Endothelin and aged blood vessels: One more reason to get off the couch?

Hypertension

Volumn 50, Issue 2, 2007, Pages 292-293

  Thijssen, Dick H J ^a   Hopman, Maria T E ^a   Levine, Benjamin D ^b  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN;

AGING; BLOOD VESSEL TONE; CARDIOVASCULAR RISK; EDITORIAL; EXERCISE; HEART HEMODYNAMICS; HUMAN; IMMOBILIZATION; NONHUMAN; PRIORITY JOURNAL; SENESCENCE;

ADULT; AGED; AGING; ANIMALS; BIOLOGICAL MARKERS; BLOOD VESSELS; CARDIOVASCULAR DISEASES; DISEASE MODELS, ANIMAL; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; EXERCISE; FEMALE; HUMANS; HYPERTENSION; LIFE STYLE; MALE; MIDDLE AGED; PROGNOSIS; RATS; RATS, INBRED SHR; RISK ASSESSMENT; TUNICA MEDIA; VASCULAR RESISTANCE;

EID: 34547615144     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.107.091686     Document Type: Editorial

References (13)

1. Arbab-Zadeh A, Dijk E, Prasad A, Fu Q, Torres P, Zhang R, Thomas JD, Palmer D, Levine BD. Effect of aging and physical activity on left ventricular compliance. Circulation. 2004;110:1799-1805.
2. Dinenno FA, Tanaka H, Stauffer BL, Seals DR. Reductions in basal limb blood flow and vascular conductance with human aging: role for augmented alpha-adrenergic vasoconstriction. J Physiol. 2001;536:977-983.
3. Lind L, Lithell H. Decreased peripheral blood flow in the pathogenesis of the metabolic syndrome comprising hypertension, hyperlipidemia, and hyperinsulinemia. Am Heart J. 1993;125:1494 -1497.
4. Schiffrin EL. Vascular endothelin in hypertension. Vascul Pharmacol. 2005;43:19-29.
5. Korzick DH, Muller-Delp JM, Dougherty P, Heaps CL, Bowles DK, Krick KK. Exaggerated coronary vasoreactivity to endothelin-1 in aged rats: role of protein kinase C. Cardiovasc Res. 2005;66:384-392.
6. Goodwin AT, Amrani M, Marchbank AJ, Gray CC, Jayakumar J, Yacoub MH. Coronary vasoconstriction to endothelin-1 increases with age before and after ischaemia and reperfusion. Cardiovasc Res. 1999;41:554-562.
7. Donato AJ, Lesniewski LA, Delp MD. The effects of aging and exercise training on endothelin-1 vasoconstrictor responses in rat skeletal muscle arterioles. Cardiovasc Res. 2005;66:393- 401.
8. Van Guilder GP, Westby CM, Greiner JJ, Stauffer BL, DeSouza CA. Endothelin-1 vasoconstrictor tone increases with age in healthy men but can be reduced by regular aerobic exercise. Hypertension. 2007;50:403-409.
9. Pawelczyk JA, Levine BD. Heterogeneous responses of human limbs to infused adrenergic agonists: a gravitational effect? J Appl Physiol. 2002;92:2105-2113.
10. O'Leary DS. Regional vascular resistance vs conductance: which index for baroreflex responses? Am J Physiol. 1991;260:H632-H637.
11. McGuire DK, Levine BD, Williamson JW, Snell PG, Blomqvist CG, Saltin B, Mitchell JH. A 30-year follow-up of the Dallas Bedrest and Training Study: I. effect of age on the cardiovascular response to exercise. Circulation. 2001;104:1350-1357.
12. Thijssen DH, Ellenkamp R, Kooijman M, Pickkers P, Rongen GA, Hopman MT, Smits P. A causal role for endothelin-1 in the vascular adaptation to skeletal muscle deconditioning in spinal cord injury. Arterioscler Thromb Vasc Biol. 2007;27:325-331.
13. Kelland NF, Webb DJ. Clinical trials of endothelin antagonists in heart failure: a question of dose? Exp Biol Med (Maywood). 2006;231:696-699.