Rat α- and γ-motoneuron soma size and succinate dehydrogenase activity are independent of neuromuscular activity level

Muscle and Nerve

Volumn 36, Issue 2, 2007, Pages 234-241

  Roy, Roland R ^a   Matsumoto, Akiko ^b   Zhong, Hui ^a   Ishihara, Akihiko ^b   Edgerton, V Reggie ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Inactivity; Motoneuron number; Motoneuron plasticity; Motoneuron soma size; Motoneuron soma succinate dehydrogenase activity

Indexed keywords

FLUORESCENT DYE; NUCLEAR YELLOW; SUCCINATE DEHYDROGENASE; UNCLASSIFIED DRUG;

ADAPTATION; AEROBIC METABOLISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LABELING; CONTROLLED STUDY; ENZYME ACTIVITY; EXTENSOR MUSCLE; FEMALE; FLEXOR MUSCLE; MORPHOLOGY; MOTONEURON; MUSCLE ACTION POTENTIAL; MUSCLE INNERVATION; MUSCLE METABOLISM; NEUROMUSCULAR FUNCTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; SOLEUS MUSCLE; SPINAL CORD; SPINAL CORD TRANSSECTION; TIBIALIS ANTERIOR MUSCLE; WEIGHT BEARING;

ANALYSIS OF VARIANCE; ANIMALS; AORTIC BODIES; CELL COUNT; CELL SIZE; ELECTROMYOGRAPHY; FEMALE; MOTOR NEURONS; MOTOR NEURONS, GAMMA; MUSCLE, SKELETAL; NEUROMUSCULAR JUNCTION; ORGAN SIZE; RATS; SPINAL CORD; SUCCINATE DEHYDROGENASE;

EID: 34547677744     PISSN: 0148639X     EISSN: 10974598     Source Type: Journal    
DOI: 10.1002/mus.20810     Document Type: Article

References (49)

