Serum levels of stem cell factor and thrombopoietin are markedly decreased in fulminant hepatic failure patients with a poor prognosis

Journal of Gastroenterology and Hepatology (Australia)

Volumn 22, Issue 8, 2007, Pages 1265-1270

  Okumoto, Kazuo ^a   Saito, Takafumi ^a   Onodera, Motoyuki ^a   Sakamoto, Ayuka ^a   Tanaka, Mamiko ^a   Hattori, Etsuko ^a   Haga, Hiroaki ^a   Ito, Jun Itsu ^a   Sugahara, Kazuhiko ^a   Saito, Koji ^a   Togashi, Hitoshi ^a   Kawata, Sumio ^a  

^a YAMAGATA UNIVERSITY   (Japan)

Author keywords

Bone marrow; Fulminant hepatitis; Growth factor; Liver regeneration; Stem cell

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; STEM CELL FACTOR; THROMBOPOIETIN;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL;

EID: 34547675753     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2006.04497.x     Document Type: Article

References (38)

1. Bucher NL. Experimental aspects of hepatic regeneration. N. Engl. J. Med. 1967 277 : 686 96.
2. Rubin EM, Martin AA, Thung SN, Gerber MA. Morphometric and immunohistochemical characterization of human liver regeneration. Am. J. Pathol. 1995 147 : 397 404.
3. Thorgeirsson SS. Hepatic stem cells in liver regeneration. FASEB J. 1996 10 : 1249 56.
4. Alison MR, Golding M, Sarraf CE, Edwards RJ, Lalani EN. Liver damage in the rat induces hepatocyte stem cells from biliary epithelial cells. Gastroenterology 1996 110 : 1182 90.
5. Fausto N. Hepatocyte differentiation and progenitor cells. Curr. Opin. Cell Biol. 1990 2 : 1036 42.
6. Pack R, Heck R, Dienes HP, Oesch F, Steinberg P. Isolation, biochemical characterization, long-term culture, and phenotype modulation of oval cells from carcinogen-fed rats. Exp. Cell Res. 1993 204 : 198 209.
7. Lemire JM, Shiojiri N, Fausto N. Oval cell proliferation and the origin of small hepatocytes in liver injury induced by d-galactosamine. Am. J. Pathol. 1991 139 : 535 52.
8. Yasui O, Miura N, Terada K, Kawarada Y, Koyama K, Sugiyama T. Isolation of oval cells from Long-Evans cinnamon rats and their transformation into hepatocytes in vivo in the rat liver. Hepatology 1997 25 : 329 34.
9. Petersen BE, Bowen WC, Patrene KD et al. Bone marrow as a potential source of hepatic oval cells. Science 1999 284 : 1168 70.
10. Lagasse E, Connors H, Al-Dhalimy M et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat. Med. 2000 6 : 1229 34.
11. Okumoto K, Saito T, Hattori E et al. Differentiation of bone marrow cells into cells that express liver-specific genes in vitro: implication of the Notch signals in differentiation. Biochem. Biophys. Res. Commun. 2003 304 : 691 5.
12. Okumoto K, Saito T, Hattori E et al. Expression of Notch signalling markers in bone marrow cells that differentiate into a liver cell lineage in a rat transplant model. Hepatol. Res. 2005 31 : 7 12.
13. Okumoto K, Saito T, Hattori E et al. Differentiation of rat bone marrow cells cultured on artificial basement membrane containing extracellular matrix into a liver cell lineage. J. Hepatol. 2005 43 : 110 16.
14. McNiece IK, Briddell RA, Hartley CA, Andrews RG. The role of stem cell factor in mobilization of peripheral blood progenitor cells: synergy with G-CSF. Stem Cells 1993 11 (Suppl. 3 83 8.
15. Uchida N, Dykstra B, Lyons KJ, Leung FY, Eaves CJ. Different in vivo repopulating activities of purified hematopoietic stem cells before and after being stimulated to divide in vitro with the same kinetics. Exp. Hematol. 2003 31 : 1338 47.
16. Ramsfjell V, Borge OJ, Veiby OP et al. Thrombopoietin, but not erythropoietin, directly stimulates multilineage growth of primitive murine bone marrow progenitor cells in synergy with early acting cytokines: distinct interactions with the ligands for c-kit and FLT3. Blood 1996 88 : 4481 92.
17. Fujio K, Evarts RP, Hu Z, Marsden ER, Thorgeirsson SS. Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat. Lab. Invest. 1994 70 : 511 16.
18. Matsusaka S, Tsujimura T, Toyosaka A et al. Role of c-kit receptor tyrosine kinase in development of oval cells in the rat 2-acetylaminofluorene/ partial hepatectomy model. Hepatology 1999 29 : 670 6.
