIBITION; DRUG MECHANISM; DRUG UPTAKE; FORCED SWIMMING TEST; GUTTIFERAE; HYPERICUM; HYPERICUM PERFOLIATUM; IC 50; LOCOMOTION; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; DEPRESSION; DISEASE MODELS, ANIMAL; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPERICUM; MALE; MICE; MOTOR ACTIVITY; NEUROTRANSMITTER UPTAKE INHIBITORS; NOREPINEPHRINE; PHLOROGLUCINOL; PHYTOTHERAPY; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; SEROTONIN; SWIMMING; TRITERPENES;

EID: 34547681319     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.05.008     Document Type: Article

References (50)

1. Barnes J., Anderson L., and Phillipson J.D. St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties. J. Pharm. Pharmacol. 53 (2001) 583-600
2. Beerhues L. Molecules of interest. Hyperforin. Phytochem. 67 (2006) 2201-2207
3. Benkiki N., Kabouche Z., Tillequin F., Vérité P., Chosson E., and Seguin E. A new polyisoprenylated phloroglucinol derivative from Hypericum perfoliatum (Clusiaceae). Z. Naturforsch. 58C (2003) 655-658
4. Bhattacharya S., Chakrabarti A., and Chatterjee S. Activity profiles of two hyperforin-containing Hypericum extracts in behavioral models. Pharmacopsychiatry 31 (1998) 22-29
5. Bourin M. Is it possible to predict the activity of a new antidepressant in animals with simple psychopharmacological test?. Fund. Clin. Pharmacol. 4 (1990) 49-64
6. Butterweck V., Lieflander-Wulf U., Winterhoff H., and Nahrstedt A. Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity. Pharmacopsychiatry 30 (1997) 11-24
7. Butterweck V., Petereit F., Winterhoff H., and Nahrstedt A. Solubilized hypericin and pseudo-hypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test. Planta Med. 64 (1998) 291-294
8. Butterweck V., Jürgenliemk G., Nahrstedt A., and Winterhoff H. Flavonoids from Hypericum perforatum show antidepressant activity in forced swimming test. Planta Med. 66 (2000) 3-6
9. Bystrov N.S., Chernov B., Dobrynin V.N., and Kolosov M.N. The structure of hyperforin. Tetrahedron Lett. 16 (1975) 2791-2794
10. Chatterjee S.S., Nöldner M., Koch E., and Erdelmeier C. Antidepressant activity of Hypericum perforatum and hyperforin, the neglected possibility. Pharmacopsychiatry 31 (1998) 7-15
11. Chatterjee S.S., Bhattacharya S.K., Wonnemann M., Singer A., and Müller W.E. Hyperforin as a possible antidepressant component of Hypericum extracts. Life Sci. 63 (1998) 499-510
12. Cryan J.F., Markou A., and Lucki I. Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol. Sci. 23 (2002) 238-245
13. Da Silva G., Matteussi A., Santos A.R.S., Calixto J.B., and Rodrigues A.L.S. Evidence for dual effects of nitric oxide in the forced swimming test and in the tail suspension test in mice. NeuroReport 11 (2000) 3699-3702
14. Daudt R., Von Poser G.L., Neves G., and Rates S.M.K. Screening for the antidepressant activity of some species of Hypericum from South Brazil. Phytother. Res. 15 (2000) 344-346
15. Do-Rego J.C., Suaudeau C., Chapouthier G., and Costentin J. Mouse lines differing in sensitivity to β-CCM differ in tasks used for testing antidepressants. Pharmacol. Biochem. Behav. 72 (2002) 411-416
16. Do-Rego J.C., Chatenet D., Orta M.-H., Naudin B., Le Cudennec C., Leprince J., Scalbert E., Vaudry H., and Costentin J. Behavioral effects of urotensin-II centrally administered in mice. Psychopharmacology 183 (2005) 103-117
17. Duterte-Boucher D., Leclère J.F., Panissaud C., and Costentin J. Acute effects of direct dopamine agonists in the mouse behavioral despair test. Eur. J. Pharmacol. 154 (1988) 185-190
18. Ernst E. St John's wort, an antidepressant ? A systematic criteria-based review. Phytomedicine 2 (1995) 67-71
19. Gobbi M., Valle F.D., Ciapparelli C., Diomede L., Morazzoni P., Verotta L., Caccia S., Cervo L., and Mennini T. Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex. Naunyn-Schmiedeberg's Arch. Pharmacol. 360 (1999) 262-269
20. Jensen A.G., Hansen S.H., and Nielsen E.O. Adhyperforin as contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity. Life Sci. 68 (2001) 1593-1605
21. Linde K., Ramirez G., Mulrow C.D., Pauls A., Weidenhammer W., and Melchardt D. St. John's Wort for depression - an overview and meta-analysis of randomized clinical trials. Br. Med. J. 313 (1996) 253-258
22. Lowry O.H., Rosenbrough N.J., Farr A.L., and Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
23. Maisenbacher P., and Kovar K.A. Adhyperforin: a homologue of hyperforin from Hypericum perforatum. Planta Med. 58 (1992) 291-293
24. Manji H.K., Drevets W.C., and Charney D.S. The cellular neurobiology of depression. Nat. Med. 7 (2001) 541-547
25. Millan M.J. The role of monoamines in the actions of established and "novel" antidepressant agents: a critical review. Eur. J. Pharmacol. 500 (2004) 371-384
