Aging impairs neurogenic contraction in guinea pig urinary bladder: Role of oxidative stress and melatonin

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 293, Issue 2, 2007, Pages

  Gómez Pinilla, Pedro J ^a   Pozo, Maria J ^a   Camello, Pedro J ^a,b  

^a UNIVERSITY OF EXTREMADURA   (Spain)

^b Faculty of Veterinary Sciences   (Spain)

Author keywords

Detrusor smooth muscle; Electrical field stimulation; Neuromuscular function; Sensory nerves

Indexed keywords

MELATONIN;

ADRENERGIC RECEPTOR BLOCKING; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER CONTRACTION; CONTROLLED STUDY; DETRUSOR MUSCLE; DRUG MECHANISM; ELECTROSTIMULATION; FEMALE; GUINEA PIG; MUSCLE CELL; NERVE BLOCK; NEUROMUSCULAR FUNCTION; NITRERGIC NERVE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SENSORY NERVE; TREATMENT DURATION;

AGING; ANIMALS; ANTIOXIDANTS; ELECTRIC STIMULATION; FEMALE; GUINEA PIGS; MELATONIN; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NEURONS, AFFERENT; OXIDATIVE STRESS; URINARY BLADDER;

EID: 34547634575     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00034.2007     Document Type: Article

References (47)