19. Theocharis SE, Margeli AP, Kittas CN. Effect of granulocyte colony-stimulating-factor administration on tissue regeneration due to thioacetamide-induced liver injury in rats. Dig. Dis. Sci. 1999 44 : 1990 6.
20. Theocharis SE, Papadimitriou LJ, Retsou ZP, Margeli AP, Ninos SS, Papadimitriou JD. Granulocyte-colony stimulating factor administration ameliorates liver regeneration in animal model of fulminant hepatic failure and encephalopathy. Dig. Dis. Sci. 2003 48 : 1797 803.
21. Usuki K, Tahara T, Iki S et al. Serum thrombopoietin level in various hematological diseases. Stem Cells 1996 14 : 558 65.
22. Kato T, Matsumoto A, Ogami K, Tahara T, Morita H, Miyazaki H. Native thrombopoietin: structure and function. Stem Cells 1998 16 : 11 19.
23. Sato S, Suzuki K, Takikawa Y, Endo R, Omata M, Japanese National Study Group of Fulminant Hepatitis. Clinical epidemiology of fulminant hepatitis in Japan before the substantial introduction of liver transplantation: an analysis of 1309 cases in a 15-year national survey. Heptol. Res. 2004 30 : 135 61.
24. Kojima S, Matsuyama T, Kodera Y. Plasma levels and production of soluble stem cell factor by marrow stromal cells in patients with aplastic anaemia. Br. J. Haematol. 1997 99 : 440 6.
25. Summerfield A, Horn MP, Lozano G, Carrasco CP, Atze K, McCullough K. C-kit positive porcine bone marrow progenitor cells identified and enriched using recombinant stem cell factor. J. Immunol. Methods 2003 280 : 113 23.
26. Brugger W, Mocklin W, Heimfeld S, Berenson RJ, Mertelsmann R, Kanz L. Ex vivo expansion of enriched peripheral blood CD34+ progenitor cells by stem cell factor, interleukin-1 beta (IL-1 beta), IL-6, IL-3, interferon-gamma, and erythropoietin. Blood 1993 81 : 2579 84.
27. Baumann U, Crosby HA, Ramani P, Kelly DA, Strain AJ. Expression of the stem cell factor receptor c-kit in normal and diseased pediatric liver: identification of a human hepatic progenitor cell? Hepatology 1999 30 : 112 17.
28. Simpson K, Hogaboam CM, Kunkel SL, Harrison DJ, Bone-Larson C, Lukacs NW. Stem cell factor attenuates liver damage in a murine model of acetaminophen-induced hepatic injury. Lab. Invest. 2003 83 : 199 206.
29. Ren X, Hogaboam C, Carpenter A, Colletti L. Stem cell factor restores hepatocyte proliferation in IL-6 knockout mice following 70% hepatectomy. J. Clin. Invest. 2003 112 : 1407 18.
30. Nagahisa H, Nagata Y, Ohnuki T et al. Bone marrow stromal cells produce thrombopoietin and stimulate megakaryocyte growth and maturation but suppress proplatelet formation. Blood 1996 87 : 1309 16.
31. Wolber EM, Fandrey J, Frackowski U, Jelkmann W. Hepatic thrombopoietin mRNA is increased in acute inflammation. Thromb. Haemost. 2001 86 : 1421 4.
32. Schiodt FV, Balko J, Schilsky M, Harrison ME, Thornton A, Lee WM. Thrombopoietin in acute liver failure. Acute Liver Failure Study Group. Hepatology 2003 37 : 558 61.
33. Giannini E, Borro P, Botta F et al. Serum thrombopoietin levels are linked to liver function in untreated patients with hepatitis C virus-related chronic hepatitis. J. Hepatol. 2002 37 : 572 7.
34. Freni MA, Spadaro A, Ajello A et al. Serum thrombopoietin in chronic liver disease: relation to severity of the disease and spleen size. Hepatogastroenterology 2002 49 : 1382 5.
35. Koruk M, Onuk MD, Akcay F, Savas MC. Serum thrombopoietin levels in patients with chronic hepatitis and liver cirrhosis, and its relationship with circulating thrombocyte counts. Hepatogastroenterology 2002 49 : 1645 8.
36. Dokter WH, Dijkstra AJ, Koopmans SB et al. G (AnH) MTetra, a naturally occurring 1,6-anhydro muramyl dipeptide, induces granulocyte colony-stimulating factor expression in human monocytes: a molecular analysis. Infect. Immun. 1994 62 : 2953 7.
37. Hematti P, Tuchman S, Larochelle A, Metzger ME, Donahue RE, Tisdale JF. Comparison of retroviral transduction efficiency in CD34+ cells derived from bone marrow versus G-CSF-mobilized or G-CSF plus stem cell factor-mobilized peripheral blood in nonhuman primates. Stem Cells 2004 22 : 1062 9.
38. Fujii K, Ishimaru F, Kozuka T et al. Elevation of serum hepatocyte growth factor during granulocyte colony-stimulating factor-induced peripheral blood steG-CSFm cell mobilization. Br. J. Haematol. 2004 124 : 190 4.