26. Miller N.D. St John's wort (Hypericum perforatum): clinical effects on depression and other conditions. Altern. Med. Rev. 3 (1998) 18-26
27. Morilak D.A., and Frazer A. Antidepressants and brain monoaminergic system: a dimensional approach to understanding their behavioural effects in depression and anxiety disorders. Int. J. Neuropsychopharmacol. 7 (2004) 193-218
28. Müller W.E. St John's wort research from mode of action to clinical efficacy. Pharmacol. Res. 47 (2003) 101-109
29. Müller W.E., Rolli M., Schafer C., and Hafner U. Effects Hypericum extract (LI 160) in biochemical models of antidepressant activity. Pharmacopsychiatry 30 (1997) 102-107
30. Müller W.E., Singer A., Wonemann M., Hafner U., Rolli M., and Schafer C. Hyperforin represents the neurotransmitter reuptake inhibiting constituent of Hypericum extract. Pharmacopsychiatry 31 (1998) 16-21
31. Müller W.E., Singer A., and Wonemann M. Hyperforin - antidepressant activity by a novel mechanism of action. Pharmacopsychiatry 34 (2001) 98-102
32. Panocka I., Perfumi M., Angeletti S., Ciccocioppo R., and Massi M. Effects of Hypericum perforatum extract on ethanol intake, and on behavioral despair: a search for the neurochemical systems involved. Pharmacol. Biochem. Behav. 66 (2000) 105-111
33. Petit-Demouliere B., Chenu F., and Bourin M. Forced swimming test in mice: a review of antidepressant activity. Psychopharmacology 177 (2005) 245-255
34. Porsolt R.D., Bertin A., and Jalfre M. Behavioral despair in mice: a primary screening test for antidepressants. Arch. Int. Pharmacodyn. Ther. 229 (1977) 327-336
35. Porsolt R.D., Anton G., Blavet N., and Jalfre M. Behavioral despair in rats, a new model sensitive to antidepressant treatments. Eur. J. Pharmacol. 47 (1978) 379-391
36. Porsolt R.D., Lenègere A., and McArthur R.A. Pharmacological models of depression. Advances in pharmacological sciences. Animal Models in Psychopharmacology (1991), Birkhäuser Verlag, Basel
37. Rocha L., Marston A., Kaplan M.A.C., Stoeckli-Evans H., Thull U., Testa B., and Hostettmann K. An antifungal gamma-pyrone and xanthones with monoamino oxidase inhibitory activity from Hypericum brasiliense. Phytochemistry 6 (1994) 1381-1385
38. Rosa A.O., Lin J., Calixto J.B., Santos A.R.S., and Rodrigues A.L.S. Involvement of NMDA receptors and l-arginine-nitric oxide pathway in the antidepressant-like effects of zinc in mice. Behav. Brain Res. 144 (2003) 87-93
39. Roz N., and Rehavi M. Hyperforin inhibits vesicular uptake of monoamines by dissipating pH gradient across synaptic vesicle membrane. Life Sci. 73 (2003) 461-470
40. Roz N., Mazur Y., Hirshfeld A., and Rehavi M. Inhibition of vesicular uptake of monoamines by hyperforin. Life Sci. 71 (2002) 2227-2237
41. Sanchez-Mateo C.C., Prado B., and Rabanal R.M. Antidepressant effects of the methanol extracts of several Hypericum species from the Canary Islands. J. Ethnopharmacol. 79 (2002) 119-127
42. Semba J., and Takahashi R. Effect of monoamine precursors on the forced-swimming test in mice. Psychopharmacology 95 (1988) 222-225
43. Stevinson C., and Ernst E. Hypericum for depression - an update of the clinical evidence. Eur. Neuropsychopharmacol. 9 (1999) 501-505
44. Sunal R., Gümüsel B., and Kayaalp S.O. Effect of changes in swimming area on results of behavioral despair test. Pharmacol. Biochem. Behav. 49 (1994) 891-896
45. Tanaka N., Takaishi Y., Shikishima Y., Nakanishi Y., Bastow K., Lee K.H., Honda G., Ito M., Takeda Y., Kodzhimatov O.K., and Ashurmetov O. Prenyllated benzophenones and xanthones from Hypericum scabrum. J. Nat. Prod. 67 (2004) 1870-1875
46. Viana A., do Rego J.C., von Poser G., Ferraz A., Heckler A.P., Costentin J., and Kuze-Rates S.M. The antidepressant-like effect of Hypericum caprifoliatum Cham & Schlecht (Guttiferae) on forced swimming test results from an inhibition of neuronal monoamine uptake. Neuropharmacology 49 (2005) 1042-1052
47. Viana A.F., do Rego J.C., Munari L., Dourmap N., Heckler A.P., Costa T.D., von Poser G., Costentin J., and Kuze-Rates S.M. Hypericum caprifoliatum (Guttiferae) Cham. & Schltdl.: a species native to South Brazil with antidepressant-like activity. Fund. Clin. Pharmacol. 20 (2006) 507-514
48. Volz H.P. Controlled clinical trials of Hypericum extracts in depressed patients - an overview. Pharmacopsychiatry 30 Suppl. 2 (1997) 72-76
49. Yoshitake T., Lizuka R., Yoshitake S., Weikop P., Müller W.E., Ögren S.O., and Kehr J. Hypericum perforatum L (St John's wort) preferentially increases extracellular dopamine levels in the rat prefrontal cortex. Br. J. Pharmacol. 142 (2004) 414-418
50. Zomkowski A.D., Hammes L., Lin J., Calixto J.B., Santos A.R., and Rodrigues A.L. Agmatine produces antidepressant-like effects in two models of depression in mice. NeuroReport 13 (2002) 387-391