1. Alaimo MA, Smith JL, Roy RR, Edgerton VR. EMG activity of slow and fast ankle extensors following spinal cord transection. J Appl Physiol 1984;56:1608-1613.
2. Beaumont E, Gardiner P. Effects of daily spontaneous running on the electrophysiological properties of hindlimb motoneurones in rats. J Physiol (Lond) 2002;540:129-138.
3. Beaumont E, Gardiner PF. Endurance training alters the biophysical properties of hindlimb motoneurons in rats. Muscle Nerve 2003;27:228-236.
4. Beaumont E, Houle JD, Peterson CA, Gardiner PF. Passive exercise and fetal spinal cord transplant both help to restore motoneuronal properties after spinal cord transection in rats. Muscle Nerve 2004;29:234-242.
5. Bjugn R, Nyengaard JR, Rosland JH. Spinal cord transection - no loss of distal ventral horn neurons. Modern stereological techniques reveal no transneuronal changes in the ventral horns of the mouse lumbar spinal cord after thoracic cord transection. Exp Neurol 1997;148:179-186.
6. Chalmers GR, Edgerton VR. Marked and variable inhibition by chemical fixation of cytochrome oxidase and succinate dehydrogenase in single motoneurons. J Histochem Cytochem 1989;37:899-901.
7. Chalmers GR, Roy RR, Edgerton VR. Adaptability of the oxidative capacity of motoneurons. Brain Res 1992;570:1-10.
8. Chalmers GR, Roy RR, Edgerton VR. Motoneuron and muscle fiber succinate dehydrogenase activity in control and overloaded plantaris. J Appl Physiol 1991;71:1589-1592.
9. Cope TC, Bodine SC, Fournier M, Edgerton VR. Soleus motor units in chronic spinal transected cats: physiological and morphological alterations. J Neurophysiol 1986;55:1202-1220.
10. Cormery B, Beaumont E, Csukly K, Gardiner P. Hindlimb unweighting for 2 weeks alters physiological properties of rat hindlimb motoneurones. J Physiol (Lond) 2005;568:841-850.
11. Cormery B, Marini JF, Gardiner PF. Changes in electrophysiological properties of tibial motoneurones in the rat following 4 weeks of tetrodotoxin-induced paralysis. Neurosci Lett 2000;287:21-24.
12. Desaulniers P, Lavoie PA, Gardiner PF. Habitual exercise enhances neuromuscular transmission efficacy of rat soleus muscle in situ. J Appl Physiol 2001;90:1041-1048.
13. Donselaar Y, Kernell D, Eerbeek O. Soma size and oxidative enzyme activity in normal and chronically stimulated motoneurones of the cat's spinal cord. Brain Res 1986;385:22-29.
14. Edgerton VR, Bodine-Fowler S, Roy RR, Ishihara A, Hodgson JA. Neuromuscular adaptation. In: Rowell LB, Shepherd, JT, editors. Handbook of physiology. Section 12. Exercise: regulation and integration of multiple systems. New York: Oxford University Press; 1996. p 54-88.
15. Edgerton VR, Roy RR. Nervous system and sensory adaptation: neural plasticity associated with chronic neuromuscular activity. In: Bouchard C, Shephard RJ, Stephens T, editors. Physical activity, fitness, and health: international proceedings and consensus statement, 2nd ed. Champaign, IL: Human Kinetics; 1994. p 511-520.
16. Gardiner PF, Seburn KL. The effects of tetrodotoxin-induced muscle paralysis on the physiological properties of muscle units and their innervating motoneurons in rat. J Physiol (Lond) 1997;499:207-216.
17. Gardiner PF. Changes in alpha-motoneuron properties with altered physical activity levels. Exerc Sport Sci Rev 2006;34:54-58.
18. Gerchman LB, Edgerton VR, Carrow RE. Effects of physical training on the histochemistry and morphology of ventral motor neurons. Exp Neurol 1975;49:790-801.
19. Gilliam TB, Roy RR, Taylor JF, Heusner WW, Van Huss WD. Ventral motor neuron alterations in rat spinal cord after chronic exercise. Experientia 1977;33:665-667.
20. Gomez-Pinilla F, Ying L, Opazo P, Roy RR, Edgerton VR. Exercise up-regulates the mRNA and protein for BDNF in the spinal cord and skeletal muscle. Eur J Neurosci 2001;13:1078-1084.
21. Grossman EJ, Roy RR, Talmadge RJ, Zhong H, Edgerton VR. Effects of inactivity on myosin heavy chain composition and size of rat soleus fibers. Muscle Nerve 1998;21:375-389.
22. Hensbergen E, Kernell D. Daily durations of spontaneous activity in cat's ankle muscles. Exp Brain Res 1997;115:325-332.
23. Hochman S, McCrea DA. Effects of chronic spinalization on ankle extensor motoneurons. II. Motoneuron electrical properties. J Neurophysiol 1994;71:1468-1479.
24. Hodgson JA, Roy RR, Higuchi N, Monti RJ, Zhong H, Grossman E, et al. Does daily activity level determine muscle phenotype? J Exp Biol 2005;208:3761-3770.