1. Abalo R, Rivera AJ, Vera G, Suardiaz M, Martin MI. Evaluation of the effect of age on cannabinoid receptor functionality and expression in guinea-pig ileum longitudinal muscle-myenteric plexus preparations. Neurosci Lett 383: 176-181, 2005.
2. Andersson KE. Overactive bladder: pharmacological aspects. Scand J Urol Nephrol 36: 72-81, 2002.
3. Andersson KE, Arner A. Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiol Rev 84: 935-986, 2004.
4. Andersson KE, Wein AJ. Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence. Pharmacol Rev 56: 581-631, 2004.
5. Brading AF, Turner WH. The unstable bladder: towards a common mechanism. Br J Urol 73: 3-8, 1994.
6. Burnstock G, Williams M. P2 purinergic receptors: modulation of cell function and therapeutic potential. J Pharmacol Exp Ther 295: 862-869, 2000.
7. Chai TC, Andersson KE, Tuttle JB, Steers WD. Altered neural control of micturition in the aged F344 rat. Urol Res 28: 348-354, 2000.
8. Chess-Williams R, Chapple CR, Yamanishi T, Yasuda K, Sellers DJ. The minor population of M3-receptors mediate contraction of human detrusor muscle in vitro. J Auton Pharmacol 21: 243-248, 2001.
9. Daneshgari F, Huang X, Liu G, Bena J, Saffore L, Powell CT. Temporal differences in bladder dysfunction caused by diabetes, diuresis, and treated diabetes in mice. Am J Physiol Regul Integr Comp Physiol 290: R1728-R1735, 2006.
10. de Jongh R, Haenen GR, van Koeveringe GA, Dambros M, De Mey JG, van Kerrebroeck PE. Oxidative stress reduces the muscarinic receptor function in the urinary bladder. Neurourol Urodyn 26: 302-308, 2007.
11. Drake MJ, Mills IW, Noble JG. Melatonin pharmacotherapy for nocturia in men with benign prostatic enlargement. J Urol 171: 1199-1202, 2004.
12. Ehren I, Adolfsson J, Wiklund NP. Nitric-oxide synthase activity in the human urogenital tract. Urol Res 22: 287-290, 1994.
13. Ferguson DR, Kennedy I, Burton TJ. ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes: a possible sensory mechanism? J Physiol 505: 503-511, 1997.
14. Gilpin SA, Gilpin CJ, Dixon JS, Gosling JA, Kirby RS. The effect of age on the autonomic innervation of the urinary-bladder. Br J Urol 58: 378-381, 1986.
15. Goepel M, Wittmann A, Rubben H, Michel MC. Comparison of adrenoceptor subtype expression in porcine and human bladder and prostate. Urol Res 25: 199-206, 1997.
16. Gomez-Pinilla PJ, Camello-Almaraz C, Moreno R, Camello PJ, Pozo MJ. Melatonin treatment reverts age-related changes in Guinea pig gallbladder neuromuscular transmission and contractility. J Pharmacol Exp Ther 319: 847-856, 2006.
17. Gomez-Pinilla PJ, Gomez MF, Hedlund P, Swärd K, Hellstrand P, Camello PJ, Pozo MJ, Andersson KE. Effect of melatonin on age associated changes in Guinea pig bladder function. J Urol 177: 1558-1561, 2007.
18. Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 11: 298-300, 1956.
19. Hissin PJ, Hilf R. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 74: 214-226, 1976.
20. Hof PR, Morrison JH. The aging brain: morphomolecular senescence of cortical circuits. Trends Neurosci 27: 607-613, 2004.
21. Ishizuka J, Murakami M, Nichols GA, Cooper CW, Greeley GH Jr, Thompson JC. Age-related changes in gallbladder contractility and cytoplasmic Ca2 concentration in the guinea pig. Am J Physiol Gastrointest Liver Physiol 264: G624-G629, 1993.
22. James MJ, Birmingham AT, Hill SJ. Partial mediation by nitric-oxide of the relaxation of human isolated detrusor strips in response to electrical-field stimulation. Br J Clin Pharmacol 35: 366-372, 1993.
23. Karasek M. Melatonin, human aging, and age-related diseases. Exp Gerontol 39: 1723-1729, 2004.
24. Kinder RB, Mundy AR. Atropine blockade of nerve-mediated stimulation of the human detrusor. Br J Urol 57: 418-421, 1985.
25. Klarskov P. Noncholinergic, nonadrenergic inhibitory nerve responses of bladder outlet smooth-muscle in vitro. Br J Urol 60: 337-342, 1987.
26. Kolta MG, Wallace LJ, Gerald MC. Age-related changes in sensitivity of rat urinary bladder to autonomic agents. Mech Ageing Dev 27: 183-188, 1984.
27. Lecci A, Capriati A, Altamura M, Maggi CA. Tachykinins and tachykinin receptors in the gut, with special reference to NK2 receptors in human. Auton Neurosci 126-127: 232-249, 2006.
28. Lecci A, Maggi CA. Tachykinins as modulators of the micturition reflex in the central and peripheral nervous system. Regul Pept 101: 1-18, 2001.
29. Leon J, Acuna-Castroviejo D, Escames G, Tan DX, Reiter RJ. Melatonin mitigates mitochondrial malfunction. J Pineal Res 38: 1-9, 2005.
30. Lin AT, Chen MT, Yang CH, Chang LS. Blood flow of the urinary bladder: effects of outlet obstruction and correlation with bioenergetic metabolism. Neurourol Urodyn 14: 285-292, 1995.
31. Lluel P, Deplanne V, Heudes D, Bruneval P, Palea S. Age-related changes in urethrovesical coordination in male rats: relationship with bladder instability? Am J Physiol Regul Integr Comp Physiol 284: R1287-R1295, 2003.
32. Lluel P, Palea S, Barras M, Grandadam F, Heudes D, Bruneval P, Corman B, Martin DJ. Functional and morphological modifications of the urinary bladder in aging female rats. Am J Physiol Regul Integr Comp Physiol 278: R964-R972, 2000.
33. Mumtaz FH, Khan MA, Thompson CS, Morgan RJ, Mikhailidis DP. Nitric oxide in the lower urinary tract: physiological and pathological implications. BJU Int 85: 567-578, 2000.
34. Munro DD, Wendt IR. Contractile and metabolic properties of longitudinal smooth muscle from rat urinary bladder and the effects of aging. J Urol 150: 529-536, 1993.
35. Nava M, Romero F, Quiroz Y, Parra G, Bonet L, Rodriguez-Iturbe B. Melatonin attenuates acute renal failure and oxidative stress induced by mercuric chloride in rats. Am J Physiol Renal Physiol 279: F910-F918, 2000.
36. Paskaloglu K, Sener G, Ayanoglu-Dulger G. Melatonin treatment protects against diabetes-induced functional and biochemical changes in rat aorta and corpus cavernosum. Eur J Pharmacol 499: 345-354, 2004.
37. Perlberg S, Caine M. Adrenergic response of bladder muscle in prostatic obstruction: its relation to detrusor instability. Urology 20: 524-527, 1982.
38. Pieri C, Marra M, Moroni F, Recchioni R, Marcheselli F. Melatonin: a peroxyl radical scavenger more effective than vitamin E. Life Sci 55: L271-L276, 1994.
39. Sainz RM, Mayo JC, Uria H, Kotler M, Antolin I, Rodriguez C, Menendez-Pelaez A. The pineal neurohormone melatonin prevents in vivo and in vitro apoptosis in thymocytes. J Pineal Res 19: 178-188, 1995.
40. Saito M, Kondo A, Gotoh M, Kato K, Levin RM. Age-related changes in the response of the rat urinary bladder to neurotransmitters. Neurourol Urodyn 12: 191-200, 1993.
41. Saito M, Wada K, Kamisaki Y, Miyagawa I. Effect of ischemiareperfusion on contractile function of rat urinary bladder: possible role of nitric oxide. Life Sci 62: L149-L156, 1998.
42. Taira N. The autonomic pharmacology of bladder. Annu Rev Pharmacol 12: 197-208, 1972.
43. Tan DX, Chen LD, Poeggeler B, Manchester LC, Reiter RJ. Melatonin: a potent endogenous hydroxyl radical scavenger. Endocr J 1: 57-60, 1993.
44. Toyoshima A, Onodera S, Yoshinaga M, Takenaga K, Uchiyama T. Effects of aging and the autonomic nervous system-related agents on the intravesical pressure of the bladder in situ in female rats. Nippon Yakurigaku Zasshi 96: 103-115, 1990.
45. Waller RL, Recknagel RO. Determination of lipid conjugated dienes with tetracyanoethylene-14C: significance for study of the pathology of lipid peroxidation. Lipids 12: 914-921, 1977.
46. Yoshida M, Homma Y, Inadome A, Yono M, Seshita H, Miyamoto Y, Murakami S, Kawabe K, Ueda S. Age-related changes in cholinergic and purinergic neurotransmission in human isolated bladder smooth muscles. Exp Gerontol 36: 99-109, 2001.
47. Yu HJ, Wein AJ, Levin RM. Age-related differential susceptibility to calcium channel blocker and low calcium medium in rat detrusor muscle: response to field stimulation. Neurourol Urodyn 15: 563-576, 1996.