25. Ishihara A, Ohira Y, Roy RR, Nagaoka S, Sekiguchi C, Hinds WE, et al. Influence of spaceflight on succinate dehydrogenase activity and soma size of rat ventral horn neurons. Acta Anat 1996;157:303-308.
26. Ishihara A, Oishi Y, Roy RR, Edgerton VR. Influence of two weeks of non-weight bearing on rat soleus motoneurons and muscle fibers. Aviat Space Environ Med 1997;68:421-425.
27. Ishihara A, Roy RR, Edgerton VR. Succinate dehydrogenase activity and soma size of motoneurons innervating different portions of the rat tibialis anterior. Neuroscience 1995;68:813-822.
28. Ishihara A, Roy RR, Ohira Y, Edgerton VR. Motoneuron and sensory neuron plasticity to varying neuromuscular activity levels. Exerc Sports Sci Rev 2002;30:152-158.
29. Ishihara A, Yamashiro J, Matsumoto A, Higashibata A, Ishioka N, Shimazu T, et al. Comparison of cell body size and oxidative enzyme activity in motoneurons between the cervical and lumbar segments in the rat spinal cord after spaceflight and recovery. Neurochem Res 2006;31:411-415.
30. Ishihara A, Ohira Y, Roy RR, Nagaoka S, Sekiguchi C, Hinds W, et al. Comparison of the response of motoneurons innervating perineal and hindlimb muscles to spaceflight and recovery. Muscle Nerve 2000;23:753-762.
31. Jiang B, Roy RR, Polyakov IV, Krasnov IB, Edgerton VR. Ventral horn cell responses to spaceflight and hindlimb suspension. J Appl Physiol 1992;73(suppl):107S-111S.
32. Kang CM, Lavoie PA, Gardiner PF. Chronic exercise increases SNAP-25 abundance in fast-transported proteins of rat motoneurones. Neuroreport 1995;6:549-553.
33. Kavvano F, Nomura T, Ishihara A, Nonaka I, Ohira Y. Afferent input-associated reduction of muscle activity in microgravity environment. Neuroscience 2002;114:1133-1138.
34. McBride RL, Feringa ER. Ventral horn motoneurons 10, 20 and 52 weeks after T-9 spinal cord transection. Brain Res Bull 1992;28:57-60.
35. Miyata H, Kawai Y. Relationship between soma diameter and oxidative enzyme activity of alpha-motoneurons. Brain Res 1992;581:101-107.
36. Nakano H, Masuda K, Sasaki S, Katsuta S. Oxidative enzyme activity and soma size in motoneurons innervating the rat slow-twitch and fast-twitch muscles after chronic activity. Brain Res Bull 1997;43:149-154.
37. Pette D, Vrbova G. Neural control of phenotypic expression in mammalian muscle fibers. Muscle Nerve 1985;8:676-689.
38. Pierotti DJ, Roy RR, Bodine-Fowler SC, Hodgson JA, Edgerton VR. Mechanical and morphological properties of chronically inactive cat tibialis anterior motor units. J Physiol (Lond) 1991;444:175-192.
39. Pierotti DJ, Roy RR, Hodgson JA, Edgerton VR. Level of independence of motor unit properties from neuromuscular activity. Muscle Nerve 1994;17:1324-1335.
40. Recktenwald MR, Hodgson JA, Roy RR, Riazanski S, McCall GE, Koslovskaya I, et al. Effects of spaceflight on rhesus quadrupedal locomotion after return to 1G. J Neurophysiol 1999;81:2451-2463.
41. Roy RR, Baldwin KM, Edgerton VR. The plasticity of skeletal muscle: effects of neuromuscular activity. In: Holloszy JO, editor. Exercise and sport sciences reviews. Baltimore, MD: Williams & Wilkins; 1991. p 269-312.
42. Roy RR, Edgerton VR, Ishihara A. Influence of endurance training and detraining on motoneurone and sensory neurone morphology and metabolism. In: Shephard RJ, Astrand PO, editors. Endurance in sport, encyclopaedia of sports medicine, 2nd ed. Oxford: Blackwell Scientific; 2000. p 136-157.
43. Roy RR, Hodgson JA, Lauretz S, Pierotti DJ, Gaeak RJ, Edgerton VR. Chronic spinal cord injured cats: surgical procedures and management. Lab Anim Sci 1992;42:335-343.
44. Roy RR, Ishihara A, Kim JA, Lee M, Fox K, Edgerton VR. Metabolic and morphologic stability of motoneurons in response to chronically elevated neuromuscular activity. Neuroscience 1999;92:361-366.
45. Seburn K, Coicou C, Gardiner P. Effects of altered muscle activation on oxidative enzyme activity in rat alpha-motoneurons. J Appl Physiol 1994;77:2269-2274.
46. Suzuki H, Tsuzimoto H, Ishiko T, Kasuga N, Taguchi S, Ishihara A. Effect of endurance training on the oxidative enzyme activity of soleus motoneurons in rats. Acta Physiol Scand 1991;143:127-128.
47. Talmadge RJ, Roy RR, Caiozzo VJ, Edgerton VR. Mechanical properties of rat soleus after long-term spinal cord transection. J Appl Physiol 2002;93:1487-1497.
48. Tower SS. Function and structure in the chronically isolated lumbo-sacral spinal cord of the dog. J Comp Neurol 1937;67:109-131.
49. Ying Z, Roy RR, Edgerton VR, Gomez-Pinilla F. Voluntary exercise increases neurotrophin-3 and its receptor TrkC in the spinal cord. Brain Res 2003;987:93-99.